KEGG   DRUG: PropericiazineHelp
Entry
D01485                      Drug                                   

Name
Propericiazine (JAN);
Periciazine;
Neuleptil (TN)
Formula
C21H23N3OS
Exact mass
365.1562
Mol weight
365.4918
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG01905  Phenothiazine antipsychotics
 DG01478  Dopamine antagonist
  DG01474  Dopamine D2-receptor antagonist
Remark
Therapeutic category: 1172
ATC code: N05AC01
Product: D01485<JP>
Efficacy
Antipsychotic, Dopamine D2 receptor antagonist
Comment
Phenothiazine derivative
Target
DRD2 [HSA:1813] [KO:K04145]
ADRA1 [HSA:148 147 146] [KO:K04135 K04136 K04137]
HTR2 [HSA:3356 3357 3358] [KO:K04157]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse
hsa04728  Dopaminergic synapse
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05A ANTIPSYCHOTICS
    N05AC Phenothiazines with piperidine structure
     N05AC01 Periciazine
      D01485  Propericiazine (JAN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1172  Phenothiazines
     D01485  Propericiazine (JAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA1
     D01485  Propericiazine (JAN) <JP>
   Dopamine
    DRD2
     D01485  Propericiazine (JAN) <JP>
   Serotonin
    HTR2
     D01485  Propericiazine (JAN) <JP>
Drug classes of therapeutic agents [br08360.html]
 Psychiatric agents
  D01485
BRITE hierarchy
Other DBs
CAS: 2622-26-6
PubChem: 7848548
ChEBI: 31981
ChEMBL: CHEMBL251940
LigandBox: D01485
NIKKAJI: J3.392H
LinkDB All DBs
KCF data Show

ATOM        26
            1   C8x C    18.4483  -18.6354
            2   C8x C    18.4483  -20.0377
            3   C8x C    19.6657  -20.7389
            4   C8x C    19.6657  -17.9342
            5   C8y C    20.8759  -18.6354
            6   C8y C    20.8700  -20.0377
            7   S2x S    22.0814  -20.7440
            8   C8y C    23.2922  -20.0443
            9   C8x C    24.4971  -20.7547
            10  C8x C    25.7147  -20.0663
            11  C8y C    25.6574  -18.6677
            12  N1y N    22.0935  -17.9395
            13  C8y C    23.2990  -18.6486
            14  C8x C    24.5158  -17.9592
            15  C1b C    22.1049  -16.5408
            16  C1b C    23.3219  -15.8515
            17  N1y N    24.5537  -13.7664
            18  C1b C    23.3358  -14.4533
            19  C1x C    25.7540  -14.4757
            20  C1x C    27.0417  -13.7888
            21  C1y C    26.9858  -12.3907
            22  C1x C    25.7818  -11.6794
            23  C1x C    24.5641  -12.3664
            24  O1a O    28.2071  -11.7016
            25  C3b C    26.8806  -17.9535
            26  N3a N    28.0700  -17.2200
BOND        29
            1     1   2 1
            2     2   3 2
            3     5   6 2
            4     6   7 1
            5    12  13 1
            6    13  14 1
            7    16  15 1
            8    15  12 1
            9     7   8 1
            10   12   5 1
            11    3   6 1
            12   17  18 1
            13   18  16 1
            14    5   4 1
            15    4   1 2
            16   13   8 2
            17    8   9 1
            18   17  19 1
            19   19  20 1
            20   20  21 1
            21   21  22 1
            22   22  23 1
            23   23  17 1
            24    9  10 2
            25   21  24 1
            26   10  11 1
            27   11  14 2
            28   11  25 1
            29   25  26 3

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