KEGG   DRUG: Fosinopril sodiumHelp
Entry
D00622                      Drug                                   

Name
Fosinopril sodium (USAN);
Monopril (TN)
Product
  Generic
FOSINOPRIL SODIUM (Bryant Ranch Prepack), FOSINOPRIL SODIUM (Solco Healthcare LLC), FOSINOPRIL SODIUM (Bryant Ranch Prepack), FOSINOPRIL SODIUM (Bryant Ranch Prepack), FOSINOPRIL SODIUM (Cipla USA), FOSINOPRIL SODIUM (A-S Medication Solutions), FOSINOPRIL SODIUM (A-S Medication Solutions), FOSINOPRIL SODIUM (A-S Medication Solutions), FOSINOPRIL SODIUM (A-S Medication Solutions), FOSINOPRIL SODIUM (Aidarex Pharmaceuticals LLC), FOSINOPRIL SODIUM (Aphena Pharma Solutions - Tennessee), FOSINOPRIL SODIUM (Aphena Pharma Solutions - Tennessee), FOSINOPRIL SODIUM (Aphena Pharma Solutions - Tennessee), FOSINOPRIL SODIUM (Aurobindo Pharma Limited), FOSINOPRIL SODIUM (Bryant Ranch Prepack), FOSINOPRIL SODIUM (Bryant Ranch Prepack), FOSINOPRIL SODIUM (Bryant Ranch Prepack), FOSINOPRIL SODIUM (Camber Pharmceuticals), FOSINOPRIL SODIUM (Dispensing Solutions), FOSINOPRIL SODIUM (Eon Labs), FOSINOPRIL SODIUM (Exelan Pharmaceuticals), FOSINOPRIL SODIUM (Teva Pharmaceuticals USA), FOSINOPRIL SODIUM (Unit Dose Services), FOSINOPRIL SODIUM (Unit Dose Services)
Formula
C30H45NO7P. Na
Exact mass
585.2831
Mol weight
585.6443
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01501  Angiotensin-converting enzyme inhibitor
 DG01925  Renin-angiotensin system inhibitor
  DG01501  Angiotensin-converting enzyme inhibitor
Remark
ATC code: C09AA09
Chemical structure group: DG00341
Product (DG00341): D00622<US>
Product (mixture): D10280<US>
Efficacy
Antihypertensive, Angiotensin-converting enzyme inhibitor
  Disease
Hypertension [DS:H01633]
Comment
Active form of prodrug: Fosinoprilat [DR:D03772]
Target
ACE (CD143) [HSA:1636] [KO:K01283]
  Pathway
hsa04614  Renin-angiotensin system
Interaction
Drug interaction
Structure map
map07217  Renin-angiotensin system inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C09 AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
   C09A ACE INHIBITORS, PLAIN
    C09AA ACE inhibitors, plain
     C09AA09 Fosinopril
      D00622  Fosinopril sodium (USAN) <US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Angiotensin-converting Enzyme (ACE) Inhibitors
   Fosinopril
    D00622  Fosinopril sodium (USAN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   Peptidyl-dipeptidases
    ACE (CD143)
     D00622  Fosinopril sodium (USAN) <US>
Prodrugs [br08324.html]
 DG00341
BRITE hierarchy
Other DBs
CAS: 88889-14-9
PubChem: 7847688
ChEBI: 5164
ChEMBL: CHEMBL3039596
DrugBank: DB00492
LigandBox: D00622
NIKKAJI: J351.178B
LinkDB All DBs
KCF data Show

ATOM        40
            1   C8x C    10.2582  -15.1697
            2   C8x C    10.2582  -16.5677
            3   C8x C    11.4466  -17.2668
            4   C8x C    12.7048  -16.5677
            5   C8y C    12.7048  -15.1697
            6   C8x C    11.4466  -14.4707
            7   C1b C    13.8932  -14.4707
            8   C1b C    15.1515  -15.1697
            9   C1b C    16.3398  -14.4707
            10  C1b C    17.5282  -15.1697
            11  P1a P    18.7864  -14.4707
            12  C1b C    19.9748  -15.1697
            13  C5a C    21.1631  -14.4707
            14  N1y N    22.4214  -15.1697
            15  O3b O    18.7864  -13.0028
            16  O5a O    21.1631  -13.0727
            17  C1x C    22.8408  -16.4978
            18  C1y C    24.2389  -16.4978
            19  C1x C    24.6583  -15.1697
            20  C1y C    23.5398  -14.3309
            21  C1y C    24.9379  -17.7561
            22  C1x C    24.2389  -18.9444
            23  C1x C    24.9379  -20.1328
            24  C1x C    26.3360  -20.1328
            25  C1x C    27.0350  -18.9444
            26  C1x C    26.3360  -17.7561
            27  C6a C    23.5398  -12.9329
            28  O6a O    24.7282  -12.2338 #-
            29  O6a O    22.3515  -12.2338
            30  O2b O    18.7864  -16.0085
            31  C1c C    18.7864  -17.4066
            32  O7a O    17.5981  -18.1056
            33  C1c C    19.9748  -18.1056
            34  C1a C    21.1631  -17.4066
            35  C1a C    19.9748  -19.5037
            36  C7a C    16.4097  -17.4066
            37  C1b C    15.2214  -18.1056
            38  O6a O    16.4097  -16.0085
            39  C1a C    14.0330  -17.4066
            40  Z   Na   26.2661  -12.2338 #+
BOND        41
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14   13  14 1
            15   11  15 2
            16   13  16 2
            17   14  17 1
            18   17  18 1
            19   18  19 1
            20   19  20 1
            21   14  20 1
            22   21  22 1
            23   22  23 1
            24   23  24 1
            25   24  25 1
            26   25  26 1
            27   21  26 1
            28   18  21 1 #Up
            29   20  27 1 #Down
            30   27  28 1
            31   27  29 2
            32   11  30 1
            33   30  31 1
            34   31  32 1 #Up
            35   31  33 1
            36   33  34 1
            37   33  35 1
            38   32  36 1
            39   36  37 1
            40   36  38 2
            41   37  39 1

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