KEGG   COMPOUND: C08526
Entry
C08526                      Compound                               

Name
Galanthamine;
Galantamine
Formula
C17H21NO3
Exact mass
287.1521
Mol weight
287.3535
Structure
Remark
Same as: D04292
Reaction
Pathway
map00950  Isoquinoline alkaloid biosynthesis
map01063  Biosynthesis of alkaloids derived from shikimate pathway
map01110  Biosynthesis of secondary metabolites
Enzyme
2.1.1.-
Brite
Phytochemical compounds [BR:br08003]
 Alkaloids
  Alkaloids derived from tyrosine
   Isoquinoline alkaloids
    C08526  Galanthamine
Natural toxins [BR:br08009]
 Phytotoxins
  Alkaloids
   Isoquinoline alkaloids
    C08526  Galanthamine
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06D ANTI-DEMENTIA DRUGS
    N06DA Anticholinesterases
     N06DA04 Galantamine
      D04292  Galantamine (USAN/INN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01595  Cholinesterase inhibitor
   DG01593  Acetylcholinesterase inhibitor
    DG00985  Galantamine
     D04292  Galantamine
  DG01968  Antidementia agent
   DG00985  Galantamine
    D04292  Galantamine
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00985  Galantamine
    D04292  Galantamine
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00985  Galantamine
     D04292  Galantamine
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   Carboxylic-ester hydrolases
    ACHE
     D04292  Galantamine (USAN/INN)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D04292
Other DBs
CAS: 357-70-0
PubChem: 10719
ChEBI: 42944
ChEMBL: CHEMBL1624158 CHEMBL659
KNApSAcK: C00001570
PDB-CCD: GNT[PDBj]
3DMET: B02196
NIKKAJI: J11.407C
LinkDB
KCF data

ATOM        21
            1   C8y C    23.0362  -23.9428
            2   C1x C    24.0864  -24.7130
            3   N1y N    25.4167  -24.4329
            4   C1x C    25.9769  -23.1727
            5   C8y C    23.0362  -22.5425
            6   C1x C    25.4167  -21.9824
            7   C1z C    24.0864  -21.4923
            8   C1a C    26.3270  -25.4832
            9   C8x C    21.8459  -24.6430
            10  C8x C    20.6556  -23.9428
            11  C8y C    20.6556  -22.5425
            12  C8y C    21.8459  -21.8423
            13  O2a O    19.4654  -21.9124
            14  O2x O    22.1960  -20.2320
            15  C1y C    23.5963  -20.1620
            16  C1x C    24.2265  -19.0417
            17  C1y C    25.6268  -19.0417
            18  C2x C    26.3270  -20.2320
            19  C2x C    25.6268  -21.4923
            20  O1a O    26.3270  -17.7814
            21  C1a C    18.2792  -22.6565
BOND        24
            1     3   4 1
            2     1   5 2
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     7   6 1 #Down
            8     3   8 1
            9     1   9 1
            10    9  10 2
            11   10  11 1
            12   11  12 2
            13    5  12 1
            14   11  13 1
            15   12  14 1
            16   14  15 1
            17    7  15 1
            18   15  16 1
            19   16  17 1
            20   17  18 1
            21    7  19 1
            22   19  18 2
            23   17  20 1 #Up
            24   13  21 1

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