KEGG   DRUG: Adomiparin
Entry
D07510                      Drug                                   

Name
Adomiparin (USAN);
Semuloparin (USAN);
Heparin (BAN);
Enoxaparin;
Bemiparin;
Parnaparin;
Nadroparin;
Heparin (TN)
Formula
(C26H40N2O36S5)n
Structure
Simcomp
Class
Cardiovascular agent
 DG01709  Heparin anticoagulant
 DG01950  Antithrombotic agent
  DG01709  Heparin anticoagulant
Remark
Same as: C00374
ATC code: B01AB01 B01AB12 C05BA03 S01XA14
Chemical structure group: DG00150
Product (DG00150): D02112<JP/US> D04427<JP> D03674<JP/US> D04977<JP> D03353<JP/US>
Efficacy
Anticoagulant, Antithrombin III activator, Platelet aggregation inhibitor
Comment
Low molecular weight heparin (LMWH)
Target
SERPINC1 (AT3) [HSA:462] [KO:K03911]
  Pathway
hsa04610  Complement and coagulation cascades
Interaction
Structure map
map07049  Antithrombosis agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B01 ANTITHROMBOTIC AGENTS
   B01A ANTITHROMBOTIC AGENTS
    B01AB Heparin group
     B01AB01 Heparin
      D07510  Adomiparin (USAN)
     B01AB12 Bemiparin
      D07510  Adomiparin (USAN)
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05B ANTIVARICOSE THERAPY
    C05BA Heparins or heparinoids for topical use
     C05BA03 Heparin
      D07510  Adomiparin (USAN)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01X OTHER OPHTHALMOLOGICALS
    S01XA Other ophthalmologicals
     S01XA14 Heparin
      D07510  Adomiparin (USAN)
Target-based classification of drugs [BR:br08310]
 Not elsewhere classified
  Organismal systems
   Complement and coagulation
    SERPINC1 (AT3)
     D07510  Adomiparin (USAN)
Other DBs
CAS: 9005-49-6
PubChem: 96024437
ChEBI: 28304
NIKKAJI: J293.322E
LinkDB
KCF data

ATOM        71
            1   C1y C    20.6500  -19.0400
            2   C1y C    21.7700  -19.6700
            3   C1y C    20.6500  -17.7100
            4   O2a O    19.0400  -19.9500
            5   C1y C    22.8900  -19.0400
            6   O2a O    21.7700  -21.0000
            7   O2x O    21.7700  -17.0800
            8   C1b C    19.4600  -17.0800
            9   C1y C    17.3600  -20.8600
            10  C1y C    22.8900  -17.7100
            11  N1b N    23.9400  -20.2300
            12  O1a O    18.3400  -17.7100
            13  C1y C    17.3600  -22.1900
            14  O2x O    16.2400  -20.2300
            15  O2a O    24.5000  -16.8000
            16  S4a S    25.9000  -20.2300
            17  C1y C    16.2400  -22.8900
            18  O2a O    18.9000  -23.8000
            19  C1y C    15.1200  -20.8600
            20  C1y C    26.1800  -15.8200
            21  O1d O    25.9000  -21.5600
            22  O1d O    25.9000  -18.9000
            23  O1d O    27.2300  -20.2300
            24  C1y C    15.1200  -22.1900
            25  O1a O    16.2400  -24.1500
            26  C6a C    14.0000  -20.2300
            27  C1y C    26.1800  -14.4900
            28  C1y C    27.3000  -16.5200
            29  O1a O    13.9300  -22.8900
            30  O6a O    12.8100  -20.8600
            31  O6a O    14.0000  -18.9000
            32  O2x O    27.3000  -13.8600
            33  C6a C    24.9900  -13.8600
            34  C1y C    28.4200  -15.8200
            35  O1a O    27.3000  -17.7800
            36  Z   *    11.1300  -22.8200
            37  C1y C    28.4200  -14.4900
            38  O6a O    23.8700  -14.4900
            39  O6a O    24.9900  -12.5300
            40  O2a O    30.8700  -17.2900
            41  O2a O    30.0300  -13.5800
            42  C1y C    31.7100  -12.6000
            43  C1y C    31.7100  -11.3400
            44  C1y C    32.8300  -13.3000
            45  O2x O    32.8300  -10.6400
            46  C1b C    30.5200  -10.6400
            47  C1y C    33.9500  -12.6000
            48  O1a O    32.8300  -14.6300
            49  C1x C    33.9500  -11.3400
            50  O2a O    29.2600  -10.6400
            51  N1b N    35.9800  -13.5800
            52  Z   *    36.4000   -9.9400
            53  S4a S    27.9300  -10.6400
            54  C5a C    35.9800  -14.9100
            55  O1d O    27.9300  -11.9700
            56  O1d O    27.9300   -9.3100
            57  O1d O    26.6000  -10.6400
            58  C1a C    37.1700  -15.5400
            59  O5a O    34.8600  -15.5400
            60  S4a S    18.9000  -25.2000
            61  O1d O    18.9000  -26.6000
            62  O1d O    20.3000  -25.2000
            63  O1d O    17.5000  -25.2000
            64  S4a S    21.7700  -22.4000
            65  O1d O    21.7700  -23.8000
            66  O1d O    23.1700  -22.4000
            67  O1d O    20.3700  -22.4000
            68  S4a S    30.8700  -18.6900
            69  O1d O    30.8700  -20.0900
            70  O1d O    32.2700  -18.6900
            71  O1d O    29.4700  -18.6900
BOND        74
            1     1   2 1
            2     1   3 1
            3     1   4 1 #Down
            4     2   5 1
            5     2   6 1 #Up
            6     3   7 1
            7     3   8 1 #Up
            8     9   4 1 #Up
            9     5  10 1
            10    5  11 1 #Down
            11    8  12 1
            12    9  13 1
            13    9  14 1
            14   10  15 1 #Down
            15   11  16 1
            16   13  17 1
            17   13  18 1 #Down
            18   14  19 1
            19   20  15 1 #Down
            20   16  21 1
            21   16  22 2
            22   16  23 2
            23   17  24 1
            24   17  25 1 #Up
            25   19  26 1 #Down
            26   20  27 1
            27   20  28 1
            28   24  29 1 #Down
            29   26  30 1
            30   26  31 2
            31   27  32 1
            32   27  33 1 #Up
            33   28  34 1
            34   28  35 1 #Up
            35   29  36 1
            36   32  37 1
            37   33  38 1
            38   33  39 2
            39   34  40 1 #Down
            40   37  41 1 #Up
            41   42  41 1 #Down
            42   42  43 1
            43   42  44 1
            44   43  45 1
            45   43  46 1 #Up
            46   44  47 1
            47   44  48 1 #Up
            48   45  49 1
            49   46  50 1
            50   47  51 1 #Down
            51   49  52 1
            52   50  53 1
            53   51  54 1
            54   53  55 1
            55   53  56 2
            56   53  57 2
            57   54  58 1
            58   54  59 2
            59    7  10 1
            60   19  24 1
            61   34  37 1
            62   47  49 1
            63   18  60 1
            64   60  61 2
            65   60  62 2
            66   60  63 1
            67    6  64 1
            68   64  65 2
            69   64  66 2
            70   64  67 1
            71   40  68 1
            72   68  69 2
            73   68  70 2
            74   68  71 1
BRACKET     1    12.3900  -23.4500   12.3900  -22.1200
            1    35.0000   -9.9400   35.0000  -11.2700
            1  n
 ORIGINAL  1    1   2   3   4   5   6   7   8   9  10  11  12  13  14  15  16
            1   17  18  19  20  21  22  23  24  25  26  27  28  29  30  31  32
            1   33  34  35  37  38  39  40  41  42  43  44  45  46  47  48  49
            1   50  51  53  54  55  56  57  58  59  60  61  62  63  64  65  66
            1   67  68  69  70  71
 REPEAT    1

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KEGG   DRUG: Heparin sodium
Entry
D02112                      Drug                                   

Name
Heparin sodium (JP18/USP/INN);
Parnaparin sodium (INN);
Liquemin sodium (TN)
Product
HEPARIN SODIUM IN SODIUM CHLORIDE (Baxter Healthcare Corporation), HEPARIN SODIUM IN SODIUM CHLORIDE (Baxter Healthcare Corporation), HEPARIN SODIUM (Cardinal Health), HEPARIN SODIUM (Cardinal Health), HEPARIN SODIUM (Cardinal Health), HEPARIN SODIUM (Cardinal Health), HEPARIN SODIUM (Civica), HEPARIN SODIUM (Fresenius Kabi USA), HEPARIN SODIUM (Fresenius Kabi USA), HEPARIN SODIUM (Fresenius Kabi USA), HEPARIN SODIUM (Fresenius Kabi USA), HEPARIN SODIUM (Fresenius Kabi USA), HEPARIN SODIUM (Fresenius Kabi USA), HEPARIN SODIUM (General Injectables & Vaccines), HEPARIN SODIUM (HF Acquisition Co LLC), HEPARIN SODIUM (HF Acquisition Co LLC), HEPARIN SODIUM (Hikma Pharmaceuticals USA), HEPARIN SODIUM (Hospira), HEPARIN SODIUM (Hospira), HEPARIN SODIUM AND DEXTROSE (Hospira), HEPARIN SODIUM (Pfizer Laboratories Div Pfizer), HEPARIN SODIUM IN SODIUM CHLORIDE (B. Braun Medical)
  Generic
HEPARIN SODIUM (B. Braun Medical), HEPARIN SODIUM (BE Pharmaceuticals), HEPARIN SODIUM (BE Pharmaceuticals), HEPARIN SODIUM (Cardinal Health), HEPARIN SODIUM (Cardinal Health), HEPARIN SODIUM (Cardinal Health), HEPARIN SODIUM (Cardinal Health), HEPARIN SODIUM (Fresenius Kabi Norge AS), HEPARIN SODIUM (Fresenius Kabi USA), HEPARIN SODIUM (Fresenius Kabi USA), HEPARIN SODIUM (General Injectables & Vaccines), HEPARIN SODIUM (General Injectables & Vaccines), HEPARIN SODIUM (Gland Pharma Limited), HEPARIN SODIUM (HF Acquisition Co LLC), HEPARIN SODIUM (HF Acquisition Co LLC), HEPARIN SODIUM (HF Acquisition Co LLC), HEPARIN SODIUM (Hospira), HEPARIN SODIUM (McKesson Packaging Services Business Unit of McKesson Corporation), HEPARIN SODIUM (McKesson Packaging Services Business Unit of McKesson Corporation), HEPARIN SODIUM (McKesson Packaging Services Business Unit of McKesson Corporation), HEPARIN SODIUM (Meitheal Pharmaceuticals), HEPARIN SODIUM (Meitheal Pharmaceuticals), HEPARIN SODIUM (Meitheal Pharmaceuticals), HEPARIN SODIUM (Meitheal Pharmaceuticals), HEPARIN SODIUM (Meitheal Pharmaceuticals), HEPARIN SODIUM (Meitheal Pharmaceuticals), HEPARIN SODIUM (Mylan Institutional LLC), HEPARIN SODIUM (Mylan Institutional LLC), HEPARIN SODIUM (Mylan Institutional LLC), HEPARIN SODIUM (Sagent Pharmaceuticals), HEPARIN SODIUM (Sagent Pharmaceuticals), HEPARIN SODIUM (Sagent Pharmaceuticals), HEPARIN SODIUM (General Injectables and Vaccines)
Class
Cardiovascular agent
 DG01709  Heparin anticoagulant
 DG01950  Antithrombotic agent
  DG01709  Heparin anticoagulant
Remark
Therapeutic category: 3334
ATC code: B01AB01 C05BA03 S01XA14
Chemical structure group: DG00150
Product (DG00150): D02112<JP/US> D04427<JP> D03674<JP/US> D04977<JP> D03353<JP/US>
Efficacy
Anticoagulant, Antithrombin III activator
  Disease
Disseminated intravascular coagulation [DS:H01587]
Target
SERPINC1 (AT3) [HSA:462] [KO:K03911]
  Pathway
hsa04610  Complement and coagulation cascades
Interaction
Structure map
map07049  Antithrombosis agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B01 ANTITHROMBOTIC AGENTS
   B01A ANTITHROMBOTIC AGENTS
    B01AB Heparin group
     B01AB01 Heparin
      D02112  Heparin sodium (JP18/USP/INN) <JP/US>
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05B ANTIVARICOSE THERAPY
    C05BA Heparins or heparinoids for topical use
     C05BA03 Heparin
      D02112  Heparin sodium (JP18/USP/INN) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01X OTHER OPHTHALMOLOGICALS
    S01XA Other ophthalmologicals
     S01XA14 Heparin
      D02112  Heparin sodium (JP18/USP/INN) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  33  Blood and body fluid agents
   333  Anticoagulants
    3334  Heparins
     D02112  Heparin sodium (JP18/USP/INN); Parnaparin sodium (INN)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for integumentary system
  55 Chilblain and chap remedies
   D02112  Heparin sodium (JP18/USP/INN)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Heparin sodium
    D02112  Heparin sodium (JP18/USP/INN)
Target-based classification of drugs [BR:br08310]
 Not elsewhere classified
  Organismal systems
   Complement and coagulation
    SERPINC1 (AT3)
     D02112  Heparin sodium (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D02112  Heparin sodium
  D02112  Heparin sodium injection
  D02112  Heparin sodium solution for dialysis
  D02112  Heparin sodium lock solution
Other DBs
CAS: 9041-08-1
PubChem: 7849173
NIKKAJI: J209.198D
LinkDB

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KEGG   DRUG: Anticoagulant heparin
Entry
D02956                      Drug                                   

Name
Anticoagulant heparin (USP)
Efficacy
Anticoagulant, Antithrombin III activator
Comment
A sterile solution of Heparin sodium [DR:D02112] in Sodium chloride [DR:D02056] injection
for storage of whole blood
Target
SERPINC1 (AT3) [HSA:462] [KO:K03911]
  Pathway
hsa04610  Complement and coagulation cascades
Structure map
map07049  Antithrombosis agents
Brite
Target-based classification of drugs [BR:br08310]
 Not elsewhere classified
  Organismal systems
   Complement and coagulation
    SERPINC1 (AT3)
     D02956  Anticoagulant heparin (USP)
Other DBs
PubChem: 17397113
LinkDB

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KEGG   DRUG: Heparin calcium
Entry
D04427                      Drug                                   

Name
Heparin calcium (JP18);
Nadroparin calcium (INN);
Calciparin;
Calciparine (TN)
Class
Cardiovascular agent
 DG01709  Heparin anticoagulant
 DG01950  Antithrombotic agent
  DG01709  Heparin anticoagulant
Remark
Therapeutic category: 3334
ATC code: B01AB01 B01AB06 C05BA03 S01XA14
Chemical structure group: DG00150
Product (DG00150): D02112<JP/US> D04427<JP> D03674<JP/US> D04977<JP> D03353<JP/US>
Efficacy
Anticoagulant, Antithrombin III activator, Platelet aggregation inhibitor
Comment
Low molecular weight heparin (LMWH)
Calcium salt of depolymerized heparin
Target
SERPINC1 (AT3) [HSA:462] [KO:K03911]
  Pathway
hsa04610  Complement and coagulation cascades
Interaction
Structure map
map07049  Antithrombosis agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B01 ANTITHROMBOTIC AGENTS
   B01A ANTITHROMBOTIC AGENTS
    B01AB Heparin group
     B01AB01 Heparin
      D04427  Heparin calcium (JP18) <JP>
     B01AB06 Nadroparin
      D04427  Heparin calcium (JP18) <JP>
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05B ANTIVARICOSE THERAPY
    C05BA Heparins or heparinoids for topical use
     C05BA03 Heparin
      D04427  Heparin calcium (JP18) <JP>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01X OTHER OPHTHALMOLOGICALS
    S01XA Other ophthalmologicals
     S01XA14 Heparin
      D04427  Heparin calcium (JP18) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  33  Blood and body fluid agents
   333  Anticoagulants
    3334  Heparins
     D04427  Heparin calcium (JP18); Nadroparin calcium (INN)
Target-based classification of drugs [BR:br08310]
 Not elsewhere classified
  Organismal systems
   Complement and coagulation
    SERPINC1 (AT3)
     D04427  Heparin calcium (JP18) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D04427  Heparin calcium
Other DBs
CAS: 37270-89-6
PubChem: 17398103
LinkDB

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KEGG   DRUG: Adomiparin sodium
Entry
D02980                      Drug                                   

Name
Adomiparin sodium (USAN);
Ardeparin sodium (USAN/INN);
Semuloparin sodium (USAN/INN);
Normiflo (TN)
Class
Cardiovascular agent
 DG01709  Heparin anticoagulant
 DG01950  Antithrombotic agent
  DG01709  Heparin anticoagulant
Remark
Chemical structure group: DG00150
Product (DG00150): D02112<JP/US> D04427<JP> D03674<JP/US> D04977<JP> D03353<JP/US>
Efficacy
Anticoagulant, Antithrombin III activator
Comment
Low molecular weight heparin (LMWH)
Target
SERPINC1 (AT3) [HSA:462] [KO:K03911]
SERPIND1 [HSA:3053] [KO:K03912]
  Pathway
hsa04610  Complement and coagulation cascades
Interaction
Structure map
map07049  Antithrombosis agents
Brite
Target-based classification of drugs [BR:br08310]
 Not elsewhere classified
  Organismal systems
   Complement and coagulation
    SERPINC1 (AT3)
     D02980  Adomiparin sodium (USAN)
    SERPIND1
     D02980  Adomiparin sodium (USAN)
Other DBs
CAS: 9041-08-1
PubChem: 17397136
NIKKAJI: J209.198D
LinkDB

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KEGG   DRUG: Dalteparin sodium
Entry
D03353                      Drug                                   

Name
Dalteparin sodium (JAN/USP/INN);
Ardeparin sodium;
Fragmin (TN)
Product
Class
Cardiovascular agent
 DG01709  Heparin anticoagulant
 DG01950  Antithrombotic agent
  DG01709  Heparin anticoagulant
Remark
Therapeutic category: 3334
ATC code: B01AB04
Chemical structure group: DG00150
Product (DG00150): D02112<JP/US> D04427<JP> D03674<JP/US> D04977<JP> D03353<JP/US>
Efficacy
Anticoagulant, Antithrombin III activator
  Disease
Deep vein thrombosis [DS:H01723]
Comment
Low molecular weight heparin (LMWH)
Target
SERPINC1 (AT3) [HSA:462] [KO:K03911]
  Pathway
hsa04610  Complement and coagulation cascades
Interaction
Structure map
map07049  Antithrombosis agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B01 ANTITHROMBOTIC AGENTS
   B01A ANTITHROMBOTIC AGENTS
    B01AB Heparin group
     B01AB04 Dalteparin
      D03353  Dalteparin sodium (JAN/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Blood Products and Modifiers
  Anticoagulants
   Low Molecular Weight Heparins
    Dalteparin
     D03353  Dalteparin sodium (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  33  Blood and body fluid agents
   333  Anticoagulants
    3334  Heparins
     D03353  Dalteparin sodium (JAN/USP/INN)
Target-based classification of drugs [BR:br08310]
 Not elsewhere classified
  Organismal systems
   Complement and coagulation
    SERPINC1 (AT3)
     D03353  Dalteparin sodium (JAN/USP/INN) <JP/US>
Other DBs
CAS: 9041-08-1
PubChem: 17397502
NIKKAJI: J209.198D
LinkDB

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