KEGG   DRUG: Carvedilol
Entry
D00255                      Drug                                   

Name
Carvedilol (JP18/USP/INN);
Artist (TN);
Coreg (TN)
Product
  Generic
CARVEDILOL (A-S Medication Solutions), CARVEDILOL (A-S Medication Solutions), CARVEDILOL (A-S Medication Solutions), CARVEDILOL (A-S Medication Solutions), CARVEDILOL (A-S Medication Solutions), CARVEDILOL (A-S Medication Solutions), CARVEDILOL (Advagen Pharma), CARVEDILOL (American Health Packaging), CARVEDILOL (Aphena Pharma Solutions - Tennessee), CARVEDILOL (Aphena Pharma Solutions - Tennessee), CARVEDILOL (Aphena Pharma Solutions - Tennessee), CARVEDILOL (Aurobindo Pharma Limited), CARVEDILOL (Bayshore Pharmaceuticals LLC), CARVEDILOL (BluePoint Laboratories), CARVEDILOL (Bryant Ranch Prepack), CARVEDILOL (Bryant Ranch Prepack), CARVEDILOL (Bryant Ranch Prepack), CARVEDILOL (Bryant Ranch Prepack), CARVEDILOL (Bryant Ranch Prepack), CARVEDILOL (Bryant Ranch Prepack), CARVEDILOL (Bryant Ranch Prepack), CARVEDILOL (Bryant Ranch Prepack), CARVEDILOL (Bryant Ranch Prepack), CARVEDILOL (Bryant Ranch Prepack), CARVEDILOL (Bryant Ranch Prepack), CARVEDILOL (Cadila Healthcare Limited), CARVEDILOL (Cardinal Health), CARVEDILOL (Cardinal Health), CARVEDILOL (Clinical Solutions Wholesale), CARVEDILOL (DIRECT RX), CARVEDILOL (DIRECT RX), CARVEDILOL (Denton Pharma), CARVEDILOL (Denton Pharma), CARVEDILOL (Denton Pharma), CARVEDILOL (Denton Pharma), CARVEDILOL (Denton Pharma), CARVEDILOL (Denton Pharma), CARVEDILOL (Denton Pharma), CARVEDILOL (Denton Pharma), CARVEDILOL (Denton Pharma), CARVEDILOL (Denton Pharma), CARVEDILOL (Denton Pharma), CARVEDILOL (Direct_Rx), CARVEDILOL (Direct_Rx), CARVEDILOL (Direct_Rx), CARVEDILOL (Direct_Rx), CARVEDILOL (Direct_Rx), CARVEDILOL (Direct_Rx), CARVEDILOL (Direct_Rx), CARVEDILOL (Dr. Reddy's Laboratories Limited), CARVEDILOL (Glenmark Pharmaceuticals), CARVEDILOL (Golden State Medical Supply), CARVEDILOL (Lake Erie Medical DBA Quality Care Products LLC), CARVEDILOL (Legacy Pharmaceutical Packaging), CARVEDILOL (Major Pharmaceuticals), CARVEDILOL (Mylan Institutional), CARVEDILOL (Mylan Pharmaceuticals), CARVEDILOL (NCS HealthCare of KY), CARVEDILOL (NCS HealthCare of KY), CARVEDILOL (Northwind Pharmaceuticals), CARVEDILOL (Northwind Pharmaceuticals), CARVEDILOL (NuCare Pharmaceuticals), CARVEDILOL (NuCare Pharmaceuticals), CARVEDILOL (NuCare Pharmaceuticals), CARVEDILOL (NuCare Pharmaceuticals), CARVEDILOL (NuCare Pharmaceuticals), CARVEDILOL (NuCare Pharmaceuticals), CARVEDILOL (NuCare Pharmaceuticals), CARVEDILOL (NuCare Pharmaceuticals), CARVEDILOL (NuCare Pharmaceuticals), CARVEDILOL (NuCare Pharmaceuticals), CARVEDILOL (NuCare Pharmaceuticals), CARVEDILOL (PD-Rx Pharmaceuticals), CARVEDILOL (PD-Rx Pharmaceuticals), CARVEDILOL (PD-Rx Pharmaceuticals), CARVEDILOL (PD-Rx Pharmaceuticals), CARVEDILOL (Preferred Pharmacdeuticals), CARVEDILOL (Preferred Pharmaceuticals), CARVEDILOL (Preferred Pharmaceuticals), CARVEDILOL (Preferred Pharmaceuticals), CARVEDILOL (Preferred Pharmaceuticals), CARVEDILOL (Preferred Pharmaceuticals), CARVEDILOL (Proficient Rx LP), CARVEDILOL (Proficient Rx LP), CARVEDILOL (Proficient Rx LP), CARVEDILOL (Proficient Rx LP), CARVEDILOL (Proficient Rx LP), CARVEDILOL (Proficient Rx LP), CARVEDILOL (QPharma), CARVEDILOL (Quality Care Products), CARVEDILOL (REMEDYREPACK), CARVEDILOL (REMEDYREPACK), CARVEDILOL (REMEDYREPACK), CARVEDILOL (REMEDYREPACK), CARVEDILOL (REMEDYREPACK), CARVEDILOL (REMEDYREPACK), CARVEDILOL (RPK Pharmaceuticals), CARVEDILOL (Sandoz), CARVEDILOL (St. Mary's Medical Park Pharmacy), CARVEDILOL (St. Mary's Medical Park Pharmacy), CARVEDILOL (St. Mary's Medical Park Pharmacy), CARVEDILOL (St. Mary's Medical Park Pharmacy), CARVEDILOL (St. Mary's Medical Park Pharmacy), CARVEDILOL (St. Mary's Medical Park Pharmacy), CARVEDILOL (Teva Pharmaceuticals USA), CARVEDILOL (Zydus Pharmaceuticals (USA))
Formula
C24H26N2O4
Exact mass
406.1893
Mol weight
406.4742
Structure
Simcomp
Class
Cardiovascular agent
 DG01466  Adrenergic receptor antagonist
  DG01464  beta-Adrenergic receptor antagonist
   DG01461  beta1-Adrenergic receptor antagonist
   DG01462  beta2-Adrenergic receptor antagonist
   DG01463  beta3-Adrenergic receptor antagonist
  DG01465  alpha-Adrenergic receptor antagonist
   DG01457  alpha1-Adrenergic receptor antagonist
Metabolizing enzyme substrate
 DG01892  CYP1A2 substrate
 DG01642  CYP2C9 substrate
 DG01644  CYP2D6 substrate
 DG02855  CYP2E1 substrate
 DG02913  CYP3A4 substrate
Transporter inhibitor
 DG01622  ABCB1 (P-GP) inhibitor
Remark
Same as: C06875
Therapeutic category: 2149
ATC code: C07AG02
Chemical structure group: DG00321
Product (DG00321): D00255<JP/US> D03415<US>
Efficacy
Antihypertensive, alpha1/beta-Adrenergic receptor antagonist
  Disease
Hypertension [DS:H01633]
Target
ADRA1 [HSA:148 147 146] [KO:K04135 K04136 K04137]
ADRB1 [HSA:153] [KO:K04141]
ADRB2 [HSA:154] [KO:K04142]
  Pathway
hsa04020  Calcium signaling pathway
hsa04022  cGMP-PKG signaling pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
hsa05414  Dilated cardiomyopathy
Metabolism
Enzyme: CYP2D6 [HSA:1565], CYP2C9 [HSA:1559], CYP3A4 [HSA:1576], CYP1A2 [HSA:1544], CYP2E1 [HSA:1571]
Interaction
Transporter inhibition: ABCB1 [HSA:5243]
Structure map
map07215  alpha-Adrenergic receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C07 BETA BLOCKING AGENTS
   C07A BETA BLOCKING AGENTS
    C07AG Alpha and beta blocking agents
     C07AG02 Carvedilol
      D00255  Carvedilol (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Beta-adrenergic Blocking Agents
   Beta-adrenergic Blocking Agents, Other
    Carvedilol
     D00255  Carvedilol (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2149  Others
     D00255  Carvedilol (JP18/USP/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA1
     D00255  Carvedilol (JP18/USP/INN) <JP/US>
    ADRB1
     D00255  Carvedilol (JP18/USP/INN) <JP/US>
    ADRB2
     D00255  Carvedilol (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00255  Carvedilol
  D00255  Carvedilol tablets
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00255
 Drug transporters
  D00255
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and mutations affecting drug response
  D00255
Other DBs
CAS: 72956-09-3
PubChem: 7847321
ChEBI: 3441
ChEMBL: CHEMBL723
DrugBank: DB01136
LigandBox: D00255
NIKKAJI: J33.955E
LinkDB
KCF data

ATOM        30
            1   C8y C    17.5000  -16.5200
            2   C8y C    16.1700  -16.0300
            3   C8y C    17.5000  -17.9200
            4   C8y C    18.7600  -15.8200
            5   C8y C    15.3300  -17.1500
            6   C8x C    15.6800  -14.7000
            7   N4x N    16.1700  -18.3400
            8   C8x C    18.6900  -18.6200
            9   C8x C    19.9500  -16.5200
            10  O2a O    18.7600  -14.4200
            11  C8x C    13.9300  -16.9400
            12  C8x C    14.2800  -14.5600
            13  C8x C    19.9500  -17.9200
            14  C1b C    20.0200  -13.7200
            15  C8x C    13.4400  -15.6800
            16  C1c C    21.2100  -14.4900
            17  C1b C    22.4700  -13.7900
            18  O1a O    21.2100  -15.8900
            19  N1b N    23.5900  -14.5600
            20  C1b C    24.8500  -13.8600
            21  C1b C    26.0400  -14.5600
            22  O2a O    27.2300  -13.9300
            23  C8y C    28.4900  -14.6300
            24  C8y C    28.4900  -16.0300
            25  C8x C    29.6800  -14.0000
            26  C8x C    29.6100  -16.8000
            27  O2a O    27.2300  -16.6600
            28  C8x C    30.8700  -14.7000
            29  C8x C    30.8700  -16.1000
            30  C1a C    25.9700  -15.9600
BOND        33
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 2
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     4   9 2
            9     4  10 1
            10    5  11 1
            11    6  12 2
            12    8  13 2
            13   10  14 1
            14   11  15 2
            15   14  16 1
            16   16  17 1
            17   16  18 1
            18   17  19 1
            19   19  20 1
            20   20  21 1
            21   21  22 1
            22   22  23 1
            23   23  24 2
            24   23  25 1
            25   24  26 1
            26   24  27 1
            27   25  28 2
            28   26  29 2
            29   27  30 1
            30    5   7 1
            31    9  13 1
            32   12  15 1
            33   28  29 1

» Japanese version   » Back

KEGG   DRUG: Carvedilol phosphate
Entry
D03415                      Drug                                   

Name
Carvedilol phosphate (USAN);
Carvedilol phosphate hydrate (JAN);
Coreg CR (TN)
Product
  Generic
Formula
(C24H26N2O4)2. 2H3PO4. H2O
Exact mass
1026.3429
Mol weight
1026.9541
Structure
Class
Cardiovascular agent
 DG01466  Adrenergic receptor antagonist
  DG01464  beta-Adrenergic receptor antagonist
   DG01461  beta1-Adrenergic receptor antagonist
   DG01462  beta2-Adrenergic receptor antagonist
   DG01463  beta3-Adrenergic receptor antagonist
  DG01465  alpha-Adrenergic receptor antagonist
   DG01457  alpha1-Adrenergic receptor antagonist
Metabolizing enzyme substrate
 DG01892  CYP1A2 substrate
 DG01642  CYP2C9 substrate
 DG01644  CYP2D6 substrate
 DG02855  CYP2E1 substrate
 DG02913  CYP3A4 substrate
Transporter inhibitor
 DG01622  ABCB1 (P-GP) inhibitor
Remark
ATC code: C07AG02
Chemical structure group: DG00321
Product (DG00321): D00255<JP/US> D03415<US>
Efficacy
Antihypertensive, alpha1/beta-Adrenergic receptor antagonist
  Disease
Hypertension [DS:H01633]
Target
ADRA1 [HSA:148 147 146] [KO:K04135 K04136 K04137]
ADRB1 [HSA:153] [KO:K04141]
ADRB2 [HSA:154] [KO:K04142]
  Pathway
hsa04020  Calcium signaling pathway
hsa04022  cGMP-PKG signaling pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
hsa05414  Dilated cardiomyopathy
Metabolism
Enzyme: CYP2D6 [HSA:1565], CYP2C9 [HSA:1559], CYP3A4 [HSA:1576], CYP1A2 [HSA:1544], CYP2E1 [HSA:1571]
Interaction
Transporter inhibition: ABCB1 [HSA:5243]
Structure map
map07215  alpha-Adrenergic receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C07 BETA BLOCKING AGENTS
   C07A BETA BLOCKING AGENTS
    C07AG Alpha and beta blocking agents
     C07AG02 Carvedilol
      D03415  Carvedilol phosphate (USAN) <US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Beta-adrenergic Blocking Agents
   Beta-adrenergic Blocking Agents, Other
    Carvedilol
     D03415  Carvedilol phosphate (USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA1
     D03415  Carvedilol phosphate (USAN) <US>
    ADRB1
     D03415  Carvedilol phosphate (USAN) <US>
    ADRB2
     D03415  Carvedilol phosphate (USAN) <US>
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D03415
 Drug transporters
  D03415
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and mutations affecting drug response
  D03415
Other DBs
CAS: 610309-89-2
PubChem: 17397555
DrugBank: DB01136
LigandBox: D03415
LinkDB
KCF data

ATOM        71
            1   P1b P    25.2157   -4.9627
            2   O1c O    25.2085   -3.5620
            3   O1c O    26.6165   -4.9627
            4   O1c O    23.8149   -4.9556
            5   O1c O    25.2085   -6.3635
            6   O0  O    25.8276   -8.5395
            7   C8y C     7.0000   -6.2300
            8   C8y C     5.6700   -5.7400
            9   C8y C     7.0000   -7.6300
            10  C8y C     8.2600   -5.5300
            11  C8y C     4.8300   -6.8600
            12  C8x C     5.1800   -4.4100
            13  N4x N     5.6700   -8.0500
            14  C8x C     8.1900   -8.3300
            15  C8x C     9.4500   -6.2300
            16  O2a O     8.2600   -4.1300
            17  C8x C     3.4300   -6.6500
            18  C8x C     3.7800   -4.2700
            19  C8x C     9.4500   -7.6300
            20  C1b C     9.5200   -3.4300
            21  C8x C     2.9400   -5.3900
            22  C1c C    10.7100   -4.2000
            23  C1b C    11.9700   -3.5000
            24  O1a O    10.7100   -5.6000
            25  N1b N    13.0900   -4.2700
            26  C1b C    14.3500   -3.5700
            27  C1b C    15.5400   -4.2700
            28  O2a O    16.7300   -3.6400
            29  C8y C    17.9900   -4.3400
            30  C8y C    17.9900   -5.7400
            31  C8x C    19.1800   -3.7100
            32  C8x C    19.1100   -6.5100
            33  O2a O    16.7300   -6.3700
            34  C8x C    20.3700   -4.4100
            35  C8x C    20.3700   -5.8100
            36  C1a C    15.4700   -5.6700
            37  P1b P    25.2157   -4.9627
            38  O1c O    25.2085   -3.5620
            39  O1c O    26.6165   -4.9627
            40  O1c O    23.8149   -4.9556
            41  O1c O    25.2085   -6.3635
            42  C8y C     7.0000   -6.2300
            43  C8y C     5.6700   -5.7400
            44  C8y C     4.8300   -6.8600
            45  C8x C     3.4300   -6.6500
            46  C8x C     2.9400   -5.3900
            47  C8x C     3.7800   -4.2700
            48  C8x C     5.1800   -4.4100
            49  N4x N     5.6700   -8.0500
            50  C8y C     7.0000   -7.6300
            51  C8x C     8.1900   -8.3300
            52  C8x C     9.4500   -7.6300
            53  C8x C     9.4500   -6.2300
            54  C8y C     8.2600   -5.5300
            55  O2a O     8.2600   -4.1300
            56  C1b C     9.5200   -3.4300
            57  C1c C    10.7100   -4.2000
            58  C1b C    11.9700   -3.5000
            59  N1b N    13.0900   -4.2700
            60  C1b C    14.3500   -3.5700
            61  C1b C    15.5400   -4.2700
            62  O2a O    16.7300   -3.6400
            63  C8y C    17.9900   -4.3400
            64  C8y C    17.9900   -5.7400
            65  C8x C    19.1100   -6.5100
            66  C8x C    20.3700   -5.8100
            67  C8x C    20.3700   -4.4100
            68  C8x C    19.1800   -3.7100
            69  O2a O    16.7300   -6.3700
            70  C1a C    15.4700   -5.6700
            71  O1a O    10.7100   -5.6000
BOND        74
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     1   5 1
            5    37  38 2
            6    37  39 1
            7    37  40 1
            8    37  41 1
            9     7   8 1
            10    7   9 2
            11    7  10 1
            12    8  11 2
            13    8  12 1
            14    9  13 1
            15    9  14 1
            16   10  15 2
            17   10  16 1
            18   11  17 1
            19   12  18 2
            20   14  19 2
            21   16  20 1
            22   17  21 2
            23   20  22 1
            24   22  23 1
            25   22  24 1
            26   23  25 1
            27   25  26 1
            28   26  27 1
            29   27  28 1
            30   28  29 1
            31   29  30 2
            32   29  31 1
            33   30  32 1
            34   30  33 1
            35   31  34 2
            36   32  35 2
            37   33  36 1
            38   11  13 1
            39   15  19 1
            40   18  21 1
            41   34  35 1
            42   42  43 1
            43   42  50 2
            44   42  54 1
            45   43  44 2
            46   43  48 1
            47   50  49 1
            48   50  51 1
            49   54  53 2
            50   54  55 1
            51   44  45 1
            52   48  47 2
            53   51  52 2
            54   55  56 1
            55   45  46 2
            56   56  57 1
            57   57  58 1
            58   57  71 1
            59   58  59 1
            60   59  60 1
            61   60  61 1
            62   61  62 1
            63   62  63 1
            64   63  64 2
            65   63  68 1
            66   64  65 1
            67   64  69 1
            68   68  67 2
            69   65  66 2
            70   69  70 1
            71   44  49 1
            72   53  52 1
            73   47  46 1
            74   67  66 1
BRACKET     1    22.5400   -6.9300   22.5400   -2.8700
            1    27.7200   -2.8700   27.7200   -6.9300
            1  2
 ORIGINAL  1    1   2   3   4   5
 REPEAT    1   37  38  39  40  41
            2     2.8700   -9.2400    2.8700   -2.7300
            2    20.8600   -2.7300   20.8600   -9.2400
            2  2
 ORIGINAL  2    7   8  11  17  21  18  12  13   9  14  19  15  10  16  20  22
            2   23  25  26  27  28  29  30  32  35  34  31  33  36  24
 REPEAT    2   42  43  44  45  46  47  48  49  50  51  52  53  54  55  56  57
            2   58  59  60  61  62  63  64  65  66  67  68  69  70  71

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