KEGG   DRUG: Rasagiline mesylate
Entry
D02562                      Drug                                   
Name
Rasagiline mesylate (USAN);
Rasagiline mesilate (JAN);
Azilect (TN)
Product
AZILECT (Teva Neuroscience)
  Generic
RASAGILINE (Alvogen), RASAGILINE (Ascend Laboratories), RASAGILINE (AvKARE), RASAGILINE (Bryant Ranch Prepack), RASAGILINE (Chartwell RX), RASAGILINE (Macleods Pharmaceuticals Limited), RASAGILINE (Micro Labs Limited), RASAGILINE (NorthStar RxLLC), RASAGILINE (Teva Pharmaceuticals USA), RASAGILINE MESYLATE (Avet Pharmaceuticals)
Formula
C12H13N. CH4SO3
Exact mass
267.0929
Mol weight
267.35
Structure
Class
Neuropsychiatric agent
 DG01568  MAO inhibitor
  DG01512  Monoamine oxidase B inhibitor
 DG01967  Antiparkinson agent
Metabolizing enzyme substrate
 DG01892  CYP1A2 substrate
Remark
Therapeutic category: 1169
ATC code: N04BD02
Chemical structure group: DG00865
Product (DG00865): D02562<JP/US>
Efficacy
Antiparkinsonian, Monoamine oxidase B (MAO-B) inhibitor
  Disease
Parkinson's disease [DS:H00057]
Target
MAOB [HSA:4129] [KO:K00274]
  Pathway
hsa04726  Serotonergic synapse
hsa04728  Dopaminergic synapse
Metabolism
Enzyme: CYP1A2 [HSA:1544]
Interaction
Structure map
map07027  Antidepressants
map07057  Antiparkinsonian agents
map07216  Catecholamine transferase inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N04 ANTI-PARKINSON DRUGS
   N04B DOPAMINERGIC AGENTS
    N04BD Monoamine oxidase B inhibitors
     N04BD02 Rasagiline
      D02562  Rasagiline mesylate (USAN) <JP/US>
USP drug classification [BR:br08302]
 Antiparkinson Agents
  Monoamine Oxidase B (MAO-B) Inhibitors
   Rasagiline
    D02562  Rasagiline mesylate (USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   116  Antiparkinsonian agents
    1169  Others
     D02562  Rasagiline mesylate (USAN); Rasagiline mesilate (JAN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01568  MAO inhibitor
   DG01512  Monoamine oxidase B inhibitor
    DG00865  Rasagiline
     D02562  Rasagiline mesylate
  DG01967  Antiparkinson agent
   DG00865  Rasagiline
    D02562  Rasagiline mesylate
 Metabolizing enzyme substrate
  DG01892  CYP1A2 substrate
   DG00865  Rasagiline
    D02562  Rasagiline mesylate
Drug classes [BR:br08332]
 Neuropsychiatric agent
  DG01967  Antiparkinson agent
   D02562  Rasagiline mesylate
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Amine oxidases
    MAOB
     D02562  Rasagiline mesylate (USAN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D02562
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D02562
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D02562
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D02562
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D02562
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01568  MAO inhibitor
   DG01512  Monoamine oxidase B inhibitor
    DG00865  Rasagiline
  DG01967  Antiparkinson agent
   DG00865  Rasagiline
 Metabolizing enzyme substrate
  DG01892  CYP1A2 substrate
   DG00865  Rasagiline
Other DBs
CAS: 161735-79-1
PubChem: 17396733
LigandBox: D02562
LinkDB
KCF data

ATOM        18
            1   C8y C    19.8358  -20.6271
            2   C8y C    19.8358  -19.2233
            3   C8x C    18.6201  -18.5214
            4   C8x C    17.4042  -19.2233
            5   C8x C    17.4042  -20.6271
            6   C8x C    18.6201  -21.3291
            7   C1y C    21.1709  -21.0609
            8   C1x C    21.9961  -19.9252
            9   C1x C    21.1709  -18.7895
            10  N1b N    21.1694  -22.4521
            11  C1b C    22.3845  -23.1554
            12  C3b C    23.5851  -22.4638
            13  C3a C    24.7493  -21.7502
            14  O1d O    30.5752  -19.7146
            15  S4a S    30.5752  -21.1185
            16  C1a C    29.1714  -21.1185
            17  O1d O    31.9791  -21.1185
            18  O1d O    30.5752  -22.5223
BOND        18
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     1   7 1
            8     7   8 1
            9     8   9 1
            10    2   9 1
            11    7  10 1 #Up
            12   10  11 1
            13   11  12 1
            14   12  13 3
            15   14  15 2
            16   15  16 1
            17   15  17 1
            18   15  18 2

» Japanese version   » Back

KEGG   DRUG: Rasagiline
Entry
D08469                      Drug                                   
Name
Rasagiline (USAN/INN);
Azilect (TN)
Formula
C12H13N
Exact mass
171.1048
Mol weight
171.24
Structure
Class
Neuropsychiatric agent
 DG01568  MAO inhibitor
  DG01512  Monoamine oxidase B inhibitor
 DG01967  Antiparkinson agent
Metabolizing enzyme substrate
 DG01892  CYP1A2 substrate
Remark
ATC code: N04BD02
Chemical structure group: DG00865
Product (DG00865): D02562<JP/US>
Efficacy
Antiparkinsonian, Neuroprotectant, Monoamine oxidase B (MAO-B) inhibitor
Comment
Treatment of Parkinson's disease
Target
MAOB [HSA:4129] [KO:K00274]
  Pathway
hsa04726  Serotonergic synapse
hsa04728  Dopaminergic synapse
Metabolism
Enzyme: CYP1A2 [HSA:1544]
Interaction
Structure map
map07027  Antidepressants
map07057  Antiparkinsonian agents
map07216  Catecholamine transferase inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N04 ANTI-PARKINSON DRUGS
   N04B DOPAMINERGIC AGENTS
    N04BD Monoamine oxidase B inhibitors
     N04BD02 Rasagiline
      D08469  Rasagiline (USAN/INN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01568  MAO inhibitor
   DG01512  Monoamine oxidase B inhibitor
    DG00865  Rasagiline
     D08469  Rasagiline
  DG01967  Antiparkinson agent
   DG00865  Rasagiline
    D08469  Rasagiline
 Metabolizing enzyme substrate
  DG01892  CYP1A2 substrate
   DG00865  Rasagiline
    D08469  Rasagiline
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Amine oxidases
    MAOB
     D08469  Rasagiline (USAN/INN)
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D08469
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D08469
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01568  MAO inhibitor
   DG01512  Monoamine oxidase B inhibitor
    DG00865  Rasagiline
  DG01967  Antiparkinson agent
   DG00865  Rasagiline
 Metabolizing enzyme substrate
  DG01892  CYP1A2 substrate
   DG00865  Rasagiline
Other DBs
CAS: 136236-51-6
PubChem: 96025155
ChEBI: 63620
PDB-CCD: RAU[PDBj]
LigandBox: D08469
NIKKAJI: J573.894F
LinkDB
KCF data

ATOM        13
            1   C8y C    22.8900  -17.7100
            2   C8y C    22.8900  -16.3100
            3   C8x C    21.7000  -15.6100
            4   C8x C    20.5100  -16.3100
            5   C8x C    20.5100  -17.7100
            6   C8x C    21.7000  -18.4100
            7   C1y C    24.2200  -18.1300
            8   C1x C    25.0600  -17.0100
            9   C1x C    24.2200  -15.8200
            10  N1b N    24.2200  -19.5300
            11  C1b C    25.4800  -20.2300
            12  C3b C    26.6700  -19.5300
            13  C3a C    27.8600  -18.8300
BOND        14
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     1   7 1
            8     7   8 1
            9     8   9 1
            10    2   9 1
            11    7  10 1 #Up
            12   10  11 1
            13   11  12 1
            14   12  13 3

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