KEGG   DRUG: Tobramycin
Entry
D00063                      Drug                                   

Name
Tobramycin (JP18/USP);
Tobi (TN);
Tobracin (TN);
Tobrex (TN);
Bethkis (TN)
Product
  Generic
TOBRAMYCIN (A-S Medication Solutions), TOBRAMYCIN (A-S Medication Solutions), TOBRAMYCIN (Akorn), TOBRAMYCIN (Akorn), TOBRAMYCIN (Amneal Pharmaceuticals LLC), TOBRAMYCIN (Asclemed USA), TOBRAMYCIN (Aurobindo Pharma Limited), TOBRAMYCIN (Bausch & Lomb Incorporated), TOBRAMYCIN (DirectRX), TOBRAMYCIN (FOSUN PHARMA USA), TOBRAMYCIN (Genericus), TOBRAMYCIN (Gland Pharma Limited), TOBRAMYCIN (Henry Schein), TOBRAMYCIN (Lupin Pharmaceuticals), TOBRAMYCIN (MWI), TOBRAMYCIN (Medsource Pharmaceuticals), TOBRAMYCIN (Medsource Pharmaceuticals), TOBRAMYCIN (NuCare Pharmaceuticals), TOBRAMYCIN (NuCare Pharmaceuticals), TOBRAMYCIN (Preferred Pharmaceuticals), TOBRAMYCIN (Proficient Rx LP), TOBRAMYCIN (Proficient Rx LP), TOBRAMYCIN (Proficient Rx LP), TOBRAMYCIN (Proficient Rx LP), TOBRAMYCIN (Quality Care Products), TOBRAMYCIN (REMEDYREPACK), TOBRAMYCIN (RPK Pharmaceuticals), TOBRAMYCIN (RPK Pharmaceuticals), TOBRAMYCIN (RPK Pharmaceuticals), TOBRAMYCIN (RPK Pharmaceuticals), TOBRAMYCIN (Sandoz), TOBRAMYCIN (Somerset Therapeutics), TOBRAMYCIN (St. Mary's Medical Park Pharmacy), TOBRAMYCIN (Sun Pharmaceutical Industries), TOBRAMYCIN (Teva Pharmaceuticals USA), TOBRAMYCIN (Teva Pharmaceuticals USA), TOBRAMYCIN INHALATION (Prasco), TOBRAMYCIN INHALATION SOLUTION (Dr. Reddy's Laboratories), TOBRAMYCIN INHALATION SOLUTION (NorthStar RxLLC), TOBRAMYCIN OPHTHALMIC SOLUTION (Alembic Pharmaceuticals)
Formula
C18H37N5O9
Exact mass
467.2591
Mol weight
467.5145
Structure
Simcomp
Source
Streptomyces tenebrarius [TAX:1933]
Class
Antibacterial
 DG01447  Aminoglycoside antibiotic
Remark
Same as: C00397
Therapeutic category: 1317 6123
ATC code: J01GB01 S01AA12
Chemical structure group: DG00608
Product (DG00608): D00063<JP/US> D02542<US>
Product (mixture): D11178<US> D12133<US>
Efficacy
Antibacterial, Protein biosynthesis inhibitor
  Disease
Cystic fibrosis patients with Pseudomonas aeruginosa [DS:H00218]
Target
50S ribosomal subunit
30S ribosomal subunit
  Pathway
ko03010  Ribosome
Interaction
Biosynthesis
map00524  Neomycin, kanamycin and gentamicin biosynthesis
Structure map
map07021  Aminoglycosides
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01G AMINOGLYCOSIDE ANTIBACTERIALS
    J01GB Other aminoglycosides
     J01GB01 Tobramycin
      D00063  Tobramycin (JP18/USP) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AA Antibiotics
     S01AA12 Tobramycin
      D00063  Tobramycin (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
 Antibacterials
  Aminoglycosides
   Tobramycin
    D00063  Tobramycin (JP18/USP)
 Ophthalmic Agents
  Ophthalmic Anti-Infectives
   Antibacterials, Ophthalmic
    Tobramycin
     D00063  Tobramycin (JP18/USP)
 Respiratory Tract/Pulmonary Agents
  Cystic Fibrosis Agents
   Inhaled Anti-infectives
    Tobramycin
     D00063  Tobramycin (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1317  Ophthalmic antibiotics
     D00063  Tobramycin (JP18/USP)
 6  Agents against pathologic organisms and parasites
  61  Antibiotics
   612  Acting mainly on gram-negative bacteria
    6123  Amino sugars
     D00063  Tobramycin (JP18/USP)
Antimicrobials [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   Aminoglycoside
    D00063  Tobramycin (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00063  Tobramycin
  D00063 Tobramycin injection
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D00063
Antimicrobials abbreviations [BR:br08327]
 Antibacterials
  Protein biosynthesis inhibitor
   Aminoglycoside
    DG00608  Tobramycin
Other DBs
CAS: 32986-56-4
PubChem: 7847131
ChEBI: 28864
ChEMBL: CHEMBL1747
DrugBank: DB00684
PDB-CCD: TOY[PDBj]
LigandBox: D00063
NIKKAJI: J4.533K
LinkDB
KCF data

ATOM        32
            1   C1y C    20.6560  -20.0968
            2   C1y C    20.6560  -21.4973
            3   C1y C    21.8689  -22.1975
            4   C1y C    23.0818  -21.4973
            5   C1y C    23.0818  -20.0968
            6   O2x O    21.8689  -19.3965
            7   C1b C    19.4432  -19.3965
            8   O1a O    18.2473  -20.0872
            9   O1a O    19.4432  -22.1975
            10  N1a N    21.8689  -23.5978
            11  O1a O    24.3134  -22.2085
            12  O2a O    24.3134  -19.3855
            13  C1y C    25.4878  -18.6963
            14  C1y C    26.7056  -19.3879
            15  C1x C    27.9134  -18.6791
            16  C1y C    27.9035  -17.2786
            17  C1y C    26.6857  -16.5869
            18  C1y C    25.4779  -17.2958
            19  N1a N    26.7157  -20.7965
            20  N1a N    29.0779  -16.5893
            21  O1a O    24.2675  -16.6084
            22  O2a O    26.6757  -15.1950
            23  C1y C    27.8854  -14.4851
            24  O2x O    29.0946  -15.1718
            25  C1y C    30.3025  -14.4631
            26  C1y C    30.2926  -13.0626
            27  C1x C    29.0835  -12.3758
            28  C1y C    27.8755  -13.0846
            29  C1b C    31.5468  -15.1693
            30  N1a N    31.5569  -16.5953
            31  O1a O    31.5060  -12.3503
            32  N1a N    26.6567  -12.3923
BOND        34
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     1   7 1 #Up
            8     7   8 1
            9     2   9 1 #Down
            10    3  10 1 #Up
            11    4  11 1 #Down
            12    5  12 1 #Down
            13   13  12 1 #Down
            14   13  14 1
            15   14  15 1
            16   15  16 1
            17   16  17 1
            18   17  18 1
            19   13  18 1
            20   14  19 1 #Up
            21   16  20 1 #Up
            22   18  21 1 #Up
            23   17  22 1 #Down
            24   23  22 1 #Down
            25   23  24 1
            26   24  25 1
            27   25  26 1
            28   26  27 1
            29   27  28 1
            30   23  28 1
            31   25  29 1 #Up
            32   29  30 1
            33   26  31 1 #Down
            34   28  32 1 #Down

» Japanese version   » Back

KEGG   DRUG: Tobramycin sulfate
Entry
D02542                      Drug                                   

Name
Tobramycin sulfate (USP);
Nebcin (TN)
Product
  Generic
Formula
(C18H37N5O9)2. 5H2SO4
Exact mass
1424.3552
Mol weight
1425.4214
Structure
Class
Antibacterial
 DG01447  Aminoglycoside antibiotic
Remark
ATC code: J01GB01 S01AA12
Chemical structure group: DG00608
Product (DG00608): D00063<JP/US> D02542<US>
Efficacy
Antibacterial, Protein biosynthesis inhibitor
Target
50S ribosomal subunit
30S ribosomal subunit
  Pathway
ko03010  Ribosome
Interaction
Structure map
map07021  Aminoglycosides
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01G AMINOGLYCOSIDE ANTIBACTERIALS
    J01GB Other aminoglycosides
     J01GB01 Tobramycin
      D02542  Tobramycin sulfate (USP) <US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AA Antibiotics
     S01AA12 Tobramycin
      D02542  Tobramycin sulfate (USP) <US>
USP drug classification [BR:br08302]
 Antibacterials
  Aminoglycosides
   Tobramycin
    D02542  Tobramycin sulfate (USP)
 Ophthalmic Agents
  Ophthalmic Anti-Infectives
   Antibacterials, Ophthalmic
    Tobramycin
     D02542  Tobramycin sulfate (USP)
 Respiratory Tract/Pulmonary Agents
  Cystic Fibrosis Agents
   Inhaled Anti-infectives
    Tobramycin
     D02542  Tobramycin sulfate (USP)
Antimicrobials [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   Aminoglycoside
    D02542  Tobramycin sulfate (USP) <US>
Antimicrobials abbreviations [BR:br08327]
 Antibacterials
  Protein biosynthesis inhibitor
   Aminoglycoside
    DG00608  Tobramycin
Other DBs
CAS: 79645-27-5
PubChem: 17396713
ChEMBL: CHEMBL3989564
DrugBank: DB00684
LigandBox: D02542
LinkDB
KCF data

ATOM        89
            1   C1y C    16.6047  -20.3920
            2   C1y C    16.6047  -21.7937
            3   C1y C    17.7961  -22.4945
            4   C1y C    19.0576  -21.7937
            5   C1y C    19.0576  -20.3920
            6   O2x O    17.7961  -19.6912
            7   C1b C    15.4133  -19.6912
            8   O1a O    14.2218  -20.3920
            9   O1a O    15.4133  -22.4945
            10  N1a N    17.7961  -23.8962
            11  O1a O    20.2490  -22.4945
            12  O2a O    20.2490  -19.6912
            13  C1y C    21.4404  -18.9904
            14  C1y C    22.7019  -19.6912
            15  C1x C    23.8933  -18.9904
            16  C1y C    23.8933  -17.5887
            17  C1y C    22.6318  -16.8879
            18  C1y C    21.4404  -17.5887
            19  N1a N    22.7019  -21.0929
            20  N1a N    25.0146  -16.8879
            21  O1a O    20.2490  -16.8879
            22  O2a O    22.6318  -15.4862
            23  C1y C    23.8232  -14.7854
            24  O2x O    25.0847  -15.4862
            25  C1y C    26.2761  -14.7854
            26  C1y C    26.2761  -13.3838
            27  C1x C    25.0146  -12.6829
            28  C1y C    23.8232  -13.3838
            29  C1b C    27.5376  -15.4862
            30  N1a N    27.5376  -16.8879
            31  O1a O    27.4675  -12.6128
            32  N1a N    22.6318  -12.6829
            33  S4a S    33.9151  -18.7101
            34  O1d O    33.9151  -20.1117
            35  O1d O    33.9151  -17.3084
            36  O1d O    35.3168  -18.7101
            37  O1d O    32.5135  -18.7101
            38  C1y C    16.6047  -20.3920
            39  C1y C    16.6047  -21.7937
            40  C1y C    17.7961  -22.4945
            41  C1y C    19.0576  -21.7937
            42  C1y C    19.0576  -20.3920
            43  O2x O    17.7961  -19.6912
            44  O2a O    20.2490  -19.6912
            45  C1y C    21.4404  -18.9904
            46  C1y C    22.7019  -19.6912
            47  C1x C    23.8933  -18.9904
            48  C1y C    23.8933  -17.5887
            49  C1y C    22.6318  -16.8879
            50  C1y C    21.4404  -17.5887
            51  O1a O    20.2490  -16.8879
            52  O2a O    22.6318  -15.4862
            53  C1y C    23.8232  -14.7854
            54  O2x O    25.0847  -15.4862
            55  C1y C    26.2761  -14.7854
            56  C1y C    26.2761  -13.3838
            57  C1x C    25.0146  -12.6829
            58  C1y C    23.8232  -13.3838
            59  N1a N    22.6318  -12.6829
            60  O1a O    27.4675  -12.6128
            61  C1b C    27.5376  -15.4862
            62  N1a N    27.5376  -16.8879
            63  N1a N    25.0146  -16.8879
            64  N1a N    22.7019  -21.0929
            65  O1a O    20.2490  -22.4945
            66  N1a N    17.7961  -23.8962
            67  O1a O    15.4133  -22.4945
            68  C1b C    15.4133  -19.6912
            69  O1a O    14.2218  -20.3920
            70  S4a S    33.9151  -18.7101
            71  O1d O    33.9151  -20.1117
            72  O1d O    33.9151  -17.3084
            73  O1d O    35.3168  -18.7101
            74  O1d O    32.5135  -18.7101
            75  S4a S    33.9151  -18.7101
            76  O1d O    33.9151  -20.1117
            77  O1d O    33.9151  -17.3084
            78  O1d O    35.3168  -18.7101
            79  O1d O    32.5135  -18.7101
            80  S4a S    33.9151  -18.7101
            81  O1d O    33.9151  -20.1117
            82  O1d O    33.9151  -17.3084
            83  O1d O    35.3168  -18.7101
            84  O1d O    32.5135  -18.7101
            85  S4a S    33.9151  -18.7101
            86  O1d O    33.9151  -20.1117
            87  O1d O    33.9151  -17.3084
            88  O1d O    35.3168  -18.7101
            89  O1d O    32.5135  -18.7101
BOND        88
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     1   7 1 #Up
            8     7   8 1
            9     2   9 1 #Down
            10    3  10 1 #Up
            11    4  11 1 #Down
            12    5  12 1 #Down
            13   13  12 1 #Down
            14   13  14 1
            15   14  15 1
            16   15  16 1
            17   16  17 1
            18   17  18 1
            19   13  18 1
            20   14  19 1 #Up
            21   16  20 1 #Up
            22   18  21 1 #Up
            23   17  22 1 #Down
            24   23  22 1 #Down
            25   23  24 1
            26   24  25 1
            27   25  26 1
            28   26  27 1
            29   27  28 1
            30   23  28 1
            31   25  29 1 #Up
            32   29  30 1
            33   26  31 1 #Down
            34   28  32 1 #Down
            35   38  39 1
            36   39  40 1
            37   40  41 1
            38   41  42 1
            39   42  43 1
            40   38  43 1
            41   38  68 1 #Up
            42   68  69 1
            43   39  67 1 #Down
            44   40  66 1 #Up
            45   41  65 1 #Down
            46   42  44 1 #Down
            47   45  44 1 #Down
            48   45  46 1
            49   46  47 1
            50   47  48 1
            51   48  49 1
            52   49  50 1
            53   45  50 1
            54   46  64 1 #Up
            55   48  63 1 #Up
            56   50  51 1 #Up
            57   49  52 1 #Down
            58   53  52 1 #Down
            59   53  54 1
            60   54  55 1
            61   55  56 1
            62   56  57 1
            63   57  58 1
            64   53  58 1
            65   55  61 1 #Up
            66   61  62 1
            67   56  60 1 #Down
            68   58  59 1 #Down
            69   33  34 2
            70   33  35 2
            71   33  36 1
            72   33  37 1
            73   70  71 2
            74   70  72 2
            75   70  73 1
            76   70  74 1
            77   75  76 2
            78   75  77 2
            79   75  78 1
            80   75  79 1
            81   80  81 2
            82   80  82 2
            83   80  83 1
            84   80  84 1
            85   85  86 2
            86   85  87 2
            87   85  88 1
            88   85  89 1
BRACKET     1    12.8100  -24.7100   12.8100  -11.2000
            1    29.4000  -11.2000   29.4000  -24.7100
            1  2
 ORIGINAL  1    1   2   3   4   5   6  12  13  14  15  16  17  18  21  22  23
            1   24  25  26  27  28  32  31  29  30  20  19  11  10   9   7   8
 REPEAT    1   38  39  40  41  42  43  44  45  46  47  48  49  50  51  52  53
            1   54  55  56  57  58  59  60  61  62  63  64  65  66  67  68  69
            2    31.2200  -20.6500   31.2200  -16.5900
            2    36.7500  -16.5900   36.7500  -20.6500
            2  5
 ORIGINAL  2   33  34  35  36  37
 REPEAT    2   70  71  72  73  74  75  76  77  78  79  80  81  82  83  84  85
            2   86  87  88  89

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