KEGG   DRUG: Carvedilol
Entry
D00255                      Drug                                   
Name
Carvedilol (JP18/USP/INN);
Artist (TN);
Coreg (TN)
Product
  Generic
CARVEDILOL (A-S Medication Solutions), CARVEDILOL (Advagen Pharma), CARVEDILOL (American Health Packaging), CARVEDILOL (Aphena Pharma Solutions - Tennessee), CARVEDILOL (Aphena Pharma Solutions - Tennessee), CARVEDILOL (Aphena Pharma Solutions - Tennessee), CARVEDILOL (Aurobindo Pharma Limited), CARVEDILOL (Bayshore Pharmaceuticals LLC), CARVEDILOL (BluePoint Laboratories), CARVEDILOL (Bryant Ranch Prepack), CARVEDILOL (Bryant Ranch Prepack), CARVEDILOL (Bryant Ranch Prepack), CARVEDILOL (Bryant Ranch Prepack), CARVEDILOL (Bryant Ranch Prepack), CARVEDILOL (Bryant Ranch Prepack), CARVEDILOL (Bryant Ranch Prepack), CARVEDILOL (Bryant Ranch Prepack), CARVEDILOL (Bryant Ranch Prepack), CARVEDILOL (Bryant Ranch Prepack), CARVEDILOL (Bryant Ranch Prepack), CARVEDILOL (Bryant Ranch Prepack), CARVEDILOL (Bryant Ranch Prepack), CARVEDILOL (Bryant Ranch Prepack), CARVEDILOL (Bryant Ranch Prepack), CARVEDILOL (Bryant Ranch Prepack), CARVEDILOL (Cardinal Health 107), CARVEDILOL (Cardinal Health 107), CARVEDILOL (Clinical Solutions Wholesale), CARVEDILOL (DIRECT RX), CARVEDILOL (DIRECT RX), CARVEDILOL (Denton Pharma), CARVEDILOL (Denton Pharma), CARVEDILOL (Denton Pharma), CARVEDILOL (Denton Pharma), CARVEDILOL (Denton Pharma), CARVEDILOL (Direct_Rx), CARVEDILOL (Direct_Rx), CARVEDILOL (Direct_Rx), CARVEDILOL (Direct_Rx), CARVEDILOL (Direct_Rx), CARVEDILOL (Direct_Rx), CARVEDILOL (Direct_Rx), CARVEDILOL (Direct_Rx), CARVEDILOL (Dr. Reddy's Laboratories Limited), CARVEDILOL (Glenmark Pharmaceuticals), CARVEDILOL (Golden State Medical Supply), CARVEDILOL (Lake Erie Medical DBA Quality Care Products LLC), CARVEDILOL (Legacy Pharmaceutical Packaging), CARVEDILOL (Major Pharmaceuticals), CARVEDILOL (Mylan Institutional), CARVEDILOL (Mylan Pharmaceuticals), CARVEDILOL (NCS HealthCare of KY), CARVEDILOL (Northwind Pharmaceuticals), CARVEDILOL (Northwind Pharmaceuticals), CARVEDILOL (Northwind Pharmaceuticals), CARVEDILOL (NuCare Pharmaceuticals), CARVEDILOL (NuCare Pharmaceuticals), CARVEDILOL (NuCare Pharmaceuticals), CARVEDILOL (NuCare Pharmaceuticals), CARVEDILOL (NuCare Pharmaceuticals), CARVEDILOL (NuCare Pharmaceuticals), CARVEDILOL (PD-Rx Pharmaceuticals), CARVEDILOL (PD-Rx Pharmaceuticals), CARVEDILOL (PD-Rx Pharmaceuticals), CARVEDILOL (PD-Rx Pharmaceuticals), CARVEDILOL (Preferred Pharmacdeuticals), CARVEDILOL (Preferred Pharmaceuticals Inc.,), CARVEDILOL (Preferred Pharmaceuticals), CARVEDILOL (Preferred Pharmaceuticals), CARVEDILOL (Preferred Pharmaceuticals), CARVEDILOL (Preferred Pharmaceuticals), CARVEDILOL (Preferred Pharmaceuticals), CARVEDILOL (Preferred Pharmaceuticals), CARVEDILOL (Preferred Pharmaceuticals), CARVEDILOL (Preferred Pharmaceuticals), CARVEDILOL (Proficient Rx LP), CARVEDILOL (Proficient Rx LP), CARVEDILOL (Proficient Rx LP), CARVEDILOL (Proficient Rx LP), CARVEDILOL (Proficient Rx LP), CARVEDILOL (Proficient Rx LP), CARVEDILOL (QPharma), CARVEDILOL (Quality Care Products), CARVEDILOL (REMEDYREPACK), CARVEDILOL (REMEDYREPACK), CARVEDILOL (REMEDYREPACK), CARVEDILOL (REMEDYREPACK), CARVEDILOL (ST. MARY'S MEDICAL PARK PHARMACY), CARVEDILOL (Sandoz), CARVEDILOL (St. Mary's Medical Park Pharmacy), CARVEDILOL (St. Mary's Medical Park Pharmacy), CARVEDILOL (St. Mary's Medical Park Pharmacy), CARVEDILOL (St. Mary's Medical Park Pharmacy), CARVEDILOL (Teva Pharmaceuticals USA), CARVEDILOL (Zydus Lifesciences Limited), CARVEDILOL (Zydus Pharmaceuticals USA)
Formula
C24H26N2O4
Exact mass
406.1893
Mol weight
406.4742
Structure
Simcomp
Class
Cardiovascular agent
 DG01466  Adrenergic receptor antagonist
  DG03180  alpha1 and beta-Adrenergic receptor antagonist
 DG03231  Antihypertensive
  DG03180  alpha1 and beta-Adrenergic receptor antagonist
Metabolizing enzyme substrate
 DG01892  CYP1A2 substrate
 DG01642  CYP2C9 substrate
 DG01644  CYP2D6 substrate
 DG02855  CYP2E1 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Transporter inhibitor
 DG01622  ABCB1 inhibitor
Remark
Same as: C06875
Therapeutic category: 2149
ATC code: C07AG02
Chemical structure group: DG00321
Product (DG00321): D00255<JP/US> D03415<US>
Efficacy
Antihypertensive, alpha1/beta-Adrenergic receptor antagonist
  Disease
Hypertension [DS:H01633]
Target
ADRA1 [HSA:148 147 146] [KO:K04135 K04136 K04137]
ADRB1 [HSA:153] [KO:K04141]
ADRB2 [HSA:154] [KO:K04142]
  Pathway
hsa04020  Calcium signaling pathway
hsa04022  cGMP-PKG signaling pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
hsa05414  Dilated cardiomyopathy
Metabolism
Enzyme: CYP2D6 [HSA:1565], CYP2C9 [HSA:1559], CYP3A4 [HSA:1576], CYP1A2 [HSA:1544], CYP2E1 [HSA:1571]
Interaction
Transporter inhibition: ABCB1 [HSA:5243]
Structure map
map07215  alpha-Adrenergic receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C07 BETA BLOCKING AGENTS
   C07A BETA BLOCKING AGENTS
    C07AG Alpha and beta blocking agents
     C07AG02 Carvedilol
      D00255  Carvedilol (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Beta-adrenergic Blocking Agents
   Beta-adrenergic Blocking Agents, Other
    Carvedilol
     D00255  Carvedilol (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2149  Others
     D00255  Carvedilol (JP18/USP/INN)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01466  Adrenergic receptor antagonist
   DG03180  alpha1 and beta-Adrenergic receptor antagonist
    DG00321  Carvedilol
     D00255  Carvedilol
  DG03231  Antihypertensive
   DG03180  alpha1 and beta-Adrenergic receptor antagonist
    DG00321  Carvedilol
     D00255  Carvedilol
 Metabolizing enzyme substrate
  DG01892  CYP1A2 substrate
   DG00321  Carvedilol
    D00255  Carvedilol
  DG01642  CYP2C9 substrate
   DG00321  Carvedilol
    D00255  Carvedilol
  DG01644  CYP2D6 substrate
   DG00321  Carvedilol
    D00255  Carvedilol
  DG02855  CYP2E1 substrate
   DG00321  Carvedilol
    D00255  Carvedilol
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00321  Carvedilol
     D00255  Carvedilol
 Transporter inhibitor
  DG01622  ABCB1 inhibitor
   DG00321  Carvedilol
    D00255  Carvedilol
Drug classes [BR:br08332]
 Cardiovascular agent
  DG03231  Antihypertensive
   D00255  Carvedilol
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA1
     D00255  Carvedilol (JP18/USP/INN) <JP/US>
    ADRB1
     D00255  Carvedilol (JP18/USP/INN) <JP/US>
    ADRB2
     D00255  Carvedilol (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00255  Carvedilol
  D00255  Carvedilol tablets
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00255
 Drug transporters
  D00255
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and mutations affecting drug response
  D00255
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01466  Adrenergic receptor antagonist
   DG03180  alpha1 and beta-Adrenergic receptor antagonist
    DG00321  Carvedilol
  DG03231  Antihypertensive
   DG03180  alpha1 and beta-Adrenergic receptor antagonist
    DG00321  Carvedilol
 Metabolizing enzyme substrate
  DG01892  CYP1A2 substrate
   DG00321  Carvedilol
  DG01642  CYP2C9 substrate
   DG00321  Carvedilol
  DG01644  CYP2D6 substrate
   DG00321  Carvedilol
  DG02855  CYP2E1 substrate
   DG00321  Carvedilol
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00321  Carvedilol
 Transporter inhibitor
  DG01622  ABCB1 inhibitor
   DG00321  Carvedilol
Other DBs
CAS: 72956-09-3
PubChem: 7847321
ChEBI: 3441
LigandBox: D00255
NIKKAJI: J33.955E
LinkDB
KCF data

ATOM        30
            1   C8y C    17.5000  -16.5200
            2   C8y C    16.1700  -16.0300
            3   C8y C    17.5000  -17.9200
            4   C8y C    18.7600  -15.8200
            5   C8y C    15.3300  -17.1500
            6   C8x C    15.6800  -14.7000
            7   N4x N    16.1700  -18.3400
            8   C8x C    18.6900  -18.6200
            9   C8x C    19.9500  -16.5200
            10  O2a O    18.7600  -14.4200
            11  C8x C    13.9300  -16.9400
            12  C8x C    14.2800  -14.5600
            13  C8x C    19.9500  -17.9200
            14  C1b C    20.0200  -13.7200
            15  C8x C    13.4400  -15.6800
            16  C1c C    21.2100  -14.4900
            17  C1b C    22.4700  -13.7900
            18  O1a O    21.2100  -15.8900
            19  N1b N    23.5900  -14.5600
            20  C1b C    24.8500  -13.8600
            21  C1b C    26.0400  -14.5600
            22  O2a O    27.2300  -13.9300
            23  C8y C    28.4900  -14.6300
            24  C8y C    28.4900  -16.0300
            25  C8x C    29.6800  -14.0000
            26  C8x C    29.6100  -16.8000
            27  O2a O    27.2300  -16.6600
            28  C8x C    30.8700  -14.7000
            29  C8x C    30.8700  -16.1000
            30  C1a C    25.9700  -15.9600
BOND        33
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 2
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     4   9 2
            9     4  10 1
            10    5  11 1
            11    6  12 2
            12    8  13 2
            13   10  14 1
            14   11  15 2
            15   14  16 1
            16   16  17 1
            17   16  18 1
            18   17  19 1
            19   19  20 1
            20   20  21 1
            21   21  22 1
            22   22  23 1
            23   23  24 2
            24   23  25 1
            25   24  26 1
            26   24  27 1
            27   25  28 2
            28   26  29 2
            29   27  30 1
            30    5   7 1
            31    9  13 1
            32   12  15 1
            33   28  29 1

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