KEGG   DRUG: Prednisolone
Entry
D00472                      Drug                                   
Name
Prednisolone (JP18/USP/INN);
Delta-cortef (TN)
Product
  Generic
Formula
C21H28O5
Exact mass
360.1937
Mol weight
360.44
Structure
Simcomp
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
Remark
Same as: C07369
Therapeutic category: 2456 2646
ATC code: A01AC04 A07EA01 C05AA04 D07AA03 D07XA02 H02AB06 R01AD02 S01BA04 S01CB02 S02BA03 S03BA02
Chemical structure group: DG00093
Product (DG00093): D00472<JP/US> D00980<JP/US> D00981<JP/US> D01239<JP> D03301<JP>
Product (mixture): D04251<JP> D04753<JP>
Efficacy
Anti-inflammatory, Antirheumatic, Glucocorticoid receptor agonist
  Disease
Congenital adrenal hyperplasia [DS:H00216]
Psoriatic arthritis [DS:H01507]
Rheumatoid arthritis [DS:H00630]
Juvenile rheumatoid arthritis [DS:H01672]
Ankylosing spondylitis [DS:H01674]
Systemic lupus erythematosus [DS:H00080]
Pemphigus [DS:H01648]
Bullous dermatitis herpetiformis [DS:H01362]
Erythema multiforme [DS:H01695]
Stevens-Johnson syndrome [DS:H01694]
Mycosis fungoides [DS:H01463]
Psoriasis [DS:H01656]
Seborrheic dermatitis [DS:H01652]
Allergic rhinitis [DS:H01360]
Bronchial asthma [DS:H00079]
Contact dermatitis [DS:H01357]
Atopic dermatitis [DS:H01358]
Optic neuritis [DS:H01717]
Pulmonary tuberculosis [DS:H00342]
Acquired (autoimmune) hemolytic anemia [DS:H01585]
Nephrotic syndrome [DS:H01657]
Ulcerative colitis [DS:H01466]
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]
Interaction
Structure map
map07043  Antineoplastics - hormones
map07046  Immunosuppressive agents
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AC Corticosteroids for local oral treatment
     A01AC04 Prednisolone
      D00472  Prednisolone (JP18/USP/INN) <JP/US>
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07E INTESTINAL ANTIINFLAMMATORY AGENTS
    A07EA Corticosteroids acting locally
     A07EA01 Prednisolone
      D00472  Prednisolone (JP18/USP/INN) <JP/US>
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA04 Prednisolone
      D00472  Prednisolone (JP18/USP/INN) <JP/US>
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AA Corticosteroids, weak (group I)
     D07AA03 Prednisolone
      D00472  Prednisolone (JP18/USP/INN) <JP/US>
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XA Corticosteroids, weak, other combinations
     D07XA02 Prednisolone
      D00472  Prednisolone (JP18/USP/INN) <JP/US>
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB06 Prednisolone
      D00472  Prednisolone (JP18/USP/INN) <JP/US>
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD02 Prednisolone
      D00472  Prednisolone (JP18/USP/INN) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA04 Prednisolone
      D00472  Prednisolone (JP18/USP/INN) <JP/US>
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB02 Prednisolone
      D00472  Prednisolone (JP18/USP/INN) <JP/US>
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA03 Prednisolone
      D00472  Prednisolone (JP18/USP/INN) <JP/US>
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03B CORTICOSTEROIDS
    S03BA Corticosteroids
     S03BA02 Prednisolone
      D00472  Prednisolone (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Prednisolone
   D00472  Prednisolone (JP18/USP/INN)
 Inflammatory Bowel Disease Agents
  Glucocorticoids
   Prednisolone
    D00472  Prednisolone (JP18/USP/INN)
 Ophthalmic Agents
  Ophthalmic Anti-inflammatories
   Glucocorticoids, Ophthalmic
    Prednisolone
     D00472  Prednisolone (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   245  Adrenal hormone preparations
    2456  Prednisolones
     D00472  Prednisolone (JP18/USP/INN)
  26  Epidermides
   264  Analgesics, anti-itchings, astringents, anti-inflammatory agents
    2646  Adrenocorticotropic hormones
     D00472  Prednisolone (JP18/USP/INN)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for integumentary system
  57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
   D00472  Prednisolone (JP18/USP/INN)
 Agents for dental and stomatological use
  74 Stomatitis remedies
   D00472  Prednisolone (JP18/USP/INN)
Risk category of Japanese OTC drugs [BR:br08312]
 Designated second-class OTC drugs
  Inorganic and organic chemicals
   Prednisolone
    D00472  Prednisolone (JP18/USP/INN)
 Second-class OTC drugs
  Inorganic and organic chemicals
   Prednisolone
    D00472  Prednisolone (JP18/USP/INN)
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00093  Prednisolone
     D00472  Prednisolone
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   D00472  Prednisolone
Drug classes [BR:br08332]
 Anti-inflammatory
  DG01955  Corticosteroid
   D00472  Prednisolone
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D00472  Prednisolone (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00472  Prednisolone
  D00472  Prednisolone tablets
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00472
Topical steroids potency [br08317.html]
 Classification in Japan
  D00472
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00093  Prednisolone
Other DBs
CAS: 50-24-8
PubChem: 7847538
ChEBI: 8378
PDB-CCD: TUA[PDBj]
LigandBox: D00472
NIKKAJI: J39.548J
LinkDB
KCF data

ATOM        26
            1   C2x C     5.9500  -12.1800
            2   C5x C     5.9500  -13.5800
            3   C2x C     7.1624  -14.2800
            4   C2y C     8.3749  -13.5800
            5   C1z C     8.3749  -12.1800
            6   C2x C     7.1624  -11.4800
            7   C1x C     9.5873  -14.2800
            8   C1x C    10.7997  -13.5800
            9   C1y C    10.7997  -12.1800
            10  C1y C     9.5873  -11.4800
            11  C1y C    12.0122  -11.4800
            12  C1z C    12.0122  -10.0800
            13  C1x C    10.7997   -9.3800
            14  C1y C     9.5873  -10.0800
            15  C1x C    14.4370  -11.4800
            16  C1x C    14.4370  -10.0800
            17  C1z C    13.2246   -9.3800
            18  O5x O     4.7376  -14.2800
            19  C1a C     8.3749  -10.7800
            20  O1a O     8.3769   -9.3812
            21  C1a C    12.0122   -8.6800
            22  C5a C    13.2246   -7.7700
            23  O1a O    14.4370   -8.6800
            24  C1b C    14.4411   -7.0677
            25  O5a O    12.0162   -7.0723
            26  O1a O    15.6386   -7.7592
BOND        29
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21    2  18 2
            22    5  19 1 #Up
            23   14  20 1 #Up
            24   12  21 1 #Up
            25   17  22 1 #Up
            26   17  23 1 #Down
            27   22  24 1
            28   22  25 2
            29   24  26 1

» Japanese version   » Back

KEGG   DRUG: Prednisolone acetate
Entry
D00980                      Drug                                   
Name
Prednisolone acetate (JP18/USP/INN);
Econopred (TN);
Pred forte (TN)
Product
  Generic
Formula
C23H30O6
Exact mass
402.2042
Mol weight
402.48
Structure
Simcomp
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Remark
Same as: C08180
Therapeutic category: 1315
ATC code: A01AC04 A07EA01 C05AA04 D07AA03 D07XA02 H02AB06 R01AD02 S01BA04 S01CB02 S02BA03 S03BA02
Chemical structure group: DG00093
Product (DG00093): D00472<JP/US> D00980<JP/US> D00981<JP/US> D01239<JP> D03301<JP>
Product (mixture): D11699<US>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AC Corticosteroids for local oral treatment
     A01AC04 Prednisolone
      D00980  Prednisolone acetate (JP18/USP/INN) <JP/US>
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07E INTESTINAL ANTIINFLAMMATORY AGENTS
    A07EA Corticosteroids acting locally
     A07EA01 Prednisolone
      D00980  Prednisolone acetate (JP18/USP/INN) <JP/US>
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA04 Prednisolone
      D00980  Prednisolone acetate (JP18/USP/INN) <JP/US>
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AA Corticosteroids, weak (group I)
     D07AA03 Prednisolone
      D00980  Prednisolone acetate (JP18/USP/INN) <JP/US>
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XA Corticosteroids, weak, other combinations
     D07XA02 Prednisolone
      D00980  Prednisolone acetate (JP18/USP/INN) <JP/US>
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB06 Prednisolone
      D00980  Prednisolone acetate (JP18/USP/INN) <JP/US>
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD02 Prednisolone
      D00980  Prednisolone acetate (JP18/USP/INN) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA04 Prednisolone
      D00980  Prednisolone acetate (JP18/USP/INN) <JP/US>
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB02 Prednisolone
      D00980  Prednisolone acetate (JP18/USP/INN) <JP/US>
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA03 Prednisolone
      D00980  Prednisolone acetate (JP18/USP/INN) <JP/US>
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03B CORTICOSTEROIDS
    S03BA Corticosteroids
     S03BA02 Prednisolone
      D00980  Prednisolone acetate (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Prednisolone
   D00980  Prednisolone acetate (JP18/USP/INN)
 Ophthalmic Agents
  Ophthalmic Anti-inflammatories
   Glucocorticoids, Ophthalmic
    Prednisolone
     D00980  Prednisolone acetate (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1315  Ophthalmic cortisones
     D00980  Prednisolone acetate (JP18/USP/INN)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for  urogenital organs and anus
  30 Hemorrhoid drugs for external use
   D00980  Prednisolone acetate (JP18/USP/INN)
 Agents for integumentary system
  57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
   D00980  Prednisolone acetate (JP18/USP/INN)
Risk category of Japanese OTC drugs [BR:br08312]
 Designated second-class OTC drugs
  Inorganic and organic chemicals
   Prednisolone acetate
    D00980  Prednisolone acetate (JP18/USP/INN)
 Second-class OTC drugs
  Inorganic and organic chemicals
   Prednisolone acetate
    D00980  Prednisolone acetate (JP18/USP/INN)
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00093  Prednisolone
     D00980  Prednisolone acetate
Drug classes [BR:br08332]
 Anti-inflammatory
  DG01955  Corticosteroid
   D00980  Prednisolone acetate
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D00980  Prednisolone acetate (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00980  Prednisolone acetate
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00093  Prednisolone
Other DBs
CAS: 52-21-1
PubChem: 7848043
ChEBI: 8380
LigandBox: D00980
NIKKAJI: J4.129G
LinkDB
KCF data

ATOM        29
            1   C2x C    26.7400  -19.3900
            2   C5x C    26.7400  -20.7200
            3   C2x C    27.9300  -21.4200
            4   C2y C    29.1200  -20.7200
            5   C1z C    29.1200  -19.3900
            6   C2x C    27.9300  -18.6900
            7   C1x C    30.3100  -21.4200
            8   C1x C    31.5000  -20.7200
            9   C1y C    31.5000  -19.3900
            10  C1y C    30.3100  -18.6900
            11  C1y C    32.6900  -18.6900
            12  C1z C    32.6900  -17.2900
            13  C1x C    31.5000  -16.5900
            14  C1y C    30.3100  -17.2900
            15  C1x C    35.0000  -18.6900
            16  C1x C    35.0000  -17.2900
            17  C1z C    33.8800  -16.5900
            18  O5x O    25.6200  -21.4200
            19  C1a C    29.1200  -17.9900
            20  O1a O    29.1200  -16.5900
            21  C1a C    32.6900  -15.9600
            22  C5a C    33.8800  -14.9100
            23  O1a O    35.0000  -15.9600
            24  C1b C    35.0000  -14.2100
            25  O5a O    32.6900  -14.2100
            26  O7a O    36.1900  -14.9100
            27  C7a C    37.3800  -14.2100
            28  C1a C    38.5000  -14.9100
            29  O6a O    37.3800  -12.8800
BOND        32
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21    2  18 2
            22    5  19 1 #Up
            23   14  20 1 #Up
            24   12  21 1 #Up
            25   17  22 1 #Up
            26   17  23 1 #Down
            27   22  24 1
            28   22  25 2
            29   24  26 1
            30   26  27 1
            31   27  28 1
            32   27  29 2

» Japanese version   » Back

KEGG   DRUG: Prednisolone sodium phosphate
Entry
D00981                      Drug                                   
Name
Prednisolone sodium phosphate (JP18/USP);
Pediapred (TN)
Product
  Generic
Formula
C21H27O8P. 2Na
Exact mass
484.1239
Mol weight
484.39
Structure
Simcomp
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Remark
Therapeutic category: 2456
ATC code: A01AC04 A07EA01 C05AA04 D07AA03 D07XA02 H02AB06 R01AD02 S01BA04 S01CB02 S02BA03 S03BA02
Chemical structure group: DG00093
Product (DG00093): D00472<JP/US> D00980<JP/US> D00981<JP/US> D01239<JP> D03301<JP>
Product (mixture): D11699<US>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
  Disease
Atopic dermatitis [DS:H01358]
Allergic rhinitis [DS:H01360]
Bullous dermatitis herpetiformis [DS:H01362]
Contact dermatitis [DS:H01357]
Mycosis fungoides [DS:H01463]
Pemphigus [DS:H01648]
Severe erythema multiforme [DS:H01695]
Stevens-Johnson syndrome [DS:H01694]
Congenital adrenal hyperplasia [DS:H00216]
Primary or secondary adrenocortical insufficiency [DS:H01598]
Crohn's disease [DS:H00286]
Ulcerative colitis [DS:H01466]
Acquired (autoimmune) hemolytic anemia [DS:H01585]
Diamond-Blackfan anemia [DS:H00237]
Pure red cell aplasia [DS:H01586]
Multiple sclerosis [DS:H01490]
Acute or chronic solid organ rejection [DS:H00083]
Chronic obstructive pulmonary disease [DS:H01714]
Allergic bronchopulmonary aspergillosis [DS:H01328]
Asthma [DS:H00079]
Pulmonary tuberculosis [DS:H00342]
Hypersensitivity pneumonitis [DS:H00346]
Idiopathic bronchiolitis obliterans [DS:H01873]
Idiopathic pulmonary fibrosis [DS:H01299]
Pneumocystis carinii pneumonia [DS:H01521]
Nephrotic syndrome [DS:H01657]
Ankylosing spondylitis [DS:H01674]
Dermatomyositis and polymyositis [DS:H01604]
Polymyalgia rheumatica [DS:H01606]
Temporal arteritis [DS:H01698]
Psoriatic arthritis [DS:H01507]
Relapsing polychondritis [DS:H01758]
Rheumatoid arthritis [DS:H00630]
Juvenile rheumatoid arthritis [DS:H01672]
Sjogren's Syndrome [DS:H01502]
Systemic lupus erythematosus [DS:H00080]
Trichinosis with neurologic or myocardial involvement [DS:H01099]
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AC Corticosteroids for local oral treatment
     A01AC04 Prednisolone
      D00981  Prednisolone sodium phosphate (JP18/USP) <JP/US>
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07E INTESTINAL ANTIINFLAMMATORY AGENTS
    A07EA Corticosteroids acting locally
     A07EA01 Prednisolone
      D00981  Prednisolone sodium phosphate (JP18/USP) <JP/US>
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA04 Prednisolone
      D00981  Prednisolone sodium phosphate (JP18/USP) <JP/US>
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AA Corticosteroids, weak (group I)
     D07AA03 Prednisolone
      D00981  Prednisolone sodium phosphate (JP18/USP) <JP/US>
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XA Corticosteroids, weak, other combinations
     D07XA02 Prednisolone
      D00981  Prednisolone sodium phosphate (JP18/USP) <JP/US>
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB06 Prednisolone
      D00981  Prednisolone sodium phosphate (JP18/USP) <JP/US>
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD02 Prednisolone
      D00981  Prednisolone sodium phosphate (JP18/USP) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA04 Prednisolone
      D00981  Prednisolone sodium phosphate (JP18/USP) <JP/US>
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB02 Prednisolone
      D00981  Prednisolone sodium phosphate (JP18/USP) <JP/US>
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA03 Prednisolone
      D00981  Prednisolone sodium phosphate (JP18/USP) <JP/US>
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03B CORTICOSTEROIDS
    S03BA Corticosteroids
     S03BA02 Prednisolone
      D00981  Prednisolone sodium phosphate (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Prednisolone
   D00981  Prednisolone sodium phosphate (JP18/USP)
 Inflammatory Bowel Disease Agents
  Glucocorticoids
   Prednisolone
    D00981  Prednisolone sodium phosphate (JP18/USP)
 Ophthalmic Agents
  Ophthalmic Anti-inflammatories
   Glucocorticoids, Ophthalmic
    Prednisolone
     D00981  Prednisolone sodium phosphate (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   245  Adrenal hormone preparations
    2456  Prednisolones
     D00981  Prednisolone sodium phosphate (JP18/USP)
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00093  Prednisolone
     D00981  Prednisolone sodium phosphate
Drug classes [BR:br08332]
 Anti-inflammatory
  DG01955  Corticosteroid
   D00981  Prednisolone sodium phosphate
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D00981  Prednisolone sodium phosphate (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00981  Prednisolone sodium phosphate
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00093  Prednisolone
Other DBs
CAS: 125-02-0
PubChem: 7848044
ChEBI: 8379
LigandBox: D00981
NIKKAJI: J5.364C
LinkDB
KCF data

ATOM        32
            1   C2x C     3.4829  -12.1384
            2   C5x C     3.4829  -13.5014
            3   C2x C     4.6633  -14.1829
            4   C2y C     5.8437  -13.5014
            5   C1z C     5.8437  -12.1384
            6   C2x C     4.6633  -11.4568
            7   C1x C     7.0241  -14.1829
            8   C1x C     8.2045  -13.5014
            9   C1y C     8.2045  -12.1384
            10  C1y C     7.0241  -11.4568
            11  C1y C     9.3850  -11.4568
            12  C1z C     9.3850  -10.0938
            13  C1x C     8.2045   -9.4123
            14  C1y C     7.0241  -10.0938
            15  C1x C    11.7457  -11.4568
            16  C1x C    11.7457  -10.0938
            17  C1z C    10.5654   -9.4123
            18  O5x O     2.3025  -14.1829
            19  C1a C     5.8437  -10.7753
            20  O1a O     5.8457   -9.4135
            21  C1a C     9.3850   -8.7308
            22  C5a C    10.5654   -7.6348
            23  O1a O    11.7457   -8.7308
            24  C1b C    11.7497   -6.9511
            25  O5a O     9.3889   -6.9555
            26  O2b O    12.9156   -7.6243
            27  P1b P    14.1511   -6.9106
            28  O1c O    15.3635   -6.2106 #-
            29  O1c O    13.4565   -5.7082 #-
            30  O1c O    14.8569   -8.1325
            31  Z   Na   11.1300   -5.6700 #+
            32  Z   Na   17.5700   -6.0200 #+
BOND        33
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21    2  18 2
            22    5  19 1 #Up
            23   14  20 1 #Up
            24   12  21 1 #Up
            25   17  22 1 #Up
            26   17  23 1 #Down
            27   22  24 1
            28   22  25 2
            29   24  26 1
            30   26  27 1
            31   27  28 1
            32   27  29 1
            33   27  30 2

» Japanese version   » Back

KEGG   DRUG: Prednisolone tebutate
Entry
D00982                      Drug                                   
Name
Prednisolone tebutate (JAN/USP);
Hydeltra-TBA (TN)
Formula
C27H38O6
Exact mass
458.2668
Mol weight
458.59
Structure
Simcomp
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Remark
Same as: C08182
ATC code: A01AC04 A07EA01 C05AA04 D07AA03 D07XA02 H02AB06 R01AD02 S01BA04 S01CB02 S02BA03 S03BA02
Chemical structure group: DG00093
Product (DG00093): D00472<JP/US> D00980<JP/US> D00981<JP/US> D01239<JP> D03301<JP>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AC Corticosteroids for local oral treatment
     A01AC04 Prednisolone
      D00982  Prednisolone tebutate (JAN/USP)
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07E INTESTINAL ANTIINFLAMMATORY AGENTS
    A07EA Corticosteroids acting locally
     A07EA01 Prednisolone
      D00982  Prednisolone tebutate (JAN/USP)
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA04 Prednisolone
      D00982  Prednisolone tebutate (JAN/USP)
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AA Corticosteroids, weak (group I)
     D07AA03 Prednisolone
      D00982  Prednisolone tebutate (JAN/USP)
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XA Corticosteroids, weak, other combinations
     D07XA02 Prednisolone
      D00982  Prednisolone tebutate (JAN/USP)
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB06 Prednisolone
      D00982  Prednisolone tebutate (JAN/USP)
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD02 Prednisolone
      D00982  Prednisolone tebutate (JAN/USP)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA04 Prednisolone
      D00982  Prednisolone tebutate (JAN/USP)
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB02 Prednisolone
      D00982  Prednisolone tebutate (JAN/USP)
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA03 Prednisolone
      D00982  Prednisolone tebutate (JAN/USP)
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03B CORTICOSTEROIDS
    S03BA Corticosteroids
     S03BA02 Prednisolone
      D00982  Prednisolone tebutate (JAN/USP)
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00093  Prednisolone
     D00982  Prednisolone tebutate
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D00982  Prednisolone tebutate (JAN/USP)
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00093  Prednisolone
Other DBs
CAS: 7681-14-3
PubChem: 7848045
ChEBI: 8381
LigandBox: D00982
NIKKAJI: J8.959A
LinkDB
KCF data

ATOM        33
            1   C2x C     5.5829  -11.2284
            2   C5x C     5.5829  -12.5914
            3   C2x C     6.7633  -13.2729
            4   C2y C     7.9437  -12.5914
            5   C1z C     7.9437  -11.2284
            6   C2x C     6.7633  -10.5468
            7   C1x C     9.1241  -13.2729
            8   C1x C    10.3045  -12.5914
            9   C1y C    10.3045  -11.2284
            10  C1y C     9.1241  -10.5468
            11  C1y C    11.4850  -10.5468
            12  C1z C    11.4850   -9.1838
            13  C1x C    10.3045   -8.5023
            14  C1y C     9.1241   -9.1838
            15  C1x C    13.8457  -10.5468
            16  C1x C    13.8457   -9.1838
            17  C1z C    12.6654   -8.5023
            18  O5x O     4.4025  -13.2729
            19  C1a C     7.9437   -9.8653
            20  O1a O     7.9457   -8.5035
            21  C1a C    11.4850   -7.8208
            22  C5a C    12.6654   -6.7948
            23  O1a O    13.8457   -7.8208
            24  C1b C    13.8497   -6.1111
            25  O5a O    11.4889   -6.1155
            26  O7a O    15.0156   -6.7843
            27  C7a C    16.2511   -6.0706
            28  C1b C    17.4636   -6.7703
            29  O6a O    16.2506   -4.6900
            30  C1d C    18.6422   -6.0895
            31  C1a C    19.8382   -6.7799
            32  C1a C    18.6419   -4.6902
            33  C1a C    18.6422   -7.4895
BOND        36
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21    2  18 2
            22    5  19 1 #Up
            23   14  20 1 #Up
            24   12  21 1 #Up
            25   17  22 1 #Up
            26   17  23 1 #Down
            27   22  24 1
            28   22  25 2
            29   24  26 1
            30   26  27 1
            31   27  28 1
            32   27  29 2
            33   28  30 1
            34   30  31 1
            35   30  32 1
            36   30  33 1

» Japanese version   » Back

KEGG   DRUG: Prednisolone sodium succinate
Entry
D01239                      Drug                                   
Name
Prednisolone sodium succinate (JP18/USP);
Kohakusanin (TN)
Formula
C25H31O8. Na
Exact mass
482.1917
Mol weight
482.50
Structure
Simcomp
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Dermatological agent
 DG03243  Atopic dermatitis agent
Remark
Same as: C12666
Therapeutic category: 2456
ATC code: A01AC04 A07EA01 C05AA04 D07AA03 D07XA02 H02AB06 R01AD02 S01BA04 S01CB02 S02BA03 S03BA02
Chemical structure group: DG00093
Product (DG00093): D00472<JP/US> D00980<JP/US> D00981<JP/US> D01239<JP> D03301<JP>
Efficacy
Anti-inflammatory, Antirheumatic, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AC Corticosteroids for local oral treatment
     A01AC04 Prednisolone
      D01239  Prednisolone sodium succinate (JP18/USP) <JP>
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07E INTESTINAL ANTIINFLAMMATORY AGENTS
    A07EA Corticosteroids acting locally
     A07EA01 Prednisolone
      D01239  Prednisolone sodium succinate (JP18/USP) <JP>
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA04 Prednisolone
      D01239  Prednisolone sodium succinate (JP18/USP) <JP>
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AA Corticosteroids, weak (group I)
     D07AA03 Prednisolone
      D01239  Prednisolone sodium succinate (JP18/USP) <JP>
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XA Corticosteroids, weak, other combinations
     D07XA02 Prednisolone
      D01239  Prednisolone sodium succinate (JP18/USP) <JP>
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB06 Prednisolone
      D01239  Prednisolone sodium succinate (JP18/USP) <JP>
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD02 Prednisolone
      D01239  Prednisolone sodium succinate (JP18/USP) <JP>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA04 Prednisolone
      D01239  Prednisolone sodium succinate (JP18/USP) <JP>
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB02 Prednisolone
      D01239  Prednisolone sodium succinate (JP18/USP) <JP>
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA03 Prednisolone
      D01239  Prednisolone sodium succinate (JP18/USP) <JP>
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03B CORTICOSTEROIDS
    S03BA Corticosteroids
     S03BA02 Prednisolone
      D01239  Prednisolone sodium succinate (JP18/USP) <JP>
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Prednisolone
   D01239  Prednisolone sodium succinate (JP18/USP)
 Ophthalmic Agents
  Ophthalmic Anti-inflammatories
   Glucocorticoids, Ophthalmic
    Prednisolone
     D01239  Prednisolone sodium succinate (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   245  Adrenal hormone preparations
    2456  Prednisolones
     D01239  Prednisolone sodium succinate (JP18/USP)
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00093  Prednisolone
     D01239  Prednisolone sodium succinate
 Dermatological agent
  DG03243  Atopic dermatitis agent
   D01239  Prednisolone sodium succinate
Drug classes [BR:br08332]
 Anti-inflammatory
  DG01955  Corticosteroid
   D01239  Prednisolone sodium succinate
 Dermatological agent
  DG03243  Atopic dermatitis agent
   D01239  Prednisolone sodium succinate
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D01239  Prednisolone sodium succinate (JP18/USP) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01239  Prednisolone sodium succinate for injection
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00093  Prednisolone
Other DBs
CAS: 1715-33-9
PubChem: 7848302
ChEBI: 32044
LigandBox: D01239
NIKKAJI: J7.571J
LinkDB
KCF data

ATOM        34
            1   C1y C    21.9205  -19.8507
            2   C1y C    20.7278  -20.4930
            3   C1z C    21.9205  -18.4746
            4   C1x C    24.3058  -19.8507
            5   C1y C    19.5810  -19.8049
            6   C1x C    20.7278  -21.8691
            7   C1z C    23.1132  -17.8324
            8   C1x C    20.7737  -17.7865
            9   C1x C    24.3058  -18.5205
            10  C1z C    18.3883  -20.4930
            11  C1y C    19.5810  -18.4746
            12  C1x C    19.5351  -22.5571
            13  C5a C    23.1132  -16.1117
            14  C2y C    18.3883  -21.8691
            15  C2x C    17.1957  -19.8049
            16  O1a O    18.3883  -17.7865
            17  C1b C    24.2600  -15.4236
            18  O5a O    21.9205  -15.4236
            19  C2x C    17.1957  -22.5571
            20  C2x C    16.0490  -20.4930
            21  O7a O    25.4525  -16.1117
            22  C5x C    16.0490  -21.8691
            23  C7a C    26.5993  -15.4236
            24  O5x O    14.8563  -22.5571
            25  C1b C    27.7920  -16.1117
            26  O6a O    26.5993  -14.0475
            27  C1b C    28.9847  -15.4236
            28  C6a C    30.1773  -16.1117
            29  O6a O    31.3241  -15.4236 #-
            30  O6a O    30.1773  -17.4878
            31  C1a C    21.9205  -17.0965
            32  C1a C    18.3883  -19.1148
            33  O1a O    24.3066  -17.1433
            34  Z   Na   33.3900  -15.4700 #-
BOND        36
            1     3   7 1
            2     3   8 1
            3     4   9 1
            4     5  10 1
            5     5  11 1
            6     6  12 1
            7     7  13 1 #Up
            8    10  14 1
            9    10  15 1
            10   11  16 1 #Up
            11   13  17 1
            12   13  18 2
            13   14  19 2
            14   15  20 2
            15   17  21 1
            16   19  22 1
            17   21  23 1
            18   22  24 2
            19   23  25 1
            20   23  26 2
            21    7   9 1
            22    8  11 1
            23   12  14 1
            24   20  22 1
            25    1   2 1
            26   25  27 1
            27    1   3 1
            28   27  28 1
            29    1   4 1
            30   28  29 1
            31    2   5 1
            32   28  30 2
            33    2   6 1
            34    3  31 1 #Up
            35   10  32 1 #Up
            36    7  33 1 #Down

» Japanese version   » Back

KEGG   DRUG: Prednisolone farnesylate
Entry
D01998                      Drug                                   
Name
Prednisolone farnesylate (JAN);
PNF 21;
Farnerate (TN)
Formula
C36H50O6
Exact mass
578.3607
Mol weight
578.78
Structure
Simcomp
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Remark
ATC code: A01AC04 A07EA01 C05AA04 D07AA03 D07XA02 H02AB06 R01AD02 S01BA04 S01CB02 S02BA03 S03BA02
Chemical structure group: DG00093
Product (DG00093): D00472<JP/US> D00980<JP/US> D00981<JP/US> D01239<JP> D03301<JP>
Efficacy
Anti-inflammatory, Antirheumatic, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AC Corticosteroids for local oral treatment
     A01AC04 Prednisolone
      D01998  Prednisolone farnesylate (JAN)
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07E INTESTINAL ANTIINFLAMMATORY AGENTS
    A07EA Corticosteroids acting locally
     A07EA01 Prednisolone
      D01998  Prednisolone farnesylate (JAN)
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA04 Prednisolone
      D01998  Prednisolone farnesylate (JAN)
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AA Corticosteroids, weak (group I)
     D07AA03 Prednisolone
      D01998  Prednisolone farnesylate (JAN)
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XA Corticosteroids, weak, other combinations
     D07XA02 Prednisolone
      D01998  Prednisolone farnesylate (JAN)
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB06 Prednisolone
      D01998  Prednisolone farnesylate (JAN)
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD02 Prednisolone
      D01998  Prednisolone farnesylate (JAN)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA04 Prednisolone
      D01998  Prednisolone farnesylate (JAN)
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB02 Prednisolone
      D01998  Prednisolone farnesylate (JAN)
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA03 Prednisolone
      D01998  Prednisolone farnesylate (JAN)
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03B CORTICOSTEROIDS
    S03BA Corticosteroids
     S03BA02 Prednisolone
      D01998  Prednisolone farnesylate (JAN)
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00093  Prednisolone
     D01998  Prednisolone farnesylate
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D01998  Prednisolone farnesylate (JAN)
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00093  Prednisolone
Other DBs
CAS: 118244-44-3
PubChem: 7849060
ChEBI: 32043
LigandBox: D01998
NIKKAJI: J510.522F
LinkDB
KCF data

ATOM        42
            1   C1y C    30.8122  -21.1038
            2   C1y C    29.6006  -21.7562
            3   C1z C    30.8122  -19.7057
            4   C1x C    33.2356  -21.1038
            5   C1y C    28.4355  -21.0571
            6   C1x C    29.6006  -23.1543
            7   C1z C    32.0239  -19.0532
            8   C1x C    29.6472  -19.0066
            9   C1a C    30.7656  -18.4940
            10  C1x C    33.2356  -19.7523
            11  C1z C    27.2238  -21.7562
            12  C1y C    28.4355  -19.7057
            13  C1x C    28.3889  -23.8534
            14  C5a C    32.0239  -17.6551
            15  O1a O    33.3288  -18.6804
            16  C2y C    27.2238  -23.1543
            17  C2x C    26.0121  -21.0571
            18  C1a C    27.2238  -20.4514
            19  O1a O    27.2238  -19.0066
            20  C1b C    33.1890  -16.9561
            21  O5a O    30.8122  -16.9561
            22  C2x C    26.0121  -23.8534
            23  C2x C    24.8471  -21.7562
            24  O7a O    34.4007  -17.6551
            25  C5x C    24.8471  -23.1543
            26  C7a C    35.5657  -16.9561
            27  O5x O    23.6353  -23.8534
            28  C2b C    36.7775  -17.6551
            29  O6a O    35.5657  -15.5579
            30  C2c C    37.9891  -16.9561
            31  C1b C    39.2008  -17.6551
            32  C1b C    40.3658  -16.9561
            33  C1a C    37.9891  -15.5554
            34  C2b C    41.5583  -17.6644
            35  C2c C    42.7708  -16.9643
            36  C1b C    43.9834  -17.6644
            37  C1b C    45.1960  -16.9643
            38  C2b C    46.4086  -17.6644
            39  C1a C    42.7708  -15.5641
            40  C2c C    47.6246  -16.9624
            41  C1a C    48.8395  -17.6638
            42  C1a C    47.6246  -15.5641
BOND        45
            1     3   7 1
            2     3   8 1
            3     3   9 1 #Up
            4     4  10 1
            5     5  11 1
            6     5  12 1
            7     6  13 1
            8     7  14 1 #Up
            9     7  15 1 #Down
            10   11  16 1
            11   11  17 1
            12   11  18 1 #Up
            13   12  19 1 #Up
            14   14  20 1
            15   14  21 2
            16   16  22 2
            17   17  23 2
            18   20  24 1
            19   22  25 1
            20   24  26 1
            21   25  27 2
            22   26  28 1
            23   26  29 2
            24    7  10 1
            25    8  12 1
            26   13  16 1
            27   23  25 1
            28    1   2 1
            29   28  30 2
            30    1   3 1
            31   30  31 1
            32    1   4 1
            33   31  32 1
            34    2   5 1
            35    2   6 1
            36   30  33 1
            37   32  34 1
            38   34  35 2
            39   35  36 1
            40   36  37 1
            41   37  38 1
            42   35  39 1
            43   38  40 2
            44   40  41 1
            45   40  42 1

» Japanese version   » Back

KEGG   DRUG: Prednisolone hemisuccinate
Entry
D02156                      Drug                                   
Name
Prednisolone hemisuccinate (USP);
Prednisolone succinate (JP18)
Formula
C25H32O8
Exact mass
460.2097
Mol weight
460.52
Structure
Simcomp
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Remark
ATC code: A01AC04 A07EA01 C05AA04 D07AA03 D07XA02 H02AB06 R01AD02 S01BA04 S01CB02 S02BA03 S03BA02
Chemical structure group: DG00093
Product (DG00093): D00472<JP/US> D00980<JP/US> D00981<JP/US> D01239<JP> D03301<JP>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AC Corticosteroids for local oral treatment
     A01AC04 Prednisolone
      D02156  Prednisolone hemisuccinate (USP)
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07E INTESTINAL ANTIINFLAMMATORY AGENTS
    A07EA Corticosteroids acting locally
     A07EA01 Prednisolone
      D02156  Prednisolone hemisuccinate (USP)
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA04 Prednisolone
      D02156  Prednisolone hemisuccinate (USP)
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AA Corticosteroids, weak (group I)
     D07AA03 Prednisolone
      D02156  Prednisolone hemisuccinate (USP)
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XA Corticosteroids, weak, other combinations
     D07XA02 Prednisolone
      D02156  Prednisolone hemisuccinate (USP)
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB06 Prednisolone
      D02156  Prednisolone hemisuccinate (USP)
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD02 Prednisolone
      D02156  Prednisolone hemisuccinate (USP)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA04 Prednisolone
      D02156  Prednisolone hemisuccinate (USP)
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB02 Prednisolone
      D02156  Prednisolone hemisuccinate (USP)
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA03 Prednisolone
      D02156  Prednisolone hemisuccinate (USP)
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03B CORTICOSTEROIDS
    S03BA Corticosteroids
     S03BA02 Prednisolone
      D02156  Prednisolone hemisuccinate (USP)
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00093  Prednisolone
     D02156  Prednisolone hemisuccinate
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D02156  Prednisolone hemisuccinate (USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D02156  Prednisolone succinate
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00093  Prednisolone
Other DBs
CAS: 2920-86-7
PubChem: 7849217
ChEBI: 135745
LigandBox: D02156
NIKKAJI: J7.936G
LinkDB
KCF data

ATOM        33
            1   C1y C    21.8417  -19.6680
            2   C1y C    20.6301  -20.3204
            3   C1z C    21.8417  -18.2700
            4   C1x C    24.2649  -19.6680
            5   C1y C    19.4651  -19.6214
            6   C1x C    20.6301  -21.7184
            7   C1z C    23.0533  -17.6176
            8   C1x C    20.6767  -17.5710
            9   C1x C    24.2649  -18.3166
            10  C1z C    18.2535  -20.3204
            11  C1y C    19.4651  -18.2700
            12  C1x C    19.4185  -22.4173
            13  C5a C    23.0533  -15.8696
            14  C2y C    18.2535  -21.7184
            15  C2x C    17.0419  -19.6214
            16  O1a O    18.2535  -17.5710
            17  C1b C    24.2183  -15.1706
            18  O5a O    21.8417  -15.1706
            19  C2x C    17.0419  -22.4173
            20  C2x C    15.8770  -20.3204
            21  O7a O    25.4298  -15.8696
            22  C5x C    15.8770  -21.7184
            23  C7a C    26.5948  -15.1706
            24  O5x O    14.6654  -22.4173
            25  C1b C    27.8064  -15.8696
            26  O6a O    26.5948  -13.7727
            27  C1b C    29.0180  -15.1706
            28  C6a C    30.2296  -15.8696
            29  O6a O    31.3946  -15.1706
            30  O6a O    30.2296  -17.2676
            31  C1a C    21.8417  -16.8700
            32  C1a C    18.2535  -18.9204
            33  O1a O    24.2657  -16.9176
BOND        36
            1     3   7 1
            2     3   8 1
            3     4   9 1
            4     5  10 1
            5     5  11 1
            6     6  12 1
            7     7  13 1 #Up
            8    10  14 1
            9    10  15 1
            10   11  16 1 #Up
            11   13  17 1
            12   13  18 2
            13   14  19 2
            14   15  20 2
            15   17  21 1
            16   19  22 1
            17   21  23 1
            18   22  24 2
            19   23  25 1
            20   23  26 2
            21    7   9 1
            22    8  11 1
            23   12  14 1
            24   20  22 1
            25    1   2 1
            26   25  27 1
            27    1   3 1
            28   27  28 1
            29    1   4 1
            30   28  29 1
            31    2   5 1
            32   28  30 2
            33    2   6 1
            34    3  31 1 #Up
            35   10  32 1 #Up
            36    7  33 1 #Down

» Japanese version   » Back

KEGG   DRUG: Prednisolone valerate acetate
Entry
D03301                      Drug                                   
Name
Prednisolone valerate acetate (JAN);
PDL;
Spirazon (TN)
Formula
C28H38O7
Exact mass
486.2618
Mol weight
486.60
Structure
Simcomp
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Dermatological agent
 DG03243  Atopic dermatitis agent
Remark
Therapeutic category: 2646
ATC code: A01AC04 A07EA01 C05AA04 D07AA03 D07XA02 H02AB06 R01AD02 S01BA04 S01CB02 S02BA03 S03BA02
Chemical structure group: DG00093
Product (DG00093): D00472<JP/US> D00980<JP/US> D00981<JP/US> D01239<JP> D03301<JP>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AC Corticosteroids for local oral treatment
     A01AC04 Prednisolone
      D03301  Prednisolone valerate acetate (JAN) <JP>
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07E INTESTINAL ANTIINFLAMMATORY AGENTS
    A07EA Corticosteroids acting locally
     A07EA01 Prednisolone
      D03301  Prednisolone valerate acetate (JAN) <JP>
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA04 Prednisolone
      D03301  Prednisolone valerate acetate (JAN) <JP>
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AA Corticosteroids, weak (group I)
     D07AA03 Prednisolone
      D03301  Prednisolone valerate acetate (JAN) <JP>
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XA Corticosteroids, weak, other combinations
     D07XA02 Prednisolone
      D03301  Prednisolone valerate acetate (JAN) <JP>
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB06 Prednisolone
      D03301  Prednisolone valerate acetate (JAN) <JP>
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD02 Prednisolone
      D03301  Prednisolone valerate acetate (JAN) <JP>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA04 Prednisolone
      D03301  Prednisolone valerate acetate (JAN) <JP>
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB02 Prednisolone
      D03301  Prednisolone valerate acetate (JAN) <JP>
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA03 Prednisolone
      D03301  Prednisolone valerate acetate (JAN) <JP>
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03B CORTICOSTEROIDS
    S03BA Corticosteroids
     S03BA02 Prednisolone
      D03301  Prednisolone valerate acetate (JAN) <JP>
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Prednisolone
   D03301  Prednisolone valerate acetate (JAN)
 Ophthalmic Agents
  Ophthalmic Anti-inflammatories
   Glucocorticoids, Ophthalmic
    Prednisolone
     D03301  Prednisolone valerate acetate (JAN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  26  Epidermides
   264  Analgesics, anti-itchings, astringents, anti-inflammatory agents
    2646  Adrenocorticotropic hormones
     D03301  Prednisolone valerate acetate (JAN)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for integumentary system
  57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
   D03301  Prednisolone valerate acetate (JAN)
Risk category of Japanese OTC drugs [BR:br08312]
 Designated second-class OTC drugs
  Inorganic and organic chemicals
   Prednisolone valerate
    D03301  Prednisolone valerate acetate (JAN)
 Second-class OTC drugs
  Inorganic and organic chemicals
   Prednisolone acetate
    D03301  Prednisolone valerate acetate (JAN)
   Prednisolone valerate
    D03301  Prednisolone valerate acetate (JAN)
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00093  Prednisolone
     D03301  Prednisolone valerate acetate
 Dermatological agent
  DG03243  Atopic dermatitis agent
   D03301  Prednisolone valerate acetate
Drug classes [BR:br08332]
 Anti-inflammatory
  DG01955  Corticosteroid
   D03301  Prednisolone valerate acetate
 Dermatological agent
  DG03243  Atopic dermatitis agent
   D03301  Prednisolone valerate acetate
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D03301  Prednisolone valerate acetate (JAN) <JP>
Topical steroids potency [br08317.html]
 Classification in Japan
  D03301
Rx-to-OTC switch list in Japan [br08314.html]
 D03301
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00093  Prednisolone
Other DBs
CAS: 72064-79-0
PubChem: 17397452
LigandBox: D03301
NIKKAJI: J67.022G
LinkDB
KCF data

ATOM        35
            1   C2x C    25.7532  -19.2868
            2   C5x C    25.7532  -20.6665
            3   C2x C    26.9481  -21.3564
            4   C2y C    28.1430  -20.6665
            5   C1z C    28.1430  -19.2868
            6   C2x C    26.9481  -18.5969
            7   C1x C    29.3379  -21.3564
            8   C1x C    30.5327  -20.6665
            9   C1y C    30.5327  -19.2868
            10  C1y C    29.3379  -18.5969
            11  C1y C    31.7276  -18.5969
            12  C1z C    31.7276  -17.2172
            13  C1x C    30.5327  -16.5273
            14  C1y C    29.3379  -17.2172
            15  C1x C    34.1173  -18.5969
            16  C1x C    34.1173  -17.2172
            17  C1z C    32.9225  -16.5273
            18  C5a C    32.9225  -14.7286
            19  O7a O    34.1173  -15.8375
            20  C7a C    35.3153  -16.5120
            21  O6a O    35.3454  -17.8829
            22  C1b C    36.4875  -15.8004
            23  C1b C    37.6972  -16.4639
            24  C1b C    38.8604  -15.7579
            25  C1a C    40.0674  -16.4198
            26  C1a C    31.7276  -15.9755
            27  O1a O    28.1450  -16.5285
            28  C1a C    28.1430  -17.9071
            29  O5x O    24.5584  -21.3564
            30  C1b C    34.1300  -14.0313
            31  O5a O    31.6806  -14.0121
            32  O7a O    35.3507  -14.7363
            33  C7a C    36.5480  -14.0456
            34  C1a C    37.7646  -14.7485
            35  O6a O    36.5484  -12.6700
BOND        38
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21   17  18 1 #Up
            22   17  19 1 #Down
            23   19  20 1
            24   20  21 2
            25   20  22 1
            26   22  23 1
            27   23  24 1
            28   24  25 1
            29   12  26 1 #Up
            30   14  27 1 #Up
            31    5  28 1 #Up
            32    2  29 2
            33   18  30 1
            34   18  31 2
            35   30  32 1
            36   32  33 1
            37   33  34 1
            38   33  35 2

» Japanese version   » Back

KEGG   DRUG: Prednisolone pivalate
Entry
D08412                      Drug                                   
Name
Prednisolone pivalate;
Prednisolone 21-pivalate;
Ultracortenol (TN)
Formula
C26H36O6
Exact mass
444.2512
Mol weight
444.56
Structure
Simcomp
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Remark
ATC code: A01AC04 A07EA01 C05AA04 D07AA03 D07XA02 H02AB06 R01AD02 S01BA04 S01CB02 S02BA03 S03BA02
Chemical structure group: DG00093
Product (DG00093): D00472<JP/US> D00980<JP/US> D00981<JP/US> D01239<JP> D03301<JP>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AC Corticosteroids for local oral treatment
     A01AC04 Prednisolone
      D08412  Prednisolone pivalate
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07E INTESTINAL ANTIINFLAMMATORY AGENTS
    A07EA Corticosteroids acting locally
     A07EA01 Prednisolone
      D08412  Prednisolone pivalate
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA04 Prednisolone
      D08412  Prednisolone pivalate
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AA Corticosteroids, weak (group I)
     D07AA03 Prednisolone
      D08412  Prednisolone pivalate
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XA Corticosteroids, weak, other combinations
     D07XA02 Prednisolone
      D08412  Prednisolone pivalate
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB06 Prednisolone
      D08412  Prednisolone pivalate
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD02 Prednisolone
      D08412  Prednisolone pivalate
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA04 Prednisolone
      D08412  Prednisolone pivalate
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB02 Prednisolone
      D08412  Prednisolone pivalate
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA03 Prednisolone
      D08412  Prednisolone pivalate
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03B CORTICOSTEROIDS
    S03BA Corticosteroids
     S03BA02 Prednisolone
      D08412  Prednisolone pivalate
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00093  Prednisolone
     D08412  Prednisolone pivalate
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D08412  Prednisolone pivalate
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00093  Prednisolone
Other DBs
CAS: 1107-99-9
PubChem: 96025098
LigandBox: D08412
NIKKAJI: J127.983A
LinkDB
KCF data

ATOM        32
            1   C2x C    18.2278  -20.1917
            2   C5x C    18.2278  -21.5939
            3   C2x C    19.3495  -22.2249
            4   C2y C    20.5414  -21.5939
            5   C1z C    20.5414  -20.1917
            6   C2x C    19.3495  -19.4906
            7   C1x C    21.7333  -22.2249
            8   C1x C    22.9252  -21.5939
            9   C1y C    22.9252  -20.1917
            10  C1y C    21.7333  -19.4906
            11  C1y C    24.1170  -19.4906
            12  C1z C    24.1170  -18.1585
            13  C1x C    22.9252  -17.4574
            14  C1y C    21.7333  -18.1585
            15  C1x C    26.4307  -19.4906
            16  C1x C    26.4307  -18.1585
            17  C1z C    25.3089  -17.4574
            18  O5x O    17.0359  -22.2249
            19  C1a C    20.5414  -18.8596
            20  O1a O    20.5414  -17.4574
            21  C1a C    24.1170  -16.8264
            22  C5a C    25.3089  -15.7748
            23  O1a O    26.4307  -16.8264
            24  C1b C    26.5008  -15.0737
            25  O5a O    24.1170  -15.0737
            26  O7a O    27.6225  -15.7748
            27  C7a C    28.8845  -15.0737
            28  C1d C    30.0764  -15.7748
            29  O6a O    28.8845  -13.6715
            30  C1a C    31.2907  -16.4759
            31  C1a C    29.3704  -16.9863
            32  C1a C    30.7824  -14.5633
BOND        35
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21    2  18 2
            22    5  19 1 #Up
            23   14  20 1 #Up
            24   12  21 1 #Up
            25   17  22 1 #Up
            26   17  23 1 #Down
            27   22  24 1
            28   22  25 2
            29   24  26 1
            30   26  27 1
            31   27  28 1
            32   27  29 2
            33   28  30 1
            34   28  31 1
            35   28  32 1

» Japanese version   » Back

KEGG   DRUG: Prednisolone sodium metazoate
Entry
D08413                      Drug                                   
Name
Prednisolone sodium metazoate (USAN);
Prednisolone metasulfobenzoate sodium;
Prednisolone 21-(sodium 3-sulfobenzoate);
Predenema (TN)
Formula
C28H31O9S. Na
Exact mass
566.1586
Mol weight
566.60
Structure
Simcomp
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Remark
ATC code: A01AC04 A07EA01 C05AA04 D07AA03 D07XA02 H02AB06 R01AD02 S01BA04 S01CB02 S02BA03 S03BA02
Chemical structure group: DG00093
Product (DG00093): D00472<JP/US> D00980<JP/US> D00981<JP/US> D01239<JP> D03301<JP>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AC Corticosteroids for local oral treatment
     A01AC04 Prednisolone
      D08413  Prednisolone sodium metazoate (USAN)
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07E INTESTINAL ANTIINFLAMMATORY AGENTS
    A07EA Corticosteroids acting locally
     A07EA01 Prednisolone
      D08413  Prednisolone sodium metazoate (USAN)
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA04 Prednisolone
      D08413  Prednisolone sodium metazoate (USAN)
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AA Corticosteroids, weak (group I)
     D07AA03 Prednisolone
      D08413  Prednisolone sodium metazoate (USAN)
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XA Corticosteroids, weak, other combinations
     D07XA02 Prednisolone
      D08413  Prednisolone sodium metazoate (USAN)
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB06 Prednisolone
      D08413  Prednisolone sodium metazoate (USAN)
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD02 Prednisolone
      D08413  Prednisolone sodium metazoate (USAN)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA04 Prednisolone
      D08413  Prednisolone sodium metazoate (USAN)
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB02 Prednisolone
      D08413  Prednisolone sodium metazoate (USAN)
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA03 Prednisolone
      D08413  Prednisolone sodium metazoate (USAN)
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03B CORTICOSTEROIDS
    S03BA Corticosteroids
     S03BA02 Prednisolone
      D08413  Prednisolone sodium metazoate (USAN)
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00093  Prednisolone
     D08413  Prednisolone sodium metazoate
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D08413  Prednisolone sodium metazoate (USAN)
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00093  Prednisolone
Other DBs
CAS: 630-67-1
PubChem: 96025099
LigandBox: D08413
NIKKAJI: J205.901K
LinkDB
KCF data

ATOM        39
            1   C2x C    18.2000  -20.1600
            2   C5x C    18.2000  -21.5600
            3   C2x C    19.3200  -22.1900
            4   C2y C    20.5100  -21.5600
            5   C1z C    20.5100  -20.1600
            6   C2x C    19.3200  -19.4600
            7   C1x C    21.7000  -22.1900
            8   C1x C    22.9600  -21.5600
            9   C1y C    22.9600  -20.1600
            10  C1y C    21.7000  -19.4600
            11  C1y C    24.1500  -19.4600
            12  C1z C    24.1500  -18.1300
            13  C1x C    22.9600  -17.4300
            14  C1y C    21.7000  -18.1300
            15  C1x C    26.4600  -19.4600
            16  C1x C    26.4600  -18.1300
            17  C1z C    25.3400  -17.4300
            18  O5x O    17.0100  -22.1900
            19  C1a C    20.5100  -18.8300
            20  O1a O    20.5100  -17.4300
            21  C1a C    24.1500  -16.8000
            22  C5a C    25.3400  -15.7500
            23  O1a O    26.4600  -16.8000
            24  C1b C    26.5300  -15.0500
            25  O5a O    24.1500  -15.0500
            26  O7a O    27.6500  -15.7500
            27  C7a C    28.9100  -15.0500
            28  O6a O    28.9100  -13.6500
            29  C8y C    30.1166  -15.7600
            30  C8x C    30.1050  -17.1500
            31  C8y C    31.3116  -17.8601
            32  C8x C    32.5298  -17.1702
            33  C8x C    32.5414  -15.7802
            34  C8x C    31.3348  -15.0701
            35  S4a S    31.3116  -19.2601
            36  O1d O    31.3116  -20.6601 #-
            37  O1d O    32.6900  -19.2599
            38  O1d O    29.8900  -19.2602
            39  Z   Na   28.0700  -22.6800 #+
BOND        42
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21    2  18 2
            22    5  19 1 #Up
            23   14  20 1 #Up
            24   12  21 1 #Up
            25   17  22 1 #Up
            26   17  23 1 #Down
            27   22  24 1
            28   22  25 2
            29   24  26 1
            30   26  27 1
            31   27  28 2
            32   27  29 1
            33   29  30 2
            34   30  31 1
            35   31  32 2
            36   32  33 1
            37   33  34 2
            38   29  34 1
            39   31  35 1
            40   35  36 1
            41   35  37 2
            42   35  38 2

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