KEGG   DRUG: CloranololHelp
Entry
D07183                      Drug                                   

Name
Cloranolol (INN)
Formula
C13H19Cl2NO2
Exact mass
291.0793
Mol weight
292.2015
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01653  Antiarrhythmics
  DG01806  Class II antiarrhythmic agent
 DG01466  Adrenergic receptor antagonist
  DG01464  beta-Adrenergic receptor antagonist
   DG01461  beta1-Adrenergic receptor antagonist
   DG01462  beta2-Adrenergic receptor antagonist
   DG01463  beta3-Adrenergic receptor antagonist
Remark
ATC code: C07AA27
Efficacy
beta-Adrenergic receptor antagonist
Comment
Propranolol derivative
Target
ADRB [HSA:153 154 155] [KO:K04141 K04142 K04143]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C07 BETA BLOCKING AGENTS
   C07A BETA BLOCKING AGENTS
    C07AA Beta blocking agents, non-selective
     C07AA27 Cloranolol
      D07183  Cloranolol (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRB
     D07183  Cloranolol (INN)
BRITE hierarchy
Other DBs
CAS: 39563-28-5
PubChem: 51091521
ChEMBL: CHEMBL156791
LigandBox: D07183
NIKKAJI: J16.607C
LinkDB All DBs
KCF data Show

ATOM        18
            1   O2a O    16.8000  -17.5700
            2   C1b C    18.0600  -16.8700
            3   C1c C    19.2500  -17.5700
            4   C1b C    20.4400  -16.8700
            5   N1b N    21.6300  -17.5700
            6   C1d C    22.8900  -16.8700
            7   O1a O    19.2500  -18.9700
            8   C1a C    24.0907  -17.5899
            9   C1a C    22.9131  -15.4702
            10  C1a C    24.1024  -16.1700
            11  C8y C    16.7828  -18.9699
            12  C8y C    15.5749  -19.6476
            13  C8x C    15.5578  -21.0475
            14  C8x C    16.7616  -21.7623
            15  C8y C    17.9694  -21.0846
            16  C8x C    17.9865  -19.6847
            17  X   Cl   14.3558  -18.9232
            18  X   Cl   19.1817  -21.8047
BOND        18
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     3   7 1
            7     6   8 1
            8     6   9 1
            9     6  10 1
            10    1  11 1
            11   11  12 2
            12   12  13 1
            13   13  14 2
            14   14  15 1
            15   15  16 2
            16   11  16 1
            17   12  17 1
            18   15  18 1

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