KEGG   DRUG: Saprisartan potassium
Entry
D05801                      Drug                                   

Name
Saprisartan potassium (USAN)
Formula
C25H21BrF3N4O4S. K
Exact mass
648.0056
Mol weight
649.5212
Structure
Class
Cardiovascular agent
 DG01495  Angiotensin II receptor antagonist
 DG01925  Renin-angiotensin system inhibitor
  DG01495  Angiotensin II receptor antagonist
Efficacy
Antihypertensive, Angiotensin II receptor antagonist
Comment
Treatment of hypertension and heart failure
Target
AGTR1 [HSA:185] [KO:K04166]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
hsa04614  Renin-angiotensin system
hsa04924  Renin secretion
hsa04925  Aldosterone synthesis and secretion
Interaction
Brite
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Angiotensin
    AGTR1
     D05801  Saprisartan potassium (USAN)
Other DBs
CAS: 146613-90-3
PubChem: 47207462
LigandBox: D05801
NIKKAJI: J776.888E
LinkDB
KCF data

ATOM        39
            1   C8y C    14.0362  -19.3830
            2   C8x C    14.0362  -20.7778
            3   C8x C    15.2217  -21.4751
            4   C8x C    16.4073  -20.7778
            5   C8y C    16.4073  -19.3830
            6   C8x C    15.2217  -18.6856
            7   C8y C    17.6626  -18.6856
            8   N1b N    12.7809  -18.6856 #-
            9   S4a S    11.5954  -19.3830
            10  C1d C    10.4099  -18.6856
            11  O3c O    10.4099  -20.0804
            12  O3c O    12.7809  -20.0804
            13  X   F     9.2243  -19.3830
            14  X   F    10.4099  -17.2909
            15  X   F     9.2243  -17.9883
            16  O2x O    18.9178  -19.1738
            17  C8y C    19.8244  -18.0580
            18  C8y C    19.0573  -16.8027
            19  C8y C    17.6626  -17.2212
            20  C8x C    21.2191  -18.0580
            21  X   Br   16.5468  -16.3843
            22  C8x C    21.9863  -16.8725
            23  C8y C    21.2889  -15.6869
            24  C8x C    19.8941  -15.6869
            25  N4y N    23.3810  -14.4317
            26  C1b C    21.9863  -14.4317
            27  C8y C    24.2876  -15.5475
            28  N5x N    25.5429  -15.0593
            29  C8y C    25.5429  -13.5948
            30  C8y C    24.1481  -13.2461
            31  C1y C    26.6587  -12.7580
            32  C5a C    23.6600  -11.9211
            33  O5a O    22.2652  -11.7119
            34  N1a N    24.5665  -10.8751
            35  C1b C    23.8692  -16.8725
            36  C1a C    24.8455  -17.8488
            37  C1x C    28.0534  -12.7580
            38  C1x C    27.3560  -11.5724
            39  Z   K    12.7231  -16.1323 #+
BOND        42
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     1   8 1
            9     8   9 1
            10    9  10 1
            11    9  11 2
            12    9  12 2
            13   10  13 1
            14   10  14 1
            15   10  15 1
            16    7  16 1
            17   16  17 1
            18   17  18 2
            19   18  19 1
            20    7  19 2
            21   17  20 1
            22   19  21 1
            23   20  22 2
            24   22  23 1
            25   23  24 2
            26   24  18 1
            27   25  26 1
            28   23  26 1
            29   25  27 1
            30   27  28 2
            31   28  29 1
            32   29  30 2
            33   25  30 1
            34   29  31 1
            35   30  32 1
            36   32  33 2
            37   32  34 1
            38   27  35 1
            39   35  36 1
            40   31  37 1
            41   37  38 1
            42   38  31 1

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