KEGG   DRUG: MethimazoleHelp
Entry
D00401                      Drug                                   

Name
Methimazole (USP);
Thiamazole (JP17/INN);
Tapazole (TN)
Product
  Generic
METHIMAZOLE (A-S Medication Solutions), METHIMAZOLE (American Health Packaging), METHIMAZOLE (American Health Packaging), METHIMAZOLE (Bryant Ranch Prepack), METHIMAZOLE (Bryant Ranch Prepack), METHIMAZOLE (Bryant Ranch Prepack), METHIMAZOLE (Bryant Ranch Prepack), METHIMAZOLE (Dispensing Solutions), METHIMAZOLE (ECI Pharmaceuticals), METHIMAZOLE (Eon Labs), METHIMAZOLE (Golden State Medical Supply), METHIMAZOLE (Heritage Pharmaceuticals), METHIMAZOLE (NCS HealthCare of KY), METHIMAZOLE (NuCare Pharmaceuticals), METHIMAZOLE (Par Pharmaceutical), TAPAZOLE (Pfizer Laboratories Div Pfizer), METHIMAZOLE (Preferred Pharmaceuticals), METHIMAZOLE (Preferred Pharmaceuticals), METHIMAZOLE (REMEDYREPACK), METHIMAZOLE (REMEDYREPACK), METHIMAZOLE (Rebel Distributors Corp.), METHIMAZOLE (Rising Pharmaceuticals), METHIMAZOLE (State of Florida DOH Central Pharmacy), METHIMAZOLE (State of Florida DOH Central Pharmacy), METHIMAZOLE (State of Florida DOH Central Pharmacy), METHIMAZOLE (Unit Dose Services)
Formula
C4H6N2S
Exact mass
114.0252
Mol weight
114.1688
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Other
 DG01934  Antithyroid agent
Remark
Same as: C07190
Therapeutic category: 2432
ATC code: H03BB02
Product: D00401<JP/US>
Efficacy
Antithyroid, Thyroid hormone synthesis inhibitor
  Disease
Graves' disease [DS:H00082]
Hyperthyroidism [DS:H01645]
Target
TPO [HSA:7173] [KO:K00431]
  Pathway
hsa04918  Thyroid hormone synthesis
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H03 THYROID THERAPY
   H03B ANTITHYROID PREPARATIONS
    H03BB Sulfur-containing imidazole derivatives
     H03BB02 Thiamazole
      D00401  Methimazole (USP) <JP/US>
USP drug classification [BR:br08302]
 Hormonal Agents, Suppressant (Thyroid)
  Antithyroid Agents
   Methimazole
    D00401  Methimazole (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   243  Thyroid and parathyroid hormone preparations
    2432  Antithyroid hormones
     D00401  Methimazole (USP); Thiamazole (JP17/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Thyroid peroxidase
    TPO
     D00401  Methimazole (USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00401  Thiamazole
  D00401  Thiamazole tablets
Drug classes of therapeutic agents [br08360.html]
 Endocrine and hormonal agents
  D00401
BRITE hierarchy
Other DBs
CAS: 60-56-0
PubChem: 7847467
ChEBI: 50673
ChEMBL: CHEMBL1515
DrugBank: DB00763
PDB-CCD: MMZ[PDBj]
LigandBox: D00401
NIKKAJI: J1.400A
LinkDB All DBs
KCF data Show

ATOM        7
            1   C8y C    26.1871  -18.2805
            2   N4y N    25.7487  -19.6075
            3   N4x N    25.0529  -17.4502
            4   S0  S    27.5142  -17.8478
            5   C8x C    24.3513  -19.6075
            6   C1a C    26.5730  -20.7418
            7   C8x C    23.9186  -18.2805
BOND        7
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     5   7 2

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