| Entry |
|
|---|
| Name |
Amantadine hydrochloride (JP18/USP);
Symmetrel (TN);
Gocovri (TN);
Osmolex er (TN) |
|---|
| Product |
|
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| Generic |
AMANTADINE (Alembic Pharmaceuticals Limited), AMANTADINE (Alembic Pharmaceuticals Limited), AMANTADINE (Alembic Pharmaceuticals), AMANTADINE (Alembic Pharmaceuticals), AMANTADINE (American Health Packaging), AMANTADINE HCL (AvKARE), AMANTADINE HCL (AvPAK), AMANTADINE HCL (Bionpharma), AMANTADINE HCL (Direct_Rx), AMANTADINE HCL (Direct_Rx), AMANTADINE HYDROCHLORIDE (APNAR PHARMA LP), AMANTADINE HYDROCHLORIDE (ATHEM LLC), AMANTADINE HYDROCHLORIDE (ATLANTIC BIOLOGICALS CORP.), AMANTADINE HYDROCHLORIDE (ATLANTIC BIOLOGICALS CORP.), AMANTADINE HYDROCHLORIDE (Actavis Pharma), AMANTADINE HYDROCHLORIDE (Advagen Pharma Limited), AMANTADINE HYDROCHLORIDE (American Health Packaging), AMANTADINE HYDROCHLORIDE (Apnar Pharma LP), AMANTADINE HYDROCHLORIDE (Bryant Ranch Prepack), AMANTADINE HYDROCHLORIDE (Bryant Ranch Prepack), AMANTADINE HYDROCHLORIDE (Cardinal Health 107), AMANTADINE HYDROCHLORIDE (Chartwell RX), AMANTADINE HYDROCHLORIDE (Chartwell RX), AMANTADINE HYDROCHLORIDE (EPIC PHARMA LLC), AMANTADINE HYDROCHLORIDE (Edenbridge Pharmaceuticals LLC.), AMANTADINE HYDROCHLORIDE (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), AMANTADINE HYDROCHLORIDE (Major Pharmaceuticals), AMANTADINE HYDROCHLORIDE (Marlex Pharmaceuticals), AMANTADINE HYDROCHLORIDE (NCS HealthCare of KY), AMANTADINE HYDROCHLORIDE (PAI Holdings), AMANTADINE HYDROCHLORIDE (Patrin Pharma), AMANTADINE HYDROCHLORIDE (Proficient Rx LP), AMANTADINE HYDROCHLORIDE (Proficient Rx LP), AMANTADINE HYDROCHLORIDE (RPK Pharmaceuticals), AMANTADINE HYDROCHLORIDE (Rising Pharma Holdings), AMANTADINE HYDROCHLORIDE (Strides Pharma Science Limited), AMANTADINE HYDROCHLORIDE (Strides Pharma), AMANTADINE HYDROCHLORIDE (Strides Pharma), AMANTADINE HYDROCHLORIDE (Upsher-Smith Laboratories), AMANTADINE HYDROCHLORIDE (Upsher-Smith Laboratories), AMANTADINE HYDROCHLORIDE (Zydus Lifesciences Limited), AMANTADINE HYDROCHLORIDE (Zydus Pharmaceuticals (USA)) |
|---|
| Formula |
C10H17N. HCl
|
|---|
| Exact mass |
187.1128
|
|---|
| Mol weight |
187.71
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Antiviral
DG03029 Anti-influenza virus agent
DG02841 Viral uncoating inhibitor
Neuropsychiatric agent
DG01498 NMDA receptor antagonist
DG01967 Antiparkinson agent
Transporter substrate
DG02854 SLC22A2 substrate
|
|---|
| Remark |
| Product (DG00860): | D00777<JP/US> |
|
|---|
| Efficacy |
Antiviral, M2 protein inhibitor, Antiparkinsonian, Dopamine secretagogue |
|---|
| Disease |
|
|---|
| Comment |
Adamantane derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Metabolism |
Transporter: SLC22A2 [HSA: 6582]
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07235 | N-Methyl-D-aspartic acid (NMDA) receptor antagonists |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N04 ANTI-PARKINSON DRUGS
N04B DOPAMINERGIC AGENTS
N04BB Adamantane derivatives
N04BB01 Amantadine
D00777 Amantadine hydrochloride (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
Antiparkinson Agents
Antiparkinson Agents, Other
Amantadine
D00777 Amantadine hydrochloride (JP18/USP)
Antivirals
Anti-influenza Agents
Amantadine
D00777 Amantadine hydrochloride (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
116 Antiparkinsonian agents
1161 Amantadines
D00777 Amantadine hydrochloride (JP18/USP)
117 Psychotropics
1179 Others
D00777 Amantadine hydrochloride (JP18/USP)
6 Agents against pathologic organisms and parasites
62 Chemotherapeutics
625 Antivirals
6250 Antivirals
D00777 Amantadine hydrochloride (JP18/USP)
Drug groups [BR:br08330]
Antiviral
DG03029 Anti-influenza virus agent
DG02841 Viral uncoating inhibitor
DG00860 Amantadine
D00777 Amantadine hydrochloride
Neuropsychiatric agent
DG01498 NMDA receptor antagonist
DG00860 Amantadine
D00777 Amantadine hydrochloride
DG01967 Antiparkinson agent
DG00860 Amantadine
D00777 Amantadine hydrochloride
Transporter substrate
DG02854 SLC22A2 substrate
DG00860 Amantadine
D00777 Amantadine hydrochloride
Drug classes [BR:br08332]
Antiviral
DG03029 Anti-influenza virus agent
D00777 Amantadine hydrochloride
Neuropsychiatric agent
DG01967 Antiparkinson agent
D00777 Amantadine hydrochloride
Target-based classification of drugs [BR:br08310]
Ion channels
Ligand-gated ion channels
Glutamate (ionotropic), NMDA
GRIN (NMDAR)
D00777 Amantadine hydrochloride (JP18/USP) <JP/US>
Antimicrobials [BR:br08307]
Antivirals
Entry, fusion or uncoating inhibitor
Influenza virus uncoating inhibitor
D00777 Amantadine hydrochloride (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00777 Amantadine hydrochloride
Drug metabolizing enzymes and transporters [br08309.html]
Drug transporters
D00777
Drug groups [BR:br08330]
Antiviral
DG03029 Anti-influenza virus agent
DG02841 Viral uncoating inhibitor
DG00860 Amantadine
Neuropsychiatric agent
DG01498 NMDA receptor antagonist
DG00860 Amantadine
DG01967 Antiparkinson agent
DG00860 Amantadine
Transporter substrate
DG02854 SLC22A2 substrate
DG00860 Amantadine
Antimicrobials abbreviations [BR:br08327]
Antivirals
Entry, fusion or uncoating inhibitor
Influenza virus uncoating inhibitor
DG00860 Amantadine
|
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 12
1 C1z C 26.1041 -16.1171
2 C1x C 25.0596 -16.7181
3 C1x C 25.4857 -17.5815
4 C1x C 27.1483 -16.7181
5 N1a N 26.1098 -14.9037
6 C1y C 25.0596 -17.9199
7 C1y C 25.4857 -18.6958
8 C1y C 27.1483 -17.9199
9 C1x C 23.7761 -19.1627
10 C1x C 26.1041 -18.5267
11 C1x C 26.6408 -19.7694
12 X Cl 29.9600 -17.4300
BOND 13
1 1 2 1
2 1 3 1
3 1 4 1
4 1 5 1
5 2 6 1
6 3 7 1
7 4 8 1
8 6 9 1
9 6 10 1
10 7 11 1
11 7 9 1
12 8 10 1
13 8 11 1
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