KEGG   DRUG: Ciprofloxacin
Entry
D00186                      Drug                                   
Name
Ciprofloxacin (JP18/USP/INN);
Cipro (TN);
Otiprio (TN)
Product
  Generic
CIPROFLOXACIN (Baxter Healthcare Corporation), CIPROFLOXACIN (Baxter Healthcare Corporation), CIPROFLOXACIN (Sagent Pharmaceuticals), CIPROFLOXACIN (Sagent Pharmaceuticals), CIPROFLOXACIN IN DEXTROSE (Hospira)
Formula
C17H18FN3O3
Exact mass
331.1332
Mol weight
331.34
Structure
Simcomp
Class
Antibacterial
 DG01550  Quinolone
  DG01549  Fluoroquinolone
Metabolizing enzyme inhibitor
 DG01634  CYP1A2 inhibitor
Remark
Same as: C05349
Therapeutic category: 6241
ATC code: J01MA02 S01AE03 S02AA15 S03AA07
Chemical structure group: DG00617
Product (DG00617): D00186<JP/US> D02216<JP/US>
Efficacy
Antibacterial, Nucleic acid biosynthesis inhibitor
  Disease
Inhalational anthrax [DS:H00328]
Plague [DS:H00297]
Target
DNA gyrase [KO:K02469 K02470]
Interaction
CYP inhibition: CYP1A2 [HSA:1544]
Structure map
map07014  Quinolones
Other map
map04976  Bile secretion
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01M QUINOLONE ANTIBACTERIALS
    J01MA Fluoroquinolones
     J01MA02 Ciprofloxacin
      D00186  Ciprofloxacin (JP18/USP/INN) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AE Fluoroquinolones
     S01AE03 Ciprofloxacin
      D00186  Ciprofloxacin (JP18/USP/INN) <JP/US>
  S02 OTOLOGICALS
   S02A ANTIINFECTIVES
    S02AA Antiinfectives
     S02AA15 Ciprofloxacin
      D00186  Ciprofloxacin (JP18/USP/INN) <JP/US>
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03A ANTIINFECTIVES
    S03AA Antiinfectives
     S03AA07 Ciprofloxacin
      D00186  Ciprofloxacin (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Antibacterials
  Quinolones
   Ciprofloxacin
    D00186  Ciprofloxacin (JP18/USP/INN)
 Ophthalmic Agents
  Ophthalmic Anti-Infectives
   Antibacterials, Ophthalmic
    Ciprofloxacin
     D00186  Ciprofloxacin (JP18/USP/INN)
 Otic Agents
  Otic Anti-Infectives
   Ciprofloxacin
    D00186  Ciprofloxacin (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   624  Synthetic antibacterials
    6241  Pyridonecarboxylic acids
     D00186  Ciprofloxacin (JP18/USP/INN)
Drug groups [BR:br08330]
 Antibacterial
  DG01550  Quinolone
   DG01549  Fluoroquinolone
    DG00617  Ciprofloxacin
     D00186  Ciprofloxacin
 Metabolizing enzyme inhibitor
  DG01634  CYP1A2 inhibitor
   DG00617  Ciprofloxacin
    D00186  Ciprofloxacin
Drug classes [BR:br08332]
 Antibacterial
  DG01549  Fluoroquinolone
   D00186  Ciprofloxacin
Antimicrobials [BR:br08307]
 Antibacterials
  Nucleic acid synthesis inhibitor
   Fluoroquinolone
    D00186  Ciprofloxacin (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00186  Ciprofloxacin
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00186
Drug groups [BR:br08330]
 Antibacterial
  DG01550  Quinolone
   DG01549  Fluoroquinolone
    DG00617  Ciprofloxacin
 Metabolizing enzyme inhibitor
  DG01634  CYP1A2 inhibitor
   DG00617  Ciprofloxacin
Antimicrobials abbreviations [BR:br08327]
 Antibacterials
  Nucleic acid synthesis inhibitor
   Fluoroquinolone
    DG00617  Ciprofloxacin
Other DBs
CAS: 85721-33-1
PubChem: 7847254
ChEBI: 100241
PDB-CCD: CPF[PDBj]
LigandBox: D00186
NIKKAJI: J21.732H
LinkDB
KCF data

ATOM        24
            1   C8y C    19.6700   -6.0900
            2   C8y C    19.6700   -7.4900
            3   C8x C    20.8600   -8.1900
            4   C8y C    22.1200   -7.4900
            5   C8y C    22.1200   -6.0900
            6   C8x C    20.8600   -5.3900
            7   N4y N    23.3100   -8.1900
            8   C8x C    24.5000   -7.4900
            9   C8y C    24.5000   -6.0900
            10  C8y C    23.3100   -5.3900
            11  N1y N    18.4800   -8.1900
            12  C1x C    17.2900   -7.4900
            13  C1x C    16.0300   -8.1900
            14  N1x N    16.0300   -9.5900
            15  C1x C    17.2200  -10.2900
            16  C1x C    18.4800   -9.5900
            17  X   F    18.4800   -5.3900
            18  O5x O    23.3100   -3.9900
            19  C6a C    25.6900   -5.3900
            20  O6a O    26.8800   -6.0900
            21  O6a O    25.6900   -3.9900
            22  C1y C    23.3100   -9.5900
            23  C1x C    24.0100  -10.7800
            24  C1x C    22.6100  -10.7800
BOND        27
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 2
            10    9  10 1
            11    5  10 1
            12    2  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   14  15 1
            17   15  16 1
            18   11  16 1
            19    1  17 1
            20   10  18 2
            21    9  19 1
            22   19  20 1
            23   19  21 2
            24    7  22 1
            25   22  23 1
            26   22  24 1
            27   23  24 1

» Japanese version   » Back

KEGG   DRUG: Ciprofloxacin hydrochloride
Entry
D02216                      Drug                                   
Name
Ciprofloxacin hydrochloride (USP);
Ciprofloxacin hydrochloride hydrate (JP18);
Ciloxan (TN);
Cipro (TN);
Proquin XR (TN)
Product
CETRAXAL (Wraser Llc), CILOXAN (Novartis Pharmaceuticals Corporation), CIPRO (Bayer HealthCare Pharmaceuticals), CIPROFLOXACIN (DIRECT RX), CIPROFLOXACIN OTIC (Xspire Pharma)
  Generic
CIPROFLOXACIN (A-S Medication Solutions), CIPROFLOXACIN (A-S Medication Solutions), CIPROFLOXACIN (A-S Medication Solutions), CIPROFLOXACIN (A-S Medication Solutions), CIPROFLOXACIN (A-S Medication Solutions), CIPROFLOXACIN (A-S Medication Solutions), CIPROFLOXACIN (A-S Medication Solutions), CIPROFLOXACIN (A-S Medication Solutions), CIPROFLOXACIN (A-S Medication Solutions), CIPROFLOXACIN (A-S Medication Solutions), CIPROFLOXACIN (A-S Medication Solutions), CIPROFLOXACIN (Actavis Pharma), CIPROFLOXACIN (Advanced Rx Pharmacy of Tennessee), CIPROFLOXACIN (American Health Packaging), CIPROFLOXACIN (Amneal Pharmaceuticals NY LLC), CIPROFLOXACIN (Aphena Pharma Solutions - Tennessee), CIPROFLOXACIN (Aphena Pharma Solutions - Tennessee), CIPROFLOXACIN (Aphena Pharma Solutions - Tennessee), CIPROFLOXACIN (Asclemed USA), CIPROFLOXACIN (Asclemed USA), CIPROFLOXACIN (Asclemed USA), CIPROFLOXACIN (Aurobindo Pharma Limited), CIPROFLOXACIN (Aurobindo Pharma Limited), CIPROFLOXACIN (Bryant Ranch Prepack), CIPROFLOXACIN (Bryant Ranch Prepack), CIPROFLOXACIN (Bryant Ranch Prepack), CIPROFLOXACIN (Bryant Ranch Prepack), CIPROFLOXACIN (Bryant Ranch Prepack), CIPROFLOXACIN (Bryant Ranch Prepack), CIPROFLOXACIN (Bryant Ranch Prepack), CIPROFLOXACIN (Bryant Ranch Prepack), CIPROFLOXACIN (Bryant Ranch Prepack), CIPROFLOXACIN (Bryant Ranch Prepack), CIPROFLOXACIN (Bryant Ranch Prepack), CIPROFLOXACIN (Bryant Ranch Prepack), CIPROFLOXACIN (Bryant Ranch Prepack), CIPROFLOXACIN (Bryant Ranch Prepack), CIPROFLOXACIN (Bryant Ranch Prepack), CIPROFLOXACIN (Bryant Ranch Prepack), CIPROFLOXACIN (Bryant Ranch Prepack), CIPROFLOXACIN (CHARTWELL GOVERNMENTAL & SPECIALTY RX LLC), CIPROFLOXACIN (Cardinal Health 107), CIPROFLOXACIN (Carlsbad Technology), CIPROFLOXACIN (Chartwell RX), CIPROFLOXACIN (Chartwell RX), CIPROFLOXACIN (DIRECT RX), CIPROFLOXACIN (DIRECT RX), CIPROFLOXACIN (DRUG OCEAN LLC), CIPROFLOXACIN (Denton Pharma), CIPROFLOXACIN (Denton Pharma), CIPROFLOXACIN (Denton Pharma), CIPROFLOXACIN (Direct Rx), CIPROFLOXACIN (DirectRx), CIPROFLOXACIN (DirectRx), CIPROFLOXACIN (Direct_Rx), CIPROFLOXACIN (Direct_Rx), CIPROFLOXACIN (Dr. Reddy's Laboratories Limited), CIPROFLOXACIN (Golden State Medical Supply), CIPROFLOXACIN (Golden State Medical Supply), CIPROFLOXACIN (Golden State Medical Supply), CIPROFLOXACIN (Hikma Pharmaceuticals USA), CIPROFLOXACIN (Leading Pharma), CIPROFLOXACIN (Major Pharmaceuticals), CIPROFLOXACIN (Major Pharmaceuticals), CIPROFLOXACIN (Major Pharmaceuticals), CIPROFLOXACIN (McKesson Corporation dba SKY Packaging), CIPROFLOXACIN (Mckesson Corporation DBA SKY Packaginng), CIPROFLOXACIN (Medsource Pharmaceuticals), CIPROFLOXACIN (Medsource Pharmaceuticals), CIPROFLOXACIN (Medsource Pharmaceuticals), CIPROFLOXACIN (Medsource Pharmaceuticals), CIPROFLOXACIN (Medsource Pharmaceuticals), CIPROFLOXACIN (Method Pharmaceuticals), CIPROFLOXACIN (NCS HealthCare of KY), CIPROFLOXACIN (NorthStar Rx LLC), CIPROFLOXACIN (Northwind Pharmaceuticals), CIPROFLOXACIN (Northwind Pharmaceuticals), CIPROFLOXACIN (Northwind Pharmaceuticals), CIPROFLOXACIN (Northwind Pharmaceuticals), CIPROFLOXACIN (NuCare Pharmaceuticals), CIPROFLOXACIN (NuCare Pharmaceuticals), CIPROFLOXACIN (NuCare Pharmaceuticals), CIPROFLOXACIN (NuCare Pharmaceuticals), CIPROFLOXACIN (NuCare Pharmaceuticals), CIPROFLOXACIN (NuCare Pharmaceuticals), CIPROFLOXACIN (NuCare Pharmaceuticals), CIPROFLOXACIN (NuCare Pharmaceuticals), CIPROFLOXACIN (NuCare Pharmaceuticals), CIPROFLOXACIN (NuCare Pharmaceuticals), CIPROFLOXACIN (NuCare Pharmaceuticals), CIPROFLOXACIN (NuCare Pharmaceuticals), CIPROFLOXACIN (NuCare Pharmaceuticals), CIPROFLOXACIN (NuCare Pharmaceuticals), CIPROFLOXACIN (NuCare Pharmaceuticals), CIPROFLOXACIN (PD-Rx Pharmaceuticals), CIPROFLOXACIN (PD-Rx Pharmaceuticals), CIPROFLOXACIN (PD-Rx Pharmaceuticals), CIPROFLOXACIN (PD-Rx Pharmaceuticals), CIPROFLOXACIN (PD-Rx Pharmaceuticals), CIPROFLOXACIN (PD-Rx Pharmaceuticals), CIPROFLOXACIN (PD-Rx Pharmaceuticals), CIPROFLOXACIN (PD-Rx Pharmaceuticals), CIPROFLOXACIN (PD-Rx Pharmaceuticals), CIPROFLOXACIN (PD-Rx Pharmaceuticals), CIPROFLOXACIN (PD-Rx Pharmaceuticals), CIPROFLOXACIN (PD-Rx Pharmaceuticals), CIPROFLOXACIN (PD-Rx Pharmaceuticals), CIPROFLOXACIN (PharmPak), CIPROFLOXACIN (PharmPak), CIPROFLOXACIN (Pharmasource Meds), CIPROFLOXACIN (Preferred Pharmaceuticals), CIPROFLOXACIN (Preferred Pharmaceuticals), CIPROFLOXACIN (Preferred Pharmaceuticals), CIPROFLOXACIN (Preferred Pharmaceuticals), CIPROFLOXACIN (Preferred Pharmaceuticals), CIPROFLOXACIN (Preferred Pharmaceuticals), CIPROFLOXACIN (Preferred Pharmaceuticals), CIPROFLOXACIN (Proficient Rx LP), CIPROFLOXACIN (Proficient Rx LP), CIPROFLOXACIN (Proficient Rx LP), CIPROFLOXACIN (Proficient Rx LP), CIPROFLOXACIN (Proficient Rx LP), CIPROFLOXACIN (Proficient Rx LP), CIPROFLOXACIN (Proficient Rx LP), CIPROFLOXACIN (Proficient Rx LP), CIPROFLOXACIN (Proficient Rx LP), CIPROFLOXACIN (Proficient Rx LP), CIPROFLOXACIN (QPharma), CIPROFLOXACIN (QPharma), CIPROFLOXACIN (QPharma), CIPROFLOXACIN (Quality Care Products), CIPROFLOXACIN (Quality Care Products), CIPROFLOXACIN (Quality Care Products), CIPROFLOXACIN (REMEDYREPACK), CIPROFLOXACIN (REMEDYREPACK), CIPROFLOXACIN (REMEDYREPACK), CIPROFLOXACIN (REMEDYREPACK), CIPROFLOXACIN (REMEDYREPACK), CIPROFLOXACIN (REMEDYREPACK), CIPROFLOXACIN (REMEDYREPACK), CIPROFLOXACIN (REMEDYREPACK), CIPROFLOXACIN (REMEDYREPACK), CIPROFLOXACIN (REMEDYREPACK), CIPROFLOXACIN (REMEDYREPACK), CIPROFLOXACIN (RPK Pharmaceuticals), CIPROFLOXACIN (RPK Pharmaceuticals), CIPROFLOXACIN (RPK Pharmaceuticals), CIPROFLOXACIN (RPK Pharmaceuticals), CIPROFLOXACIN (RPK Pharmaceuticals), CIPROFLOXACIN (RPK Pharmaceuticals), CIPROFLOXACIN (RPK Pharmaceuticals), CIPROFLOXACIN (RPK Pharmaceuticals), CIPROFLOXACIN (RPK Pharmaceuticals), CIPROFLOXACIN (RPK Pharmaceuticals), CIPROFLOXACIN (RedPharm Drug), CIPROFLOXACIN (RedPharm Drug), CIPROFLOXACIN (RedPharm Drug), CIPROFLOXACIN (RedPharm Drug), CIPROFLOXACIN (RedPharm Drug), CIPROFLOXACIN (RedPharm Drug), CIPROFLOXACIN (RedPharm Drug), CIPROFLOXACIN (Redpharm Drug), CIPROFLOXACIN (Redpharm Drug), CIPROFLOXACIN (Rising Pharma Holdings), CIPROFLOXACIN (ST. MARY'S MEDICAL PARK PHARMACY), CIPROFLOXACIN (Solco Healthcare US), CIPROFLOXACIN (St Mary's Medical Park Pharmacy), CIPROFLOXACIN (St. Mary's Medical Park Pharmacy), CIPROFLOXACIN (Yiling Pharmaceutical), CIPROFLOXACIN (direct rx), CIPROFLOXACIN (medsource pharmaceuticals), CIPROFLOXACIN HCL (Advanced Rx Pharmacy of Tennessee), CIPROFLOXACIN HCL (Advanced Rx Pharmacy of Tennessee), CIPROFLOXACIN HCL OPHTHALMIC (Altaire Pharmaceuticals), CIPROFLOXACIN HYDROCHLORIDE (A-S Medication Solutions), CIPROFLOXACIN HYDROCHLORIDE (NuCare Pharmaceuticals), CIPROFLOXACIN HYDROCHLORIDE (NuCare Pharmaceuticals), CIPROFLOXACIN HYDROCHLORIDE (NuCare Pharmaceuticals), CIPROFLOXACIN HYDROCHLORIDE (Preferred Pharmaceuticals), CIPROFLOXACIN HYDROCHLORIDE (Proficient Rx LP), CIPROFLOXACIN HYDROCHLORIDE (REMEDYREPACK), CIPROFLOXACIN HYDROCHLORIDE (RPK Pharmaceuticals), CIPROFLOXACIN HYDROCHLORIDE (Redpharm Drug), CIPROFLOXACIN HYDROCHLORIDE (Sandoz), CIPROFLOXACIN HYDROCHLORIDE (Westminster Pharmaceuticals), CIPROFLOXACIN HYDROCHLORIDE (medsource pharmaceuticals)
Formula
C17H18FN3O3. HCl. H2O
Exact mass
385.1205
Mol weight
385.82
Structure
Simcomp
Class
Antibacterial
 DG01550  Quinolone
  DG01549  Fluoroquinolone
Metabolizing enzyme inhibitor
 DG01634  CYP1A2 inhibitor
Remark
Same as: C13993
Therapeutic category: 6241
ATC code: J01MA02 S01AE03 S02AA15 S03AA07
Chemical structure group: DG00617
Product (DG00617): D00186<JP/US> D02216<JP/US>
Product (mixture): D10296<US> D11089<US> D11582<US>
Efficacy
Antibacterial, Nucleic acid biosynthesis inhibitor
  Disease
Typhoid fever [DS:H00111]
Gonorrhea [DS:H00315]
Anthrax [DS:H00328]
Plague [DS:H00297]
Uncomplicated urinary tract infections [DS:H01176]
Target
DNA gyrase [KO:K02469 K02470]
Interaction
CYP inhibition: CYP1A2 [HSA:1544]
Structure map
map07014  Quinolones
Other map
map04976  Bile secretion
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01M QUINOLONE ANTIBACTERIALS
    J01MA Fluoroquinolones
     J01MA02 Ciprofloxacin
      D02216  Ciprofloxacin hydrochloride (USP) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AE Fluoroquinolones
     S01AE03 Ciprofloxacin
      D02216  Ciprofloxacin hydrochloride (USP) <JP/US>
  S02 OTOLOGICALS
   S02A ANTIINFECTIVES
    S02AA Antiinfectives
     S02AA15 Ciprofloxacin
      D02216  Ciprofloxacin hydrochloride (USP) <JP/US>
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03A ANTIINFECTIVES
    S03AA Antiinfectives
     S03AA07 Ciprofloxacin
      D02216  Ciprofloxacin hydrochloride (USP) <JP/US>
USP drug classification [BR:br08302]
 Antibacterials
  Quinolones
   Ciprofloxacin
    D02216  Ciprofloxacin hydrochloride (USP)
 Ophthalmic Agents
  Ophthalmic Anti-Infectives
   Antibacterials, Ophthalmic
    Ciprofloxacin
     D02216  Ciprofloxacin hydrochloride (USP)
 Otic Agents
  Otic Anti-Infectives
   Ciprofloxacin
    D02216  Ciprofloxacin hydrochloride (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   624  Synthetic antibacterials
    6241  Pyridonecarboxylic acids
     D02216  Ciprofloxacin hydrochloride (USP); Ciprofloxacin hydrochloride hydrate (JP18)
Drug groups [BR:br08330]
 Antibacterial
  DG01550  Quinolone
   DG01549  Fluoroquinolone
    DG00617  Ciprofloxacin
     D02216  Ciprofloxacin hydrochloride
 Metabolizing enzyme inhibitor
  DG01634  CYP1A2 inhibitor
   DG00617  Ciprofloxacin
    D02216  Ciprofloxacin hydrochloride
Drug classes [BR:br08332]
 Antibacterial
  DG01549  Fluoroquinolone
   D02216  Ciprofloxacin hydrochloride
Antimicrobials [BR:br08307]
 Antibacterials
  Nucleic acid synthesis inhibitor
   Fluoroquinolone
    D02216  Ciprofloxacin hydrochloride (USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D02216  Ciprofloxacin hydrochloride hydrate
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D02216
Drug groups [BR:br08330]
 Antibacterial
  DG01550  Quinolone
   DG01549  Fluoroquinolone
    DG00617  Ciprofloxacin
 Metabolizing enzyme inhibitor
  DG01634  CYP1A2 inhibitor
   DG00617  Ciprofloxacin
Antimicrobials abbreviations [BR:br08327]
 Antibacterials
  Nucleic acid synthesis inhibitor
   Fluoroquinolone
    DG00617  Ciprofloxacin
Other DBs
CAS: 86393-32-0
PubChem: 7849275
ChEBI: 59936
LigandBox: D02216
NIKKAJI: J245.528E
LinkDB
KCF data

ATOM        26
            1   C8y C    21.5369  -16.2638
            2   N4y N    22.7985  -16.9648
            3   C8y C    21.5369  -14.8622
            4   C8x C    20.3688  -16.9648
            5   C1y C    22.7984  -18.3665
            6   C8x C    23.9665  -16.2171
            7   C8y C    22.7518  -14.1613
            8   C8x C    20.3221  -14.1613
            9   C8y C    19.1539  -16.2638
            10  C1x C    23.4993  -19.5812
            11  C1x C    22.0975  -19.5812
            12  C8y C    23.9665  -14.8622
            13  O5x O    22.7518  -12.7596
            14  C8y C    19.1539  -14.8622
            15  C6a C    25.1813  -14.1613
            16  X   F    17.8924  -14.1613
            17  O6a O    26.3962  -14.8622
            18  O6a O    25.1813  -12.7596
            19  N1y N    17.9391  -17.0115
            20  C1x C    16.7243  -16.3106
            21  C1x C    15.5094  -17.0115
            22  N1x N    15.5094  -18.4132
            23  C1x C    16.7243  -19.1140
            24  C1x C    17.9391  -18.3665
            25  X   Cl   30.1710  -15.3771
            26  O0  O    33.2977  -15.4005
BOND        27
            1     3   7 1
            2     3   8 1
            3     4   9 2
            4     5  10 1
            5     5  11 1
            6     6  12 2
            7     7  13 2
            8     8  14 2
            9    12  15 1
            10   14  16 1
            11   15  17 1
            12   15  18 2
            13    7  12 1
            14    9  14 1
            15   10  11 1
            16    9  19 1
            17    1   2 1
            18    1   3 2
            19    1   4 1
            20   19  20 1
            21   20  21 1
            22   21  22 1
            23   22  23 1
            24   23  24 1
            25   24  19 1
            26    2   5 1
            27    2   6 1

» Japanese version   » Back

KEGG   DRUG: Ciprofloxacin lactate
Entry
D07702                      Drug                                   
Name
Ciprofloxacin lactate;
Ciproxin (TN)
Formula
C17H18FN3O3. C3H6O3
Exact mass
421.1649
Mol weight
421.42
Structure
Simcomp
Class
Antibacterial
 DG01550  Quinolone
  DG01549  Fluoroquinolone
Metabolizing enzyme inhibitor
 DG01634  CYP1A2 inhibitor
Remark
ATC code: J01MA02 S01AE03 S02AA15 S03AA07
Chemical structure group: DG00617
Product (DG00617): D00186<JP/US> D02216<JP/US>
Efficacy
Antibacterial, Nucleic acid biosynthesis inhibitor
Target
DNA gyrase [KO:K02469 K02470]
Interaction
CYP inhibition: CYP1A2 [HSA:1544]
Structure map
map07014  Quinolones
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01M QUINOLONE ANTIBACTERIALS
    J01MA Fluoroquinolones
     J01MA02 Ciprofloxacin
      D07702  Ciprofloxacin lactate
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AE Fluoroquinolones
     S01AE03 Ciprofloxacin
      D07702  Ciprofloxacin lactate
  S02 OTOLOGICALS
   S02A ANTIINFECTIVES
    S02AA Antiinfectives
     S02AA15 Ciprofloxacin
      D07702  Ciprofloxacin lactate
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03A ANTIINFECTIVES
    S03AA Antiinfectives
     S03AA07 Ciprofloxacin
      D07702  Ciprofloxacin lactate
Drug groups [BR:br08330]
 Antibacterial
  DG01550  Quinolone
   DG01549  Fluoroquinolone
    DG00617  Ciprofloxacin
     D07702  Ciprofloxacin lactate
 Metabolizing enzyme inhibitor
  DG01634  CYP1A2 inhibitor
   DG00617  Ciprofloxacin
    D07702  Ciprofloxacin lactate
Antimicrobials [BR:br08307]
 Antibacterials
  Nucleic acid synthesis inhibitor
   Fluoroquinolone
    D07702  Ciprofloxacin lactate
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D07702
Drug groups [BR:br08330]
 Antibacterial
  DG01550  Quinolone
   DG01549  Fluoroquinolone
    DG00617  Ciprofloxacin
 Metabolizing enzyme inhibitor
  DG01634  CYP1A2 inhibitor
   DG00617  Ciprofloxacin
Antimicrobials abbreviations [BR:br08327]
 Antibacterials
  Nucleic acid synthesis inhibitor
   Fluoroquinolone
    DG00617  Ciprofloxacin
Other DBs
CAS: 97867-33-9
PubChem: 51092000
LigandBox: D07702
LinkDB
KCF data

ATOM        30
            1   C8y C    21.8133  -17.0568
            2   C8y C    21.8133  -18.4608
            3   C8x C    23.0066  -19.1627
            4   C8y C    24.2702  -18.4608
            5   C8y C    24.2702  -17.0568
            6   C8x C    23.0066  -16.3549
            7   N4y N    25.4635  -19.1627
            8   C8x C    26.6569  -18.4608
            9   C8y C    26.6569  -17.0568
            10  C8y C    25.4635  -16.3549
            11  N1y N    20.6199  -19.1627
            12  C1x C    19.4266  -18.4608
            13  C1x C    18.1631  -19.1627
            14  N1x N    18.1631  -20.5667
            15  C1x C    19.3564  -21.2686
            16  C1x C    20.6199  -20.5667
            17  X   F    20.6199  -16.3549
            18  O5x O    25.4635  -14.9509
            19  C6a C    27.8502  -16.3549
            20  O6a O    29.0435  -17.0568
            21  O6a O    27.8502  -14.9509
            22  C1y C    25.4635  -20.5667
            23  C1x C    26.1655  -21.7600
            24  C1x C    24.7615  -21.7600
            25  C6a C    34.0900  -18.3400
            26  O6a O    35.3024  -19.0400
            27  C1c C    32.8776  -19.0400
            28  O6a O    34.0900  -16.9400
            29  O1a O    31.6821  -18.3496
            30  C1a C    32.8775  -20.4398
BOND        32
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 2
            10    9  10 1
            11    5  10 1
            12    2  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   14  15 1
            17   15  16 1
            18   11  16 1
            19    1  17 1
            20   10  18 2
            21    9  19 1
            22   19  20 1
            23   19  21 2
            24    7  22 1
            25   22  23 1
            26   22  24 1
            27   23  24 1
            28   25  26 1
            29   25  27 1
            30   25  28 2
            31   27  29 1
            32   27  30 1

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