KEGG   DRUG: Cefoxitin
Entry
D02345                      Drug                                   
Name
Cefoxitin (USAN/INN)
Formula
C16H17N3O7S2
Exact mass
427.0508
Mol weight
427.46
Structure
Simcomp
Class
Antibacterial
 DG01710  beta-Lactam antibiotic
  DG01714  Cephalosporin skeleton group
   DG01488  Cephem
 DG01775  Second-generation cephalosporin
Remark
Same as: C06887
ATC code: J01DC01
Chemical structure group: DG00557
Product (DG00557): D00913<US>
Efficacy
Antibacterial, Cell wall biosynthesis inhibitor
Target
penicillin binding protein
  Pathway
ko00550  Peptidoglycan biosynthesis
Interaction
Structure map
map07012  Cephalosporins - parenteral agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01D OTHER BETA-LACTAM ANTIBACTERIALS
    J01DC Second-generation cephalosporins
     J01DC01 Cefoxitin
      D02345  Cefoxitin (USAN/INN)
Drug groups [BR:br08330]
 Antibacterial
  DG01710  beta-Lactam antibiotic
   DG01714  Cephalosporin skeleton group
    DG01488  Cephem
     DG00557  Cefoxitin
      D02345  Cefoxitin
  DG01775  Second-generation cephalosporin
   DG00557  Cefoxitin
    D02345  Cefoxitin
Antimicrobials [BR:br08307]
 Antibacterials
  Cell wall biosynthesis inhibitor, beta-lactam
   Second-generation cephalosporin
    D02345  Cefoxitin (USAN/INN)
Drug groups [BR:br08330]
 Antibacterial
  DG01710  beta-Lactam antibiotic
   DG01714  Cephalosporin skeleton group
    DG01488  Cephem
     DG00557  Cefoxitin
  DG01775  Second-generation cephalosporin
   DG00557  Cefoxitin
Antimicrobials abbreviations [BR:br08327]
 Antibacterials
  Cell wall biosynthesis inhibitor, beta-lactam
   Second-generation cephalosporin
    DG00557  Cefoxitin
Other DBs
CAS: 35607-66-0
PubChem: 7849404
ChEBI: 209807
PDB-CCD: CFX[PDBj]
LigandBox: D02345
NIKKAJI: J17.441F
LinkDB
KCF data

ATOM        28
            1   C1y C    29.4154  -15.3449
            2   N1y N    29.4154  -16.7127
            3   C2y C    30.6000  -17.3964
            4   C2y C    31.7845  -16.7127
            5   C1x C    31.7845  -15.3449
            6   S2x S    30.6000  -14.6611
            7   C1z C    28.0476  -15.3449
            8   C5x C    28.0476  -16.7127
            9   N1b N    26.8633  -14.6611
            10  C5a C    25.6788  -15.3449
            11  O5a O    25.6788  -16.7127
            12  O5x O    26.8633  -17.3964
            13  C1b C    24.4943  -14.6611
            14  C1b C    32.9871  -17.4074
            15  C6a C    30.6000  -18.7640
            16  O6a O    29.3990  -19.4575
            17  O6a O    31.7678  -19.4383
            18  O2a O    28.0476  -13.1561
            19  C1a C    29.2296  -12.4736
            20  O7a O    34.1771  -16.7209
            21  C7a C    35.3803  -17.4162
            22  N1a N    36.5643  -16.7333
            23  O6a O    35.3800  -18.8297
            24  C8y C    23.2996  -15.3504
            25  S2x S    22.1731  -14.5147
            26  C8x C    21.0322  -15.3260
            27  C8x C    21.4512  -16.6618
            28  C8x C    22.8511  -16.6761
BOND        30
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     1   7 1
            8     7   8 1
            9     2   8 1
            10    7   9 1 #Up
            11    9  10 1
            12   10  11 2
            13    8  12 2
            14   10  13 1
            15    4  14 1
            16    3  15 1
            17   15  16 2
            18   15  17 1
            19    7  18 1 #Down
            20   18  19 1
            21   14  20 1
            22   20  21 1
            23   21  22 1
            24   21  23 2
            25   13  24 1
            26   24  25 1
            27   25  26 1
            28   26  27 2
            29   27  28 1
            30   24  28 2

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KEGG   DRUG: Cefoxitin sodium
Entry
D00913                      Drug                                   
Name
Cefoxitin sodium (JAN/USP);
Mefoxin (TN)
Product
CEFOXITIN AND DEXTROSE (B. Braun Medical)
  Generic
CEFOXITIN (Fresenius Kabi USA), CEFOXITIN (Fresenius Kabi USA), CEFOXITIN (Hikma Pharmaceuticals USA), CEFOXITIN (Hikma Pharmaceuticals USA), CEFOXITIN (SAMSON MEDICAL TECHNOLOGIES LLC), CEFOXITIN (Sagent Pharmaceuticals), CEFOXITIN (Sagent Pharmaceuticals), CEFOXITIN (WG Critical Care), CEFOXITIN (WG Critical Care), CEFOXITIN (WG Critical Care)
Formula
C16H16N3O7S2. Na
Exact mass
449.0327
Mol weight
449.44
Structure
Simcomp
Class
Antibacterial
 DG01710  beta-Lactam antibiotic
  DG01714  Cephalosporin skeleton group
   DG01488  Cephem
 DG01775  Second-generation cephalosporin
Remark
Same as: C08106
ATC code: J01DC01
Chemical structure group: DG00557
Product (DG00557): D00913<US>
Efficacy
Antibacterial, Cell wall biosynthesis inhibitor
Target
penicillin binding protein
  Pathway
ko00550  Peptidoglycan biosynthesis
Interaction
Structure map
map07012  Cephalosporins - parenteral agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01D OTHER BETA-LACTAM ANTIBACTERIALS
    J01DC Second-generation cephalosporins
     J01DC01 Cefoxitin
      D00913  Cefoxitin sodium (JAN/USP) <US>
USP drug classification [BR:br08302]
 Antibacterials
  Beta-lactam, Cephalosporins
   Cefoxitin
    D00913  Cefoxitin sodium (JAN/USP)
Drug groups [BR:br08330]
 Antibacterial
  DG01710  beta-Lactam antibiotic
   DG01714  Cephalosporin skeleton group
    DG01488  Cephem
     DG00557  Cefoxitin
      D00913  Cefoxitin sodium
  DG01775  Second-generation cephalosporin
   DG00557  Cefoxitin
    D00913  Cefoxitin sodium
Drug classes [BR:br08332]
 Antibacterial
  DG01488  Cephem
   D00913  Cefoxitin sodium
Antimicrobials [BR:br08307]
 Antibacterials
  Cell wall biosynthesis inhibitor, beta-lactam
   Second-generation cephalosporin
    D00913  Cefoxitin sodium (JAN/USP) <US>
Drug groups [BR:br08330]
 Antibacterial
  DG01710  beta-Lactam antibiotic
   DG01714  Cephalosporin skeleton group
    DG01488  Cephem
     DG00557  Cefoxitin
  DG01775  Second-generation cephalosporin
   DG00557  Cefoxitin
Antimicrobials abbreviations [BR:br08327]
 Antibacterials
  Cell wall biosynthesis inhibitor, beta-lactam
   Second-generation cephalosporin
    DG00557  Cefoxitin
Other DBs
CAS: 33564-30-6
PubChem: 7847976
ChEBI: 3501
LigandBox: D00913
NIKKAJI: J17.424F
LinkDB
KCF data

ATOM        29
            1   C1y C    27.7461  -15.3839
            2   N1y N    27.7461  -16.7490
            3   C2y C    28.9283  -17.4313
            4   C2y C    30.1104  -16.7490
            5   C1x C    30.1104  -15.3839
            6   S2x S    28.9283  -14.7015
            7   C1z C    26.3810  -15.3839
            8   C5x C    26.3810  -16.7490
            9   N1b N    25.1991  -14.7015
            10  C5a C    24.0170  -15.3839
            11  O5a O    24.0170  -16.7490
            12  O5x O    25.1991  -17.4313
            13  C1b C    22.8349  -14.7015
            14  C1b C    31.3106  -17.4423
            15  C6a C    28.9283  -18.7961
            16  O6a O    27.7297  -19.4882
            17  O6a O    30.0937  -19.4691 #-
            18  O2a O    26.3810  -13.1996
            19  C1a C    27.5606  -12.5184
            20  O7a O    32.4982  -16.7572
            21  C7a C    33.6989  -17.4511
            22  N1a N    34.8805  -16.7695
            23  O6a O    33.6986  -18.8617
            24  C8y C    21.6426  -15.3894
            25  S2x S    20.5184  -14.5554
            26  C8x C    19.3798  -15.3651
            27  C8x C    19.7979  -16.6982
            28  C8x C    21.1950  -16.7125
            29  Z   Na   31.5700  -19.4600 #+
BOND        30
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     1   7 1
            8     7   8 1
            9     2   8 1
            10    7   9 1 #Up
            11    9  10 1
            12   10  11 2
            13    8  12 2
            14   10  13 1
            15    4  14 1
            16    3  15 1
            17   15  16 2
            18   15  17 1
            19    7  18 1 #Down
            20   18  19 1
            21   14  20 1
            22   20  21 1
            23   21  22 1
            24   21  23 2
            25   13  24 1
            26   24  25 1
            27   25  26 1
            28   26  27 2
            29   27  28 1
            30   24  28 2

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