KEGG   DRUG: MoxonidineHelp
Entry
D05087                      Drug                                   

Name
Moxonidine (USAN/INN);
Cynt (TN)
Formula
C9H12ClN5O
Exact mass
241.073
Mol weight
241.6775
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01738  Centrally-acting antiadrenergic
Remark
Same as: C07451
ATC code: C02AC05
Efficacy
Antihypertensive
Comment
Imidazoline (clonidine type) derivative
Treatment of congestive heart failure, Treatment of type 2 diabetes (centrally acting sympatholytic)
Target
ADRA2 [HSA:150 151 152] [KO:K04138 K04139 K04140]
  Pathway
hsa04022  cGMP-PKG signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C02 ANTIHYPERTENSIVES
   C02A ANTIADRENERGIC AGENTS, CENTRALLY ACTING
    C02AC Imidazoline receptor agonists
     C02AC05 Moxonidine
      D05087  Moxonidine (USAN/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA2
     D05087  Moxonidine (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 75438-57-2
PubChem: 47206814
ChEBI: 7009
ChEMBL: CHEMBL19236
LigandBox: D05087
NIKKAJI: J32.886C
LinkDB All DBs
KCF data Show

ATOM        16
            1   C8y C    31.5823  -16.4683
            2   C8y C    31.5823  -17.8612
            3   C8y C    30.3641  -15.7629
            4   N1b N    32.7946  -15.7629
            5   N5x N    30.3641  -18.5607
            6   O2a O    32.7888  -18.5607
            7   N5x N    29.1459  -16.4683
            8   X   Cl   30.3582  -14.3582
            9   C2y C    34.0128  -16.4683
            10  C8y C    29.1516  -17.8729
            11  C1a C    32.7888  -19.9537
            12  N1x N    35.3390  -16.0368
            13  N2x N    34.0114  -17.8738
            14  C1a C    27.9510  -18.5781
            15  C1x C    36.1594  -17.1652
            16  C1x C    35.3442  -18.2992
BOND        17
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 2
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     4   9 1
            9     5  10 1
            10    6  11 1
            11    9  12 1
            12    9  13 2
            13   10  14 1
            14   12  15 1
            15   13  16 1
            16    7  10 2
            17   15  16 1

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