KEGG   DRUG: PramipexoleHelp
Entry
D05575                      Drug                                   

Name
Pramipexole (USAN/INN)
Formula
C10H17N3S
Exact mass
211.1143
Mol weight
211.3271
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG01472  Dopamine agonist
  DG01468  Dopamine D2-receptor agonist
  DG01469  Dopamine D3-receptor agonist
  DG01470  Dopamine D4-receptor agonist
 DG01967  Antiparkinson agent
Remark
ATC code: N04BC05
Chemical structure group: DG00863
Product (DG00863): D00559<JP/US>
Efficacy
Antiparkinsonian, Antidepressant, Dopamine receptor agonist
Target
DRD2 [HSA:1813] [KO:K04145]
DRD3 [HSA:1814] [KO:K04146]
DRD4 [HSA:1815] [KO:K04147]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04728  Dopaminergic synapse
hsa05012  Parkinson disease
Interaction
Drug interaction
Structure map
map07057  Antiparkinsonian agents
map07213  Dopamine receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N04 ANTI-PARKINSON DRUGS
   N04B DOPAMINERGIC AGENTS
    N04BC Dopamine agonists
     N04BC05 Pramipexole
      D05575  Pramipexole (USAN/INN)
USP drug classification [BR:br08302]
 Antiparkinson Agents
  Dopamine Agonists
   Pramipexole
    D05575  Pramipexole (USAN/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    DRD2
     D05575  Pramipexole (USAN/INN)
    DRD3
     D05575  Pramipexole (USAN/INN)
    DRD4
     D05575  Pramipexole (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 104632-26-0
PubChem: 47207239
ChEBI: 8356
ChEMBL: CHEMBL301265
DrugBank: DB00413
LigandBox: D05575
NIKKAJI: J419.937E
LinkDB All DBs
KCF data Show

ATOM        14
            1   C8y C    21.1335  -18.9431
            2   C8y C    21.1744  -17.5455
            3   N5x N    22.5777  -19.3681
            4   C1x C    20.0330  -19.6475
            5   C1x C    20.0274  -16.8467
            6   S2x S    22.5720  -17.1086
            7   C8y C    23.3987  -18.2384
            8   C1x C    18.8276  -18.9548
            9   C1y C    18.8219  -17.5513
            10  N1a N    24.8023  -18.2793
            11  N1b N    17.6048  -16.8524
            12  C1b C    16.3936  -17.5572
            13  C1b C    15.1884  -16.8583
            14  C1a C    13.9771  -17.5629
BOND        15
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 2
            7     4   8 1
            8     5   9 1
            9     7  10 1
            10    9  11 1 #Down
            11   11  12 1
            12   12  13 1
            13   13  14 1
            14    6   7 1
            15    8   9 1

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