KEGG   DRUG: Clonidine
Entry
D00281                      Drug                                   
Name
Clonidine (JAN/USP/INN);
Catarpres-TTS (TN)
Product
  Generic
Formula
C9H9Cl2N3
Exact mass
229.0174
Mol weight
230.09
Structure
Simcomp
Class
Cardiovascular agent
 DG01738  Centrally-acting antiadrenergic
 DG01456  Adrenergic receptor agonist
  DG01450  alpha-Adrenergic receptor agonist
   DG01449  alpha2-Adrenergic receptor agonist
 DG03231  Antihypertensive
Remark
ATC code: C02AC01 N02CX02 S01EA04
Chemical structure group: DG00249
Product (DG00249): D00281<US> D00604<JP/US>
Efficacy
Antihypertensive, alpha2-Adrenergic receptor agonist
Comment
Imidazoline derivative
Target
ADRA2 [HSA:150 151 152] [KO:K04138 K04139 K04140]
  Pathway
hsa04022  cGMP-PKG signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Structure map
map07215  alpha-Adrenergic receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C02 ANTIHYPERTENSIVES
   C02A ANTIADRENERGIC AGENTS, CENTRALLY ACTING
    C02AC Imidazoline receptor agonists
     C02AC01 Clonidine
      D00281  Clonidine (JAN/USP/INN) <US>
 N NERVOUS SYSTEM
  N02 ANALGESICS
   N02C ANTIMIGRAINE PREPARATIONS
    N02CX Other antimigraine preparations
     N02CX02 Clonidine
      D00281  Clonidine (JAN/USP/INN) <US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01EA Sympathomimetics in glaucoma therapy
     S01EA04 Clonidine
      D00281  Clonidine (JAN/USP/INN) <US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Alpha-adrenergic Agonists
   Clonidine
    D00281  Clonidine (JAN/USP/INN)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01738  Centrally-acting antiadrenergic
   DG00249  Clonidine
    D00281  Clonidine
  DG01456  Adrenergic receptor agonist
   DG01450  alpha-Adrenergic receptor agonist
    DG01449  alpha2-Adrenergic receptor agonist
     DG00249  Clonidine
      D00281  Clonidine
  DG03231  Antihypertensive
   DG00249  Clonidine
    D00281  Clonidine
Drug classes [BR:br08332]
 Cardiovascular agent
  DG03231  Antihypertensive
   D00281  Clonidine
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA2
     D00281  Clonidine (JAN/USP/INN) <US>
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01738  Centrally-acting antiadrenergic
   DG00249  Clonidine
  DG01456  Adrenergic receptor agonist
   DG01450  alpha-Adrenergic receptor agonist
    DG01449  alpha2-Adrenergic receptor agonist
     DG00249  Clonidine
  DG03231  Antihypertensive
   DG00249  Clonidine
Other DBs
CAS: 4205-90-7
PubChem: 7847347
ChEBI: 3757
PDB-CCD: CLU[PDBj]
LigandBox: D00281
NIKKAJI: J9.618K
LinkDB
KCF data

ATOM        14
            1   C8x C     8.2600  -20.5100
            2   C8x C     8.2600  -21.9100
            3   C8x C     9.4724  -22.6100
            4   C8y C    10.6849  -21.9100
            5   C8y C    10.6849  -20.5100
            6   C8y C     9.4724  -19.8100
            7   X   Cl   11.8973  -22.6100
            8   N1x N    13.1097  -21.9100
            9   C2y C    13.1097  -20.5100
            10  N2b N    11.8973  -19.8100
            11  C1x C    14.4412  -22.3426
            12  C1x C    15.2641  -21.2100
            13  N1x N    14.4412  -20.0774
            14  X   Cl    9.4724  -18.4102
BOND        15
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     8   9 1
            9     9  10 2
            10    5  10 1
            11    8  11 1
            12   11  12 1
            13   12  13 1
            14    9  13 1
            15    6  14 1

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KEGG   DRUG: Clonidine hydrochloride
Entry
D00604                      Drug                                   
Name
Clonidine hydrochloride (JP18/USP);
Nexiclon (TN);
Kapvay (TN);
Duraclon (TN);
Catapres (TN)
Product
  Generic
CLONIDINE (Ingenus Pharmaceuticals), CLONIDINE (PALMETTO PHARMACEUTICALS), CLONIDINE (XGen Pharmaceuticals DJB), CLONIDINE HCI (HF Acquisition Co LLC), CLONIDINE HYDROCHLORIDE (A-S Medication Solutions), CLONIDINE HYDROCHLORIDE (A-S Medication Solutions), CLONIDINE HYDROCHLORIDE (A-S Medication Solutions), CLONIDINE HYDROCHLORIDE (A-S Medication Solutions), CLONIDINE HYDROCHLORIDE (A-S Medication Solutions), CLONIDINE HYDROCHLORIDE (A-S Medication Solutions), CLONIDINE HYDROCHLORIDE (A-S Medication Solutions), CLONIDINE HYDROCHLORIDE (A-S Medication Solutions), CLONIDINE HYDROCHLORIDE (Actavis Pharma), CLONIDINE HYDROCHLORIDE (Actavis Pharma), CLONIDINE HYDROCHLORIDE (Ajanta Pharma USA), CLONIDINE HYDROCHLORIDE (Alembic Pharmaceuticals Limited), CLONIDINE HYDROCHLORIDE (Alembic Pharmaceuticals), CLONIDINE HYDROCHLORIDE (American Health Packaging), CLONIDINE HYDROCHLORIDE (American Health Packaging), CLONIDINE HYDROCHLORIDE (Amneal Pharmaceuticals NY LLC), CLONIDINE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), CLONIDINE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), CLONIDINE HYDROCHLORIDE (Asclemed USA), CLONIDINE HYDROCHLORIDE (Asclemed USA), CLONIDINE HYDROCHLORIDE (Aurobindo Pharma Limited), CLONIDINE HYDROCHLORIDE (AvPAK), CLONIDINE HYDROCHLORIDE (BluePoint Laboratories), CLONIDINE HYDROCHLORIDE (BluePoint Laboratories), CLONIDINE HYDROCHLORIDE (Bryant Ranch Prepack), CLONIDINE HYDROCHLORIDE (Bryant Ranch Prepack), CLONIDINE HYDROCHLORIDE (Bryant Ranch Prepack), CLONIDINE HYDROCHLORIDE (Bryant Ranch Prepack), CLONIDINE HYDROCHLORIDE (Bryant Ranch Prepack), CLONIDINE HYDROCHLORIDE (Bryant Ranch Prepack), CLONIDINE HYDROCHLORIDE (Bryant Ranch Prepack), CLONIDINE HYDROCHLORIDE (Bryant Ranch Prepack), CLONIDINE HYDROCHLORIDE (Bryant Ranch Prepack), CLONIDINE HYDROCHLORIDE (Bryant Ranch Prepack), CLONIDINE HYDROCHLORIDE (Bryant Ranch Prepack), CLONIDINE HYDROCHLORIDE (Bryant Ranch Prepack), CLONIDINE HYDROCHLORIDE (Bryant Ranch Prepack), CLONIDINE HYDROCHLORIDE (Bryant Ranch Prepack), CLONIDINE HYDROCHLORIDE (Bryant Ranch Prepack), CLONIDINE HYDROCHLORIDE (Bryant Ranch Prepack), CLONIDINE HYDROCHLORIDE (Bryant Ranch Prepack), CLONIDINE HYDROCHLORIDE (Cardinal Health 107), CLONIDINE HYDROCHLORIDE (Denton Pharma), CLONIDINE HYDROCHLORIDE (DirectRX), CLONIDINE HYDROCHLORIDE (DirectRX), CLONIDINE HYDROCHLORIDE (DirectRX), CLONIDINE HYDROCHLORIDE (Hikma Pharmaceuticals USA), CLONIDINE HYDROCHLORIDE (Lupin Pharmaceuticals), CLONIDINE HYDROCHLORIDE (Method Pharmaceuticals), CLONIDINE HYDROCHLORIDE (NCS HealthCare of KY), CLONIDINE HYDROCHLORIDE (NCS HealthCare of KY), CLONIDINE HYDROCHLORIDE (NCS HealthCare of KY), CLONIDINE HYDROCHLORIDE (Northwind Pharmaceuticals), CLONIDINE HYDROCHLORIDE (Northwind Pharmaceuticals), CLONIDINE HYDROCHLORIDE (Northwind Pharmaceuticals), CLONIDINE HYDROCHLORIDE (Northwind Pharmaceuticals), CLONIDINE HYDROCHLORIDE (Northwind Pharmaceuticals), CLONIDINE HYDROCHLORIDE (Northwind Pharmaceuticals), CLONIDINE HYDROCHLORIDE (NuCare Pharmaceuticals), CLONIDINE HYDROCHLORIDE (NuCare Pharmaceuticals), CLONIDINE HYDROCHLORIDE (NuCare Pharmaceuticals), CLONIDINE HYDROCHLORIDE (NuCare Pharmaceuticals), CLONIDINE HYDROCHLORIDE (NuCare Pharmaceuticals), CLONIDINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), CLONIDINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), CLONIDINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), CLONIDINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), CLONIDINE HYDROCHLORIDE (Preferred Pharmaceuticals), CLONIDINE HYDROCHLORIDE (Preferred Pharmaceuticals), CLONIDINE HYDROCHLORIDE (Preferred Pharmaceuticals), CLONIDINE HYDROCHLORIDE (Preferred Pharmaceuticals), CLONIDINE HYDROCHLORIDE (Proficient Rx LP), CLONIDINE HYDROCHLORIDE (Proficient Rx LP), CLONIDINE HYDROCHLORIDE (Proficient Rx LP), CLONIDINE HYDROCHLORIDE (Proficient Rx LP), CLONIDINE HYDROCHLORIDE (Proficient Rx LP), CLONIDINE HYDROCHLORIDE (Quality Care Products), CLONIDINE HYDROCHLORIDE (Quality Care Products), CLONIDINE HYDROCHLORIDE (REMEDYREPACK), CLONIDINE HYDROCHLORIDE (REMEDYREPACK), CLONIDINE HYDROCHLORIDE (REMEDYREPACK), CLONIDINE HYDROCHLORIDE (REMEDYREPACK), CLONIDINE HYDROCHLORIDE (REMEDYREPACK), CLONIDINE HYDROCHLORIDE (REMEDYREPACK), CLONIDINE HYDROCHLORIDE (REMEDYREPACK), CLONIDINE HYDROCHLORIDE (RPK Pharmaceuticals), CLONIDINE HYDROCHLORIDE (RPK Pharmaceuticals), CLONIDINE HYDROCHLORIDE (RPK Pharmaceuticals), CLONIDINE HYDROCHLORIDE (Solco Healthcare LLC), CLONIDINE HYDROCHLORIDE (Solco Healthcare LLC), CLONIDINE HYDROCHLORIDE (St. Mary's Medical Park Pharmacy), CLONIDINE HYDROCHLORIDE (TruPharma), CLONIDINE HYDROCHLORIDE (Unichem Pharmaceuticals (USA)), CLONIDINE HYDROCHLORIDE (Xiamen LP Pharmaceutical), CLONIDINE HYDROCHLORIDE (Zydus Lifesciences Limited), CLONIDINE HYDROCHLORIDE (Zydus Pharmaceuticals USA), CLONIDINE HYDROCHLORIDE (medsource pharmaceuticals)
Formula
C9H9Cl2N3. HCl
Exact mass
264.9940
Mol weight
266.55
Structure
Simcomp
Class
Cardiovascular agent
 DG01738  Centrally-acting antiadrenergic
 DG01456  Adrenergic receptor agonist
  DG01450  alpha-Adrenergic receptor agonist
   DG01449  alpha2-Adrenergic receptor agonist
 DG03231  Antihypertensive
Remark
Therapeutic category: 2149
ATC code: C02AC01 N02CX02 S01EA04
Chemical structure group: DG00249
Product (DG00249): D00281<US> D00604<JP/US>
Efficacy
Antihypertensive, alpha2-Adrenergic receptor agonist
  Disease
Hypertension [DS:H01633]
Comment
Imidazoline derivative
Target
ADRA2 [HSA:150 151 152] [KO:K04138 K04139 K04140]
  Pathway
hsa04022  cGMP-PKG signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Structure map
map07215  alpha-Adrenergic receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C02 ANTIHYPERTENSIVES
   C02A ANTIADRENERGIC AGENTS, CENTRALLY ACTING
    C02AC Imidazoline receptor agonists
     C02AC01 Clonidine
      D00604  Clonidine hydrochloride (JP18/USP) <JP/US>
 N NERVOUS SYSTEM
  N02 ANALGESICS
   N02C ANTIMIGRAINE PREPARATIONS
    N02CX Other antimigraine preparations
     N02CX02 Clonidine
      D00604  Clonidine hydrochloride (JP18/USP) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01EA Sympathomimetics in glaucoma therapy
     S01EA04 Clonidine
      D00604  Clonidine hydrochloride (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
 Antineoplastics
  Antineoplastic Adjuncts/Mitigators
   Clonidine
    D00604  Clonidine hydrochloride (JP18/USP)
 Cardiovascular Agents
  Alpha-adrenergic Agonists
   Clonidine
    D00604  Clonidine hydrochloride (JP18/USP)
 Central Nervous System Agents
  Attention Deficit Hyperactivity Disorder Agents, Non-amphetamines
   Clonidine
    D00604  Clonidine hydrochloride (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2149  Others
     D00604  Clonidine hydrochloride (JP18/USP)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01738  Centrally-acting antiadrenergic
   DG00249  Clonidine
    D00604  Clonidine hydrochloride
  DG01456  Adrenergic receptor agonist
   DG01450  alpha-Adrenergic receptor agonist
    DG01449  alpha2-Adrenergic receptor agonist
     DG00249  Clonidine
      D00604  Clonidine hydrochloride
  DG03231  Antihypertensive
   DG00249  Clonidine
    D00604  Clonidine hydrochloride
Drug classes [BR:br08332]
 Cardiovascular agent
  DG03231  Antihypertensive
   D00604  Clonidine hydrochloride
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA2
     D00604  Clonidine hydrochloride (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00604  Clonidine hydrochloride
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01738  Centrally-acting antiadrenergic
   DG00249  Clonidine
  DG01456  Adrenergic receptor agonist
   DG01450  alpha-Adrenergic receptor agonist
    DG01449  alpha2-Adrenergic receptor agonist
     DG00249  Clonidine
  DG03231  Antihypertensive
   DG00249  Clonidine
Other DBs
CAS: 4205-91-8
PubChem: 7847670
ChEBI: 3758
LigandBox: D00604
NIKKAJI: J237.323H
LinkDB
KCF data

ATOM        15
            1   X   Cl   21.5859  -16.5853
            2   C8x C    12.8800  -15.9600
            3   C8x C    12.8800  -17.3600
            4   C8x C    14.0700  -18.0600
            5   C8y C    15.3300  -17.3600
            6   C8y C    15.3300  -15.9600
            7   C8y C    14.0700  -15.2600
            8   X   Cl   16.5200  -18.0600
            9   N1x N    17.7100  -17.3600
            10  C2y C    17.7100  -15.9600
            11  N2b N    16.5200  -15.2600
            12  C1x C    19.0400  -17.7800
            13  C1x C    19.8800  -16.6600
            14  N1x N    19.0400  -15.5400
            15  X   Cl   14.0700  -13.8600
BOND        15
            1     2   3 2
            2     3   4 1
            3     4   5 2
            4     5   6 1
            5     6   7 2
            6     2   7 1
            7     5   8 1
            8     9  10 1
            9    10  11 2
            10    6  11 1
            11    9  12 1
            12   12  13 1
            13   13  14 1
            14   10  14 1
            15    7  15 1

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