KEGG   DRUG: Fluvoxamine maleate
Entry
D00824                      Drug                                   

Name
Fluvoxamine maleate (JP18/USP);
Luvox (TN)
Product
  Generic
Formula
C15H21F3N2O2. C4H4O4
Exact mass
434.1665
Mol weight
434.4068
Structure
Class
Neuropsychiatric agent
 DG01659  Selective serotonin reuptake inhibitor (SSRI)
Metabolizing enzyme substrate
 DG01644  CYP2D6 substrate
Metabolizing enzyme inhibitor
 DG01634  CYP1A2 inhibitor
 DG01643  CYP2C9 inhibitor
 DG01933  CYP2C19 inhibitor
 DG01645  CYP2D6 inhibitor
 DG01522  CYP3A4 inhibitor
Remark
Therapeutic category: 1179
ATC code: N06AB08
Chemical structure group: DG00946
Product (DG00946): D00824<JP/US>
Efficacy
Antidepressant, Selective serotonin reuptake inhibitor (SSRI)
  Disease
Obsessive compulsive disorder [DS:H01450]
Target
SLC6A4 (HTT) [HSA:6532] [KO:K05037]
  Pathway
hsa04726  Serotonergic synapse
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
CYP inhibition: CYP1A2 [HSA:1544], CYP2C19 [HSA:1557]; CYP2C9 [HSA:1559], CYP2D6 [HSA:1565], CYP3A4 [HSA:1576]
Structure map
map07027  Antidepressants
map07234  Neurotransmitter transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AB Selective serotonin reuptake inhibitors
     N06AB08 Fluvoxamine
      D00824  Fluvoxamine maleate (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
 Antidepressants
  SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors)
   Fluvoxamine
    D00824  Fluvoxamine maleate (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D00824  Fluvoxamine maleate (JP18/USP)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A4 (HTT)
     D00824  Fluvoxamine maleate (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00824  Fluvoxamine maleate
  D00824  Fluvoxamine maleate tablets
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00824
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and mutations affecting drug response
  D00824
Other DBs
CAS: 61718-82-9
PubChem: 7847889
ChEBI: 5139
ChEMBL: CHEMBL1409
DrugBank: DB00176
LigandBox: D00824
NIKKAJI: J529.785K
LinkDB
KCF data

ATOM        30
            1   C2b C    39.7600  -15.4000
            2   C2b C    41.4400  -15.4000
            3   C6a C    39.0600  -16.5900
            4   C6a C    42.1400  -16.5900
            5   O6a O    37.6600  -16.5900
            6   O6a O    39.7600  -17.7800
            7   O6a O    41.4400  -17.7800
            8   O6a O    43.5400  -16.5900
            9   C8y C    23.5900  -14.4900
            10  C8x C    23.5900  -15.8900
            11  C8x C    24.7800  -16.5900
            12  C8y C    26.0400  -15.8900
            13  C8x C    26.0400  -14.4900
            14  C8x C    24.7800  -13.7900
            15  C1d C    22.4000  -13.7900
            16  X   F    21.1400  -13.0900
            17  X   F    23.0300  -12.5300
            18  X   F    21.7700  -15.0500
            19  C2c C    27.2300  -16.5900
            20  C1b C    28.4900  -15.8900
            21  N2b N    27.2300  -17.9900
            22  O2a O    28.4900  -18.6900
            23  C1b C    29.6800  -17.9900
            24  C1b C    30.8700  -18.6900
            25  N1a N    32.0600  -17.9900
            26  C1b C    29.6100  -16.5900
            27  C1b C    30.8700  -15.8900
            28  C1b C    32.0600  -16.5900
            29  O2a O    33.2500  -15.8900
            30  C1a C    34.4400  -16.5900
BOND        29
            1     1   2 2
            2     1   3 1
            3     2   4 1
            4     3   5 1
            5     3   6 2
            6     4   7 1
            7     4   8 2
            8     9  10 2
            9    10  11 1
            10   11  12 2
            11   12  13 1
            12   13  14 2
            13    9  14 1
            14    9  15 1
            15   15  16 1
            16   15  17 1
            17   15  18 1
            18   12  19 1
            19   19  20 1
            20   19  21 2
            21   21  22 1
            22   22  23 1
            23   23  24 1
            24   24  25 1
            25   20  26 1
            26   26  27 1
            27   27  28 1
            28   28  29 1
            29   29  30 1

» Japanese version   » Back

KEGG   DRUG: Fluvoxamine
Entry
D07984                      Drug                                   

Name
Fluvoxamine (INN)
Formula
C15H21F3N2O2
Exact mass
318.1555
Mol weight
318.3347
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01659  Selective serotonin reuptake inhibitor (SSRI)
Metabolizing enzyme substrate
 DG01644  CYP2D6 substrate
Metabolizing enzyme inhibitor
 DG01634  CYP1A2 inhibitor
 DG01643  CYP2C9 inhibitor
 DG01933  CYP2C19 inhibitor
 DG01645  CYP2D6 inhibitor
 DG01522  CYP3A4 inhibitor
Remark
Same as: C07571
ATC code: N06AB08
Chemical structure group: DG00946
Product (DG00946): D00824<JP/US>
Efficacy
Antidepressant, Selective serotonin reuptake inhibitor (SSRI)
Target
SLC6A4 (HTT) [HSA:6532] [KO:K05037]
  Pathway
hsa04726  Serotonergic synapse
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
CYP inhibition: CYP1A2 [HSA:1544], CYP2C19 [HSA:1557]; CYP2C9 [HSA:1559], CYP2D6 [HSA:1565], CYP3A4 [HSA:1576]
Structure map
map07027  Antidepressants
map07234  Neurotransmitter transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AB Selective serotonin reuptake inhibitors
     N06AB08 Fluvoxamine
      D07984  Fluvoxamine (INN)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A4 (HTT)
     D07984  Fluvoxamine (INN)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D07984
Other DBs
CAS: 54739-18-3
PubChem: 96024678
ChEBI: 5138
ChEMBL: CHEMBL814
DrugBank: DB00176
PDB-CCD: FVX[PDBj]
LigandBox: D07984
NIKKAJI: J11.936I
LinkDB
KCF data

ATOM        22
            1   C8y C    19.9500  -16.8000
            2   C8x C    19.9500  -18.2000
            3   C8x C    21.1400  -18.9000
            4   C8y C    22.4000  -18.2000
            5   C8x C    22.4000  -16.8000
            6   C8x C    21.1400  -16.1000
            7   C1d C    18.7600  -16.1000
            8   X   F    17.5000  -15.4000
            9   X   F    19.3900  -14.8400
            10  X   F    18.1300  -17.3600
            11  C2c C    23.5900  -18.9000
            12  C1b C    24.8500  -18.2000
            13  N2b N    23.5900  -20.3000
            14  O2a O    24.8500  -21.0000
            15  C1b C    26.0400  -20.3000
            16  C1b C    27.2300  -21.0000
            17  N1a N    28.4200  -20.3000
            18  C1b C    25.9700  -18.9000
            19  C1b C    27.2300  -18.2000
            20  C1b C    28.4200  -18.9000
            21  O2a O    29.6100  -18.2000
            22  C1a C    30.8000  -18.9000
BOND        22
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     1   7 1
            8     7   8 1
            9     7   9 1
            10    7  10 1
            11    4  11 1
            12   11  12 1
            13   11  13 2
            14   13  14 1
            15   14  15 1
            16   15  16 1
            17   16  17 1
            18   12  18 1
            19   18  19 1
            20   19  20 1
            21   20  21 1
            22   21  22 1

» Japanese version   » Back

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