KEGG   DRUG: Aztreonam
Entry
D00240                      Drug                                   
Name
Aztreonam (JP18/USP/INN);
Azactam (TN)
Product
AZACTAM (E.R. Squibb & Sons), CAYSTON (Gilead Sciences)
  Generic
AZTREONAM (Fresenius Kabi USA), AZTREONAM (Fresenius Kabi USA), AZTREONAM (Fresenius Kabi USA), AZTREONAM (Hospira)
Formula
C13H17N5O8S2
Exact mass
435.0519
Mol weight
435.44
Structure
Simcomp
Class
Antibacterial
 DG01710  beta-Lactam antibiotic
  DG01454  Monobactam
 DG01804  Oxyimino beta-lactam
Remark
Same as: C06840
Therapeutic category: 6122
ATC code: J01DF01
Chemical structure group: DG00589
Product (DG00589): D00240<JP/US>
Efficacy
Antibacterial, Cell wall biosynthesis inhibitor
  Disease
Urinary tract infections [DS:H01176]
Target
penicillin binding protein
  Pathway
ko00550  Peptidoglycan biosynthesis
Interaction
Structure map
map07012  Cephalosporins - parenteral agents
Other map
map04976  Bile secretion
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01D OTHER BETA-LACTAM ANTIBACTERIALS
    J01DF Monobactams
     J01DF01 Aztreonam
      D00240  Aztreonam (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Antibacterials
  Antibacterials, Other
   Aztreonam
    D00240  Aztreonam (JP18/USP/INN)
 Respiratory Tract/Pulmonary Agents
  Cystic Fibrosis Agents
   Inhaled Anti-infectives
    Aztreonam
     D00240  Aztreonam (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  61  Antibiotics
   612  Acting mainly on gram-negative bacteria
    6122  Monobactams
     D00240  Aztreonam (JP18/USP/INN)
Drug groups [BR:br08330]
 Antibacterial
  DG01710  beta-Lactam antibiotic
   DG01454  Monobactam
    DG00589  Aztreonam
     D00240  Aztreonam
  DG01804  Oxyimino beta-lactam
   DG00589  Aztreonam
    D00240  Aztreonam
Antimicrobials [BR:br08307]
 Antibacterials
  Cell wall biosynthesis inhibitor, beta-lactam
   Monobactam
    D00240  Aztreonam (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00240  Aztreonam
  D00240  Aztreonam for injection
Drug groups [BR:br08330]
 Antibacterial
  DG01710  beta-Lactam antibiotic
   DG01454  Monobactam
    DG00589  Aztreonam
  DG01804  Oxyimino beta-lactam
   DG00589  Aztreonam
Antimicrobials abbreviations [BR:br08327]
 Antibacterials
  Cell wall biosynthesis inhibitor, beta-lactam
   Monobactam
    DG00589  Aztreonam
Other DBs
CAS: 78110-38-0
PubChem: 7847306
ChEBI: 161680
LigandBox: D00240
NIKKAJI: J20.598B
LinkDB
KCF data

ATOM        28
            1   C2c C    15.4000  -22.4000
            2   C5a C    16.6124  -23.1000
            3   C8y C    14.1876  -23.1000
            4   N1b N    17.8079  -22.4096
            5   C1y C    18.9953  -23.0951
            6   O5a O    16.6125  -24.4998
            7   C8x C    13.0547  -22.3092
            8   S2x S    11.9564  -23.1439
            9   C8y C    12.4109  -24.4464
            10  N5x N    13.7900  -24.4167
            11  N1a N    11.6135  -25.5950 #+
            12  N2b N    15.4000  -21.0000
            13  O2a O    16.6124  -20.3000
            14  C5x C    18.9535  -24.4990
            15  N1y N    20.3512  -24.4712
            16  C1y C    20.3934  -23.0735
            17  S4a S    21.3599  -25.4900
            18  O5x O    17.9666  -25.4763
            19  C1a C    21.3655  -22.1157
            20  O1d O    22.3498  -24.5001
            21  O1d O    20.3699  -26.4800
            22  O1d O    22.4099  -26.4700 #-
            23  C1d C    16.6124  -18.9000
            24  C1a C    16.6124  -17.5000
            25  C1a C    15.2124  -18.9000
            26  C6a C    17.9900  -18.9000
            27  O6a O    18.6900  -20.1124
            28  O6a O    18.6900  -17.6876
BOND        29
            1     1   2 1
            2     1   3 1
            3     2   4 1
            4     5   4 1 #Up
            5     2   6 2
            6     3   7 2
            7     7   8 1
            8     8   9 1
            9     9  10 2
            10    3  10 1
            11    9  11 1
            12    1  12 2
            13   12  13 1
            14    5  14 1
            15   14  15 1
            16   15  16 1
            17    5  16 1
            18   15  17 1
            19   14  18 2
            20   16  19 1 #Down
            21   17  20 2
            22   17  21 2
            23   17  22 1
            24   13  23 1
            25   23  24 1
            26   23  25 1
            27   23  26 1
            28   26  27 2
            29   26  28 1

» Japanese version   » Back

KEGG   DRUG: Aztreonam lysine
Entry
D06558                      Drug                                   
Name
Aztreonam lysine (USAN);
Cayston (TN)
Formula
C13H17N5O8S2. C6H14N2O2
Exact mass
581.1574
Mol weight
581.63
Structure
Class
Antibacterial
 DG01710  beta-Lactam antibiotic
  DG01454  Monobactam
 DG01804  Oxyimino beta-lactam
Remark
ATC code: J01DF01
Chemical structure group: DG00589
Product (DG00589): D00240<JP/US>
Efficacy
Antibacterial, Cell wall biosynthesis inhibitor
Target
penicillin binding protein
  Pathway
ko00550  Peptidoglycan biosynthesis
Interaction
Structure map
map07012  Cephalosporins - parenteral agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01D OTHER BETA-LACTAM ANTIBACTERIALS
    J01DF Monobactams
     J01DF01 Aztreonam
      D06558  Aztreonam lysine (USAN)
Drug groups [BR:br08330]
 Antibacterial
  DG01710  beta-Lactam antibiotic
   DG01454  Monobactam
    DG00589  Aztreonam
     D06558  Aztreonam lysine
  DG01804  Oxyimino beta-lactam
   DG00589  Aztreonam
    D06558  Aztreonam lysine
Antimicrobials [BR:br08307]
 Antibacterials
  Cell wall biosynthesis inhibitor, beta-lactam
   Monobactam
    D06558  Aztreonam lysine (USAN)
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D06558
Drug groups [BR:br08330]
 Antibacterial
  DG01710  beta-Lactam antibiotic
   DG01454  Monobactam
    DG00589  Aztreonam
  DG01804  Oxyimino beta-lactam
   DG00589  Aztreonam
Antimicrobials abbreviations [BR:br08327]
 Antibacterials
  Cell wall biosynthesis inhibitor, beta-lactam
   Monobactam
    DG00589  Aztreonam
Other DBs
CAS: 827611-49-4
PubChem: 47208214
LigandBox: D06558
LinkDB
KCF data

ATOM        38
            1   C1c C    23.8451  -16.5560
            2   C1b C    25.0603  -15.8782
            3   C6a C    22.6942  -15.8081
            4   N1a N    23.8860  -17.9641
            5   C1b C    26.2698  -16.5911
            6   O6a O    21.4672  -16.4918
            7   O6a O    22.6941  -14.4057
            8   C1b C    27.4970  -15.9073
            9   C1b C    28.7065  -16.6262
            10  N1a N    29.9334  -15.9424
            11  C2c C    11.9700  -16.5900
            12  C5a C    13.1600  -17.2900
            13  C8y C    10.7100  -17.2900
            14  N1b N    14.3500  -16.5900
            15  C1y C    15.5400  -17.2900
            16  O5a O    13.1600  -18.6900
            17  C8x C     9.5900  -16.5200
            18  S2x S     8.4700  -17.3600
            19  C8y C     8.9600  -18.6900
            20  N5x N    10.3600  -18.6200
            21  N1a N     8.1900  -19.8100 #+
            22  N2b N    11.9700  -15.1900
            23  O2a O    13.1600  -14.4900
            24  C5x C    15.5400  -18.6900
            25  N1y N    16.9400  -18.6900
            26  C1y C    16.9400  -17.2900
            27  S4a S    17.9200  -19.7400
            28  O5x O    14.5600  -19.6700
            29  C1a C    17.9200  -16.3100
            30  O1d O    18.9700  -18.6900
            31  O1d O    16.9400  -20.7200
            32  O1d O    18.9700  -20.7200 #-
            33  C1d C    13.1600  -13.0900
            34  C1a C    13.1600  -11.6900
            35  C1a C    11.7600  -13.0900
            36  C6a C    14.5600  -13.0900
            37  O6a O    15.2600  -14.2800
            38  O6a O    15.2600  -11.9000
BOND        38
            1     1   2 1
            2     1   3 1
            3     1   4 1 #Down
            4     2   5 1
            5     3   6 1
            6     3   7 2
            7     5   8 1
            8     8   9 1
            9     9  10 1
            10   11  12 1
            11   11  13 1
            12   12  14 1
            13   15  14 1 #Up
            14   12  16 2
            15   13  17 2
            16   17  18 1
            17   18  19 1
            18   19  20 2
            19   13  20 1
            20   19  21 1
            21   11  22 2
            22   22  23 1
            23   15  24 1
            24   24  25 1
            25   25  26 1
            26   15  26 1
            27   25  27 1
            28   24  28 2
            29   26  29 1 #Down
            30   27  30 2
            31   27  31 2
            32   27  32 1
            33   23  33 1
            34   33  34 1
            35   33  35 1
            36   33  36 1
            37   36  37 2
            38   36  38 1

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