KEGG   DRUG: Tranylcypromine sulfate
Entry
D00826                      Drug                                   
Name
Tranylcypromine sulfate (USP);
Parnate (TN)
Product
PARNATE (Concordia Pharmaceuticals)
  Generic
TRANYLCYPROMINE (Marlex Pharmaceuticals), TRANYLCYPROMINE (Novitium Pharma LLC), TRANYLCYPROMINE SULFATE (Actavis Pharma), TRANYLCYPROMINE SULFATE (Par Pharmaceutical), TRANYLCYPROMINE SULFATE (Strides Pharma Science Limited)
Formula
(C9H11N)2. H2SO4
Exact mass
364.1457
Mol weight
364.46
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01568  MAO inhibitor
  DG01519  Non-selective monoamine oxidase inhibitor
Remark
ATC code: N06AF04
Chemical structure group: DG00949
Product (DG00949): D00826<US>
Efficacy
Antidepressant, Monoamine oxidase (MAO) inhibitor
  Disease
Major depressive disorder [DS:H01646]
Target
MAO [HSA:4128 4129] [KO:K00274]
  Pathway
hsa00260  Glycine, serine and threonine metabolism
hsa00330  Arginine and proline metabolism
hsa00340  Histidine metabolism
hsa00350  Tyrosine metabolism
hsa00360  Phenylalanine metabolism
hsa00380  Tryptophan metabolism
hsa00982  Drug metabolism - cytochrome P450
hsa04726  Serotonergic synapse
hsa04728  Dopaminergic synapse
Interaction
Structure map
map07027  Antidepressants
map07216  Catecholamine transferase inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AF Monoamine oxidase inhibitors, non-selective
     N06AF04 Tranylcypromine
      D00826  Tranylcypromine sulfate (USP) <US>
USP drug classification [BR:br08302]
 Antidepressants
  Monoamine Oxidase Inhibitors
   Tranylcypromine
    D00826  Tranylcypromine sulfate (USP)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01568  MAO inhibitor
   DG01519  Non-selective monoamine oxidase inhibitor
    DG00949  Tranylcypromine
     D00826  Tranylcypromine sulfate
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Amine oxidases
    MAO
     D00826  Tranylcypromine sulfate (USP) <US>
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01568  MAO inhibitor
   DG01519  Non-selective monoamine oxidase inhibitor
    DG00949  Tranylcypromine
Other DBs
CAS: 13492-01-8
PubChem: 7847891
ChEBI: 9653
LigandBox: D00826
LinkDB
KCF data

ATOM        25
            1   C1y C    16.6589  -16.1557
            2   C8y C    15.4841  -16.8746
            3   C1y C    18.0323  -16.1557
            4   C1x C    17.3486  -14.9167
            5   C8x C    14.2976  -16.1557
            6   C8x C    15.4841  -18.3007
            7   N1a N    19.2247  -16.8746
            8   C8x C    13.0994  -16.8746
            9   C8x C    14.2976  -19.0197
            10  C8x C    13.0994  -18.3007
            11  S4a S    24.7388  -17.0375
            12  O1d O    24.7330  -15.6405
            13  O1d O    24.7330  -18.4343
            14  O1d O    23.3420  -17.0316
            15  O1d O    26.1356  -17.0375
            16  C1y C    16.6589  -16.1557
            17  C8y C    15.4841  -16.8746
            18  C8x C    14.2976  -16.1557
            19  C8x C    13.0994  -16.8746
            20  C8x C    13.0994  -18.3007
            21  C8x C    14.2976  -19.0197
            22  C8x C    15.4841  -18.3007
            23  C1y C    18.0323  -16.1557
            24  N1a N    19.2247  -16.8746
            25  C1x C    17.3486  -14.9167
BOND        26
            1    11  12 2
            2    11  13 2
            3    11  14 1
            4    11  15 1
            5     1   2 1
            6     1   3 1
            7     1   4 1
            8     2   5 2
            9     2   6 1
            10    3   7 1 #Up
            11    5   8 1
            12    6   9 2
            13    8  10 2
            14    3   4 1
            15    9  10 1
            16   16  17 1
            17   16  23 1
            18   16  25 1
            19   17  18 2
            20   17  22 1
            21   23  24 1 #Up
            22   18  19 1
            23   22  21 2
            24   19  20 2
            25   23  25 1
            26   21  20 1
BRACKET     1    12.6700  -19.6000   12.6700  -14.3500
            1    21.0000  -14.3500   21.0000  -19.6000
            1  2
 ORIGINAL  1    1   2   5   8  10   9   6   3   7   4
 REPEAT    1   16  17  18  19  20  21  22  23  24  25

» Japanese version   » Back

KEGG   DRUG: Tranylcypromine
Entry
D08625                      Drug                                   
Name
Tranylcypromine (INN);
Parnate (TN)
Formula
C9H11N
Exact mass
133.0891
Mol weight
133.19
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01568  MAO inhibitor
  DG01519  Non-selective monoamine oxidase inhibitor
Remark
Same as: C07155
ATC code: N06AF04
Chemical structure group: DG00949
Product (DG00949): D00826<US>
Efficacy
Antidepressant, Monoamine oxidase (MAO) inhibitor
Target
MAO [HSA:4128 4129] [KO:K00274]
  Pathway
hsa00260  Glycine, serine and threonine metabolism
hsa00330  Arginine and proline metabolism
hsa00340  Histidine metabolism
hsa00350  Tyrosine metabolism
hsa00360  Phenylalanine metabolism
hsa00380  Tryptophan metabolism
hsa00982  Drug metabolism - cytochrome P450
hsa04726  Serotonergic synapse
hsa04728  Dopaminergic synapse
Interaction
Structure map
map07027  Antidepressants
map07216  Catecholamine transferase inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AF Monoamine oxidase inhibitors, non-selective
     N06AF04 Tranylcypromine
      D08625  Tranylcypromine (INN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01568  MAO inhibitor
   DG01519  Non-selective monoamine oxidase inhibitor
    DG00949  Tranylcypromine
     D08625  Tranylcypromine
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Amine oxidases
    MAO
     D08625  Tranylcypromine (INN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01568  MAO inhibitor
   DG01519  Non-selective monoamine oxidase inhibitor
    DG00949  Tranylcypromine
Other DBs
CAS: 155-09-9
PubChem: 96025309
ChEBI: 182949 9652
LigandBox: D08625
NIKKAJI: J252.803G
LinkDB
KCF data

ATOM        10
            1   C1y C    24.7100  -17.1500
            2   C8y C    23.5200  -17.8500
            3   C1y C    26.1100  -17.1500
            4   C1x C    25.4100  -15.8900
            5   C8x C    22.2600  -17.1500
            6   C8x C    23.5200  -19.2500
            7   N1a N    27.3000  -17.8500
            8   C8x C    21.0700  -17.8500
            9   C8x C    22.2600  -19.9500
            10  C8x C    21.0700  -19.2500
BOND        11
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 2
            5     2   6 1
            6     3   7 1 #Up
            7     5   8 1
            8     6   9 2
            9     8  10 2
            10    3   4 1
            11    9  10 1

» Japanese version   » Back

DBGET integrated database retrieval system