KEGG   DRUG: Amfetamine
Entry
D07445                      Drug                                   
Name
Amfetamine (INN);
Amphetamine;
Amfetamin (TN);
Adzenys (TN);
Dyanavel (TN)
Product
Formula
C9H13N
Exact mass
135.1048
Mol weight
135.21
Structure
Simcomp
Class
Metabolizing enzyme substrate
 DG01644  CYP2D6 substrate
Remark
Same as: C07514
ATC code: N06BA01
Chemical structure group: DG00966
Product (DG00966): D07445<US> D02074<US>
Efficacy
Stimulant (central)
  Disease
Attention deficit hyperactivity disorder [DS:H01895]
Target
SLC18A2 (VMAT2) [HSA:6571] [KO:K08155]
SLC6A2 (NAT1) [HSA:6530] [KO:K05035]
SLC6A3 (DAT1) [HSA:6531] [KO:K05036]
  Pathway
hsa04721  Synaptic vesicle cycle
hsa04726  Serotonergic synapse
hsa04728  Dopaminergic synapse
hsa05031  Amphetamine addiction
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Structure map
map07234  Neurotransmitter transporter inhibitors
Other map
map05031  Amphetamine addiction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06B PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS
    N06BA Centrally acting sympathomimetics
     N06BA01 Amfetamine
      D07445  Amfetamine (INN) <US>
USP drug classification [BR:br08302]
 Central Nervous System Agents
  Attention Deficit Hyperactivity Disorder Agents, Amphetamines
   Amphetamine
    D07445  Amfetamine (INN)
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00966  Amfetamine
    D07445  Amfetamine
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A2 (NAT1)
     D07445  Amfetamine (INN) <US>
    SLC6A3 (DAT1)
     D07445  Amfetamine (INN) <US>
   SLC18
    SLC18A2 (VMAT2)
     D07445  Amfetamine (INN) <US>
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D07445
Prodrugs [br08324.html]
 D07445
Narcotics and psychotropics in Japan [br08308.html]
 Stimulants by Control Act Article 2 Appended Table and Cabinet Order
  D07445
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00966  Amfetamine
Other DBs
CAS: 300-62-9
PubChem: 51091776
ChEBI: 2679
LigandBox: D07445
NIKKAJI: J231.296D
LinkDB
KCF data

ATOM        10
            1   C8y C    18.0426  -15.4812
            2   C8x C    16.8566  -14.7835
            3   C8x C    18.0426  -16.8766
            4   C1b C    19.2287  -14.7835
            5   C8x C    15.6008  -15.4812
            6   C8x C    16.8566  -17.5742
            7   C1c C    20.4845  -15.4812
            8   C8x C    15.6008  -16.8766
            9   N1a N    21.6705  -14.7835
            10  C1a C    20.4845  -16.8766
BOND        10
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     3   6 2
            6     4   7 1
            7     5   8 2
            8     7   9 1
            9     7  10 1
            10    6   8 1

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KEGG   DRUG: Amphetamine sulfate
Entry
D02074                      Drug                                   
Name
Amphetamine sulfate (USP);
Benzedrine (TN);
Evekeo (TN)
Product
  Generic
Formula
(C9H13N)2. H2SO4
Exact mass
368.1770
Mol weight
368.49
Structure
Simcomp
Class
Metabolizing enzyme substrate
 DG01644  CYP2D6 substrate
Remark
ATC code: N06BA01
Chemical structure group: DG00966
Product (DG00966): D07445<US> D02074<US>
Product (mixture): D11624<US>
Efficacy
Stimulant (central)
  Disease
Narcolepsy [DS:H01293]
Attention deficit disorder with hyperactivity [DS:H01895]
Target
SLC18A2 (VMAT2) [HSA:6571] [KO:K08155]
SLC6A2 (NAT1) [HSA:6530] [KO:K05035]
SLC6A3 (DAT1) [HSA:6531] [KO:K05036]
  Pathway
hsa04721  Synaptic vesicle cycle
hsa04728  Dopaminergic synapse
hsa05031  Amphetamine addiction
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Structure map
map07234  Neurotransmitter transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06B PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS
    N06BA Centrally acting sympathomimetics
     N06BA01 Amfetamine
      D02074  Amphetamine sulfate (USP) <US>
USP drug classification [BR:br08302]
 Central Nervous System Agents
  Attention Deficit Hyperactivity Disorder Agents, Amphetamines
   Amphetamine
    D02074  Amphetamine sulfate (USP)
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00966  Amfetamine
    D02074  Amphetamine sulfate
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A2 (NAT1)
     D02074  Amphetamine sulfate (USP) <US>
    SLC6A3 (DAT1)
     D02074  Amphetamine sulfate (USP) <US>
   SLC18
    SLC18A2 (VMAT2)
     D02074  Amphetamine sulfate (USP) <US>
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D02074
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00966  Amfetamine
Other DBs
CAS: 60-13-9
PubChem: 7849136
ChEBI: 51063
LigandBox: D02074
NIKKAJI: J281.197I
LinkDB
KCF data

ATOM        25
            1   C8y C    21.4900  -16.1000
            2   C8x C    20.3000  -15.4000
            3   C8x C    21.4900  -17.5000
            4   C1b C    22.6800  -15.4000
            5   C8x C    19.0400  -16.1000
            6   C8x C    20.3000  -18.2000
            7   C1c C    23.9400  -16.1000
            8   C8x C    19.0400  -17.5000
            9   C1a C    25.1300  -15.4000
            10  N1a N    23.9400  -17.5000
            11  S4a S    30.3800  -16.6600
            12  O1d O    30.3800  -15.2600
            13  O1d O    30.3800  -18.0600
            14  O1d O    31.7800  -16.6600
            15  O1d O    28.9800  -16.6600
            16  C8y C    21.4900  -16.1000
            17  C8x C    20.3000  -15.4000
            18  C8x C    19.0400  -16.1000
            19  C8x C    19.0400  -17.5000
            20  C8x C    20.3000  -18.2000
            21  C8x C    21.4900  -17.5000
            22  C1b C    22.6800  -15.4000
            23  C1c C    23.9400  -16.1000
            24  C1a C    25.1300  -15.4000
            25  N1a N    23.9400  -17.5000
BOND        24
            1    11  12 2
            2    11  13 2
            3    11  14 1
            4    11  15 1
            5     1   2 2
            6     1   3 1
            7     1   4 1
            8     2   5 1
            9     3   6 2
            10    4   7 1
            11    5   8 2
            12    7   9 1
            13    7  10 1
            14    6   8 1
            15   16  17 2
            16   16  21 1
            17   16  22 1
            18   17  18 1
            19   21  20 2
            20   22  23 1
            21   18  19 2
            22   23  24 1
            23   23  25 1
            24   20  19 1
BRACKET     1    18.4800  -19.2500   18.4800  -14.3500
            1    26.6700  -14.3500   26.6700  -19.2500
            1  2
 ORIGINAL  1    1   2   5   8   6   3   4   7   9  10
 REPEAT    1   16  17  18  19  20  21  22  23  24  25

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