KEGG   COMPOUND: C14819
Entry
C14819                      Compound                               
Name
Fe3+;
Fe(III);
Ferric ion;
Iron(3+)
Formula
Fe
Exact mass
55.9349
Mol weight
55.85
Structure
Reaction
R00078 R00092 R04155 R05318 R09422 R09541 R09739
Pathway
map00860  Porphyrin metabolism
map02010  ABC transporters
map02020  Two-component system
map04216  Ferroptosis
map04350  TGF-beta signaling pathway
map04978  Mineral absorption
Network
nt06525  Ferroptosis
Enzyme
1.9.98.1        1.16.1.7        1.16.1.9        1.16.3.1        
7.2.1.3
Other DBs
PubChem: 17395817
ChEBI: 29034
PDB-CCD: FE[PDBj]
NIKKAJI: J300.942D
LinkDB
KCF data

ATOM        1
            1   Z   Fe   27.9300  -17.6400 #3+
BOND        0

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KEGG   Homo sapiens (human): 2495
Entry
2495              CDS       T01001                                 
Symbol
FTH1, FHC, FTH, FTHL6, HFE5, NBIA9, PIG15, PLIF
Name
(RefSeq) ferritin heavy chain 1
  KO
K00522  ferritin heavy chain [EC:1.16.3.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00860  Porphyrin metabolism
hsa04216  Ferroptosis
hsa04217  Necroptosis
hsa04978  Mineral absorption
Network
nt06525  Ferroptosis
  Element
N01588  Fe3+ Ferritin transport
Disease
H00211  Hemochromatosis
H00833  Neurodegeneration with brain iron accumulation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00860 Porphyrin metabolism
    2495 (FTH1)
 09140 Cellular Processes
  09143 Cell growth and death
   04216 Ferroptosis
    2495 (FTH1)
   04217 Necroptosis
    2495 (FTH1)
 09150 Organismal Systems
  09154 Digestive system
   04978 Mineral absorption
    2495 (FTH1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    2495 (FTH1)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.16  Oxidizing metal ions
   1.16.3  With oxygen as acceptor
    1.16.3.1  ferroxidase
     2495 (FTH1)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   2495 (FTH1)
  Exosomal proteins of bladder cancer cells
   2495 (FTH1)
SSDB
Motif
Pfam: Ferritin Rubrerythrin wnt
Other DBs
NCBI-GeneID: 2495
NCBI-ProteinID: NP_002023
OMIM: 134770
HGNC: 3976
Ensembl: ENSG00000167996
UniProt: P02794
Structure
LinkDB
Position
11:complement(61964285..61967634)
AA seq 183 aa
MTTASTSQVRQNYHQDSEAAINRQINLELYASYVYLSMSYYFDRDDVALKNFAKYFLHQS
HEEREHAEKLMKLQNQRGGRIFLQDIKKPDCDDWESGLNAMECALHLEKNVNQSLLELHK
LATDKNDPHLCDFIETHYLNEQVKAIKELGDHVTNLRKMGAPESGLAEYLFDKHTLGDSD
NES
NT seq 552 nt   +upstreamnt  +downstreamnt
atgacgaccgcgtccacctcgcaggtgcgccagaactaccaccaggactcagaggccgcc
atcaaccgccagatcaacctggagctctacgcctcctacgtttacctgtccatgtcttac
tactttgaccgcgatgatgtggctttgaagaactttgccaaatactttcttcaccaatct
catgaggagagggaacatgctgagaaactgatgaagctgcagaaccaacgaggtggccga
atcttccttcaggatatcaagaaaccagactgtgatgactgggagagcgggctgaatgca
atggagtgtgcattacatttggaaaaaaatgtgaatcagtcactactggaactgcacaaa
ctggccactgacaaaaatgacccccatttgtgtgacttcattgagacacattacctgaat
gagcaggtgaaagccatcaaagaattgggtgaccacgtgaccaacttgcgcaagatggga
gcgcccgaatctggcttggcggaatatctctttgacaagcacaccctgggagacagtgat
aatgaaagctaa

KEGG   Homo sapiens (human): 2512
Entry
2512              CDS       T01001                                 
Symbol
FTL, FTL1, LFTD, NBIA3
Name
(RefSeq) ferritin light chain
  KO
K13625  ferritin light chain
Organism
hsa  Homo sapiens (human)
Pathway
hsa00860  Porphyrin metabolism
hsa04216  Ferroptosis
hsa04217  Necroptosis
hsa04978  Mineral absorption
Network
nt06525  Ferroptosis
  Element
N01588  Fe3+ Ferritin transport
Disease
H00833  Neurodegeneration with brain iron accumulation
H01779  Neuroferritinopathy
H02204  Hereditary hyperferritinaemia-cataract syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00860 Porphyrin metabolism
    2512 (FTL)
 09140 Cellular Processes
  09143 Cell growth and death
   04216 Ferroptosis
    2512 (FTL)
   04217 Necroptosis
    2512 (FTL)
 09150 Organismal Systems
  09154 Digestive system
   04978 Mineral absorption
    2512 (FTL)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    2512 (FTL)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   2512 (FTL)
SSDB
Motif
Pfam: Ferritin Amidohydro_1 EIAV_Rev
Other DBs
NCBI-GeneID: 2512
NCBI-ProteinID: NP_000137
OMIM: 134790
HGNC: 3999
Ensembl: ENSG00000087086
UniProt: P02792 A0A384MDR3
Structure
LinkDB
Position
19:48965309..48966879
AA seq 175 aa
MSSQIRQNYSTDVEAAVNSLVNLYLQASYTYLSLGFYFDRDDVALEGVSHFFRELAEEKR
EGYERLLKMQNQRGGRALFQDIKKPAEDEWGKTPDAMKAAMALEKKLNQALLDLHALGSA
RTDPHLCDFLETHFLDEEVKLIKKMGDHLTNLHRLGGPEAGLGEYLFERLTLKHD
NT seq 528 nt   +upstreamnt  +downstreamnt
atgagctcccagattcgtcagaattattccaccgacgtggaggcagccgtcaacagcctg
gtcaatttgtacctgcaggcctcctacacctacctctctctgggcttctatttcgaccgc
gatgatgtggctctggaaggcgtgagccacttcttccgcgaattggccgaggagaagcgc
gagggctacgagcgtctcctgaagatgcaaaaccagcgtggcggccgcgctctcttccag
gacatcaagaagccagctgaagatgagtggggtaaaaccccagacgccatgaaagctgcc
atggccctggagaaaaagctgaaccaggcccttttggatcttcatgccctgggttctgcc
cgcacggacccccatctctgtgacttcctggagactcacttcctagatgaggaagtgaag
cttatcaagaagatgggtgaccacctgaccaacctccacaggctgggtggcccggaggct
gggctgggcgagtatctcttcgaaaggctcactctcaagcacgactaa

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