| Entry |
|
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| Name |
Mosapramine hydrochloride (JAN);
Cremin (TN) |
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| Formula |
C28H35ClN4O. 2HCl
|
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| Exact mass |
550.2033
|
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| Mol weight |
551.9786
|
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| Structure |
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| Simcomp |
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| Class |
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG03200 Antipsychotic agent
DG01942 Iminobenzyl antipsychotic
|
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| Remark |
| Therapeutic category: | 1179 |
| Product (DG00905): | D01548<JP> |
|
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| Efficacy |
Antipsychotic |
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| Comment |
Iminodibenzyl derivative
|
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| Target |
|
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
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| Interaction |
|
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| Structure map |
| map07213 | Dopamine receptor agonists/antagonists |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N05 PSYCHOLEPTICS
N05A ANTIPSYCHOTICS
N05AX Other antipsychotics
N05AX10 Mosapramine
D01548 Mosapramine hydrochloride (JAN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
117 Psychotropics
1179 Others
D01548 Mosapramine hydrochloride (JAN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG00905 Mosapramine
D01548 Mosapramine hydrochloride
DG03200 Antipsychotic agent
DG01942 Iminobenzyl antipsychotic
DG00905 Mosapramine
D01548 Mosapramine hydrochloride
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Dopamine
DRD2
D01548 Mosapramine hydrochloride (JAN) <JP>
Serotonin
HTR2A
D01548 Mosapramine hydrochloride (JAN) <JP>
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG00905 Mosapramine
DG03200 Antipsychotic agent
DG01942 Iminobenzyl antipsychotic
DG00905 Mosapramine
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 36
1 C1x C 29.0129 -21.5541
2 C8y C 28.1757 -20.4379
3 C8y C 28.5246 -19.1125
4 N1y N 29.7802 -18.5544
5 C1x C 30.4080 -21.5541
6 C8y C 31.0359 -19.1823
7 C8y C 31.3149 -20.5077
8 C8x C 27.4782 -18.1359
9 C8x C 26.1528 -18.5544
10 C8y C 25.8040 -19.8798
11 C8x C 26.8504 -20.8565
12 C8x C 32.6404 -20.9262
13 C8x C 33.6866 -20.0193
14 C8x C 33.4076 -18.6241
15 C8x C 32.0823 -18.2056
16 X Cl 24.4786 -20.2984
17 C1b C 29.7419 -17.1597
18 C1b C 30.9412 -16.5028
19 C1b C 32.1643 -17.2457
20 N1y N 33.3850 -16.5768
21 C1x C 34.6047 -17.3173
22 C1x C 35.8281 -16.6466
23 C1z C 35.8589 -15.2518
24 C1x C 34.6391 -14.5112
25 C1x C 33.4158 -15.1818
26 N1y N 36.9217 -16.1774
27 C1y C 38.1302 -15.4533
28 N1x N 37.8152 -14.0801
29 C5x C 36.4119 -13.9555
30 C1x C 36.8745 -17.5860
31 C1x C 38.1057 -18.2705
32 C1x C 39.3143 -17.5466
33 C1x C 39.3615 -16.1379
34 O5x O 35.6977 -12.7628
35 X Cl 38.3606 -20.5174
36 X Cl 38.3606 -20.5174
BOND 39
1 3 4 1
2 1 5 1
3 4 6 1
4 2 3 1
5 5 7 1
6 1 2 1
7 6 7 1
8 3 8 2
9 8 9 1
10 9 10 2
11 10 11 1
12 2 11 2
13 7 12 2
14 12 13 1
15 13 14 2
16 14 15 1
17 6 15 2
18 10 16 1
19 4 17 1
20 17 18 1
21 18 19 1
22 19 20 1
23 20 21 1
24 21 22 1
25 22 23 1
26 23 24 1
27 24 25 1
28 20 25 1
29 23 26 1
30 26 27 1
31 27 28 1
32 28 29 1
33 23 29 1
34 26 30 1
35 30 31 1
36 31 32 1
37 32 33 1
38 27 33 1
39 29 34 2
BRACKET 1 36.6800 -21.1400 36.6800 -19.8100
1 39.0600 -19.8100 39.0600 -21.1400
1 2
ORIGINAL 1 35
REPEAT 1 36
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