KEGG   DRUG: Insulin human
Entry
D03230                      Drug                                   
Name
Insulin human (USP/INN);
Insulin human (genetical recombination) (JP18);
Insulin human (biosynthesis) (JAN);
Insulin human (synthesis) (JAN);
Humulin (TN)
Product
AFREZZA (Mannkind Corporation), HUMULIN (Eli Lilly and Company), MYXREDLIN (Baxter Healthcare Corporation)
Formula
C257H383N65O77S6
Exact mass
5803.6377
Mol weight
5807.58
Sequence
(A chain) Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr
Gln Leu Glu Asn Tyr Cys Asn
(B chain) Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala
Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr
(Disulfide bridge: A6-A11, A7-B7, A20-B19)
  Type
Peptide
Class
Antidiabetic agent
 DG01636  Insulin preparation
  DG01802  Human insulin
Metabolizing enzyme inducer
 DG01637  CYP1A2 inducer
Remark
Therapeutic category: 2492
ATC code: A10AB01 A10AC01 A10AD01 A10AE01 A10AF01
Product: D03230<JP/US>
Efficacy
Antidiabetic, Insulin receptor agonist
  Disease
Diabetes mellitus [DS:H00408 H00409]
Target
INSR (CD220) [HSA:3643] [KO:K04527]
  Pathway
hsa04910  Insulin signaling pathway
hsa04930  Type II diabetes mellitus
Interaction
CYP induction: CYP1A2 [HSA:1544]
Structure map
map07051  Antidiabetics
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10A INSULINS AND ANALOGUES
    A10AB Insulins and analogues for injection, fast-acting
     A10AB01 Insulin (human)
      D03230  Insulin human (USP/INN) <JP/US>
    A10AC Insulins and analogues for injection, intermediate-acting
     A10AC01 Insulin (human)
      D03230  Insulin human (USP/INN) <JP/US>
    A10AD Insulins and analogues for injection, intermediate- or long-acting combined with fast-acting
     A10AD01 Insulin (human)
      D03230  Insulin human (USP/INN) <JP/US>
    A10AE Insulins and analogues for injection, long-acting
     A10AE01 Insulin (human)
      D03230  Insulin human (USP/INN) <JP/US>
    A10AF Insulins and analogues for inhalation
     A10AF01 Insulin (human)
      D03230  Insulin human (USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Blood Glucose Regulators
  Insulins
   Insulin, Rapid-acting
    Insulin Human (Inhaled)
     D03230  Insulin human (USP/INN)
   Insulin, Short-acting
    Insulin Human
     D03230  Insulin human (USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   249  Miscellaneous
    2492  Pancreatic hormones
     D03230  Insulin human (USP/INN); Insulin human (genetical recombination) (JP18); Insulin human (biosynthesis) (JAN); Insulin human (synthesis) (JAN)
Drug groups [BR:br08330]
 Antidiabetic agent
  DG01636  Insulin preparation
   DG01802  Human insulin
    D03230  Insulin human
 Metabolizing enzyme inducer
  DG01637  CYP1A2 inducer
   D03230  Insulin human
Drug classes [BR:br08332]
 Antidiabetic agent
  DG01636  Insulin preparation
   D03230  Insulin human
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Receptor tyrosine kinases (RTK)
   INSR family
    INSR (CD220)
     D03230  Insulin human (USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D03230  Insulin human (genetical recombination)
  D03230  Insulin human (genetical recombination) injection
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D03230
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D03230
Other DBs
CAS: 11061-68-0
PubChem: 17397383
LinkDB

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