KEGG   DRUG: Tetracaine hydrochloride
Entry
D00741                      Drug                                   

Name
Tetracaine hydrochloride (JP18/USP);
Protocaine hydrochloride (TN)
Product
Formula
C15H24N2O2. HCl
Exact mass
300.1605
Mol weight
300.8242
Structure
Simcomp
Class
Neuropsychiatric agent
 DG02030  Anesthetics
  DG01675  Local anesthetic
   DG01674  Esterified local anesthetic
Remark
Therapeutic category: 1211 2710
ATC code: C05AD02 D04AB06 N01BA03 S01HA03
Chemical structure group: DG00296
Product (DG00296): D00741<JP/US>
Product (mixture): D04816<JP>
Efficacy
Anesthetic (local)
Comment
Ester-type
Target
SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]
  Pathway
hsa04728  Dopaminergic synapse
Interaction
Structure map
map07015  Local analgesics
map07231  Sodium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AD Local anesthetics
     C05AD02 Tetracaine
      D00741  Tetracaine hydrochloride (JP18/USP) <JP/US>
 D DERMATOLOGICALS
  D04 ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
   D04A ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
    D04AB Anesthetics for topical use
     D04AB06 Tetracaine
      D00741  Tetracaine hydrochloride (JP18/USP) <JP/US>
 N NERVOUS SYSTEM
  N01 ANESTHETICS
   N01B ANESTHETICS, LOCAL
    N01BA Esters of aminobenzoic acid
     N01BA03 Tetracaine
      D00741  Tetracaine hydrochloride (JP18/USP) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01H LOCAL ANESTHETICS
    S01HA Local anesthetics
     S01HA03 Tetracaine
      D00741  Tetracaine hydrochloride (JP18/USP) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  12  Agents affecting peripheral nervous system
   121  Local anesthetics
    1211  Aminobenzoate alkamine esters
     D00741  Tetracaine hydrochloride (JP18/USP)
 2  Agents affecting individual organs
  27  Dental preparations
   271  Local anesthetics
    2710  Local anesthetics
     D00741  Tetracaine hydrochloride (JP18/USP)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D00741  Tetracaine hydrochloride (JP18/USP) <JP/US>
    SCN2A
     D00741  Tetracaine hydrochloride (JP18/USP) <JP/US>
    SCN3A
     D00741  Tetracaine hydrochloride (JP18/USP) <JP/US>
    SCN4A
     D00741  Tetracaine hydrochloride (JP18/USP) <JP/US>
    SCN5A
     D00741  Tetracaine hydrochloride (JP18/USP) <JP/US>
    SCN8A
     D00741  Tetracaine hydrochloride (JP18/USP) <JP/US>
    SCN9A
     D00741  Tetracaine hydrochloride (JP18/USP) <JP/US>
    SCN10A
     D00741  Tetracaine hydrochloride (JP18/USP) <JP/US>
    SCN11A
     D00741  Tetracaine hydrochloride (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00741  Tetracaine hydrochloride
Other DBs
CAS: 136-47-0
PubChem: 7847806
ChEBI: 9469
ChEMBL: CHEMBL1255654
LigandBox: D00741
NIKKAJI: J139.065A
LinkDB
KCF data

ATOM        20
            1   C8y C    25.5966  -17.9141
            2   C7a C    26.8041  -18.6141
            3   C8x C    25.5966  -16.5083
            4   C8x C    24.3891  -18.6141
            5   O7a O    28.0117  -17.9200
            6   O6a O    26.7925  -20.0199
            7   C8x C    24.3891  -15.8140
            8   C8x C    23.1699  -17.9141
            9   C1b C    29.2249  -18.6258
            10  C8y C    23.1699  -16.5083
            11  C1b C    30.4384  -17.9257
            12  N1b N    21.9566  -15.8140
            13  N1c N    31.6517  -18.6315
            14  C1b C    20.7491  -16.5083
            15  C1a C    32.8649  -17.9257
            16  C1a C    31.6457  -20.0315
            17  C1b C    19.5356  -15.8140
            18  C1b C    18.3224  -16.5083
            19  C1a C    17.1090  -15.8140
            20  X   Cl   31.6373  -15.9623
BOND        19
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     2   6 2
            6     3   7 2
            7     4   8 1
            8     5   9 1
            9     7  10 1
            10    9  11 1
            11   10  12 1
            12   11  13 1
            13   12  14 1
            14   13  15 1
            15   13  16 1
            16   14  17 1
            17   17  18 1
            18   18  19 1
            19    8  10 2

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