KEGG   DRUG: UfenamateHelp
Entry
D01823                      Drug                                   

Name
Ufenamate (JAN/INN);
Flufenamic acid butyl ester;
Combec (TN)
Formula
C18H18F3NO2
Exact mass
337.129
Mol weight
337.3362
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01911  Antiinflammatory drug, fenamic acid derivatives
 DG01504  Nonsteroidal antiinflammatory drug (NSAID)
  DG01911  Antiinflammatory drug, fenamic acid derivatives
Remark
Therapeutic category: 2649
ATC code: M01AG03
Chemical structure group: DG00757
Product (DG00757): D01823<JP> D03254<JP>
Efficacy
Analgesic, Anti-inflammatory (topical), COX inhibitor
Comment
Fenamic acid derivative
Target
PTGS1 (COX1) [HSA:5742] [KO:K00509]
PTGS2 (COX2) [HSA:5743] [KO:K11987]
  Pathway
hsa00590  Arachidonic acid metabolism
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 M MUSCULO-SKELETAL SYSTEM
  M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
   M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
    M01AG Fenamates
     M01AG03 Flufenamic acid
      D01823  Ufenamate (JAN/INN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  26  Epidermides
   264  Analgesics, anti-itchings, astringents, anti-inflammatory agents
    2649  Others
     D01823  Ufenamate (JAN/INN)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for integumentary system
  57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
   D01823  Ufenamate (JAN/INN)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Ufenamate
    D01823  Ufenamate (JAN/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Prostaglandin synthase
    PTGS1 (COX1)
     D01823  Ufenamate (JAN/INN) <JP>
    PTGS2 (COX2)
     D01823  Ufenamate (JAN/INN) <JP>
Rx-to-OTC switch list in Japan [br08314.html]
 D01823
BRITE hierarchy
Other DBs
CAS: 67330-25-0
PubChem: 7848885
ChEBI: 32276
ChEMBL: CHEMBL2105605
LigandBox: D01823
NIKKAJI: J22.205D
LinkDB All DBs
KCF data Show

ATOM        24
            1   C8x C    11.6200  -22.0500
            2   C8x C    11.6200  -23.4500
            3   C8x C    12.8800  -24.2200
            4   C8x C    14.0700  -23.4500
            5   C8y C    14.0700  -22.0500
            6   C8y C    12.8800  -21.3500
            7   C8x C    16.5200  -23.4500
            8   C8y C    16.5200  -22.0500
            9   N1b N    15.2600  -21.3500
            10  C8x C    17.7100  -24.2200
            11  C8x C    18.9000  -23.4500
            12  C8y C    18.9000  -22.0500
            13  C8x C    17.7100  -21.3500
            14  C7a C    12.8800  -19.9500
            15  O6a O    11.6200  -19.2500
            16  O7a O    14.0700  -19.2500
            17  C1b C    14.0700  -17.8500
            18  C1b C    15.2824  -17.1500
            19  C1b C    16.4779  -17.8404
            20  C1a C    17.6653  -17.1549
            21  C1d C    20.1153  -21.3549
            22  X   F    19.4153  -20.1425
            23  X   F    20.8153  -22.5674
            24  X   F    21.3277  -20.6549
BOND        25
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     7   8 2
            8     8   9 1
            9     5   9 1
            10    7  10 1
            11   10  11 2
            12   11  12 1
            13   12  13 2
            14    8  13 1
            15    6  14 1
            16   14  15 2
            17   14  16 1
            18   16  17 1
            19   17  18 1
            20   18  19 1
            21   19  20 1
            22   12  21 1
            23   21  22 1
            24   21  23 1
            25   21  24 1

» Japanese version   » Back

DBGET integrated database retrieval system