KEGG   DRUG: Fentanyl
Entry
D00320                      Drug                                   
Name
Fentanyl (JAN/USP/INN);
Duragesic (TN);
Subsys (TN)
Product
  Generic
FENTANYL (Apotex Corp.), FENTANYL (Apotex Corp.), FENTANYL (Bryant Ranch Prepack), FENTANYL (Bryant Ranch Prepack), FENTANYL (Bryant Ranch Prepack), FENTANYL (Mylan Pharmaceuticals), FENTANYL (Quality Care Products), FENTANYL SYSTEM (ALVOGEN), FENTANYL SYSTEM (Lake Erie Medical DBA Quality Care Products LLC), FENTANYL SYSTEM (Quality Care Products), FENTANYL TRANSDERMAL (SpecGx LLC)
Formula
C22H28N2O
Exact mass
336.2202
Mol weight
336.47
Structure
Simcomp
Class
Neuropsychiatric agent
 DG02030  Anesthetics
  DG02027  General anesthetics
   DG02026  Opioid anesthetics
 DG01564  Opioid receptor agonist
  DG01563  mu-Opioid receptor agonist
Analgesic
 DG01984  Opioid analgesics
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Therapeutic category: 8219
ATC code: N01AH01 N02AB03
Chemical structure group: DG00791
Product (DG00791): D00320<JP/US> D01399<JP/US>
Efficacy
Analgesic (narcotic), Opioid receptor agonist
Comment
synthetic-opioid
Phenylpiperidine derivative
Target
OPRM1 [HSA:4988] [KO:K04215]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Structure map
map07039  Opioid analgesics
map07224  Opioid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N01 ANESTHETICS
   N01A ANESTHETICS, GENERAL
    N01AH Opioid anesthetics
     N01AH01 Fentanyl
      D00320  Fentanyl (JAN/USP/INN) <JP/US>
  N02 ANALGESICS
   N02A OPIOIDS
    N02AB Phenylpiperidine derivatives
     N02AB03 Fentanyl
      D00320  Fentanyl (JAN/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Analgesics
  Opioid Analgesics, Long-acting
   Fentanyl
    D00320  Fentanyl (JAN/USP/INN)
  Opioid Analgesics, Short-acting
   Fentanyl
    D00320  Fentanyl (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 8  Narcotics
  82  Non-alkaloidal narcotics
   821  Synthetic narcotics
    8219  Others
     D00320  Fentanyl (JAN/USP/INN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG02030  Anesthetics
   DG02027  General anesthetics
    DG02026  Opioid anesthetics
     DG00791  Fentanyl
      D00320  Fentanyl
  DG01564  Opioid receptor agonist
   DG01563  mu-Opioid receptor agonist
    DG00791  Fentanyl
     D00320  Fentanyl
 Analgesic
  DG01984  Opioid analgesics
   DG00791  Fentanyl
    D00320  Fentanyl
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00791  Fentanyl
     D00320  Fentanyl
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Opioid
    OPRM1
     D00320  Fentanyl (JAN/USP/INN) <JP/US>
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00320
Narcotics and psychotropics in Japan [br08308.html]
 Narcotics by Cabinet Order Article 1 (157 substances)
  D00320
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG02030  Anesthetics
   DG02027  General anesthetics
    DG02026  Opioid anesthetics
     DG00791  Fentanyl
  DG01564  Opioid receptor agonist
   DG01563  mu-Opioid receptor agonist
    DG00791  Fentanyl
 Analgesic
  DG01984  Opioid analgesics
   DG00791  Fentanyl
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00791  Fentanyl
Other DBs
CAS: 437-38-7
PubChem: 7847386
ChEBI: 119915
PDB-CCD: 7V7[PDBj]
LigandBox: D00320
NIKKAJI: J5.736C
LinkDB
KCF data

ATOM        25
            1   N1c N    28.2800  -14.2100
            2   C1y C    29.5400  -14.9100
            3   C8y C    27.0900  -14.9100
            4   C5a C    28.2800  -12.8100
            5   C1x C    29.5400  -16.3100
            6   C1x C    30.7300  -14.2100
            7   C8x C    25.9000  -14.2100
            8   C8x C    27.0900  -16.3100
            9   C1b C    29.5400  -12.1100
            10  O5a O    27.0900  -12.1100
            11  C1x C    30.7300  -17.0100
            12  C1x C    31.9200  -14.9100
            13  C8x C    24.6400  -14.9100
            14  C8x C    25.8300  -17.0100
            15  C1a C    30.7300  -12.8100
            16  N1y N    31.9200  -16.3100
            17  C8x C    24.6400  -16.2400
            18  C1b C    33.1800  -17.0100
            19  C1b C    34.3700  -16.3100
            20  C8y C    35.5600  -17.0100
            21  C8x C    35.5600  -18.4100
            22  C8x C    36.8200  -16.3100
            23  C8x C    36.8200  -19.1100
            24  C8x C    38.0100  -17.0100
            25  C8x C    38.0100  -18.4100
BOND        27
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 2
            7     3   8 1
            8     4   9 1
            9     4  10 2
            10    5  11 1
            11    6  12 1
            12    7  13 1
            13    8  14 2
            14    9  15 1
            15   11  16 1
            16   13  17 2
            17   16  18 1
            18   18  19 1
            19   19  20 1
            20   20  21 1
            21   20  22 2
            22   21  23 2
            23   22  24 1
            24   23  25 1
            25   12  16 1
            26   14  17 1
            27   24  25 2

» Japanese version   » Back

KEGG   DRUG: Fentanyl citrate
Entry
D01399                      Drug                                   
Name
Fentanyl citrate (JP18/USP);
Abstral (TN);
Fentora (TN);
Lazanda (TN);
Oralet (TN)
Product
ACTIQ (Cephalon), FENTANYL CITRATE (Civica), FENTANYL CITRATE (Exela Pharma Sciences), FENTANYL CITRATE (Hikma Pharmaceuticals USA), FENTANYL CITRATE (Hospira), FENTANYL CITRATE (Hospira), FENTANYL CITRATE (Phlow Corp.), FENTORA (Cephalon)
  Generic
FENTANYL BUCCAL (Mayne Pharma), FENTANYL CITRATE (Fresenius Kabi USA), FENTANYL CITRATE (Fresenius Kabi USA), FENTANYL CITRATE (SpecGx LLC), FENTANYL CITRATE (Teva Pharmaceuticals USA)
Formula
C22H28N2O. C6H8O7
Exact mass
528.2472
Mol weight
528.59
Structure
Simcomp
Class
Neuropsychiatric agent
 DG02030  Anesthetics
  DG02027  General anesthetics
   DG02026  Opioid anesthetics
 DG01564  Opioid receptor agonist
  DG01563  mu-Opioid receptor agonist
Analgesic
 DG01984  Opioid analgesics
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Therapeutic category: 8219
ATC code: N01AH01 N02AB03
Chemical structure group: DG00791
Product (DG00791): D00320<JP/US> D01399<JP/US>
Efficacy
Analgesic (narcotic), Opioid receptor agonist
Comment
Phenylpiperidine derivative
Target
OPRM1 [HSA:4988] [KO:K04215]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Structure map
map07039  Opioid analgesics
map07224  Opioid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N01 ANESTHETICS
   N01A ANESTHETICS, GENERAL
    N01AH Opioid anesthetics
     N01AH01 Fentanyl
      D01399  Fentanyl citrate (JP18/USP) <JP/US>
  N02 ANALGESICS
   N02A OPIOIDS
    N02AB Phenylpiperidine derivatives
     N02AB03 Fentanyl
      D01399  Fentanyl citrate (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
 Analgesics
  Opioid Analgesics, Long-acting
   Fentanyl
    D01399  Fentanyl citrate (JP18/USP)
  Opioid Analgesics, Short-acting
   Fentanyl
    D01399  Fentanyl citrate (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 8  Narcotics
  82  Non-alkaloidal narcotics
   821  Synthetic narcotics
    8219  Others
     D01399  Fentanyl citrate (JP18/USP)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG02030  Anesthetics
   DG02027  General anesthetics
    DG02026  Opioid anesthetics
     DG00791  Fentanyl
      D01399  Fentanyl citrate
  DG01564  Opioid receptor agonist
   DG01563  mu-Opioid receptor agonist
    DG00791  Fentanyl
     D01399  Fentanyl citrate
 Analgesic
  DG01984  Opioid analgesics
   DG00791  Fentanyl
    D01399  Fentanyl citrate
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00791  Fentanyl
     D01399  Fentanyl citrate
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Opioid
    OPRM1
     D01399  Fentanyl citrate (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01399  Fentanyl citrate
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D01399
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D01399
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG02030  Anesthetics
   DG02027  General anesthetics
    DG02026  Opioid anesthetics
     DG00791  Fentanyl
  DG01564  Opioid receptor agonist
   DG01563  mu-Opioid receptor agonist
    DG00791  Fentanyl
 Analgesic
  DG01984  Opioid analgesics
   DG00791  Fentanyl
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00791  Fentanyl
Other DBs
CAS: 990-73-8
PubChem: 7848462
ChEBI: 31602
LigandBox: D01399
NIKKAJI: J281.187A
LinkDB
KCF data

ATOM        38
            1   C1d C    39.8723  -15.9084
            2   C1b C    38.6652  -16.6023
            3   C1b C    41.0794  -16.5964
            4   C6a C    40.5604  -14.6954
            5   O1a O    39.1666  -14.6954
            6   C6a C    37.4638  -15.9142
            7   C6a C    41.0677  -17.9902
            8   O6a O    39.8547  -13.4825
            9   O6a O    41.9600  -14.6954
            10  O6a O    36.2569  -16.6140
            11  O6a O    37.4522  -14.5205
            12  O6a O    42.2749  -18.6900
            13  O6a O    39.8547  -18.6840
            14  N1c N    25.4800  -15.0500
            15  C1y C    26.7400  -15.7500
            16  C8y C    24.2900  -15.7500
            17  C5a C    25.4800  -13.6500
            18  C1x C    26.7400  -17.1500
            19  C1x C    27.9300  -15.0500
            20  C8x C    23.1000  -15.0500
            21  C8x C    24.2900  -17.1500
            22  C1b C    26.7400  -12.9500
            23  O5a O    24.2900  -12.9500
            24  C1x C    27.9300  -17.8500
            25  C1x C    29.1200  -15.7500
            26  C8x C    21.8400  -15.7500
            27  C8x C    23.0300  -17.8500
            28  C1a C    27.9300  -13.6500
            29  N1y N    29.1200  -17.1500
            30  C8x C    21.8400  -17.0800
            31  C1b C    30.3800  -17.8500
            32  C1b C    31.5700  -17.1500
            33  C8y C    32.7600  -17.8500
            34  C8x C    32.7600  -19.2500
            35  C8x C    34.0200  -17.1500
            36  C8x C    34.0200  -19.9500
            37  C8x C    35.2100  -17.8500
            38  C8x C    35.2100  -19.2500
BOND        39
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     1   5 1
            5     2   6 1
            6     3   7 1
            7     4   8 1
            8     4   9 2
            9     6  10 1
            10    6  11 2
            11    7  12 1
            12    7  13 2
            13   14  15 1
            14   14  16 1
            15   14  17 1
            16   15  18 1
            17   15  19 1
            18   16  20 2
            19   16  21 1
            20   17  22 1
            21   17  23 2
            22   18  24 1
            23   19  25 1
            24   20  26 1
            25   21  27 2
            26   22  28 1
            27   24  29 1
            28   26  30 2
            29   29  31 1
            30   31  32 1
            31   32  33 1
            32   33  34 1
            33   33  35 2
            34   34  36 2
            35   35  37 1
            36   36  38 1
            37   25  29 1
            38   27  30 1
            39   37  38 2

» Japanese version   » Back

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