KEGG   DRUG: Benazepril
Entry
D07499                      Drug                                   
Name
Benazepril (INN);
Benazepril Sandoz (TN);
Forteekor [veterinary] (TN)
Formula
C24H28N2O5
Exact mass
424.1998
Mol weight
424.4895
Structure
Simcomp
Class
Cardiovascular agent
 DG01925  Renin-angiotensin system inhibitor
  DG01501  Angiotensin-converting enzyme inhibitor
 DG03231  Antihypertensive
  DG01501  Angiotensin-converting enzyme inhibitor
Metabolizing enzyme substrate
 DG02924  UGT substrate
Remark
Same as: C06843
ATC code: C09AA07
Chemical structure group: DG00339
Product (DG00339): D00620<JP/US>
Product (mixture): D11069<US>
Efficacy
Antihypertensive, Angiotensin-converting enzyme inhibitor
Comment
Active form of prodrug: Benazeprilat [DR:D03077]
Target
ACE (CD143) [HSA:1636] [KO:K01283]
  Pathway
hsa04614  Renin-angiotensin system
Metabolism
Enzyme: UGT [KO:K00699]
Interaction
Structure map
map07217  Renin-angiotensin system inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C09 AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
   C09A ACE INHIBITORS, PLAIN
    C09AA ACE inhibitors, plain
     C09AA07 Benazepril
      D07499  Benazepril (INN)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01925  Renin-angiotensin system inhibitor
   DG01501  Angiotensin-converting enzyme inhibitor
    DG00339  Benazepril
     D07499  Benazepril
  DG03231  Antihypertensive
   DG01501  Angiotensin-converting enzyme inhibitor
    DG00339  Benazepril
     D07499  Benazepril
 Metabolizing enzyme substrate
  DG02924  UGT substrate
   DG00339  Benazepril
    D07499  Benazepril
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   Peptidyl-dipeptidases
    ACE (CD143)
     D07499  Benazepril (INN)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D07499
Prodrugs [br08324.html]
 D07499
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01925  Renin-angiotensin system inhibitor
   DG01501  Angiotensin-converting enzyme inhibitor
    DG00339  Benazepril
  DG03231  Antihypertensive
   DG01501  Angiotensin-converting enzyme inhibitor
    DG00339  Benazepril
 Metabolizing enzyme substrate
  DG02924  UGT substrate
   DG00339  Benazepril
Prodrugs [br08324.html]
 DG00339
Other DBs
CAS: 86541-75-5
PubChem: 51091824
ChEBI: 3011
LigandBox: D07499
NIKKAJI: J22.179A
LinkDB
KCF data

ATOM        31
            1   C1x C    20.1600  -19.3900
            2   C8y C    19.2500  -18.2700
            3   C8y C    19.5300  -16.9400
            4   N1y N    20.7900  -16.3100
            5   C1x C    21.5600  -19.3900
            6   C5x C    22.0500  -16.8700
            7   C1y C    22.4000  -18.2000
            8   C8x C    18.4800  -15.9600
            9   C8x C    17.1500  -16.4500
            10  C8x C    16.8700  -17.7800
            11  C8x C    17.9200  -18.6900
            12  C1b C    20.7200  -14.9100
            13  C6a C    21.9100  -14.1400
            14  O6a O    23.1700  -14.8400
            15  O6a O    21.9800  -12.8100
            16  O5x O    23.1700  -15.9600
            17  N1b N    23.8000  -18.2000
            18  C1c C    24.5000  -19.4600
            19  C1b C    25.9000  -19.4600
            20  C7a C    23.8000  -20.6500
            21  C1b C    26.6000  -18.2000
            22  C8y C    28.0000  -18.2000
            23  O6a O    22.4000  -20.6500
            24  O7a O    24.5000  -21.8400
            25  C1b C    25.9000  -21.8400
            26  C1a C    26.6000  -23.0300
            27  C8x C    28.7000  -19.4600
            28  C8x C    30.1000  -19.4600
            29  C8x C    30.8000  -18.2700
            30  C8x C    30.1000  -17.0100
            31  C8x C    28.7000  -17.0100
BOND        33
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13    4  12 1
            14   12  13 1
            15   13  14 1
            16   13  15 2
            17    6  16 2
            18    7  17 1 #Up
            19   17  18 1
            20   18  19 1 #Up
            21   18  20 1
            22   19  21 1
            23   21  22 1
            24   20  23 2
            25   20  24 1
            26   24  25 1
            27   25  26 1
            28   22  27 2
            29   27  28 1
            30   28  29 2
            31   29  30 1
            32   30  31 2
            33   22  31 1

» Japanese version   » Back

KEGG   DRUG: Benazepril hydrochloride
Entry
D00620                      Drug                                   
Name
Benazepril hydrochloride (JAN/USP);
Lotensin (TN)
Product
  Generic
BENAZEPRIL (Direct_Rx), BENAZEPRIL HYDROCHLORIDE (A-S Medication Solutions), BENAZEPRIL HYDROCHLORIDE (A-S Medication Solutions), BENAZEPRIL HYDROCHLORIDE (A-S Medication Solutions), BENAZEPRIL HYDROCHLORIDE (A-S Medication Solutions), BENAZEPRIL HYDROCHLORIDE (A-S Medication Solutions), BENAZEPRIL HYDROCHLORIDE (A-S Medication Solutions), BENAZEPRIL HYDROCHLORIDE (Amneal Pharmaceuticals LLC), BENAZEPRIL HYDROCHLORIDE (Amneal Pharmaceuticals of New York LLC), BENAZEPRIL HYDROCHLORIDE (Aurobindo Pharma Limited), BENAZEPRIL HYDROCHLORIDE (AvKARE), BENAZEPRIL HYDROCHLORIDE (AvPAK), BENAZEPRIL HYDROCHLORIDE (Bryant Ranch Prepack), BENAZEPRIL HYDROCHLORIDE (Bryant Ranch Prepack), BENAZEPRIL HYDROCHLORIDE (Bryant Ranch Prepack), BENAZEPRIL HYDROCHLORIDE (Bryant Ranch Prepack), BENAZEPRIL HYDROCHLORIDE (Bryant Ranch Prepack), BENAZEPRIL HYDROCHLORIDE (Bryant Ranch Prepack), BENAZEPRIL HYDROCHLORIDE (Bryant Ranch Prepack), BENAZEPRIL HYDROCHLORIDE (Bryant Ranch Prepack), BENAZEPRIL HYDROCHLORIDE (Bryant Ranch Prepack), BENAZEPRIL HYDROCHLORIDE (Cardinal Health 107), BENAZEPRIL HYDROCHLORIDE (DIRECT RX), BENAZEPRIL HYDROCHLORIDE (DIRECT RX), BENAZEPRIL HYDROCHLORIDE (Denton Pharma), BENAZEPRIL HYDROCHLORIDE (Denton Pharma), BENAZEPRIL HYDROCHLORIDE (Denton Pharma), BENAZEPRIL HYDROCHLORIDE (Denton Pharma), BENAZEPRIL HYDROCHLORIDE (Denton Pharma), BENAZEPRIL HYDROCHLORIDE (Denton Pharma), BENAZEPRIL HYDROCHLORIDE (Denton Pharma), BENAZEPRIL HYDROCHLORIDE (Golden State Medical Supply), BENAZEPRIL HYDROCHLORIDE (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (International Laboratories), BENAZEPRIL HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), BENAZEPRIL HYDROCHLORIDE (NuCare Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (NuCare Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (NuCare Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (NuCare Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (NuCare Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (NuCare Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (NuCare Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (NuCare Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (NuCare Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (NuCare Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (NuCare Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (NuCare Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (NuCare Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (NuCare Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (NuCare Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (NuCare Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (NuCare Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (PD-Rx Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (PD-Rx Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (PD-Rx Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (Preferred Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (Preferred Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (Preferred Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (Preferred Pharmaceuticlas), BENAZEPRIL HYDROCHLORIDE (Proficient Rx LP), BENAZEPRIL HYDROCHLORIDE (Proficient Rx LP), BENAZEPRIL HYDROCHLORIDE (Proficient Rx LP), BENAZEPRIL HYDROCHLORIDE (Proficient Rx LP), BENAZEPRIL HYDROCHLORIDE (Proficient Rx LP), BENAZEPRIL HYDROCHLORIDE (REMEDYREPACK), BENAZEPRIL HYDROCHLORIDE (REMEDYREPACK), BENAZEPRIL HYDROCHLORIDE (REMEDYREPACK), BENAZEPRIL HYDROCHLORIDE (REMEDYREPACK), BENAZEPRIL HYDROCHLORIDE (REMEDYREPACK), BENAZEPRIL HYDROCHLORIDE (REMEDYREPACK), BENAZEPRIL HYDROCHLORIDE (RPK Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (RPK Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (Solco healthcare U.S.), BENAZEPRIL HYDROCHLORIDE (St. Mary's Medical Park Pharmacy), BENAZEPRIL HYDROCHLORIDE (St. Mary's Medical Park Pharmacy), BENAZEPRIL HYDROCHLORIDE (Zydus Lifesciences Limited)
Formula
C24H28N2O5. HCl
Exact mass
460.1765
Mol weight
460.9505
Structure
Simcomp
Class
Cardiovascular agent
 DG01925  Renin-angiotensin system inhibitor
  DG01501  Angiotensin-converting enzyme inhibitor
 DG03231  Antihypertensive
  DG01501  Angiotensin-converting enzyme inhibitor
Metabolizing enzyme substrate
 DG02924  UGT substrate
Remark
Same as: C07701
Therapeutic category: 2144
ATC code: C09AA07
Chemical structure group: DG00339
Product (DG00339): D00620<JP/US>
Product (mixture): D10279<US> D11069<US>
Efficacy
Antihypertensive, Angiotensin-converting enzyme inhibitor
  Disease
Hypertension [DS:H01633]
Comment
Active form of prodrug: Benazeprilat [DR:D03077]
Target
ACE (CD143) [HSA:1636] [KO:K01283]
  Pathway
hsa04614  Renin-angiotensin system
Metabolism
Enzyme: UGT [KO:K00699]
Interaction
Structure map
map07217  Renin-angiotensin system inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C09 AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
   C09A ACE INHIBITORS, PLAIN
    C09AA ACE inhibitors, plain
     C09AA07 Benazepril
      D00620  Benazepril hydrochloride (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Angiotensin-converting Enzyme (ACE) Inhibitors
   Benazepril
    D00620  Benazepril hydrochloride (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2144  Angiotensin converting enzyme inhibitors
     D00620  Benazepril hydrochloride (JAN/USP)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01925  Renin-angiotensin system inhibitor
   DG01501  Angiotensin-converting enzyme inhibitor
    DG00339  Benazepril
     D00620  Benazepril hydrochloride
  DG03231  Antihypertensive
   DG01501  Angiotensin-converting enzyme inhibitor
    DG00339  Benazepril
     D00620  Benazepril hydrochloride
 Metabolizing enzyme substrate
  DG02924  UGT substrate
   DG00339  Benazepril
    D00620  Benazepril hydrochloride
Drug classes [BR:br08332]
 Cardiovascular agent
  DG01501  Angiotensin-converting enzyme inhibitor
   D00620  Benazepril hydrochloride
  DG03231  Antihypertensive
   D00620  Benazepril hydrochloride
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   Peptidyl-dipeptidases
    ACE (CD143)
     D00620  Benazepril hydrochloride (JAN/USP) <JP/US>
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00620
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01925  Renin-angiotensin system inhibitor
   DG01501  Angiotensin-converting enzyme inhibitor
    DG00339  Benazepril
  DG03231  Antihypertensive
   DG01501  Angiotensin-converting enzyme inhibitor
    DG00339  Benazepril
 Metabolizing enzyme substrate
  DG02924  UGT substrate
   DG00339  Benazepril
Prodrugs [br08324.html]
 DG00339
Other DBs
CAS: 86541-74-4
PubChem: 7847686
ChEBI: 3012
LigandBox: D00620
NIKKAJI: J550.745F
LinkDB
KCF data

ATOM        32
            1   C1x C    23.3231  -19.6615
            2   C8y C    22.4372  -18.5840
            3   C8y C    22.7197  -17.2133
            4   N1y N    23.9591  -16.5857
            5   C1x C    24.7308  -19.7019
            6   C5x C    25.2377  -17.1596
            7   C1y C    25.5777  -18.5180
            8   C8x C    21.6743  -16.2838
            9   C8x C    20.3466  -16.7242
            10  C8x C    20.0641  -18.0949
            11  C8x C    21.1095  -19.0246
            12  C1b C    23.9262  -15.1817
            13  C6a C    25.1248  -14.4519
            14  O6a O    26.3615  -15.1276
            15  O6a O    25.1625  -13.0836
            16  O5x O    26.3330  -16.2423
            17  N1b N    26.9766  -18.5180
            18  C1c C    27.6929  -19.7595
            19  C1b C    29.1069  -19.7602
            20  C7a C    27.0102  -20.9405
            21  C1b C    29.8213  -18.5252
            22  C8y C    31.2056  -18.5264
            23  O6a O    25.6102  -20.9399
            24  O7a O    27.6989  -22.1343
            25  C1b C    29.1070  -22.1349
            26  C1a C    29.7937  -23.3254
            27  C8x C    31.9096  -19.7481
            28  C8x C    33.3085  -19.7492
            29  C8x C    34.0091  -18.5383
            30  C8x C    33.3051  -17.3167
            31  C8x C    31.9062  -17.3155
            32  X   Cl   34.6331  -22.3162
BOND        33
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13    4  12 1
            14   12  13 1
            15   13  14 1
            16   13  15 2
            17    6  16 2
            18    7  17 1 #Up
            19   17  18 1
            20   18  19 1 #Up
            21   18  20 1
            22   19  21 1
            23   21  22 1
            24   20  23 2
            25   20  24 1
            26   24  25 1
            27   25  26 1
            28   22  27 2
            29   27  28 1
            30   28  29 2
            31   29  30 1
            32   30  31 2
            33   22  31 1

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