KEGG   DRUG: Scopolamine
Entry
D00138                      Drug                                   
Name
Scopolamine (INN);
Transderm scop (TN)
Product
  Generic
Formula
C17H21NO4
Exact mass
303.1471
Mol weight
303.3529
Structure
Simcomp
Source
Atropa belladonna [TAX:33113]
Class
Neuropsychiatric agent
 DG01491  Muscarinic cholinergic receptor antagonist
Gastrointestinal agent
 DG01762  Antiemetic
Remark
Same as: C01851
ATC code: A04AD01 N05CM05 S01FA02
Chemical structure group: DG00065
Product (DG00065): D00138<US> D02071<JP>
Efficacy
Antiemetic, Mydriatic, Muscarinic acetylcholine receptor antagonist
Comment
Tropane derivative
Target
  Pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04725  Cholinergic synapse
Interaction
Structure map
map07220  Cholinergic and anticholinergic drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A04 ANTIEMETICS AND ANTINAUSEANTS
   A04A ANTIEMETICS AND ANTINAUSEANTS
    A04AD Other antiemetics
     A04AD01 Scopolamine
      D00138  Scopolamine (INN) <US>
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05C HYPNOTICS AND SEDATIVES
    N05CM Other hypnotics and sedatives
     N05CM05 Scopolamine
      D00138  Scopolamine (INN) <US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01F MYDRIATICS AND CYCLOPLEGICS
    S01FA Anticholinergics
     S01FA02 Scopolamine
      D00138  Scopolamine (INN) <US>
USP drug classification [BR:br08302]
 Antiemetics
  Antiemetics, Other
   Scopolamine
    D00138  Scopolamine (INN)
 Gastrointestinal Agents
  Antispasmodics, Gastrointestinal
   Scopolamine
    D00138  Scopolamine (INN)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Scopolamine
    D00138  Scopolamine (INN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01491  Muscarinic cholinergic receptor antagonist
   DG00065  Scopolamine
    D00138  Scopolamine
 Gastrointestinal agent
  DG01762  Antiemetic
   DG00065  Scopolamine
    D00138  Scopolamine
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    CHRM
     D00138  Scopolamine (INN) <US>
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01491  Muscarinic cholinergic receptor antagonist
   DG00065  Scopolamine
 Gastrointestinal agent
  DG01762  Antiemetic
   DG00065  Scopolamine
Other DBs
CAS: 51-34-3
PubChem: 7847206
ChEBI: 16794 182414
LigandBox: D00138
NIKKAJI: J47.151H
LinkDB
KCF data

ATOM        22
            1   C1y C    27.2691  -18.1297
            2   C1y C    27.5838  -16.9522
            3   C1y C    28.4522  -17.8207
            4   O2x O    26.2433  -16.7249
            5   C1y C    28.7612  -16.6375
            6   N1y N    27.5314  -15.3494
            7   C1x C    30.3057  -17.8264
            8   C1x C    30.0493  -16.6433
            9   C1a C    27.4790  -13.9915
            10  C1y C    31.3199  -18.3685
            11  O7a O    32.3631  -19.2836
            12  C7a C    33.7631  -19.2836
            13  O6a O    34.4427  -20.4609
            14  C1c C    34.4721  -18.0566
            15  C8y C    35.8400  -18.0572
            16  C8x C    36.5407  -19.2720
            17  C8x C    37.9407  -19.2726
            18  C8x C    38.6412  -18.0604
            19  C8x C    37.9405  -16.8456
            20  C8x C    36.5405  -16.8451
            21  C1b C    33.7664  -16.8327
            22  O1a O    34.4744  -15.6081
BOND        25
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     3   6 1
            6     3   7 1
            7     5   8 1
            8     6   9 1
            9     7  10 1
            10   10  11 1 #Down
            11    2   4 1
            12    5   6 1
            13    8  10 1
            14   11  12 1
            15   12  13 2
            16   12  14 1
            17   14  15 1
            18   15  16 2
            19   16  17 1
            20   17  18 2
            21   18  19 1
            22   19  20 2
            23   15  20 1
            24   14  21 1 #Down
            25   21  22 1

» Japanese version   » Back

KEGG   DRUG: Scopolamine hydrobromide
Entry
D02071                      Drug                                   
Name
Scopolamine hydrobromide (USP);
Scopolamine hydrobromide hydrate (JP18);
Scopolamine hydrobromide trihydrate;
Hysco (TN);
Isopto hyoscine (TN)
Formula
C17H21NO4. 3H2O. HBr
Exact mass
437.1049
Mol weight
438.3107
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01491  Muscarinic cholinergic receptor antagonist
Gastrointestinal agent
 DG01762  Antiemetic
Remark
Therapeutic category: 1242
ATC code: A04AD01 N05CM05 S01FA02
Chemical structure group: DG00065
Product (DG00065): D00138<US> D02071<JP>
Efficacy
Antispasmodic, Midriatic, Muscarinic acetylcholine receptor antagonist
Comment
Tropane derivative
Target
  Pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04725  Cholinergic synapse
Interaction
Structure map
map07220  Cholinergic and anticholinergic drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A04 ANTIEMETICS AND ANTINAUSEANTS
   A04A ANTIEMETICS AND ANTINAUSEANTS
    A04AD Other antiemetics
     A04AD01 Scopolamine
      D02071  Scopolamine hydrobromide (USP) <JP>
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05C HYPNOTICS AND SEDATIVES
    N05CM Other hypnotics and sedatives
     N05CM05 Scopolamine
      D02071  Scopolamine hydrobromide (USP) <JP>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01F MYDRIATICS AND CYCLOPLEGICS
    S01FA Anticholinergics
     S01FA02 Scopolamine
      D02071  Scopolamine hydrobromide (USP) <JP>
USP drug classification [BR:br08302]
 Gastrointestinal Agents
  Antispasmodics, Gastrointestinal
   Scopolamine
    D02071  Scopolamine hydrobromide (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  12  Agents affecting peripheral nervous system
   124  Antispasmodics
    1242  Atropines
     D02071  Scopolamine hydrobromide (USP); Scopolamine hydrobromide hydrate (JP18)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for nervous and sensory systems
  06 Antivertigo drugs (incl. motion/morning sickness remedies)
   D02071  Scopolamine hydrobromide (USP)
 Agents for digestive organs
  15 Stomach pain and cramp relievers
   D02071  Scopolamine hydrobromide (USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Scopolamine
    D02071  Scopolamine hydrobromide (USP)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01491  Muscarinic cholinergic receptor antagonist
   DG00065  Scopolamine
    D02071  Scopolamine hydrobromide
 Gastrointestinal agent
  DG01762  Antiemetic
   DG00065  Scopolamine
    D02071  Scopolamine hydrobromide
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    CHRM
     D02071  Scopolamine hydrobromide (USP) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D02071  Scopolamine hydrobromide hydrate
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01491  Muscarinic cholinergic receptor antagonist
   DG00065  Scopolamine
 Gastrointestinal agent
  DG01762  Antiemetic
   DG00065  Scopolamine
Other DBs
CAS: 6533-68-2
PubChem: 7849133
ChEBI: 61272
LigandBox: D02071
NIKKAJI: J1.587.796K
LinkDB
KCF data

ATOM        26
            1   X   Br   38.4301  -16.1700
            2   O0  O    38.8500  -18.6900
            3   C1y C    24.3600  -17.8500
            4   C1y C    24.6400  -16.6600
            5   C1y C    25.4800  -17.5700
            6   O2x O    23.3100  -16.4500
            7   C1y C    25.8300  -16.3800
            8   N1y N    24.5700  -15.0500
            9   C1x C    27.3700  -17.5700
            10  C1x C    27.0900  -16.3800
            11  C1a C    24.5700  -13.7200
            12  C1y C    28.3500  -18.0600
            13  O7a O    29.4000  -18.9700
            14  C7a C    30.8000  -18.9700
            15  O6a O    31.5000  -20.1600
            16  C1c C    31.5000  -17.7800
            17  C8y C    32.9000  -17.7800
            18  C8x C    33.6000  -18.9700
            19  C8x C    35.0000  -18.9700
            20  C8x C    35.7000  -17.7800
            21  C8x C    35.0000  -16.5900
            22  C8x C    33.6000  -16.5900
            23  C1b C    30.8000  -16.5200
            24  O1a O    31.5000  -15.3300
            25  O0  O    38.8500  -18.6900
            26  O0  O    38.8500  -18.6900
BOND        25
            1     3   4 1
            2     3   5 1
            3     3   6 1
            4     4   7 1
            5     5   8 1
            6     5   9 1
            7     7  10 1
            8     8  11 1
            9     9  12 1
            10   12  13 1 #Down
            11    4   6 1
            12    7   8 1
            13   10  12 1
            14   13  14 1
            15   14  15 2
            16   14  16 1
            17   16  17 1
            18   17  18 2
            19   18  19 1
            20   19  20 2
            21   20  21 1
            22   21  22 2
            23   17  22 1
            24   16  23 1 #Down
            25   23  24 1
BRACKET     1    36.8200  -19.8100   36.8200  -17.6400
            1    39.4100  -17.6400   39.4100  -19.8100
            1  3
 ORIGINAL  1    2
 REPEAT    1   27  28

» Japanese version   » Back

DBGET integrated database retrieval system