KEGG   DRUG: Meprednisone
Entry
D06673                      Drug                                   

Name
Meprednisone (USP/INN)
Formula
C22H28O5
Exact mass
372.1937
Mol weight
372.4547
Structure
Simcomp
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Remark
ATC code: H02AB15
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Structure map
map07046  Immunosuppressive agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB15 Meprednisone
      D06673  Meprednisone (USP/INN)
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    D06673  Meprednisone
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D06673  Meprednisone (USP/INN)
Other DBs
CAS: 1247-42-3
PubChem: 47208324
ChEMBL: CHEMBL113044 CHEMBL1201148
LigandBox: D06673
NIKKAJI: J7.472A
LinkDB
KCF data

ATOM        27
            1   C2x C    22.7500  -19.8800
            2   C5x C    22.7500  -21.2800
            3   C2x C    23.9400  -21.9800
            4   C2y C    25.0600  -21.2800
            5   C1z C    25.0600  -19.8800
            6   C2x C    23.9400  -19.2500
            7   C1x C    26.2500  -21.9800
            8   C1x C    27.4400  -21.2800
            9   C1y C    27.4400  -19.8800
            10  C1y C    26.2500  -19.2500
            11  C1y C    28.6300  -19.2500
            12  C1z C    28.6300  -17.8500
            13  C1x C    27.4400  -17.1500
            14  C5x C    26.2500  -17.8500
            15  C1x C    31.0100  -19.2500
            16  C1y C    31.0100  -17.8500
            17  C1z C    29.8200  -17.1500
            18  O5x O    21.5600  -21.9800
            19  C1a C    25.0600  -18.5500
            20  O5x O    25.1300  -17.1500
            21  C1a C    28.6300  -16.5200
            22  C5a C    29.8200  -15.6100
            23  O1a O    31.0100  -16.5200
            24  C1b C    31.0100  -14.9100
            25  O5a O    28.6300  -14.9100
            26  O1a O    32.2000  -15.6100
            27  C1a C    32.4082  -17.7792
BOND        30
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21    2  18 2
            22    5  19 1 #Up
            23   14  20 2
            24   12  21 1 #Up
            25   17  22 1 #Up
            26   17  23 1 #Down
            27   22  24 1
            28   22  25 2
            29   24  26 1
            30   16  27 1 #Up

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KEGG   DRUG: Prednisone
Entry
D00473                      Drug                                   

Name
Prednisone (USP);
Prednisone monohydrate;
Deltasone (TN);
Meticorten (TN);
Rayos (TN)
Product
  Generic
PREDNISONE (A-S Medication Solutions), PREDNISONE (A-S Medication Solutions), PREDNISONE (A-S Medication Solutions), PREDNISONE (A-S Medication Solutions), PREDNISONE (A-S Medication Solutions), PREDNISONE (A-S Medication Solutions), PREDNISONE (A-S Medication Solutions), PREDNISONE (A-S Medication Solutions), PREDNISONE (A-S Medication Solutions), PREDNISONE (A-S Medication Solutions), PREDNISONE (A-S Medication Solutions), PREDNISONE (A-S Medication Solutions), PREDNISONE (A-S Medication Solutions), PREDNISONE (A-S Medication Solutions), PREDNISONE (A-S Medication Solutions), PREDNISONE (A-S Medication Solutions), PREDNISONE (A-S Medication Solutions), PREDNISONE (A-S Medication Solutions), PREDNISONE (A-S Medication Solutions), PREDNISONE (A-S Medication Solutions), PREDNISONE (A-S Medication Solutions), PREDNISONE (A-S Medication Solutions), PREDNISONE (A-S Medication Solutions), PREDNISONE (A-S Medication Solutions), PREDNISONE (Actavis Pharma), PREDNISONE (Advanced Rx Pharmacy of Tennessee), PREDNISONE (Advanced Rx Pharmacy of Tennessee), PREDNISONE (Advanced Rx Pharmacy of Tennessee), PREDNISONE (American Health Packaging), PREDNISONE (Amneal Pharmaceuticals NY LLC), PREDNISONE (Amneal Pharmaceuticals NY LLC), PREDNISONE (Aphena Pharma Solutions - Tennessee), PREDNISONE (Aphena Pharma Solutions - Tennessee), PREDNISONE (Asclemed USA), PREDNISONE (Aurobindo Pharma Limited), PREDNISONE (AvKARE), PREDNISONE (AvKARE), PREDNISONE (Bryant Ranch Prepack), PREDNISONE (Bryant Ranch Prepack), PREDNISONE (Bryant Ranch Prepack), PREDNISONE (Bryant Ranch Prepack), PREDNISONE (Bryant Ranch Prepack), PREDNISONE (Bryant Ranch Prepack), PREDNISONE (Bryant Ranch Prepack), PREDNISONE (Bryant Ranch Prepack), PREDNISONE (Bryant Ranch Prepack), PREDNISONE (Bryant Ranch Prepack), PREDNISONE (Bryant Ranch Prepack), PREDNISONE (Bryant Ranch Prepack), PREDNISONE (Bryant Ranch Prepack), PREDNISONE (Bryant Ranch Prepack), PREDNISONE (Bryant Ranch Prepack), PREDNISONE (Bryant Ranch Prepack), PREDNISONE (Bryant Ranch Prepack), PREDNISONE (Bryant Ranch Prepack), PREDNISONE (Bryant Ranch Prepack), PREDNISONE (Bryant Ranch Prepack), PREDNISONE (Bryant Ranch Prepack), PREDNISONE (Bryant Ranch Prepack), PREDNISONE (Bryant Ranch Prepack), PREDNISONE (Bryant Ranch Prepack), PREDNISONE (Bryant Ranch Prepack), PREDNISONE (Bryant Ranch Prepack), PREDNISONE (Bryant Ranch Prepack), PREDNISONE (Bryant Ranch Prepack), PREDNISONE (Bryant Ranch Prepack), PREDNISONE (Bryant Ranch Prepack), PREDNISONE (Bryant Ranch Prepack), PREDNISONE (Bryant Ranch Prepack), PREDNISONE (Bryant Ranch Prepack), PREDNISONE (Bryant Ranch Prepack), PREDNISONE (Cambridge Therapeutics Technologies), PREDNISONE (Cardinal Health), PREDNISONE (Cardinal Health), PREDNISONE (Clinical Solutions Wholesale), PREDNISONE (Clinical Solutions Wholesale), PREDNISONE (DIRECT RX), PREDNISONE (DIRECT RX), PREDNISONE (DIRECT RX), PREDNISONE (DIRECT RX), PREDNISONE (DIRECT RX), PREDNISONE (Denton Pharma), PREDNISONE (Denton Pharma), PREDNISONE (Denton Pharma), PREDNISONE (Denton Pharma), PREDNISONE (Denton Pharma), PREDNISONE (Denton Pharma), PREDNISONE (Denton Pharma), PREDNISONE (Diect_Rx), PREDNISONE (Direct Rx), PREDNISONE (DirectRX), PREDNISONE (Direct_Rx), PREDNISONE (Direct_Rx), PREDNISONE (Direct_Rx), PREDNISONE (Direct_Rx), PREDNISONE (Direct_Rx), PREDNISONE (Direct_Rx), PREDNISONE (Direct_Rx), PREDNISONE (Direct_Rx), PREDNISONE (GeneYork Pharmaceuticals Group LLC), PREDNISONE (GeneYork Pharmaceuticals Group LLC), PREDNISONE (GeneYork Pharmaceuticals Group LLC), PREDNISONE (Golden State Medical Supply), PREDNISONE (Hikma Pharmaceuticals USA), PREDNISONE (Hikma Pharmaceuticals USA), PREDNISONE (JUBILANT CADISTA PHARMACEUTICALS), PREDNISONE (JUBILANT CADISTA PHARMACEUTICALS), PREDNISONE (Lake Erie Medical DBA Quality Care Products LLC), PREDNISONE (Lake Erie medical DBA Quality Care Products LLC), PREDNISONE (Lannett Company), PREDNISONE (Lannett Company), PREDNISONE (Lannett Company), PREDNISONE (Major Pharmaceuticals), PREDNISONE (Major Pharmaceuticals), PREDNISONE (McKesson Corporation dba SKY Packaging), PREDNISONE (Medsource Pharmaceuticals), PREDNISONE (Medsource Pharmaceuticals), PREDNISONE (Mylan Pharmaceuticals), PREDNISONE (NCS HealthCare of KY), PREDNISONE (NCS HealthCare of KY), PREDNISONE (NCS HealthCare of KY), PREDNISONE (NCS HealthCare of KY), PREDNISONE (NORTHWIND PHARMACEUTICALS), PREDNISONE (Northwind Pharmaceuticals), PREDNISONE (Northwind Pharmaceuticals), PREDNISONE (Northwind Pharmaceuticals), PREDNISONE (Novitium Pharma LLC), PREDNISONE (Novitium Pharma LLC), PREDNISONE (NuCare Pharmaceuticals), PREDNISONE (NuCare Pharmaceuticals), PREDNISONE (NuCare Pharmaceuticals), PREDNISONE (NuCare Pharmaceuticals), PREDNISONE (NuCare Pharmaceuticals), PREDNISONE (NuCare Pharmaceuticals), PREDNISONE (NuCare Pharmaceuticals), PREDNISONE (NuCare Pharmaceuticals), PREDNISONE (NuCare Pharmaceuticals), PREDNISONE (NuCare Pharmaceuticals), PREDNISONE (NuCare Pharmaceuticals), PREDNISONE (NuCare Pharmaceuticals), PREDNISONE (NuCare Pharmaceuticals), PREDNISONE (NuCare Pharmaceuticals), PREDNISONE (NuCare Pharmaceuticals), PREDNISONE (NuCare Pharmaceuticals), PREDNISONE (NuCare Pharmaceuticals), PREDNISONE (NuCare Pharmaceuticals), PREDNISONE (NuCare Pharmaceuticals), PREDNISONE (NuCare Pharmaceuticals), PREDNISONE (NuCare Pharmaceuticals), PREDNISONE (NuCare Pharmaceuticals), PREDNISONE (NuCare Pharmaceuticls), PREDNISONE (PD-Rx Pharmaceuticals), PREDNISONE (PD-Rx Pharmaceuticals), PREDNISONE (PD-Rx Pharmaceuticals), PREDNISONE (PD-Rx Pharmaceuticals), PREDNISONE (PD-Rx Pharmaceuticals), PREDNISONE (Par Pharmaceutical), PREDNISONE (PharmPak), PREDNISONE (Preferred Pharmaceuticals), PREDNISONE (Preferred Pharmaceuticals), PREDNISONE (Preferred Pharmaceuticals), PREDNISONE (Preferred Pharmaceuticals), PREDNISONE (Preferred Pharmaceuticals), PREDNISONE (Preferred Pharmaceuticals), PREDNISONE (Preferred Pharmaceuticals), PREDNISONE (Preferred Pharmaceuticals), PREDNISONE (Preferred Pharmaceuticals), PREDNISONE (Proficient Rx LP), PREDNISONE (Proficient Rx LP), PREDNISONE (Proficient Rx LP), PREDNISONE (Proficient Rx LP), PREDNISONE (Proficient Rx LP), PREDNISONE (Proficient Rx LP), PREDNISONE (Proficient Rx LP), PREDNISONE (Proficient Rx LP), PREDNISONE (Proficient Rx LP), PREDNISONE (Proficient Rx LP), PREDNISONE (Proficient Rx LP), PREDNISONE (Proficient Rx LP), PREDNISONE (Proficient Rx LP), PREDNISONE (Proficient Rx LP), PREDNISONE (Proficient Rx LP), PREDNISONE (QPharma), PREDNISONE (QPharma), PREDNISONE (QPharma), PREDNISONE (QPharma), PREDNISONE (QPharma), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (REMEDYREPACK), PREDNISONE (RPK Pharmaceuticals), PREDNISONE (RPK Pharmaceuticals), PREDNISONE (RPK Pharmaceuticals), PREDNISONE (RPK Pharmaceuticals), PREDNISONE (RPK Pharmaceuticals), PREDNISONE (RPK Pharmaceuticals), PREDNISONE (RedPharm Drug), PREDNISONE (RedPharm Drug), PREDNISONE (RedPharm Drug), DELTASONE (Sonoma Pharmaceuticals), PREDNISONE (St. Mary's Medical Park Pharmacy), PREDNISONE (St. Mary's Medical Park Pharmacy), PREDNISONE (St. Mary's Medical Park Pharmacy), PREDNISONE (St. Mary's Medical Park Pharmacy), PREDNISONE (St. Mary's Medical Park Pharmacy), PREDNISONE (Strides Pharma Science Limited), PREDNISONE (Strides Pharma Science Limited), PREDNISONE (Strides Pharma Science Limited), PREDNISONE (West-ward Pharmaceuticals Corp)
Formula
C21H26O5. H2O
Exact mass
376.1886
Mol weight
376.4434
Structure
Simcomp
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Remark
ATC code: A07EA03 H02AB07
Chemical structure group: DG00094
Product (DG00094): D00473<US>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
  Disease
Atopic dermatitis [DS:H01358]
Allergic rhinitis [DS:H01360]
Bullous dermatitis herpetiformis [DS:H01362]
Contact dermatitis [DS:H01357]
Mycosis fungoides [DS:H01463]
Pemphigus [DS:H01648]
Severe erythema multiforme (Stevens-Johnson syndrome) [DS:H01694]
Congenital adrenal hyperplasia [DS:H00216]
Primary or secondary adrenocortical insufficiency [DS:H01598]
Crohn's disease [DS:H00286]
Ulcerative colitis [DS:H01466]
Acquired (autoimmune) hemolytic anemia [DS:H01585]
Diamond-Blackfan anemia [DS:H00237]
Idiopathic thrombocytopenic purpura [DS:H01240]
Pure red cell aplasia [DS:H01586]
Multiple sclerosis [DS:H01490]
Chronic obstructive pulmonary disease [DS:H01714]
Allergic bronchopulmonary aspergillosis [DS:H01328]
Asthma [DS:H00079]
Pulmonary tuberculosis [DS:H00342]
Hypersensitivity pneumonitis [DS:H00346]
Idiopathic pulmonary fibrosis [DS:H01299]
Pneumocystis carinii pneumonia [DS:H01521]
Ankylosing spondylitis [DS:H01674]
Dermatomyositis and polymyositis [DS:H01604]
Polymyalgia rheumatica [DS:H01606]
Psoriatic arthritis [DS:H01507]
Relapsing polychondritis [DS:H01758]
Rheumatoid arthritis [DS:H00630]
Juvenile rheumatoid arthritis [DS:H01672]
Sjogren's syndrome [DS:H01502]
Systemic lupus erythematosus [DS:H00080]
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Structure map
map07043  Antineoplastics - hormones
map07046  Immunosuppressive agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07E INTESTINAL ANTIINFLAMMATORY AGENTS
    A07EA Corticosteroids acting locally
     A07EA03 Prednisone
      D00473  Prednisone (USP) <US>
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB07 Prednisone
      D00473  Prednisone (USP) <US>
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Prednisone
   D00473  Prednisone (USP)
 Inflammatory Bowel Disease Agents
  Glucocorticoids
   Prednisone
    D00473  Prednisone (USP)
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00094  Prednisone
     D00473  Prednisone
Drug classes [BR:br08332]
 Anti-inflammatory
  DG01955  Corticosteroid
   D00473  Prednisone
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D00473  Prednisone (USP) <US>
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00094  Prednisone
Other DBs
PubChem: 7847539
DrugBank: DB00635
LigandBox: D00473
LinkDB
KCF data

ATOM        27
            1   C2x C     4.2529  -10.3884
            2   C5x C     4.2529  -11.7514
            3   C2x C     5.4333  -12.4329
            4   C2y C     6.6137  -11.7514
            5   C1z C     6.6137  -10.3884
            6   C2x C     5.4333   -9.7068
            7   C1x C     7.7941  -12.4329
            8   C1x C     8.9745  -11.7514
            9   C1y C     8.9745  -10.3884
            10  C1y C     7.7941   -9.7068
            11  C1y C    10.1550   -9.7068
            12  C1z C    10.1550   -8.3438
            13  C1x C     8.9745   -7.6623
            14  C5x C     7.7941   -8.3438
            15  C1x C    12.5157   -9.7068
            16  C1x C    12.5157   -8.3438
            17  C1z C    11.3354   -7.6623
            18  O5x O     3.0725  -12.4329
            19  C1a C     6.6137   -9.0253
            20  O5x O     6.6157   -7.6635
            21  C1a C    10.1550   -6.9808
            22  C5a C    11.3354   -6.0948
            23  O1a O    12.5157   -6.9808
            24  C1b C    12.5197   -5.4111
            25  O5a O    10.1589   -5.4155
            26  O1a O    13.6856   -6.0843
            27  O0  O    15.8200   -9.8700
BOND        29
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21    2  18 2
            22    5  19 1 #Up
            23   14  20 2
            24   12  21 1 #Up
            25   17  22 1 #Up
            26   17  23 1 #Down
            27   22  24 1
            28   22  25 2
            29   24  26 1

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