KEGG   DRUG: Diphenhydramine hydrochlorideHelp
Entry
D00669                      Drug                                   

Name
Diphenhydramine hydrochloride (JP17/USP);
Benadryl (TN)
Product
  Generic
DIPHENHYDRAMINE HYDROCHLORIDE (Cardinal Health), DIPHENHYDRAMINE HYDROCHLORIDE (Cardinal Health), DIPHENHYDRAMINE HYDROCHLORIDE (Cardinal Health), DIPHENHYDRAMINE HYDROCHLORIDE (Contract Pharmacy Services-PA), DIPHENHYDRAMINE HYDROCHLORIDE (Dispensing Solutions), DIPHENHYDRAMINE HYDROCHLORIDE (Fresenius Kabi USA), DIPHENHYDRAMINE (Fresenius Kabi USA), DIPHENHYDRAMINE (Fresenius Kabi USA), DIPHENHYDRAMINE HYDROCHLORIDE (General Injectables & Vaccines), DIPHENHYDRAMINE HYDROCHLORIDE (General Injectables and Vaccines), DIPHENHYDRAMINE HYDROCHLORIDE (General Injectables and Vaccines), DIPHENHYDRAMINE HYDROCHLORIDE (HF Acquisition Co. LLC), DIPHENHYDRAMINE HYDROCHLORIDE (Hospira), DIPHENHYDRAMINE HYDROCHLORIDE (Medical Purchasing Solutions), DIPHENHYDRAMINE HYDROCHLORIDE (Mylan Institutional LLC), DIPHENHYDRAMINE HYDROCHLORIDE (NuCare Pharmaceuticals), DIPHENHYDRAMINE HYDROCHLORIDE (Pharmaceutical Associates), DIPHENHYDRAMINE HYDROCHLORIDE (REMEDYREPACK), DIPHENHYDRAMINE HYDROCHLORIDE (Rebel Distributors Corp), DIPHENHYDRAMINE HYDROCHLORIDE (Sina Health), DIPHENHYDRAMINE HYDROCHLORIDE (State of Florida DOH Central Pharmacy), DIPHENHYDRAMINE HYDROCHLORIDE (TYA Pharmaceuticals), DIPHENHYDRAMINE HYDROCHLORIDE (West-ward Pharmaceutical Corp.)
Formula
C17H21NO. HCl
Exact mass
291.139
Mol weight
291.8157
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-allergic agent
 DG01557  Histamine receptor antagonist
  DG01482  Histamine receptor H1 antagonist
Enzyme substrate
 DG01644  CYP2D6 substrate
Enzyme inhibitor
 DG01645  CYP2D6 inhibitor
Transporter inhibitor
 DG02863  SLC22A2 (OCT2) inhibitor
Remark
Same as: C07784
Therapeutic category: 4411
ATC code: D04AA32 R06AA02
Chemical structure group: DG00390
Product (DG00390): D00300<JP> D00669<JP/US> D03360<JP>
Product (mixture): D04259<JP> D04299<JP> D04806<JP> D08769<JP> D08720<JP>
Efficacy
Antiallergic, H1 receptor antagonist
  Disease
Parkinsonism [DS:H01600]
Nighttime sleep-aid [DS:H01609]
Comment
Diphenhydramine derivative
Target
HRH1 [HSA:3269] [KO:K04149]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Drug interaction
Structure map
map07028  Antipsychotics
map07032  Hypnotics
map07212  Histamine H1 receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D04 ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
   D04A ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
    D04AA Antihistamines for topical use
     D04AA32 Diphenhydramine
      D00669  Diphenhydramine hydrochloride (JP17/USP) <JP/US>
 R RESPIRATORY SYSTEM
  R06 ANTIHISTAMINES FOR SYSTEMIC USE
   R06A ANTIHISTAMINES FOR SYSTEMIC USE
    R06AA Aminoalkyl ethers
     R06AA02 Diphenhydramine
      D00669  Diphenhydramine hydrochloride (JP17/USP) <JP/US>
USP drug classification [BR:br08302]
 Antiemetics
  Antiemetics, Other
   Diphenhydramine
    D00669  Diphenhydramine hydrochloride (JP17/USP)
 Antiparkinson Agents
  Anticholinergics
   Diphenhydramine
    D00669  Diphenhydramine hydrochloride (JP17/USP)
 Respiratory Tract/Pulmonary Agents
  Antihistamines
   Diphenhydramine
    D00669  Diphenhydramine hydrochloride (JP17/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  44  Allergic agents
   441  Antihistamines
    4411  Diphenhydramines
     D00669  Diphenhydramine hydrochloride (JP17/USP)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for nervous and sensory systems
  01 Cold remedy (oral use)
   D00669  Diphenhydramine hydrochloride (JP17/USP)
  04 Sedative hypnotic agents
   D00669  Diphenhydramine hydrochloride (JP17/USP)
  06 Antivertigo drugs (incl. motion/morning sickness remedies)
   D00669  Diphenhydramine hydrochloride (JP17/USP)
 Allergic agents
  52 Antihistamine based drugs
   D00669  Diphenhydramine hydrochloride (JP17/USP)
 Agents for integumentary system
  57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
   D00669  Diphenhydramine hydrochloride (JP17/USP)
 Agents for ophthalmologic use
  64 Allergy eye drops
   D00669  Diphenhydramine hydrochloride (JP17/USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Designated second-class OTC drugs
  Inorganic and organic chemicals
   Diphenhydramine
    D00669  Diphenhydramine hydrochloride (JP17/USP)
 Second-class OTC drugs
  Inorganic and organic chemicals
   Diphenhydramine
    D00669  Diphenhydramine hydrochloride (JP17/USP)
 Third-class OTC drugs
  Inorganic and organic chemicals
   Diphenhydramine
    D00669  Diphenhydramine hydrochloride (JP17/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    HRH1
     D00669  Diphenhydramine hydrochloride (JP17/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00669  Diphenhydramine hydrochloride
Drug classes of therapeutic agents [br08360.html]
 Anti-allergic agents
  D00669
Rx-to-OTC switch list in the USA [br08315.html]
 D00669
BRITE hierarchy
Other DBs
CAS: 147-24-0
PubChem: 7847735
ChEBI: 4637
ChEMBL: CHEMBL1620
DrugBank: DB01075
LigandBox: D00669
NIKKAJI: J237.227D
LinkDB All DBs
KCF data Show

ATOM        20
            1   X   Cl   34.6500  -16.2400
            2   C1c C    28.0247  -15.1856
            3   C8y C    26.8139  -15.8899
            4   C8y C    29.2415  -15.8899
            5   O2a O    28.0306  -13.7884
            6   C8x C    26.8139  -17.2930
            7   C8x C    25.6030  -15.1856
            8   C8x C    29.2358  -17.2930
            9   C8x C    30.4465  -15.1856
            10  C1b C    29.2415  -13.0840
            11  C8x C    25.6030  -17.9856
            12  C8x C    24.3862  -15.8899
            13  C8x C    30.4465  -17.9856
            14  C8x C    31.6632  -15.8899
            15  C8x C    24.3862  -17.2930
            16  C8x C    31.6573  -17.2930
            17  C1b C    30.4774  -13.7950
            18  N1c N    31.6739  -13.1016
            19  C1a C    32.8632  -13.7857
            20  C1a C    31.6717  -11.6927
BOND        20
            1     6  11 2
            2     7  12 1
            3     8  13 1
            4     9  14 2
            5    11  15 1
            6    13  16 2
            7    12  15 2
            8    14  16 1
            9     2   3 1
            10    2   4 1
            11    2   5 1
            12    3   6 1
            13    3   7 2
            14    4   8 2
            15    4   9 1
            16    5  10 1
            17   10  17 1
            18   17  18 1
            19   18  19 1
            20   18  20 1

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