KEGG   DRUG: Brimonidine tartrate
Entry
D02076                      Drug                                   

Name
Brimonidine tartrate (JAN/USAN);
Alphagan (TN)
Product
  Generic
Formula
C11H10BrN5. C4H6O6
Exact mass
441.0284
Mol weight
442.2214
Structure
Class
Cardiovascular agent
 DG01456  Adrenergic receptor agonist
  DG01450  alpha-Adrenergic receptor agonist
   DG01449  alpha2-Adrenergic receptor agonist
Ophthalmic agent
 DG03201  Intraocular pressure lowering agent
Remark
Therapeutic category: 1319
ATC code: D11AX21 S01EA05 S01GA07
Chemical structure group: DG00442
Product (DG00442): D02076<JP/US>
Product (mixture): D10298<JP/US> D10854<JP/US>
Efficacy
Antiglaucoma, alpha-Adrenergic receptor agonist
  Disease
Open-angle glaucoma [DS:H00612]
Comment
Clonidine derivative
Target
ADRA2 [HSA:150 151 152] [KO:K04138 K04139 K04140]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Structure map
map07054  Antiglaucoma agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D11 OTHER DERMATOLOGICAL PREPARATIONS
   D11A OTHER DERMATOLOGICAL PREPARATIONS
    D11AX Other dermatologicals
     D11AX21 Brimonidine
      D02076  Brimonidine tartrate (JAN/USAN) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01EA Sympathomimetics in glaucoma therapy
     S01EA05 Brimonidine
      D02076  Brimonidine tartrate (JAN/USAN) <JP/US>
   S01G DECONGESTANTS AND ANTIALLERGICS
    S01GA Sympathomimetics used as decongestants
     S01GA07 Brimonidine
      D02076  Brimonidine tartrate (JAN/USAN) <JP/US>
USP drug classification [BR:br08302]
 Dermatological Agents
  Acne and Rosacea Agents
   Acne and Rosea, Other
    Brimonidine
     D02076  Brimonidine tartrate (JAN/USAN)
 Ophthalmic Agents
  Intraocular Pressure Lowering Agents
   Alpha-adrenergic Agonists, Ophthalmic
    Brimonidine
     D02076  Brimonidine tartrate (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1319  Others
     D02076  Brimonidine tartrate (JAN/USAN)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01456  Adrenergic receptor agonist
   DG01450  alpha-Adrenergic receptor agonist
    DG01449  alpha2-Adrenergic receptor agonist
     DG00442  Brimonidine
      D02076  Brimonidine tartrate
 Ophthalmic agent
  DG03201  Intraocular pressure lowering agent
   DG00442  Brimonidine
    D02076  Brimonidine tartrate
Drug classes [BR:br08332]
 Ophthalmic agent
  DG03201  Intraocular pressure lowering agent
   D02076  Brimonidine tartrate
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA2
     D02076  Brimonidine tartrate (JAN/USAN) <JP/US>
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D02076
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D02076
Rx-to-OTC switch list in the USA [br08315.html]
 D02076
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01456  Adrenergic receptor agonist
   DG01450  alpha-Adrenergic receptor agonist
    DG01449  alpha2-Adrenergic receptor agonist
     DG00442  Brimonidine
 Ophthalmic agent
  DG03201  Intraocular pressure lowering agent
   DG00442  Brimonidine
Other DBs
CAS: 79570-19-7
PubChem: 7849138
ChEBI: 51157
ChEMBL: CHEMBL1200389
DrugBank: DB00484
LigandBox: D02076
LinkDB
KCF data

ATOM        27
            1   O6a O    21.8870  -16.5436
            2   C6a C    23.0994  -15.8436
            3   C1c C    24.3119  -16.5436
            4   C1c C    25.5244  -15.8436
            5   C6a C    26.7368  -16.5436
            6   O6a O    27.9492  -15.8436
            7   O6a O    23.1003  -14.4436
            8   O6a O    26.7404  -17.9435
            9   O1a O    24.3119  -17.9435
            10  O1a O    25.5244  -14.4436
            11  C8x C     9.7300  -16.3100
            12  C8x C     9.7300  -17.7100
            13  N5x N    10.9424  -18.4100
            14  C8y C    12.1549  -17.7100
            15  C8y C    12.1549  -16.3100
            16  N5x N    10.9424  -15.6100
            17  C8x C    13.3673  -18.4100
            18  C8x C    14.5797  -17.7100
            19  C8y C    14.5797  -16.3100
            20  C8y C    13.3673  -15.6100
            21  N2x N    17.0046  -17.7100
            22  C2y C    17.0046  -16.3100
            23  N1b N    15.7922  -15.6100
            24  C1x C    18.3361  -18.1426
            25  C1x C    19.1590  -17.0100
            26  N1x N    18.3361  -15.8774
            27  X   Br   13.3673  -14.2100
BOND        28
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     2   7 2
            7     5   8 2
            8     3   9 1 #Up
            9     4  10 1 #Up
            10   11  12 2
            11   12  13 1
            12   13  14 2
            13   14  15 1
            14   15  16 2
            15   11  16 1
            16   14  17 1
            17   17  18 2
            18   18  19 1
            19   19  20 2
            20   15  20 1
            21   21  22 2
            22   22  23 1
            23   19  23 1
            24   21  24 1
            25   24  25 1
            26   25  26 1
            27   22  26 1
            28   20  27 1

» Japanese version   » Back

KEGG   DRUG: Brimonidine
Entry
D07540                      Drug                                   

Name
Brimonidine (INN)
Formula
C11H10BrN5
Exact mass
291.012
Mol weight
292.1346
Structure
Simcomp
Class
Cardiovascular agent
 DG01456  Adrenergic receptor agonist
  DG01450  alpha-Adrenergic receptor agonist
   DG01449  alpha2-Adrenergic receptor agonist
Ophthalmic agent
 DG03201  Intraocular pressure lowering agent
Remark
Same as: C07886
ATC code: D11AX21 S01EA05 S01GA07
Chemical structure group: DG00442
Product (DG00442): D02076<JP/US>
Efficacy
Antiglaucoma, alpha2-Adrenergic receptor agonist
Target
ADRA2 [HSA:150 151 152] [KO:K04138 K04139 K04140]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Structure map
map07054  Antiglaucoma agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D11 OTHER DERMATOLOGICAL PREPARATIONS
   D11A OTHER DERMATOLOGICAL PREPARATIONS
    D11AX Other dermatologicals
     D11AX21 Brimonidine
      D07540  Brimonidine (INN)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01EA Sympathomimetics in glaucoma therapy
     S01EA05 Brimonidine
      D07540  Brimonidine (INN)
   S01G DECONGESTANTS AND ANTIALLERGICS
    S01GA Sympathomimetics used as decongestants
     S01GA07 Brimonidine
      D07540  Brimonidine (INN)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01456  Adrenergic receptor agonist
   DG01450  alpha-Adrenergic receptor agonist
    DG01449  alpha2-Adrenergic receptor agonist
     DG00442  Brimonidine
      D07540  Brimonidine
 Ophthalmic agent
  DG03201  Intraocular pressure lowering agent
   DG00442  Brimonidine
    D07540  Brimonidine
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA2
     D07540  Brimonidine (INN)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01456  Adrenergic receptor agonist
   DG01450  alpha-Adrenergic receptor agonist
    DG01449  alpha2-Adrenergic receptor agonist
     DG00442  Brimonidine
 Ophthalmic agent
  DG03201  Intraocular pressure lowering agent
   DG00442  Brimonidine
Other DBs
CAS: 59803-98-4
PubChem: 51091862
ChEBI: 3175
ChEMBL: CHEMBL844
LigandBox: D07540
NIKKAJI: J23.694B
LinkDB
KCF data

ATOM        17
            1   C8x C    16.3100  -16.7300
            2   C8x C    16.3100  -18.1300
            3   N5x N    17.5000  -18.8300
            4   C8y C    18.7600  -18.1300
            5   C8y C    18.7600  -16.7300
            6   N5x N    17.5000  -16.0300
            7   C8x C    19.9500  -18.8300
            8   C8x C    21.1400  -18.1300
            9   C8y C    21.1400  -16.7300
            10  C8y C    19.9500  -16.0300
            11  N2x N    23.5900  -18.1300
            12  C2y C    23.5900  -16.7300
            13  N1b N    22.4000  -16.0300
            14  C1x C    24.9200  -18.5500
            15  C1x C    25.7600  -17.4300
            16  N1x N    24.9200  -16.3100
            17  X   Br   19.9500  -14.6300
BOND        19
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 2
            11    5  10 1
            12   11  12 2
            13   12  13 1
            14    9  13 1
            15   11  14 1
            16   14  15 1
            17   15  16 1
            18   12  16 1
            19   10  17 1

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