KEGG   DRUG: Quinapril
Entry
D03752                      Drug                                   
Name
Quinapril (INN)
Formula
C25H30N2O5
Exact mass
438.2155
Mol weight
438.5161
Structure
Simcomp
Class
Cardiovascular agent
 DG01925  Renin-angiotensin system inhibitor
  DG01501  Angiotensin-converting enzyme inhibitor
 DG03231  Antihypertensive
  DG01501  Angiotensin-converting enzyme inhibitor
Remark
Same as: C07398
ATC code: C09AA06
Chemical structure group: DG00338
Product (DG00338): D00459<US>
Efficacy
Antihypertensive, Angiotensin-converting enzyme inhibitor
Comment
Active form of prodrug: Quinaprilat [DR:D03773]
Target
ACE (CD143) [HSA:1636] [KO:K01283]
  Pathway
hsa04614  Renin-angiotensin system
Interaction
Structure map
map07217  Renin-angiotensin system inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C09 AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
   C09A ACE INHIBITORS, PLAIN
    C09AA ACE inhibitors, plain
     C09AA06 Quinapril
      D03752  Quinapril (INN)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01925  Renin-angiotensin system inhibitor
   DG01501  Angiotensin-converting enzyme inhibitor
    DG00338  Quinapril
     D03752  Quinapril
  DG03231  Antihypertensive
   DG01501  Angiotensin-converting enzyme inhibitor
    DG00338  Quinapril
     D03752  Quinapril
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   Peptidyl-dipeptidases
    ACE (CD143)
     D03752  Quinapril (INN)
Prodrugs [br08324.html]
 D03752
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01925  Renin-angiotensin system inhibitor
   DG01501  Angiotensin-converting enzyme inhibitor
    DG00338  Quinapril
  DG03231  Antihypertensive
   DG01501  Angiotensin-converting enzyme inhibitor
    DG00338  Quinapril
Prodrugs [br08324.html]
 DG00338
Other DBs
CAS: 85441-61-8
PubChem: 17397841
ChEBI: 8713
LigandBox: D03752
NIKKAJI: J39.673G
LinkDB
KCF data

ATOM        32
            1   C1x C    38.2900  -20.0200
            2   C8y C    39.4800  -19.3200
            3   N1y N    37.1000  -19.3200
            4   C8y C    39.4800  -17.9200
            5   C8x C    40.7400  -20.0200
            6   C1y C    37.1000  -17.9200
            7   C1x C    38.2900  -17.2200
            8   C8x C    40.7400  -17.2200
            9   C8x C    41.9300  -19.3200
            10  C8x C    41.9300  -17.9200
            11  N1b N    33.4600  -20.0200
            12  C1c C    32.2700  -19.3200
            13  C7a C    32.2700  -17.9200
            14  C1b C    31.0100  -20.0200
            15  O7a O    33.4600  -17.2200
            16  O6a O    31.0100  -17.2200
            17  C1b C    29.8200  -19.3200
            18  C1b C    33.4600  -15.8200
            19  C8y C    28.6300  -20.0200
            20  C1a C    32.2000  -15.1200
            21  C8x C    28.6300  -21.4200
            22  C8x C    27.3700  -19.3200
            23  C8x C    27.3700  -22.1200
            24  C8x C    26.1800  -20.0200
            25  C8x C    26.1800  -21.4200
            26  C1c C    34.6500  -19.3200
            27  C5a C    35.8400  -20.0200
            28  O5a O    35.8400  -21.4200
            29  C1a C    34.6500  -17.9200
            30  C6a C    37.1000  -16.5200
            31  O6a O    38.2900  -15.7500
            32  O6a O    35.8400  -15.8200
BOND        34
            1     6   7 1
            2     9  10 1
            3     1   2 1
            4     1   3 1
            5    11  12 1
            6    12  13 1 #Up
            7    12  14 1
            8    13  15 1
            9    13  16 2
            10   14  17 1
            11   15  18 1
            12   17  19 1
            13   18  20 1
            14   19  21 1
            15   19  22 2
            16   21  23 2
            17   22  24 1
            18   23  25 1
            19   24  25 2
            20    2   4 2
            21   11  26 1
            22    2   5 1
            23   26  27 1
            24   27   3 1
            25    3   6 1
            26   27  28 2
            27    4   7 1
            28   26  29 1 #Up
            29    4   8 1
            30    6  30 1 #Down
            31    5   9 2
            32   30  31 1
            33    8  10 2
            34   30  32 2

» Japanese version   » Back

KEGG   DRUG: Quinapril hydrochloride
Entry
D00459                      Drug                                   
Name
Quinapril hydrochloride (JP18/USP);
Accupril (TN)
Product
  Generic
Formula
C25H30N2O5. HCl
Exact mass
474.1922
Mol weight
474.977
Structure
Simcomp
Class
Cardiovascular agent
 DG01925  Renin-angiotensin system inhibitor
  DG01501  Angiotensin-converting enzyme inhibitor
 DG03231  Antihypertensive
  DG01501  Angiotensin-converting enzyme inhibitor
Remark
Same as: C07340
Therapeutic category: 2144
ATC code: C09AA06
Chemical structure group: DG00338
Product (DG00338): D00459<US>
Product (mixture): D10278<US>
Efficacy
Antihypertensive, Angiotensin-converting enzyme inhibitor
  Disease
Hypertension [DS:H01633]
Comment
Active form of prodrug: Quinaprilat [DR:D03773]
Target
ACE (CD143) [HSA:1636] [KO:K01283]
  Pathway
hsa04614  Renin-angiotensin system
Interaction
Structure map
map07217  Renin-angiotensin system inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C09 AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
   C09A ACE INHIBITORS, PLAIN
    C09AA ACE inhibitors, plain
     C09AA06 Quinapril
      D00459  Quinapril hydrochloride (JP18/USP) <US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Angiotensin-converting Enzyme (ACE) Inhibitors
   Quinapril
    D00459  Quinapril hydrochloride (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2144  Angiotensin converting enzyme inhibitors
     D00459  Quinapril hydrochloride (JP18/USP)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01925  Renin-angiotensin system inhibitor
   DG01501  Angiotensin-converting enzyme inhibitor
    DG00338  Quinapril
     D00459  Quinapril hydrochloride
  DG03231  Antihypertensive
   DG01501  Angiotensin-converting enzyme inhibitor
    DG00338  Quinapril
     D00459  Quinapril hydrochloride
Drug classes [BR:br08332]
 Cardiovascular agent
  DG01501  Angiotensin-converting enzyme inhibitor
   D00459  Quinapril hydrochloride
  DG03231  Antihypertensive
   D00459  Quinapril hydrochloride
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   Peptidyl-dipeptidases
    ACE (CD143)
     D00459  Quinapril hydrochloride (JP18/USP) <US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00459  Quinapril hydrochloride
  D00459  Quinapril hydrochloride tablets
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01925  Renin-angiotensin system inhibitor
   DG01501  Angiotensin-converting enzyme inhibitor
    DG00338  Quinapril
  DG03231  Antihypertensive
   DG01501  Angiotensin-converting enzyme inhibitor
    DG00338  Quinapril
Prodrugs [br08324.html]
 DG00338
Other DBs
CAS: 82586-55-8
PubChem: 7847525
ChEBI: 8714
LigandBox: D00459
NIKKAJI: J400.159A
LinkDB
KCF data

ATOM        33
            1   C1x C    28.2490  -19.8211
            2   C8y C    29.4582  -19.1183
            3   N1y N    27.0337  -19.1187
            4   C8y C    29.4645  -17.7270
            5   C8x C    30.6604  -19.8200
            6   C1y C    27.0378  -17.7192
            7   C1x C    28.2493  -17.0245
            8   C8x C    30.6680  -17.0343
            9   C8x C    31.8720  -19.1253
            10  C8x C    31.8732  -17.7311
            11  N1b N    23.4099  -19.8234
            12  C1c C    22.1992  -19.1275
            13  C7a C    22.1933  -17.7238
            14  C1b C    20.9826  -19.8351
            15  O7a O    23.4099  -17.0219
            16  O6a O    20.9709  -17.0277
            17  C1b C    19.7661  -19.1450
            18  C1b C    23.4040  -15.6182
            19  C8y C    18.5554  -19.8351
            20  C1a C    22.1875  -14.9223
            21  C8x C    18.5554  -21.2506
            22  C8x C    17.3506  -19.1450
            23  C8x C    17.3506  -21.9582
            24  C8x C    16.1282  -19.8351
            25  C8x C    16.1282  -21.2506
            26  C1c C    24.6167  -19.1187
            27  C5a C    25.8252  -19.8183
            28  O5a O    25.8252  -21.2177
            29  C1a C    24.6140  -17.7194
            30  C6a C    27.0266  -16.3129
            31  O6a O    28.2329  -15.6036
            32  O6a O    25.8093  -15.6229
            33  X   Cl   30.5428  -21.2516
BOND        34
            1     8  10 2
            2     6   7 1
            3     9  10 1
            4    11  12 1
            5    12  13 1 #Up
            6    12  14 1
            7    13  15 1
            8    13  16 2
            9    14  17 1
            10   15  18 1
            11   17  19 1
            12   18  20 1
            13   19  21 1
            14   19  22 2
            15   21  23 2
            16   22  24 1
            17   23  25 1
            18   24  25 2
            19    1   2 1
            20   11  26 1
            21    1   3 1
            22   26  27 1
            23   27   3 1
            24    2   4 2
            25   27  28 2
            26    2   5 1
            27   26  29 1 #Up
            28    3   6 1
            29    6  30 1 #Down
            30    4   7 1
            31   30  31 1
            32    4   8 1
            33   30  32 2
            34    5   9 2

» Japanese version   » Back

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