KEGG   DRUG: Flurazepam
Entry
D00329                      Drug                                   

Name
Flurazepam (JAN/INN);
Insumin (TN)
Formula
C21H23ClFN3O
Exact mass
387.1514
Mol weight
387.8782
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01835  Benzodiazepine sedative-hypnotics
 DG01567  GABA-A receptor agonist
 DG02036  Antiepileptics, benzodiazepine derivatives
Remark
ATC code: N05CD01
Chemical structure group: DG00919
Product (DG00919): D00695<US> D01408<JP>
Efficacy
Sedative-hypnotic
Comment
Benzodiazepines
Target
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04727  GABAergic synapse
Interaction
Structure map
map07032  Hypnotics
map07230  GABA-A receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05C HYPNOTICS AND SEDATIVES
    N05CD Benzodiazepine derivatives
     N05CD01 Flurazepam
      D00329  Flurazepam (JAN/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Ligand-gated ion channels
   GABA (ionotropic)
    GABR
     D00329  Flurazepam (JAN/INN)
Other DBs
CAS: 17617-23-1
PubChem: 7847395
ChEBI: 5128
ChEMBL: CHEMBL968
DrugBank: DB00690
PDB-CCD: FL7[PDBj]
LigandBox: D00329
NIKKAJI: J3.142I
LinkDB
KCF data

ATOM        27
            1   C2y C    16.4531  -16.9578
            2   C8y C    15.6104  -15.8474
            3   C8y C    15.9459  -14.4897
            4   N1y N    17.2077  -13.9111
            5   N2x N    17.8599  -16.9130
            6   C5x C    18.4622  -14.5339
            7   C1x C    18.7489  -15.9036
            8   C8x C    14.9380  -13.5206
            9   C8x C    13.5951  -13.9089
            10  C8y C    13.2597  -15.2667
            11  C8x C    14.2675  -16.2355
            12  O5x O    19.5071  -13.5988
            13  X   Cl   11.8939  -15.6614
            14  C8y C    15.8182  -18.2084
            15  C8x C    14.4156  -18.2084
            16  C8x C    13.7151  -19.4217
            17  C8x C    14.4156  -20.6350
            18  C8x C    15.8182  -20.6350
            19  C8y C    16.5187  -19.4217
            20  X   F    17.9306  -19.4218
            21  C1b C    17.2295  -12.5353
            22  C1b C    18.4478  -11.8573
            23  N1c N    18.4698  -10.4300
            24  C1b C    19.7007   -9.7445
            25  C1b C    17.2758   -9.7159
            26  C1a C    16.0577  -10.3944
            27  C1a C    20.8732  -10.4458
BOND        29
            1     3   4 1
            2     1   5 2
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13    6  12 2
            14   10  13 1
            15    1  14 1
            16   14  15 1
            17   15  16 2
            18   16  17 1
            19   17  18 2
            20   18  19 1
            21   14  19 2
            22   19  20 1
            23    4  21 1
            24   21  22 1
            25   22  23 1
            26   23  24 1
            27   23  25 1
            28   25  26 1
            29   24  27 1

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KEGG   DRUG: Flurazepam hydrochloride
Entry
D00695                      Drug                                   

Name
Flurazepam hydrochloride (USP);
Flurazepam dihydrochloride;
Dalmane (TN)
Product
  Generic
Formula
C21H23ClFN3O. 2HCl
Exact mass
459.1047
Mol weight
460.8001
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01835  Benzodiazepine sedative-hypnotics
 DG01567  GABA-A receptor agonist
 DG02036  Antiepileptics, benzodiazepine derivatives
Remark
ATC code: N05CD01
Chemical structure group: DG00919
Product (DG00919): D00695<US> D01408<JP>
Efficacy
Anticonvulsant, Muscle relaxant, Sedative-hypnotic
Comment
Benzodiazepines
Target
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04727  GABAergic synapse
Interaction
Structure map
map07032  Hypnotics
map07230  GABA-A receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05C HYPNOTICS AND SEDATIVES
    N05CD Benzodiazepine derivatives
     N05CD01 Flurazepam
      D00695  Flurazepam hydrochloride (USP) <US>
USP drug classification [BR:br08302]
 Sleep Disorder Agents
  Sleep Promoting Agents
   Flurazepam
    D00695  Flurazepam hydrochloride (USP)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Ligand-gated ion channels
   GABA (ionotropic)
    GABR
     D00695  Flurazepam hydrochloride (USP) <US>
Other DBs
CAS: 1172-18-5
PubChem: 7847760
ChEBI: 5129
ChEMBL: CHEMBL3989724
DrugBank: DB00690
LigandBox: D00695
NIKKAJI: J293.283K
LinkDB
KCF data

ATOM        29
            1   X   Cl   36.4700  -16.9400
            2   C2y C    31.1500  -17.4300
            3   C8y C    30.3100  -16.3100
            4   C8y C    30.6600  -14.9100
            5   N1y N    31.9200  -14.3500
            6   N2x N    32.6200  -17.4300
            7   C5x C    33.1800  -14.9800
            8   C1x C    33.4600  -16.3800
            9   C8x C    29.6800  -13.9300
            10  C8x C    28.3500  -14.3500
            11  C8y C    28.0000  -15.6800
            12  C8x C    28.9800  -16.6600
            13  O5x O    34.1600  -14.0700
            14  X   Cl   26.6000  -16.1000
            15  C8y C    30.5200  -18.6900
            16  C8x C    29.1200  -18.6900
            17  C8x C    28.4200  -19.8800
            18  C8x C    29.1200  -21.0700
            19  C8x C    30.5200  -21.0700
            20  C8y C    31.2200  -19.8800
            21  X   F    32.6900  -19.8800
            22  C1b C    31.9200  -12.9500
            23  C1b C    33.1100  -12.3200
            24  N1c N    33.1100  -10.8500
            25  C1b C    34.3000  -10.1500
            26  C1b C    31.9200  -10.1500
            27  C1a C    30.7300  -10.8500
            28  C1a C    35.4900  -10.8500
            29  X   Cl   36.4700  -16.9400
BOND        29
            1     4   5 1
            2     2   6 2
            3     5   7 1
            4     3   4 1
            5     6   8 1
            6     2   3 1
            7     7   8 1
            8     4   9 2
            9     9  10 1
            10   10  11 2
            11   11  12 1
            12    3  12 2
            13    7  13 2
            14   11  14 1
            15    2  15 1
            16   15  16 1
            17   16  17 2
            18   17  18 1
            19   18  19 2
            20   19  20 1
            21   15  20 2
            22   20  21 1
            23    5  22 1
            24   22  23 1
            25   23  24 1
            26   24  25 1
            27   24  26 1
            28   26  27 1
            29   25  28 1
BRACKET     1    35.0000  -17.6400   35.0000  -16.2400
            1    37.2400  -16.2400   37.2400  -17.6400
            1  2
 ORIGINAL  1    1
 REPEAT    1   29

» Japanese version   » Back

KEGG   DRUG: Flurazepam hydrochloride
Entry
D01408                      Drug                                   

Name
Flurazepam hydrochloride (JP18);
Flurazepam monohydrochloride;
Dalmate (TN)
Formula
C21H23ClFN3O. HCl
Exact mass
423.128
Mol weight
424.3392
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01835  Benzodiazepine sedative-hypnotics
 DG01567  GABA-A receptor agonist
 DG02036  Antiepileptics, benzodiazepine derivatives
Remark
Therapeutic category: 1124
ATC code: N05CD01
Chemical structure group: DG00919
Product (DG00919): D00695<US> D01408<JP>
Efficacy
Sedative-hypnotic
Comment
Benzodiazepine derivative
Target
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04727  GABAergic synapse
Interaction
Structure map
map07032  Hypnotics
map07230  GABA-A receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05C HYPNOTICS AND SEDATIVES
    N05CD Benzodiazepine derivatives
     N05CD01 Flurazepam
      D01408  Flurazepam hydrochloride (JP18) <JP>
USP drug classification [BR:br08302]
 Sleep Disorder Agents
  Sleep Promoting Agents
   Flurazepam
    D01408  Flurazepam hydrochloride (JP18)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   112  Hypnotics and sedatives, anxiolytics
    1124  Benzodiazepins
     D01408  Flurazepam hydrochloride (JP18)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Ligand-gated ion channels
   GABA (ionotropic)
    GABR
     D01408  Flurazepam hydrochloride (JP18) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01408  Flurazepam hydrochloride
Other DBs
CAS: 36105-20-1
PubChem: 7848471
ChEBI: 31626
DrugBank: DB00690
LigandBox: D01408
NIKKAJI: J321.678K
LinkDB
KCF data

ATOM        28
            1   X   Cl   36.6766  -12.5550
            2   C2y C    31.7800  -13.0200
            3   C8y C    30.9400  -11.9000
            4   C8y C    31.2900  -10.5000
            5   N1y N    32.5500   -9.9400
            6   N2x N    33.2500  -13.0200
            7   C5x C    33.8100  -10.5700
            8   C1x C    34.0900  -11.9700
            9   C8x C    30.3100   -9.5200
            10  C8x C    28.9800   -9.9400
            11  C8y C    28.6300  -11.2700
            12  C8x C    29.6100  -12.2500
            13  O5x O    34.8600   -9.6600
            14  X   Cl   27.2300  -11.6900
            15  C8y C    31.1500  -14.2800
            16  C8x C    29.7500  -14.2800
            17  C8x C    29.0500  -15.4700
            18  C8x C    29.7500  -16.6600
            19  C8x C    31.1500  -16.6600
            20  C8y C    31.8500  -15.4700
            21  X   F    33.3200  -15.4700
            22  C1b C    32.5500   -8.5400
            23  C1b C    33.7400   -7.9100
            24  N1c N    33.7400   -6.4400
            25  C1b C    35.0000   -5.7400
            26  C1b C    32.5500   -5.7400
            27  C1a C    31.3600   -6.4400
            28  C1a C    36.1900   -6.4400
BOND        29
            1     4   5 1
            2     2   6 2
            3     5   7 1
            4     3   4 1
            5     6   8 1
            6     2   3 1
            7     7   8 1
            8     4   9 2
            9     9  10 1
            10   10  11 2
            11   11  12 1
            12    3  12 2
            13    7  13 2
            14   11  14 1
            15    2  15 1
            16   15  16 1
            17   16  17 2
            18   17  18 1
            19   18  19 2
            20   19  20 1
            21   15  20 2
            22   20  21 1
            23    5  22 1
            24   22  23 1
            25   23  24 1
            26   24  25 1
            27   24  26 1
            28   26  27 1
            29   25  28 1

» Japanese version   » Back

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