| Entry |
|
|---|
| Name |
Ropinirole hydrochloride (JAN/USP);
Requip (TN) |
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| Product |
|
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| Generic |
ROPINIROLE (A-S Medication Solutions), ROPINIROLE (A-S Medication Solutions), ROPINIROLE (A-S Medication Solutions), ROPINIROLE (Accord Healthcare), ROPINIROLE (Actavis Pharma), ROPINIROLE (Alembic Pharmaceuticals Limited), ROPINIROLE (Alembic Pharmaceuticals), ROPINIROLE (Bionpharma), ROPINIROLE (Bryant Ranch Prepack), ROPINIROLE (Bryant Ranch Prepack), ROPINIROLE (Bryant Ranch Prepack), ROPINIROLE (Bryant Ranch Prepack), ROPINIROLE (Bryant Ranch Prepack), ROPINIROLE (Bryant Ranch Prepack), ROPINIROLE (Bryant Ranch Prepack), ROPINIROLE (Bryant Ranch Prepack), ROPINIROLE (Bryant Ranch Prepack), ROPINIROLE (DIRECT RX), ROPINIROLE (Direct_Rx), ROPINIROLE (Direct_Rx), ROPINIROLE (Direct_Rx), ROPINIROLE (Dr. Reddys Laboratories Limited), ROPINIROLE (Glenmark Pharmaceuticals), ROPINIROLE (Marlex Pharmaceuticals), ROPINIROLE (REMEDYREPACK), ROPINIROLE (REMEDYREPACK), ROPINIROLE (REMEDYREPACK), ROPINIROLE (REMEDYREPACK), ROPINIROLE (Solco Healthcare US), ROPINIROLE HYDROCHLORIDE (A-S Medication Solutions), ROPINIROLE HYDROCHLORIDE (A-S Medication Solutions), ROPINIROLE HYDROCHLORIDE (Alembic Pharmaceuticals Limited), ROPINIROLE HYDROCHLORIDE (Alembic Pharmaceuticals), ROPINIROLE HYDROCHLORIDE (American Health Packaging), ROPINIROLE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), ROPINIROLE HYDROCHLORIDE (AvKARE), ROPINIROLE HYDROCHLORIDE (AvPAK), ROPINIROLE HYDROCHLORIDE (Bryant Ranch Prepack), ROPINIROLE HYDROCHLORIDE (Bryant Ranch Prepack), ROPINIROLE HYDROCHLORIDE (Bryant Ranch Prepack), ROPINIROLE HYDROCHLORIDE (Cardinal Health 107), ROPINIROLE HYDROCHLORIDE (Major Pharmaceuticals), ROPINIROLE HYDROCHLORIDE (NCS HealthCare of KY), ROPINIROLE HYDROCHLORIDE (Northwind Pharmaceuticals), ROPINIROLE HYDROCHLORIDE (Proficient Rx LP), ROPINIROLE HYDROCHLORIDE (SOLCO HEALTHCARE US), ROPINIROLE HYDROCHLORIDE (SOLCO HEALTHCARE US), ROPINIROLE HYDROCHLORIDE (Zydus Lifesciences Limited) |
|---|
| Formula |
C16H24N2O. HCl
|
|---|
| Exact mass |
296.1655
|
|---|
| Mol weight |
296.83
|
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| Structure |
|
|---|
| Simcomp |
|
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| Class |
Neuropsychiatric agent
DG01472 Dopamine agonist
DG01468 Dopamine D2-receptor agonist
DG01967 Antiparkinson agent
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
|
|---|
| Remark |
| Therapeutic category: | 1169 |
| Product (DG00862): | D00784<JP/US> |
|
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| Efficacy |
Antiparkinsonian, Dopamine receptor agonist |
|---|
| Disease |
Parkinson disease [DS: H00057] Restless legs syndrome [DS: H01597] |
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Metabolism |
Enzyme: CYP1A2 [HSA: 1544]
|
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| Interaction |
|
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| Structure map |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N04 ANTI-PARKINSON DRUGS
N04B DOPAMINERGIC AGENTS
N04BC Dopamine agonists
N04BC04 Ropinirole
D00784 Ropinirole hydrochloride (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
Antiparkinson Agents
Dopamine Agonists
Ropinirole
D00784 Ropinirole hydrochloride (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
116 Antiparkinsonian agents
1169 Others
D00784 Ropinirole hydrochloride (JAN/USP)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01472 Dopamine agonist
DG01468 Dopamine D2-receptor agonist
DG00862 Ropinirole
D00784 Ropinirole hydrochloride
DG01967 Antiparkinson agent
DG00862 Ropinirole
D00784 Ropinirole hydrochloride
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG00862 Ropinirole
D00784 Ropinirole hydrochloride
Drug classes [BR:br08332]
Neuropsychiatric agent
DG01967 Antiparkinson agent
D00784 Ropinirole hydrochloride
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Dopamine
DRD2
D00784 Ropinirole hydrochloride (JAN/USP) <JP/US>
DRD3
D00784 Ropinirole hydrochloride (JAN/USP) <JP/US>
DRD4
D00784 Ropinirole hydrochloride (JAN/USP) <JP/US>
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D00784
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00784
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01472 Dopamine agonist
DG01468 Dopamine D2-receptor agonist
DG00862 Ropinirole
DG01967 Antiparkinson agent
DG00862 Ropinirole
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG00862 Ropinirole
|
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 20
1 C8y C 26.1291 -19.3087
2 C8y C 24.9204 -18.6139
3 C8y C 26.1291 -20.7101
4 C1x C 27.4604 -18.8825
5 C1b C 24.9204 -17.2007
6 C8x C 23.6999 -19.3087
7 N1x N 27.4604 -21.1423
8 C8x C 24.9204 -21.4225
9 C5x C 28.2721 -20.0152
10 C1b C 23.7059 -16.5058
11 C8x C 23.6999 -20.7159
12 O5x O 29.6735 -20.0152
13 N1c N 22.4912 -17.2007
14 C1b C 21.2767 -16.5058
15 C1b C 22.4912 -18.5963
16 C1b C 20.0620 -17.2007
17 C1b C 21.2767 -19.2970
18 C1a C 18.8533 -16.5058
19 C1a C 21.2767 -20.6925
20 X Cl 32.6749 -19.9798
BOND 20
1 1 2 1
2 1 3 2
3 1 4 1
4 2 5 1
5 2 6 2
6 3 7 1
7 3 8 1
8 4 9 1
9 5 10 1
10 6 11 1
11 9 12 2
12 10 13 1
13 13 14 1
14 13 15 1
15 14 16 1
16 15 17 1
17 16 18 1
18 17 19 1
19 7 9 1
20 8 11 2
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