KEGG   DRUG: AprindineHelp
Entry
D02969                      Drug                                   

Name
Aprindine (USAN/INN)
Formula
C22H30N2
Exact mass
322.2409
Mol weight
322.487
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01653  Antiarrhythmics
  DG01652  Class I antiarrhythmic agent
   DG01651  Class Ib antiarrhythmic agent
Enzyme substrate
 DG01644  CYP2D6 substrate
Remark
ATC code: C01BB04
Chemical structure group: DG00199
Product (DG00199): D01326<JP>
Efficacy
Antiarrhythmic, Sodium channel blocker
Target
SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Drug interaction
Structure map
map07037  Antiarrhythmic drugs
map07231  Sodium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01B ANTIARRHYTHMICS, CLASS I AND III
    C01BB Antiarrhythmics, class Ib
     C01BB04 Aprindine
      D02969  Aprindine (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D02969  Aprindine (USAN/INN)
    SCN2A
     D02969  Aprindine (USAN/INN)
    SCN3A
     D02969  Aprindine (USAN/INN)
    SCN4A
     D02969  Aprindine (USAN/INN)
    SCN5A
     D02969  Aprindine (USAN/INN)
    SCN8A
     D02969  Aprindine (USAN/INN)
    SCN9A
     D02969  Aprindine (USAN/INN)
    SCN10A
     D02969  Aprindine (USAN/INN)
    SCN11A
     D02969  Aprindine (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 37640-71-4
PubChem: 17397126
ChEMBL: CHEMBL1213033
LigandBox: D02969
NIKKAJI: J19.264C
LinkDB All DBs
KCF data Show

ATOM        24
            1   N1c N    25.1001  -18.6544
            2   C1b C    25.1001  -17.2521
            3   C1b C    26.2920  -16.5510
            4   C1b C    27.4839  -17.2521
            5   N1c N    28.7459  -16.5510
            6   C1b C    29.9378  -17.2521
            7   C1a C    31.1297  -16.5510
            8   C1b C    28.7459  -15.1488
            9   C1a C    29.9378  -14.4477
            10  C8y C    26.2920  -19.3555
            11  C8x C    26.2920  -20.7577
            12  C8x C    27.5540  -21.4589
            13  C8x C    28.7459  -20.7577
            14  C8x C    28.7459  -19.3555
            15  C8x C    27.4839  -18.6544
            16  C1y C    23.9220  -19.3277
            17  C1x C    23.9160  -20.7198
            18  C1x C    22.6000  -18.8917
            19  C8y C    21.7768  -20.0144
            20  C8y C    22.5901  -21.1442
            21  C8x C    20.4875  -19.9974
            22  C8x C    19.8018  -21.2879
            23  C8x C    20.5119  -22.4853
            24  C8x C    21.9118  -22.4689
BOND        26
            1     2   3 1
            2     6   7 1
            3    10  11 2
            4    11  12 1
            5    12  13 2
            6    13  14 1
            7    14  15 2
            8    15  10 1
            9     5   8 1
            10    3   4 1
            11    8   9 1
            12    1   2 1
            13    1  10 1
            14    4   5 1
            15    5   6 1
            16    1  16 1
            17   16  17 1
            18   16  18 1
            19   18  19 1
            20   19  20 1
            21   17  20 1
            22   19  21 2
            23   21  22 1
            24   22  23 2
            25   23  24 1
            26   20  24 2

» Japanese version   » Back

DBGET integrated database retrieval system