 | | DRUG: Ondansetron hydrochloride hydrate | |
| Entry |
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| Name |
Ondansetron hydrochloride hydrate (JAN/USP);
Ondansetron hydrochloride;
Ondansetron hydrochloride dihydrate;
Zofran (TN) |
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| Product |
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| Generic |
ONDANSETRON (A-S Medication Solutions), ONDANSETRON (A-S Medication Solutions), ONDANSETRON (A-S Medication Solutions), ONDANSETRON (A-S Medication Solutions), ONDANSETRON (ACTAVIS PHARMA), ONDANSETRON (ATLANTIC BIOLOGICALS CORP.), ONDANSETRON (ATLANTIC BIOLOGICALS CORP.), ONDANSETRON (Accord Healthcare), ONDANSETRON (Advanced Rx Pharmacy of Tennessee), ONDANSETRON (Advanced Rx Pharmacy of Tennessee), ONDANSETRON (American Health Packaging), ONDANSETRON (Amneal Pharmaceuticals LLC), ONDANSETRON (Apotex Corp.), ONDANSETRON (Athenex Pharmaceutical Division), ONDANSETRON (Aurobindo Pharma Limited), ONDANSETRON (AvPAK), ONDANSETRON (Bryant Ranch Prepack), ONDANSETRON (Bryant Ranch Prepack), ONDANSETRON (Bryant Ranch Prepack), ONDANSETRON (Cardinal Health 107), ONDANSETRON (Cardinal Health 107), ONDANSETRON (Cardinal Health 107), ONDANSETRON (Cardinal Health 107), ONDANSETRON (Chartwell RX), ONDANSETRON (Civica), ONDANSETRON (Direct_Rx), ONDANSETRON (Direct_Rx), ONDANSETRON (Eugia US LLC), ONDANSETRON (Eywa Pharma), ONDANSETRON (Fosun Pharma USA), ONDANSETRON (Fresenius Kabi USA), ONDANSETRON (Fresenius Kabi USA), ONDANSETRON (Fresenius Kabi USA), ONDANSETRON (Gland Pharma Limited), ONDANSETRON (Gland Pharma Limited), ONDANSETRON (Glenmark Pharmaceuticals), ONDANSETRON (HF Acquisition Co LLC), ONDANSETRON (HF Acquisition Co LLC), ONDANSETRON (HF Acquisition Co LLC), ONDANSETRON (HF Acquisition Co LLC), ONDANSETRON (HF Acquisition Co LLC), ONDANSETRON (Henry Schein), ONDANSETRON (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), ONDANSETRON (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), ONDANSETRON (Hikma Pharmaceuticals USA), ONDANSETRON (Hikma Pharmaceuticals USA), ONDANSETRON (Hospira), ONDANSETRON (Lannett Company), ONDANSETRON (Major Pharmaceuticals), ONDANSETRON (Medical Purchasing Solutions), ONDANSETRON (Medical Purchasing Solutions), ONDANSETRON (Medical Purchasing Solutions), ONDANSETRON (Medical Purchasing Solutions), ONDANSETRON (Medical Purchasing Solutions), ONDANSETRON (Natco Pharma Limited), ONDANSETRON (Natco Pharma USA LLC), ONDANSETRON (NorthStar Rx LLC), ONDANSETRON (NorthStar Rx LLC), ONDANSETRON (Northwind Pharmaceuticals), ONDANSETRON (Northwind Pharmaceuticals), ONDANSETRON (NuCare Pharmaceuticals), ONDANSETRON (NuCare Pharmaceuticals), ONDANSETRON (NuCare Pharmaceuticals), ONDANSETRON (NuCare Pharmaceuticals), ONDANSETRON (NuCare Pharmaceuticals), ONDANSETRON (NuCare Pharmaceuticals), ONDANSETRON (NuCare Pharmaceuticals), ONDANSETRON (NuCare Pharmaceuticals), ONDANSETRON (NuCare Pharmaceuticals), ONDANSETRON (PD-Rx Pharmaceuticals), ONDANSETRON (PD-Rx Pharmaceuticals), ONDANSETRON (PD-Rx Pharmaceuticals), ONDANSETRON (PharmPak), ONDANSETRON (Pharmasource Meds), ONDANSETRON (Preferred Pharmaceuticals), ONDANSETRON (Preferred Pharmaceuticals), ONDANSETRON (Proficient Rx LP), ONDANSETRON (Proficient Rx LP), ONDANSETRON (Proficient Rx LP), ONDANSETRON (Proficient Rx LP), ONDANSETRON (Qilu Pharmaceutical), ONDANSETRON (Quality Care Products), ONDANSETRON (REMEDYREPACK), ONDANSETRON (REMEDYREPACK), ONDANSETRON (RPK Pharmaceuticals), ONDANSETRON (RPK Pharmaceuticals), ONDANSETRON (RPK Pharmaceuticals), ONDANSETRON (RedPharm Drug), ONDANSETRON (RedPharm Drug), ONDANSETRON (RedPharm Drug), ONDANSETRON (RedPharm Drug), ONDANSETRON (Redpharm Drug), ONDANSETRON (Redpharm Drug), ONDANSETRON (ST. MARY'S MEDICAL PARK PHARMACY), ONDANSETRON (Sagent Pharmaceuticals), ONDANSETRON (St. Mary's Medical Park Pharmacy), ONDANSETRON (Sun Pharmaceutical Industries), ONDANSETRON (Taro Pharmaceuticals U.S.A.), ONDANSETRON (West-Ward Pharmaceuticals Corp), ONDANSETRON HCL (Advanced Rx Pharmacy of Tennessee), ONDANSETRON HCL (Advanced Rx Pharmacy of Tennessee), ONDANSETRON HCL (Advanced Rx Pharmacy of Tennessee), ONDANSETRON HYDROCHLORIDE (A-S Medication Solutions), ONDANSETRON HYDROCHLORIDE (A-S Medication Solutions), ONDANSETRON HYDROCHLORIDE (A-S Medication Solutions), ONDANSETRON HYDROCHLORIDE (American Health Packaging), ONDANSETRON HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), ONDANSETRON HYDROCHLORIDE (Aurobindo Pharma Limited), ONDANSETRON HYDROCHLORIDE (AvPAK), ONDANSETRON HYDROCHLORIDE (Baxter Healthcare Corporation), ONDANSETRON HYDROCHLORIDE (Bryant Ranch Prepack), ONDANSETRON HYDROCHLORIDE (Bryant Ranch Prepack), ONDANSETRON HYDROCHLORIDE (Bryant Ranch Prepack), ONDANSETRON HYDROCHLORIDE (Bryant Ranch Prepack), ONDANSETRON HYDROCHLORIDE (Bryant Ranch Prepack), ONDANSETRON HYDROCHLORIDE (Cardinal Health 107), ONDANSETRON HYDROCHLORIDE (Cardinal Health 107), ONDANSETRON HYDROCHLORIDE (Cardinal Health 107), ONDANSETRON HYDROCHLORIDE (Chartwell RX), ONDANSETRON HYDROCHLORIDE (Denton Pharma), ONDANSETRON HYDROCHLORIDE (Denton Pharma), ONDANSETRON HYDROCHLORIDE (Dr. Reddy's Laboratories Limited), ONDANSETRON HYDROCHLORIDE (Dr. Reddy's Laboratories Limited), ONDANSETRON HYDROCHLORIDE (Hikma Pharmaceuticals USA), ONDANSETRON HYDROCHLORIDE (Major Pharmaceuticals), ONDANSETRON HYDROCHLORIDE (NCS HealthCare of KY), ONDANSETRON HYDROCHLORIDE (NUCARE PHARMACEUTICALS), ONDANSETRON HYDROCHLORIDE (Northwind Pharmaceuticals), ONDANSETRON HYDROCHLORIDE (Northwind Pharmaceuticals), ONDANSETRON HYDROCHLORIDE (Northwind Pharmaceuticals), ONDANSETRON HYDROCHLORIDE (Northwind Pharmaceuticals), ONDANSETRON HYDROCHLORIDE (NuCare Pharmaceuticals), ONDANSETRON HYDROCHLORIDE (NuCare Pharmaceuticals), ONDANSETRON HYDROCHLORIDE (NuCare Pharmaceuticals), ONDANSETRON HYDROCHLORIDE (NuCare Pharmaceuticals), ONDANSETRON HYDROCHLORIDE (NuCare Pharmaceuticals), ONDANSETRON HYDROCHLORIDE (NuCare Pharmceuticals), ONDANSETRON HYDROCHLORIDE (PD-Rx Pharmaceuticals), ONDANSETRON HYDROCHLORIDE (PD-Rx Pharmaceuticals), ONDANSETRON HYDROCHLORIDE (Pharmpak), ONDANSETRON HYDROCHLORIDE (Precision Dose), ONDANSETRON HYDROCHLORIDE (Preferred Pharmaceuticals), ONDANSETRON HYDROCHLORIDE (Preferred Pharmaceuticals), ONDANSETRON HYDROCHLORIDE (Preferred Pharmaceuticals), ONDANSETRON HYDROCHLORIDE (Proficient Rx LP), ONDANSETRON HYDROCHLORIDE (Proficient Rx LP), ONDANSETRON HYDROCHLORIDE (Proficient Rx LP), ONDANSETRON HYDROCHLORIDE (QPharma), ONDANSETRON HYDROCHLORIDE (QPharma), ONDANSETRON HYDROCHLORIDE (QPharma), ONDANSETRON HYDROCHLORIDE (Quality Care Products LLC), ONDANSETRON HYDROCHLORIDE (Quality Care Products LLC), ONDANSETRON HYDROCHLORIDE (Quality Care Products), ONDANSETRON HYDROCHLORIDE (REMEDYREPACK), ONDANSETRON HYDROCHLORIDE (REMEDYREPACK), ONDANSETRON HYDROCHLORIDE (REMEDYREPACK), ONDANSETRON HYDROCHLORIDE (RPK Pharmaceuticals), ONDANSETRON HYDROCHLORIDE (RPK Pharmaceuticals), ONDANSETRON HYDROCHLORIDE (RPK Pharmaceuticals), ONDANSETRON HYDROCHLORIDE (RedPharm Drug), ONDANSETRON HYDROCHLORIDE (RedPharm Drug), ONDANSETRON HYDROCHLORIDE (Rising Pharma Holdings), ONDANSETRON HYDROCHLORIDE (ST. MARY'S MEDICAL PARK PHARMACY), ONDANSETRON HYDROCHLORIDE (St. Mary's Medical Park Pharmacy), ONDANSETRON HYDROCHLORIDE (St. Mary's Medical Park Pharmacy), ONDANSETRON HYDROCHLORIDE (Steriscience Specialties Private Limited), ONDANSETRON HYDROCHLORIDE (Steriscience Specialties Private Limited), ONDANSETRON HYDROCHLORIDE (Sun Pharmaceutical Industries), ONDANSETRON HYDROCHLORIDE (Taro Pharmaceuticals U.S.A.), ONDANSETRON HYDROCHLORIDE (medsource pharmaceuticals) |
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| Formula |
C18H19N3O. 2H2O. HCl
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| Exact mass |
365.1506
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| Mol weight |
365.85
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| Structure |
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| Simcomp |
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| Class |
Gastrointestinal agent
DG01489 5-HT3-receptor antagonist
DG01762 Antiemetic
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG01644 CYP2D6 substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
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| Remark |
| Therapeutic category: | 2391 |
| Product (DG00060): | D00456<US> D00678<JP/US> |
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| Efficacy |
Anti-emetic, Serotonin 5-HT3 receptor antagonist |
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| Target |
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| Pathway |
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| Metabolism |
Enzyme: CYP1A2 [HSA: 1544], CYP2D6 [HSA: 1565], CYP3A4 [HSA: 1576]
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| Interaction |
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| Structure map |
| map07211 | Serotonin receptor agonists/antagonists |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A04 ANTIEMETICS AND ANTINAUSEANTS
A04A ANTIEMETICS AND ANTINAUSEANTS
A04AA Serotonin (5HT3) antagonists
A04AA01 Ondansetron
D00678 Ondansetron hydrochloride hydrate (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
Antiemetics
Emetogenic Therapy Adjuncts
Ondansetron
D00678 Ondansetron hydrochloride hydrate (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
23 Digestive organ agents
239 Miscellaneous
2391 Antiemetics
D00678 Ondansetron hydrochloride hydrate (JAN/USP)
Drug groups [BR:br08330]
Gastrointestinal agent
DG01489 5-HT3-receptor antagonist
DG00060 Ondansetron
D00678 Ondansetron hydrochloride hydrate
DG01762 Antiemetic
DG00060 Ondansetron
D00678 Ondansetron hydrochloride hydrate
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG00060 Ondansetron
D00678 Ondansetron hydrochloride hydrate
DG01644 CYP2D6 substrate
DG00060 Ondansetron
D00678 Ondansetron hydrochloride hydrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00060 Ondansetron
D00678 Ondansetron hydrochloride hydrate
Target-based classification of drugs [BR:br08310]
Ion channels
Ligand-gated ion channels
Serotonin
HTR3
D00678 Ondansetron hydrochloride hydrate (JAN/USP) <JP/US>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00678
Drug groups [BR:br08330]
Gastrointestinal agent
DG01489 5-HT3-receptor antagonist
DG00060 Ondansetron
DG01762 Antiemetic
DG00060 Ondansetron
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG00060 Ondansetron
DG01644 CYP2D6 substrate
DG00060 Ondansetron
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00060 Ondansetron
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 25
1 C8y C 27.9300 -8.4700
2 C8y C 29.2600 -8.9600
3 C8y C 27.9300 -7.0700
4 C5x C 26.7400 -9.1700
5 C8y C 30.0300 -7.7700
6 C8x C 29.8200 -10.2200
7 N4y N 29.2600 -6.6500
8 C1x C 26.7400 -6.3700
9 C1y C 25.4800 -8.4700
10 O5x O 26.7400 -10.5700
11 C8x C 31.4300 -7.9100
12 C8x C 31.2200 -10.3600
13 C1a C 29.6800 -5.3200
14 C1x C 25.4800 -7.0700
15 C1b C 24.2900 -9.1700
16 C8x C 32.0600 -9.2400
17 N4y N 23.1000 -8.4700
18 C8y C 23.1000 -7.0700
19 C8x C 21.7000 -8.8900
20 N5x N 21.7700 -6.5800
21 C1a C 24.2900 -6.3000
22 C8x C 20.9300 -7.7000
23 X Cl 34.7900 -6.5800
24 O0 O 35.4900 -8.5400
25 O0 O 35.4900 -8.5400
BOND 25
1 1 2 1
2 1 3 2
3 1 4 1
4 2 5 1
5 2 6 2
6 3 7 1
7 3 8 1
8 4 9 1
9 4 10 2
10 5 11 2
11 6 12 1
12 7 13 1
13 8 14 1
14 9 15 1
15 11 16 1
16 15 17 1
17 17 18 1
18 17 19 1
19 18 20 2
20 18 21 1
21 19 22 2
22 5 7 1
23 9 14 1
24 12 16 2
25 20 22 1
BRACKET 1 33.3200 -9.3800 33.3200 -7.7700
1 35.9800 -7.7700 35.9800 -9.3800
1 2
ORIGINAL 1 24
REPEAT 1 25
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