| Entry |
|
|---|
| Name |
Brimonidine tartrate (JAN/USAN);
Alphagan (TN) |
|---|
| Product |
|
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| Generic |
BRIMONIDINE (Bryant Ranch Prepack), BRIMONIDINE (Padagis Israel Pharmaceuticals), BRIMONIDINE (Sandoz), BRIMONIDINE TARTRATE (Alembic Pharmaceuticals Limited), BRIMONIDINE TARTRATE (Alembic Pharmaceuticals), BRIMONIDINE TARTRATE (Apotex Corp.), BRIMONIDINE TARTRATE (Apotex Corp.), BRIMONIDINE TARTRATE (Bausch & Lomb Incorporated), BRIMONIDINE TARTRATE (Florida Pharmaceutical Products), BRIMONIDINE TARTRATE (Indoco Remedies Limited), BRIMONIDINE TARTRATE (Micro Labs Limited), BRIMONIDINE TARTRATE (Pacific Pharma), BRIMONIDINE TARTRATE (Sandoz), BRIMONIDINE TARTRATE (Somerset Therapeutics), BRIMONIDINE TARTRATE (Somerset Therapeutics), BRIMONIDINE TARTRATE OPHTHALMIC SOLUTION, 0.15% (Alembic Pharmaceuticals Limited), BRIMONIDINE TARTRATE OPHTHALMIC SOLUTION, 0.15% (Alembic Pharmaceuticals) |
|---|
| Formula |
C11H10BrN5. C4H6O6
|
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| Exact mass |
441.0284
|
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| Mol weight |
442.22
|
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| Structure |
|
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| Class |
Cardiovascular agent
DG01456 Adrenergic receptor agonist
DG01450 alpha-Adrenergic receptor agonist
DG01449 alpha2-Adrenergic receptor agonist
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
|
|---|
| Remark |
| Therapeutic category: | 1319 |
| Product (DG00442): | D02076<JP/US> |
| Product (mixture): | D10298<JP/US> D10854<JP/US> D12437<JP> |
|
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| Efficacy |
Antiglaucoma, alpha-Adrenergic receptor agonist |
|---|
| Disease |
Open-angle glaucoma [DS: H00612] |
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| Comment |
Clonidine derivative
|
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| Target |
|
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
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| Interaction |
|
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| Structure map |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
D DERMATOLOGICALS
D11 OTHER DERMATOLOGICAL PREPARATIONS
D11A OTHER DERMATOLOGICAL PREPARATIONS
D11AX Other dermatologicals
D11AX21 Brimonidine
D02076 Brimonidine tartrate (JAN/USAN) <JP/US>
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
S01EA Sympathomimetics in glaucoma therapy
S01EA05 Brimonidine
D02076 Brimonidine tartrate (JAN/USAN) <JP/US>
S01G DECONGESTANTS AND ANTIALLERGICS
S01GA Sympathomimetics used as decongestants
S01GA07 Brimonidine
D02076 Brimonidine tartrate (JAN/USAN) <JP/US>
USP drug classification [BR:br08302]
Dermatological Agents
Acne and Rosacea Agents
Acne and Rosacea Agents, Other
Brimonidine
D02076 Brimonidine tartrate (JAN/USAN)
Ophthalmic Agents
Intraocular Pressure Lowering Agents
Alpha-adrenergic Agonists, Ophthalmic
Brimonidine
D02076 Brimonidine tartrate (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
13 Agents affecting sensory organs
131 Ophthalmic agents
1319 Others
D02076 Brimonidine tartrate (JAN/USAN)
Risk category of Japanese OTC drugs [BR:br08312]
Drugs requiring guidance
New approved switch OTC drugs
Brimonidine tartrate
D02076 Brimonidine tartrate (JAN/USAN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01456 Adrenergic receptor agonist
DG01450 alpha-Adrenergic receptor agonist
DG01449 alpha2-Adrenergic receptor agonist
DG00442 Brimonidine
D02076 Brimonidine tartrate
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
DG00442 Brimonidine
D02076 Brimonidine tartrate
Drug classes [BR:br08332]
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
D02076 Brimonidine tartrate
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Adrenaline
ADRA2
D02076 Brimonidine tartrate (JAN/USAN) <JP/US>
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
D02076
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D02076
Rx-to-OTC switch list in the USA [br08315.html]
D02076
Drug groups [BR:br08330]
Cardiovascular agent
DG01456 Adrenergic receptor agonist
DG01450 alpha-Adrenergic receptor agonist
DG01449 alpha2-Adrenergic receptor agonist
DG00442 Brimonidine
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
DG00442 Brimonidine
|
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 27
1 O6a O 21.8870 -16.5436
2 C6a C 23.0994 -15.8436
3 C1c C 24.3119 -16.5436
4 C1c C 25.5244 -15.8436
5 C6a C 26.7368 -16.5436
6 O6a O 27.9492 -15.8436
7 O6a O 23.1003 -14.4436
8 O6a O 26.7404 -17.9435
9 O1a O 24.3119 -17.9435
10 O1a O 25.5244 -14.4436
11 C8x C 9.7300 -16.3100
12 C8x C 9.7300 -17.7100
13 N5x N 10.9424 -18.4100
14 C8y C 12.1549 -17.7100
15 C8y C 12.1549 -16.3100
16 N5x N 10.9424 -15.6100
17 C8x C 13.3673 -18.4100
18 C8x C 14.5797 -17.7100
19 C8y C 14.5797 -16.3100
20 C8y C 13.3673 -15.6100
21 N2x N 17.0046 -17.7100
22 C2y C 17.0046 -16.3100
23 N1b N 15.7922 -15.6100
24 C1x C 18.3361 -18.1426
25 C1x C 19.1590 -17.0100
26 N1x N 18.3361 -15.8774
27 X Br 13.3673 -14.2100
BOND 28
1 1 2 1
2 2 3 1
3 3 4 1
4 4 5 1
5 5 6 1
6 2 7 2
7 5 8 2
8 3 9 1 #Up
9 4 10 1 #Up
10 11 12 2
11 12 13 1
12 13 14 2
13 14 15 1
14 15 16 2
15 11 16 1
16 14 17 1
17 17 18 2
18 18 19 1
19 19 20 2
20 15 20 1
21 21 22 2
22 22 23 1
23 19 23 1
24 21 24 1
25 24 25 1
26 25 26 1
27 22 26 1
28 20 27 1
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