KEGG   DRUG: Cefuroxime
Entry
D00262                      Drug                                   
Name
Cefuroxime (USAN/INN);
Cefuroxime (TN)
Formula
C16H16N4O8S
Exact mass
424.0689
Mol weight
424.39
Structure
Simcomp
Class
Antibacterial
 DG01710  beta-Lactam antibiotic
  DG01714  Cephalosporin skeleton group
   DG01488  Cephem
 DG01775  Second-generation cephalosporin
 DG01804  Oxyimino beta-lactam
Remark
Same as: C06894
ATC code: J01DC02 S01AA27
Chemical structure group: DG00558
Product (DG00558): D00914<JP/US> D00915<US>
Efficacy
Antibacterial, Cell wall biosynthesis inhibitor
Target
penicillin binding protein
  Pathway
ko00550  Peptidoglycan biosynthesis
Interaction
Structure map
map07012  Cephalosporins - parenteral agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01D OTHER BETA-LACTAM ANTIBACTERIALS
    J01DC Second-generation cephalosporins
     J01DC02 Cefuroxime
      D00262  Cefuroxime (USAN/INN)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AA Antibiotics
     S01AA27 Cefuroxime
      D00262  Cefuroxime (USAN/INN)
Drug groups [BR:br08330]
 Antibacterial
  DG01710  beta-Lactam antibiotic
   DG01714  Cephalosporin skeleton group
    DG01488  Cephem
     DG00558  Cefuroxime
      D00262  Cefuroxime
  DG01775  Second-generation cephalosporin
   DG00558  Cefuroxime
    D00262  Cefuroxime
  DG01804  Oxyimino beta-lactam
   DG00558  Cefuroxime
    D00262  Cefuroxime
Antimicrobials [BR:br08307]
 Antibacterials
  Cell wall biosynthesis inhibitor, beta-lactam
   Second-generation cephalosporin
    D00262  Cefuroxime (USAN/INN)
Prodrugs [br08324.html]
 D00262
Drug groups [BR:br08330]
 Antibacterial
  DG01710  beta-Lactam antibiotic
   DG01714  Cephalosporin skeleton group
    DG01488  Cephem
     DG00558  Cefuroxime
  DG01775  Second-generation cephalosporin
   DG00558  Cefuroxime
  DG01804  Oxyimino beta-lactam
   DG00558  Cefuroxime
Antimicrobials abbreviations [BR:br08327]
 Antibacterials
  Cell wall biosynthesis inhibitor, beta-lactam
   Second-generation cephalosporin
    DG00558  Cefuroxime
Other DBs
CAS: 55268-75-2
PubChem: 7847328
ChEBI: 3515
PDB-CCD: KOV[PDBj]
LigandBox: D00262
NIKKAJI: J13.093A
LinkDB
KCF data

ATOM        29
            1   C1y C    32.5439  -17.8678
            2   N1y N    32.5439  -19.2637
            3   C2y C    33.7531  -19.9616
            4   C2y C    34.9620  -19.2637
            5   C1x C    34.9620  -17.8678
            6   S2x S    33.7531  -17.1697
            7   C1y C    31.1478  -17.8678
            8   C5x C    31.1478  -19.2637
            9   N1b N    29.9390  -17.1697
            10  C5a C    28.7299  -17.8678
            11  O5a O    28.7299  -19.2637
            12  O5x O    29.9390  -19.9616
            13  C2c C    27.5208  -17.1697
            14  C1b C    36.1894  -19.9728
            15  C6a C    33.7531  -21.3574
            16  O6a O    32.5271  -22.0653
            17  O6a O    34.9450  -22.0458
            18  C8y C    26.2925  -17.8794
            19  O2x O    25.1407  -17.0683
            20  C8x C    24.0088  -17.9134
            21  C8x C    24.4626  -19.2510
            22  C8x C    25.8750  -19.2329
            23  N2b N    27.5207  -15.7524
            24  O7a O    37.4156  -19.2654
            25  C7a C    38.6006  -19.9502
            26  N1a N    39.7939  -19.2616
            27  O6a O    38.6002  -21.3533
            28  O2a O    28.7331  -15.0524
            29  C1a C    28.7333  -13.6504
BOND        31
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     1   7 1
            8     7   8 1
            9     2   8 1
            10    7   9 1 #Up
            11    9  10 1
            12   10  11 2
            13    8  12 2
            14   10  13 1
            15    4  14 1
            16    3  15 1
            17   15  16 2
            18   15  17 1
            19   13  18 1
            20   18  19 1
            21   19  20 1
            22   20  21 2
            23   21  22 1
            24   18  22 2
            25   13  23 2
            26   14  24 1
            27   24  25 1
            28   25  26 1
            29   25  27 2
            30   23  28 1
            31   28  29 1

» Japanese version   » Back

KEGG   DRUG: Cefuroxime sodium
Entry
D00915                      Drug                                   
Name
Cefuroxime sodium (JAN/USP);
Zinacef (TN)
Product
CEFUROXIME AND DEXTROSE (B. Braun Medical)
  Generic
CEFUROXIME (Hikma Pharmaceuticals USA), CEFUROXIME (Hikma Pharmaceuticals USA), CEFUROXIME (Hikma Pharmaceuticals USA), CEFUROXIME (Hikma Pharmaceuticals USA), CEFUROXIME SODIUM (Sagent Pharmaceuticals), CEFUROXIME SODIUM (Sagent Pharmaceuticals)
Formula
C16H15N4O8S. Na
Exact mass
446.0508
Mol weight
446.37
Structure
Simcomp
Class
Antibacterial
 DG01710  beta-Lactam antibiotic
  DG01714  Cephalosporin skeleton group
   DG01488  Cephem
 DG01775  Second-generation cephalosporin
 DG01804  Oxyimino beta-lactam
Remark
Same as: C08108
ATC code: J01DC02 S01AA27
Chemical structure group: DG00558
Product (DG00558): D00914<JP/US> D00915<US>
Efficacy
Antibacterial, Cell wall biosynthesis inhibitor
  Disease
Gonorrhea [DS:H00315]
Target
penicillin binding protein
  Pathway
ko00550  Peptidoglycan biosynthesis
Interaction
Structure map
map07012  Cephalosporins - parenteral agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01D OTHER BETA-LACTAM ANTIBACTERIALS
    J01DC Second-generation cephalosporins
     J01DC02 Cefuroxime
      D00915  Cefuroxime sodium (JAN/USP) <US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AA Antibiotics
     S01AA27 Cefuroxime
      D00915  Cefuroxime sodium (JAN/USP) <US>
USP drug classification [BR:br08302]
 Antibacterials
  Beta-lactam, Cephalosporins
   Cefuroxime
    D00915  Cefuroxime sodium (JAN/USP)
Drug groups [BR:br08330]
 Antibacterial
  DG01710  beta-Lactam antibiotic
   DG01714  Cephalosporin skeleton group
    DG01488  Cephem
     DG00558  Cefuroxime
      D00915  Cefuroxime sodium
  DG01775  Second-generation cephalosporin
   DG00558  Cefuroxime
    D00915  Cefuroxime sodium
  DG01804  Oxyimino beta-lactam
   DG00558  Cefuroxime
    D00915  Cefuroxime sodium
Drug classes [BR:br08332]
 Antibacterial
  DG01488  Cephem
   D00915  Cefuroxime sodium
Antimicrobials [BR:br08307]
 Antibacterials
  Cell wall biosynthesis inhibitor, beta-lactam
   Second-generation cephalosporin
    D00915  Cefuroxime sodium (JAN/USP) <US>
Drug groups [BR:br08330]
 Antibacterial
  DG01710  beta-Lactam antibiotic
   DG01714  Cephalosporin skeleton group
    DG01488  Cephem
     DG00558  Cefuroxime
  DG01775  Second-generation cephalosporin
   DG00558  Cefuroxime
  DG01804  Oxyimino beta-lactam
   DG00558  Cefuroxime
Antimicrobials abbreviations [BR:br08327]
 Antibacterials
  Cell wall biosynthesis inhibitor, beta-lactam
   Second-generation cephalosporin
    DG00558  Cefuroxime
Other DBs
CAS: 56238-63-2
PubChem: 7847978
ChEBI: 3517
LigandBox: D00915
NIKKAJI: J296.618B
LinkDB
KCF data

ATOM        30
            1   C1y C    32.5439  -17.8678
            2   N1y N    32.5439  -19.2637
            3   C2y C    33.7531  -19.9616
            4   C2y C    34.9620  -19.2637
            5   C1x C    34.9620  -17.8678
            6   S2x S    33.7531  -17.1697
            7   C1y C    31.1478  -17.8678
            8   C5x C    31.1478  -19.2637
            9   N1b N    29.9390  -17.1697
            10  C5a C    28.7299  -17.8678
            11  O5a O    28.7299  -19.2637
            12  O5x O    29.9390  -19.9616
            13  C2c C    27.5208  -17.1697
            14  C1b C    36.1894  -19.9728
            15  C6a C    33.7531  -21.3574
            16  O6a O    32.5271  -22.0653
            17  O6a O    34.9450  -22.0458 #-
            18  C8y C    26.2925  -17.8794
            19  O2x O    25.1407  -17.0683
            20  C8x C    24.0088  -17.9134
            21  C8x C    24.4626  -19.2510
            22  C8x C    25.8750  -19.2329
            23  N2b N    27.5207  -15.7524
            24  O7a O    37.4156  -19.2654
            25  C7a C    38.6006  -19.9502
            26  N1a N    39.7939  -19.2616
            27  O6a O    38.6002  -21.3533
            28  O2a O    28.7261  -15.0563
            29  C1a C    28.7261  -13.6563
            30  Z   Na   36.2600  -21.9800 #+
BOND        31
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     1   7 1
            8     7   8 1
            9     2   8 1
            10    7   9 1 #Up
            11    9  10 1
            12   10  11 2
            13    8  12 2
            14   10  13 1
            15    4  14 1
            16    3  15 1
            17   15  16 2
            18   15  17 1
            19   13  18 1
            20   18  19 1
            21   19  20 1
            22   20  21 2
            23   21  22 1
            24   18  22 2
            25   13  23 2
            26   14  24 1
            27   24  25 1
            28   25  26 1
            29   25  27 2
            30   23  28 1
            31   28  29 1

» Japanese version   » Back

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