KEGG   DRUG: Floxuridine
Entry
D04197                      Drug                                   
Name
Floxuridine (USP/INN);
FUDR (TN)
Product
  Generic
Formula
C9H11FN2O5
Exact mass
246.0652
Mol weight
246.1924
Structure
Simcomp
Class
Antineoplastic
 DG02018  Antimetabolite
  DG01958  Nucleic acid derivative, antineoplastic
   DG01935  Fluoropyrimidine antineoplastic
Remark
Same as: C11736
ATC code: L01BC09
Product: D04197<US>
Efficacy
Antineoplastic, Antiviral, Antimetabolite
  Disease
Gastrointestinal adenocarcinoma [DS:H00017 H00018 H00019 H00020]
Target
TYMS [HSA:7298] [KO:K00560]
  Pathway
hsa00240  Pyrimidine metabolism
hsa00670  One carbon pool by folate
Interaction
Structure map
map07041  Antineoplastics - antimetabolic agents
Other map
map00983  Drug metabolism - other enzymes
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01B ANTIMETABOLITES
    L01BC Pyrimidine analogues
     L01BC09 Floxuridine
      D04197  Floxuridine (USP/INN) <US>
Drug groups [BR:br08330]
 Antineoplastic
  DG02018  Antimetabolite
   DG01958  Nucleic acid derivative, antineoplastic
    DG01935  Fluoropyrimidine antineoplastic
     D04197  Floxuridine
Drug classes [BR:br08332]
 Antineoplastic
  DG02018  Antimetabolite
   D04197  Floxuridine
Target-based classification of drugs [BR:br08310]
 Enzymes
  Transferases (EC2)
   Methyltransferases
    TYMS
     D04197  Floxuridine (USP/INN) <US>
Other DBs
CAS: 50-91-9
PubChem: 47206143
ChEBI: 60761
LigandBox: D04197
NIKKAJI: J4.488A
LinkDB
KCF data

ATOM        17
            1   C1y C    20.5100  -17.2900
            2   O2x O    19.3900  -16.5200
            3   C1x C    20.0900  -18.6200
            4   C1y C    18.2700  -17.2900
            5   C1y C    18.6900  -18.6200
            6   C1b C    17.0100  -16.8700
            7   O1a O    17.9200  -19.6700
            8   O1a O    16.0300  -17.7800
            9   N4y N    21.8400  -16.8000
            10  C8x C    21.8400  -15.4000
            11  C8y C    23.0300  -17.5000
            12  N4x N    24.2900  -16.8000
            13  C8y C    24.2900  -15.4000
            14  C8y C    23.0300  -14.7000
            15  X   F    23.0300  -13.3000
            16  O5x O    25.4800  -14.7000
            17  O5x O    23.0300  -18.9000
BOND        18
            1     1   2 1
            2     1   3 1
            3     2   4 1
            4     3   5 1
            5     4   6 1 #Up
            6     5   7 1 #Down
            7     6   8 1
            8     4   5 1
            9     1   9 1 #Up
            10   10   9 1
            11   11  12 1
            12   12  13 1
            13   13  14 1
            14   10  14 2
            15   14  15 1
            16   13  16 2
            17   11  17 2
            18   11   9 1

» Japanese version   » Back

KEGG   COMPOUND: C11736
Entry
C11736                      Compound                               
Name
5-Fluorodeoxyuridine;
Floxuridine
Formula
C9H11FN2O5
Exact mass
246.0652
Mol weight
246.1924
Structure
Remark
Same as: D04197
Reaction
Pathway
map00983  Drug metabolism - other enzymes
Enzyme
2.4.2.4         2.7.1.21
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01B ANTIMETABOLITES
    L01BC Pyrimidine analogues
     L01BC09 Floxuridine
      D04197  Floxuridine (USP/INN) <US>
Drug groups [BR:br08330]
 Antineoplastic
  DG02018  Antimetabolite
   DG01958  Nucleic acid derivative, antineoplastic
    DG01935  Fluoropyrimidine antineoplastic
     D04197  Floxuridine
Drug classes [BR:br08332]
 Antineoplastic
  DG02018  Antimetabolite
   D04197  Floxuridine
Target-based classification of drugs [BR:br08310]
 Enzymes
  Transferases (EC2)
   Methyltransferases
    TYMS
     D04197  Floxuridine (USP/INN) <US>
Other DBs
CAS: 50-91-9
PubChem: 13901
ChEBI: 60761
NIKKAJI: J4.488A
LinkDB
KCF data

ATOM        17
            1   C1y C    25.6512  -17.9130
            2   O2x O    24.5170  -17.1332
            3   C1x C    25.2259  -19.2599
            4   C1y C    23.3829  -17.9130
            5   C1y C    23.8082  -19.2599
            6   C1b C    22.1069  -17.4877
            7   O1a O    23.0284  -20.3232
            8   O1a O    21.1145  -18.4093
            9   N4y N    26.9867  -17.4427
            10  C8y C    27.9559  -18.4774
            11  N4x N    29.3366  -18.1553
            12  C8y C    29.7480  -16.7986
            13  C8y C    28.7787  -15.7639
            14  C8x C    27.3981  -16.0860
            15  O5x O    27.5543  -19.8004
            16  O5x O    31.1724  -16.4669
            17  X   F    29.1901  -14.4072
BOND        18
            1     1   2 1
            2     1   3 1
            3     2   4 1
            4     3   5 1
            5     4   6 1 #Up
            6     5   7 1 #Down
            7     6   8 1
            8     4   5 1
            9     1   9 1 #Up
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14   13  14 2
            15    9  14 1
            16   10  15 2
            17   12  16 2
            18   13  17 1

» Japanese version

DBGET integrated database retrieval system