KEGG   DRUG: TetracaineHelp
Entry
D00551                      Drug                                   

Name
Tetracaine (USP/INN);
Amethocaine;
Amethocaine (TN)
Formula
C15H24N2O2
Exact mass
264.1838
Mol weight
264.3633
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG02030  Anesthetics
  DG01675  Local anesthetic
   DG01674  Esterified local anesthetic
 DG01675  Local anesthetic
  DG01674  Esterified local anesthetic
Remark
Same as: C07526
ATC code: C05AD02 D04AB06 N01BA03 S01HA03
Chemical structure group: DG00296
Product (DG00296): D00741<JP/US>
Efficacy
Anesthetic (topical)
Comment
Ester-type
Target
SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]
  Pathway
hsa04728  Dopaminergic synapse
Interaction
Drug interaction
Structure map
map07015  Local analgesics
map07231  Sodium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AD Local anesthetics
     C05AD02 Tetracaine
      D00551  Tetracaine (USP/INN)
 D DERMATOLOGICALS
  D04 ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
   D04A ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
    D04AB Anesthetics for topical use
     D04AB06 Tetracaine
      D00551  Tetracaine (USP/INN)
 N NERVOUS SYSTEM
  N01 ANESTHETICS
   N01B ANESTHETICS, LOCAL
    N01BA Esters of aminobenzoic acid
     N01BA03 Tetracaine
      D00551  Tetracaine (USP/INN)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01H LOCAL ANESTHETICS
    S01HA Local anesthetics
     S01HA03 Tetracaine
      D00551  Tetracaine (USP/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D00551  Tetracaine (USP/INN)
    SCN2A
     D00551  Tetracaine (USP/INN)
    SCN3A
     D00551  Tetracaine (USP/INN)
    SCN4A
     D00551  Tetracaine (USP/INN)
    SCN5A
     D00551  Tetracaine (USP/INN)
    SCN8A
     D00551  Tetracaine (USP/INN)
    SCN9A
     D00551  Tetracaine (USP/INN)
    SCN10A
     D00551  Tetracaine (USP/INN)
    SCN11A
     D00551  Tetracaine (USP/INN)
BRITE hierarchy
Other DBs
CAS: 94-24-6
PubChem: 7847617
ChEBI: 9468
ChEMBL: CHEMBL698
PDB-CCD: TE4[PDBj]
LigandBox: D00551
NIKKAJI: J3.945D
LinkDB All DBs
KCF data Show

ATOM        19
            1   C8y C    25.5212  -17.9670
            2   C7a C    26.7355  -18.6618
            3   C8x C    25.5212  -16.5600
            4   C8x C    24.3067  -18.6677
            5   O7a O    27.9499  -17.9670
            6   O6a O    26.7355  -20.0689
            7   C8x C    24.3067  -15.8535
            8   C8x C    23.0981  -17.9728
            9   C1b C    29.1642  -18.6560
            10  C8y C    23.0923  -16.5600
            11  C1b C    30.3785  -17.9611
            12  N1b N    21.8721  -15.8594
            13  N1c N    31.5930  -18.6501
            14  C1b C    20.6695  -16.5600
            15  C1a C    32.7956  -17.9494
            16  C1a C    31.5930  -20.0513
            17  C1b C    19.4610  -15.8594
            18  C1b C    18.2524  -16.5600
            19  C1a C    17.0497  -15.8594
BOND        19
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     2   6 2
            6     3   7 2
            7     4   8 1
            8     5   9 1
            9     7  10 1
            10    9  11 1
            11   10  12 1
            12   11  13 1
            13   12  14 1
            14   13  15 1
            15   13  16 1
            16   14  17 1
            17   17  18 1
            18   18  19 1
            19    8  10 2

» Japanese version   » Back

DBGET integrated database retrieval system