KEGG   DRUG: Mianserin hydrochloride
Entry
D01358                      Drug                                   
Name
Mianserin hydrochloride (JAN/USAN);
Tetramide (TN)
Formula
C18H20N2. HCl
Exact mass
300.1393
Mol weight
300.8257
Structure
Simcomp
Class
Cardiovascular agent
 DG01466  Adrenergic receptor antagonist
  DG01465  alpha-Adrenergic receptor antagonist
   DG01460  alpha2-Adrenergic receptor antagonist
Neuropsychiatric agent
 DG01729  Tetracyclic antidepressant
Metabolizing enzyme substrate
 DG01892  CYP1A2 substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Therapeutic category: 1179
ATC code: N06AX03
Chemical structure group: DG00951
Product (DG00951): D01358<JP>
Efficacy
Antidepressant
Comment
Tetracyclic antidepressants
Antihistaminic
Target
ADRA2 [HSA:150 151 152] [KO:K04138 K04139 K04140]
HTR2A [HSA:3356] [KO:K04157]
HTR2C [HSA:3358] [KO:K04157]
HTR3 [HSA:3359 9177 170572 200909 285242] [KO:K04819]
HRH1 [HSA:3269] [KO:K04149]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP1A2 [HSA:1544], CYP2D6 [HSA:1565]
Interaction
Structure map
map07027  Antidepressants
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AX Other antidepressants
     N06AX03 Mianserin
      D01358  Mianserin hydrochloride (JAN/USAN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D01358  Mianserin hydrochloride (JAN/USAN)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01466  Adrenergic receptor antagonist
   DG01465  alpha-Adrenergic receptor antagonist
    DG01460  alpha2-Adrenergic receptor antagonist
     DG00951  Mianserin
      D01358  Mianserin hydrochloride
 Neuropsychiatric agent
  DG01729  Tetracyclic antidepressant
   DG00951  Mianserin
    D01358  Mianserin hydrochloride
 Metabolizing enzyme substrate
  DG01892  CYP1A2 substrate
   DG00951  Mianserin
    D01358  Mianserin hydrochloride
  DG01644  CYP2D6 substrate
   DG00951  Mianserin
    D01358  Mianserin hydrochloride
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00951  Mianserin
     D01358  Mianserin hydrochloride
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA2
     D01358  Mianserin hydrochloride (JAN/USAN) <JP>
   Histamine
    HRH1
     D01358  Mianserin hydrochloride (JAN/USAN) <JP>
   Serotonin
    HTR2A
     D01358  Mianserin hydrochloride (JAN/USAN) <JP>
    HTR2C
     D01358  Mianserin hydrochloride (JAN/USAN) <JP>
 Ion channels
  Ligand-gated ion channels
   Serotonin
    HTR3
     D01358  Mianserin hydrochloride (JAN/USAN) <JP>
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D01358
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01466  Adrenergic receptor antagonist
   DG01465  alpha-Adrenergic receptor antagonist
    DG01460  alpha2-Adrenergic receptor antagonist
     DG00951  Mianserin
 Neuropsychiatric agent
  DG01729  Tetracyclic antidepressant
   DG00951  Mianserin
 Metabolizing enzyme substrate
  DG01892  CYP1A2 substrate
   DG00951  Mianserin
  DG01644  CYP2D6 substrate
   DG00951  Mianserin
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00951  Mianserin
Other DBs
CAS: 21535-47-7
PubChem: 7848421
ChEBI: 31843
LigandBox: D01358
NIKKAJI: J342.139B
LinkDB
KCF data

ATOM        21
            1   X   Cl   21.7700  -20.6500
            2   C8y C    19.4600  -15.8900
            3   N1y N    18.5500  -16.9400
            4   C1y C    17.1500  -16.9400
            5   C8y C    16.3100  -15.8200
            6   C8y C    19.1800  -14.4900
            7   C8y C    16.6600  -14.4900
            8   C1x C    17.9200  -13.8600
            9   C8x C    15.6800  -13.5100
            10  C8x C    14.2800  -13.9300
            11  C8x C    14.0000  -15.2600
            12  C8x C    14.9800  -16.2400
            13  C8x C    20.7900  -16.3100
            14  C8x C    21.8400  -15.4000
            15  C8x C    21.5600  -14.0000
            16  C8x C    20.2300  -13.5800
            17  C1x C    16.4500  -18.1300
            18  N1y N    17.1500  -19.3900
            19  C1x C    18.5500  -19.3900
            20  C1x C    19.2500  -18.2000
            21  C1a C    16.4500  -20.5800
BOND        23
            1     4   5 1
            2     2   6 1
            3     5   7 1
            4     3   4 1
            5     6   8 1
            6     2   3 1
            7     7   8 1
            8     7   9 2
            9     9  10 1
            10   10  11 2
            11   11  12 1
            12    5  12 2
            13    2  13 2
            14   13  14 1
            15   14  15 2
            16   15  16 1
            17    6  16 2
            18    4  17 1
            19   17  18 1
            20   18  19 1
            21   19  20 1
            22    3  20 1
            23   18  21 1

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KEGG   DRUG: Mianserin
Entry
D08216                      Drug                                   
Name
Mianserin (INN);
Tolvon (TN)
Formula
C18H20N2
Exact mass
264.1626
Mol weight
264.3648
Structure
Simcomp
Class
Cardiovascular agent
 DG01466  Adrenergic receptor antagonist
  DG01465  alpha-Adrenergic receptor antagonist
   DG01460  alpha2-Adrenergic receptor antagonist
Neuropsychiatric agent
 DG01729  Tetracyclic antidepressant
 DG03077  Noradrenergic and specific serotonergic antidepressant (NaSSA)
Metabolizing enzyme substrate
 DG01892  CYP1A2 substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
ATC code: N06AX03
Chemical structure group: DG00951
Product (DG00951): D01358<JP>
Efficacy
Antidepressant
Comment
tetracyclic antidepressants
Target
ADRA2 [HSA:150 151 152] [KO:K04138 K04139 K04140]
HTR2A [HSA:3356] [KO:K04157]
HTR2C [HSA:3358] [KO:K04157]
HTR3 [HSA:3359 9177 170572 200909 285242] [KO:K04819]
HRH1 [HSA:3269] [KO:K04149]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP1A2 [HSA:1544], CYP2D6 [HSA:1565]
Interaction
Structure map
map07027  Antidepressants
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AX Other antidepressants
     N06AX03 Mianserin
      D08216  Mianserin (INN)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01466  Adrenergic receptor antagonist
   DG01465  alpha-Adrenergic receptor antagonist
    DG01460  alpha2-Adrenergic receptor antagonist
     DG00951  Mianserin
      D08216  Mianserin
 Neuropsychiatric agent
  DG01729  Tetracyclic antidepressant
   DG00951  Mianserin
    D08216  Mianserin
  DG03077  Noradrenergic and specific serotonergic antidepressant (NaSSA)
   D08216  Mianserin
 Metabolizing enzyme substrate
  DG01892  CYP1A2 substrate
   DG00951  Mianserin
    D08216  Mianserin
  DG01644  CYP2D6 substrate
   DG00951  Mianserin
    D08216  Mianserin
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00951  Mianserin
     D08216  Mianserin
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA2
     D08216  Mianserin (INN)
   Histamine
    HRH1
     D08216  Mianserin (INN)
   Serotonin
    HTR2A
     D08216  Mianserin (INN)
    HTR2C
     D08216  Mianserin (INN)
 Ion channels
  Ligand-gated ion channels
   Serotonin
    HTR3
     D08216  Mianserin (INN)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D08216
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01466  Adrenergic receptor antagonist
   DG01465  alpha-Adrenergic receptor antagonist
    DG01460  alpha2-Adrenergic receptor antagonist
     DG00951  Mianserin
 Neuropsychiatric agent
  DG01729  Tetracyclic antidepressant
   DG00951  Mianserin
 Metabolizing enzyme substrate
  DG01892  CYP1A2 substrate
   DG00951  Mianserin
  DG01644  CYP2D6 substrate
   DG00951  Mianserin
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00951  Mianserin
Other DBs
CAS: 24219-97-4
PubChem: 96024904
LigandBox: D08216
NIKKAJI: J16.389I
LinkDB
KCF data

ATOM        20
            1   C8y C    20.1600  -15.0500
            2   N1y N    19.2500  -16.1000
            3   C1y C    17.8500  -16.1000
            4   C8y C    17.0100  -14.9800
            5   C8y C    19.8800  -13.6500
            6   C8y C    17.3600  -13.6500
            7   C1x C    18.6200  -13.0200
            8   C8x C    16.3800  -12.6700
            9   C8x C    14.9800  -13.0900
            10  C8x C    14.7000  -14.4200
            11  C8x C    15.6800  -15.4000
            12  C8x C    21.4900  -15.4700
            13  C8x C    22.5400  -14.5600
            14  C8x C    22.2600  -13.1600
            15  C8x C    20.9300  -12.7400
            16  C1x C    17.1500  -17.2900
            17  N1y N    17.8500  -18.5500
            18  C1x C    19.2500  -18.5500
            19  C1x C    19.9500  -17.3600
            20  C1a C    17.1500  -19.7400
BOND        23
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     6   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    4  11 2
            13    1  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17    5  15 2
            18    3  16 1
            19   16  17 1
            20   17  18 1
            21   18  19 1
            22    2  19 1
            23   17  20 1

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