KEGG   DRUG: Dextroamphetamine
Entry
D03740                      Drug                                   
Name
Dextroamphetamine (USAN);
Dexamfetamine (INN)
Formula
C9H13N
Exact mass
135.1048
Mol weight
135.2062
Structure
Simcomp
Class
Neuropsychiatric agent
 DG03085  Selective norepinephrine reuptake inhibitor (NRI)
Remark
Same as: C07884
ATC code: N06BA02
Chemical structure group: DG00967
Product (DG00967): D02078<US>
Efficacy
Stimulant (central)
Comment
Compoment of Biphetamine (TN)
Target
SLC18A2 (VMAT2) [HSA:6571] [KO:K08155]
SLC6A2 (NAT1) [HSA:6530] [KO:K05035]
SLC6A3 (DAT1) [HSA:6531] [KO:K05036]
  Pathway
hsa04721  Synaptic vesicle cycle
hsa04726  Serotonergic synapse
hsa04728  Dopaminergic synapse
hsa05031  Amphetamine addiction
Interaction
Structure map
map07234  Neurotransmitter transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06B PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS
    N06BA Centrally acting sympathomimetics
     N06BA02 Dexamfetamine
      D03740  Dextroamphetamine (USAN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG03085  Selective norepinephrine reuptake inhibitor (NRI)
   DG00967  Dexamfetamine
    D03740  Dextroamphetamine
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A2 (NAT1)
     D03740  Dextroamphetamine (USAN)
    SLC6A3 (DAT1)
     D03740  Dextroamphetamine (USAN)
   SLC18
    SLC18A2 (VMAT2)
     D03740  Dextroamphetamine (USAN)
Prodrugs [br08324.html]
 D03740
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG03085  Selective norepinephrine reuptake inhibitor (NRI)
   DG00967  Dexamfetamine
Other DBs
CAS: 51-64-9
PubChem: 17397829
ChEBI: 4469
LigandBox: D03740
NIKKAJI: J4.121A
LinkDB
KCF data

ATOM        10
            1   C8y C    18.0877  -15.4841
            2   C8x C    16.8264  -14.7834
            3   C8x C    18.0877  -16.8856
            4   C1b C    19.2788  -14.7834
            5   C8x C    15.6352  -15.4841
            6   C8x C    16.8264  -17.5863
            7   C1c C    20.4700  -15.4841
            8   C8x C    15.6352  -16.8856
            9   C1a C    21.6612  -14.7834
            10  N1a N    20.4700  -16.8856
BOND        10
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     3   6 2
            6     4   7 1
            7     5   8 2
            8     7   9 1
            9    10   7 1 #Down
            10    6   8 1

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KEGG   DRUG: Dextroamphetamine sulfate
Entry
D02078                      Drug                                   
Name
Dextroamphetamine sulfate (USP);
Dexedrine (TN);
Dextrostat (TN)
Product
  Generic
Formula
(C9H13N)2. H2SO4
Exact mass
368.177
Mol weight
368.4909
Structure
Simcomp
Class
Neuropsychiatric agent
 DG03085  Selective norepinephrine reuptake inhibitor (NRI)
Remark
ATC code: N06BA02
Chemical structure group: DG00967
Product (DG00967): D02078<US>
Product (mixture): D11624<US>
Efficacy
Stimulant (central)
  Disease
Narcolepsy [DS:H01293]
Attention deficit disorder with hyperactivity [DS:H01895]
Target
SLC18A2 (VMAT2) [HSA:6571] [KO:K08155]
SLC6A2 (NAT1) [HSA:6530] [KO:K05035]
SLC6A3 (DAT1) [HSA:6531] [KO:K05036]
  Pathway
hsa04721  Synaptic vesicle cycle
hsa04728  Dopaminergic synapse
hsa05031  Amphetamine addiction
Interaction
Structure map
map07234  Neurotransmitter transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06B PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS
    N06BA Centrally acting sympathomimetics
     N06BA02 Dexamfetamine
      D02078  Dextroamphetamine sulfate (USP) <US>
USP drug classification [BR:br08302]
 Central Nervous System Agents
  Attention Deficit Hyperactivity Disorder Agents, Amphetamines
   Dextroamphetamine
    D02078  Dextroamphetamine sulfate (USP)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG03085  Selective norepinephrine reuptake inhibitor (NRI)
   DG00967  Dexamfetamine
    D02078  Dextroamphetamine sulfate
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A2 (NAT1)
     D02078  Dextroamphetamine sulfate (USP) <US>
    SLC6A3 (DAT1)
     D02078  Dextroamphetamine sulfate (USP) <US>
   SLC18
    SLC18A2 (VMAT2)
     D02078  Dextroamphetamine sulfate (USP) <US>
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG03085  Selective norepinephrine reuptake inhibitor (NRI)
   DG00967  Dexamfetamine
Other DBs
CAS: 51-63-8
PubChem: 7849140
ChEBI: 51064
LigandBox: D02078
NIKKAJI: J252.880K
LinkDB
KCF data

ATOM        25
            1   C8y C    24.7800  -14.3500
            2   C8x C    23.5900  -13.6500
            3   C8x C    24.7800  -15.7500
            4   C1b C    25.9700  -13.6500
            5   C8x C    22.3300  -14.3500
            6   C8x C    23.5900  -16.4500
            7   C1c C    27.2300  -14.3500
            8   C8x C    22.3300  -15.7500
            9   C1a C    28.4200  -13.6500
            10  N1a N    27.2300  -15.7500
            11  S4a S    33.6700  -14.9100
            12  O1d O    33.6700  -13.5100
            13  O1d O    33.6700  -16.3100
            14  O1d O    35.0700  -14.9100
            15  O1d O    32.2700  -14.9100
            16  C8y C    24.7800  -14.3500
            17  C8x C    23.5900  -13.6500
            18  C8x C    22.3300  -14.3500
            19  C8x C    22.3300  -15.7500
            20  C8x C    23.5900  -16.4500
            21  C8x C    24.7800  -15.7500
            22  C1b C    25.9700  -13.6500
            23  C1c C    27.2300  -14.3500
            24  C1a C    28.4200  -13.6500
            25  N1a N    27.2300  -15.7500
BOND        24
            1    11  12 2
            2    11  13 2
            3    11  14 1
            4    11  15 1
            5     1   2 2
            6     1   3 1
            7     1   4 1
            8     2   5 1
            9     3   6 2
            10    4   7 1
            11    5   8 2
            12    7   9 1
            13    7  10 1 #Down
            14    6   8 1
            15   16  17 2
            16   16  21 1
            17   16  22 1
            18   17  18 1
            19   21  20 2
            20   22  23 1
            21   18  19 2
            22   23  24 1
            23   23  25 1 #Down
            24   20  19 1
BRACKET     1    21.7000  -17.4300   21.7000  -12.5300
            1    29.8900  -12.5300   29.8900  -17.4300
            1  2
 ORIGINAL  1    1   2   5   8   6   3   4   7   9  10
 REPEAT    1   16  17  18  19  20  21  22  23  24  25

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