KEGG   DRUG: Triflupromazine
Entry
D00390                      Drug                                   

Name
Triflupromazine (USP/INN);
Vesprin (TN)
Formula
C18H19F3N2S
Exact mass
352.1221
Mol weight
352.4171
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01478  Dopamine antagonist
  DG01474  Dopamine D2-receptor antagonist
 DG03200  Antipsychotic agent
  DG01905  Phenothiazine antipsychotics
Remark
ATC code: N05AA05
Chemical structure group: DG00871
Efficacy
Antipsychotic, Dopamine D2 receptor antagonist
Comment
Phenothiazine derivative
Target
DRD2 [HSA:1813] [KO:K04145]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04728  Dopaminergic synapse
Interaction
Structure map
map07029  Antipsychotics - phenothiazines
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05A ANTIPSYCHOTICS
    N05AA Phenothiazines with aliphatic side-chain
     N05AA05 Triflupromazine
      D00390  Triflupromazine (USP/INN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01478  Dopamine antagonist
   DG01474  Dopamine D2-receptor antagonist
    DG00871  Triflupromazine
     D00390  Triflupromazine
  DG03200  Antipsychotic agent
   DG01905  Phenothiazine antipsychotics
    DG00871  Triflupromazine
     D00390  Triflupromazine
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    DRD2
     D00390  Triflupromazine (USP/INN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01478  Dopamine antagonist
   DG01474  Dopamine D2-receptor antagonist
    DG00871  Triflupromazine
  DG03200  Antipsychotic agent
   DG01905  Phenothiazine antipsychotics
    DG00871  Triflupromazine
Other DBs
CAS: 146-54-3
PubChem: 7847456
ChEBI: 9711
ChEMBL: CHEMBL570
DrugBank: DB00508
LigandBox: D00390
NIKKAJI: J2.957B
LinkDB
KCF data

ATOM        24
            1   C8y C    22.1709  -18.3123
            2   N1y N    23.3692  -17.6226
            3   C8y C    22.1709  -19.7036
            4   C8x C    20.9432  -17.6226
            5   C8y C    24.5967  -18.3357
            6   C1b C    23.3692  -16.2196
            7   S2x S    23.3692  -20.3993
            8   C8x C    20.9432  -20.3993
            9   C8x C    19.7216  -18.3357
            10  C8y C    24.5967  -19.6802
            11  C8x C    25.8010  -17.6459
            12  C1b C    24.5967  -15.5240
            13  C8x C    19.7216  -19.6802
            14  C8x C    25.8010  -20.3876
            15  C8y C    27.0402  -18.3534
            16  C1b C    24.5967  -14.1211
            17  C8x C    27.0402  -19.6745
            18  N1c N    25.8010  -13.4489
            19  C1a C    25.8185  -12.0283
            20  C1a C    27.0402  -14.1328
            21  C1d C    28.2414  -17.6558
            22  X   F    29.4000  -16.9400
            23  X   F    28.9100  -18.8300
            24  X   F    27.5100  -16.4500
BOND        26
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     4   9 2
            9     5  10 2
            10    5  11 1
            11    6  12 1
            12    8  13 2
            13   10  14 1
            14   11  15 2
            15   12  16 1
            16   14  17 2
            17   16  18 1
            18   18  19 1
            19   18  20 1
            20    7  10 1
            21    9  13 1
            22   15  17 1
            23   15  21 1
            24   21  22 1
            25   21  23 1
            26   21  24 1

» Japanese version   » Back

KEGG   DRUG: Triflupromazine hydrochloride
Entry
D00800                      Drug                                   

Name
Triflupromazine hydrochloride (JAN/USP);
Vesprin (TN)
Formula
C18H19F3N2S. HCl
Exact mass
388.0988
Mol weight
388.878
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01478  Dopamine antagonist
  DG01474  Dopamine D2-receptor antagonist
 DG03200  Antipsychotic agent
  DG01905  Phenothiazine antipsychotics
Remark
ATC code: N05AA05
Chemical structure group: DG00871
Efficacy
Antipsychotic, Dopamine D2 receptor antagonist
Comment
Phenothiazine derivative
Target
DRD2 [HSA:1813] [KO:K04145]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04728  Dopaminergic synapse
Interaction
Structure map
map07029  Antipsychotics - phenothiazines
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05A ANTIPSYCHOTICS
    N05AA Phenothiazines with aliphatic side-chain
     N05AA05 Triflupromazine
      D00800  Triflupromazine hydrochloride (JAN/USP)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01478  Dopamine antagonist
   DG01474  Dopamine D2-receptor antagonist
    DG00871  Triflupromazine
     D00800  Triflupromazine hydrochloride
  DG03200  Antipsychotic agent
   DG01905  Phenothiazine antipsychotics
    DG00871  Triflupromazine
     D00800  Triflupromazine hydrochloride
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    DRD2
     D00800  Triflupromazine hydrochloride (JAN/USP)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01478  Dopamine antagonist
   DG01474  Dopamine D2-receptor antagonist
    DG00871  Triflupromazine
  DG03200  Antipsychotic agent
   DG01905  Phenothiazine antipsychotics
    DG00871  Triflupromazine
Other DBs
CAS: 1098-60-8
PubChem: 7847865
ChEBI: 9712
ChEMBL: CHEMBL1201102
DrugBank: DB00508
LigandBox: D00800
NIKKAJI: J349.680E
LinkDB
KCF data

ATOM        25
            1   C8y C    21.4320  -18.2638
            2   N1y N    22.6508  -17.5641
            3   C8y C    21.4380  -19.6633
            4   C8x C    20.2250  -17.5641
            5   C8y C    23.8578  -18.2581
            6   C1b C    22.7149  -16.1646
            7   S2x S    22.6508  -20.3688
            8   C8x C    20.2250  -20.3688
            9   C8x C    19.0063  -18.2638
            10  C8y C    23.8519  -19.6576
            11  C8x C    25.0706  -17.5700
            12  C1b C    23.9219  -15.4591
            13  C8x C    19.0063  -19.6633
            14  C8x C    25.0590  -20.3631
            15  C8y C    26.2777  -18.2698
            16  C1b C    23.9219  -14.0655
            17  C8x C    26.2720  -19.6693
            18  N1c N    25.1349  -13.3658
            19  C1a C    25.1349  -11.9720
            20  C1a C    26.3477  -14.0655
            21  C1d C    27.4711  -17.5852
            22  X   F    28.6300  -16.8700
            23  X   F    28.1400  -18.7600
            24  X   F    26.7400  -16.3800
            25  X   Cl   32.6939  -18.1477
BOND        26
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     4   9 2
            9     5  10 2
            10    5  11 1
            11    6  12 1
            12    8  13 2
            13   10  14 1
            14   11  15 2
            15   12  16 1
            16   14  17 2
            17   16  18 1
            18   18  19 1
            19   18  20 1
            20    7  10 1
            21    9  13 1
            22   15  17 1
            23   15  21 1
            24   21  22 1
            25   21  23 1
            26   21  24 1

» Japanese version   » Back

DBGET integrated database retrieval system