KEGG   DRUG: Dihydroergotamine
Entry
D07837                      Drug                                   
Name
Dihydroergotamine (INN);
Neomigran (TN)
Formula
C33H37N5O5
Exact mass
583.2795
Mol weight
583.68
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01472  Dopamine agonist
  DG01468  Dopamine D2-receptor agonist
 DG01964  Ergot alkaloid
  DG01982  Antimigraine, ergot alkaloid
Analgesic
 DG01518  5-HT1B/1D-receptor agonist
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Same as: C07798
ATC code: N02CA01
Chemical structure group: DG00833
Product (DG00833): D02211<US>
Efficacy
Antimigraine, Vasoconstrictor, Serotonin receptor agonist
Comment
Ergot alkaloid
Target
HTR1B [HSA:3351] [KO:K04153]
HTR1D [HSA:3352] [KO:K04153]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Structure map
map07048  Antimigraines
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N02 ANALGESICS
   N02C ANTIMIGRAINE PREPARATIONS
    N02CA Ergot alkaloids
     N02CA01 Dihydroergotamine
      D07837  Dihydroergotamine (INN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01472  Dopamine agonist
   DG01468  Dopamine D2-receptor agonist
    DG00833  Dihydroergotamine
     D07837  Dihydroergotamine
  DG01964  Ergot alkaloid
   DG01982  Antimigraine, ergot alkaloid
    DG00833  Dihydroergotamine
     D07837  Dihydroergotamine
 Analgesic
  DG01518  5-HT1B/1D-receptor agonist
   DG00833  Dihydroergotamine
    D07837  Dihydroergotamine
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00833  Dihydroergotamine
     D07837  Dihydroergotamine
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Serotonin
    HTR1B
     D07837  Dihydroergotamine (INN)
    HTR1D
     D07837  Dihydroergotamine (INN)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D07837
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01472  Dopamine agonist
   DG01468  Dopamine D2-receptor agonist
    DG00833  Dihydroergotamine
  DG01964  Ergot alkaloid
   DG01982  Antimigraine, ergot alkaloid
    DG00833  Dihydroergotamine
 Analgesic
  DG01518  5-HT1B/1D-receptor agonist
   DG00833  Dihydroergotamine
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00833  Dihydroergotamine
Other DBs
CAS: 511-12-6
PubChem: 96024534
ChEBI: 4562
PDB-CCD: 2GM[PDBj]
LigandBox: D07837
NIKKAJI: J6.263D
LinkDB
KCF data

ATOM        43
            1   C1z C    26.9169  -15.2412
            2   N1y N    26.9868  -16.5696
            3   C1y C    28.1055  -14.6120
            4   O2x O    25.7983  -14.6120
            5   O1a O    26.9169  -13.9129
            6   C1y C    28.1055  -17.1988
            7   C5x C    24.6098  -16.5696
            8   N1y N    29.2241  -15.2412
            9   C1x C    28.1055  -13.2836
            10  C1z C    24.6098  -15.2412
            11  C5x C    29.2241  -16.5696
            12  C1b C    28.1055  -18.5272
            13  O5x O    23.7009  -17.4785
            14  C1x C    30.3427  -14.6120
            15  C1x C    30.3427  -13.2836
            16  N1b N    22.9318  -14.4722
            17  C1a C    24.6098  -13.8429
            18  O5x O    30.4126  -17.2687
            19  C8y C    29.2241  -19.2263
            20  C5a C    21.4636  -15.2412
            21  C8x C    29.2241  -20.5547
            22  C8x C    30.4126  -18.5272
            23  C1y C    21.4636  -16.5696
            24  O5a O    20.2751  -14.5421
            25  C8x C    30.3427  -21.1839
            26  C8x C    31.5312  -19.2263
            27  C1x C    20.2751  -17.1988
            28  C1x C    22.5823  -17.1988
            29  C8x C    31.5312  -20.5547
            30  C1y C    20.2751  -18.5272
            31  N1y N    22.5823  -18.5272
            32  C8y C    19.1565  -19.1564
            33  C1y C    21.4636  -19.2263
            34  C1a C    23.7708  -19.2263
            35  C8y C    19.1565  -20.4848
            36  C8x C    18.0379  -18.5272
            37  C1x C    21.4636  -20.5547
            38  C8y C    20.2751  -21.1839
            39  C8y C    18.0379  -21.1839
            40  C8x C    16.8493  -19.1564
            41  C8x C    20.2751  -22.5123
            42  N4x N    18.0379  -22.5123
            43  C8x C    16.8493  -20.4848
BOND        50
            1     1   5 1 #Down
            2     2   6 1
            3     2   7 1
            4     3   8 1
            5     3   9 1
            6     4  10 1
            7     6  11 1
            8     6  12 1 #Down
            9     7  13 2
            10    8  14 1
            11    9  15 1
            12   10  16 1
            13   10  17 1 #Up
            14   11  18 2
            15   12  19 1
            16   16  20 1
            17   19  21 2
            18   19  22 1
            19   23  20 1 #Up
            20   20  24 2
            21   21  25 1
            22   22  26 2
            23   23  27 1
            24   23  28 1
            25   25  29 2
            26   27  30 1
            27   28  31 1
            28   30  32 1
            29   30  33 1
            30   31  34 1
            31   32  35 1
            32   32  36 2
            33   33  37 1
            34   35  38 1
            35   35  39 2
            36   36  40 1
            37   38  41 2
            38   39  42 1
            39   39  43 1
            40    7  10 1
            41    8  11 1
            42   14  15 1
            43   26  29 1
            44   31  33 1
            45   37  38 1
            46   40  43 2
            47   41  42 1
            48    1   2 1
            49    1   3 1
            50    1   4 1

» Japanese version   » Back

KEGG   DRUG: Dihydroergotamine mesylate
Entry
D02211                      Drug                                   
Name
Dihydroergotamine mesylate (USP);
Dihydroergotamine mesilate (JP18);
Migranal (TN);
Trudhesa (TN)
Product
MIGRANAL (Bausch Health US), TRUDHESA (Impel Pharmaceuticals)
  Generic
DIHYDROERGOTAMINE MESYLATE (Advagen Pharma), DIHYDROERGOTAMINE MESYLATE (Gland Pharma Limited), DIHYDROERGOTAMINE MESYLATE (Hikma Pharmaceuticals USA), DIHYDROERGOTAMINE MESYLATE (Hikma Pharmaceuticals USA), DIHYDROERGOTAMINE MESYLATE (Hikma Pharmaceuticals USA), DIHYDROERGOTAMINE MESYLATE (Oceanside Pharmaceuticals), DIHYDROERGOTAMINE MESYLATE (Padagis US LLC), DIHYDROERGOTAMINE MESYLATE (Provepharm), DIHYDROERGOTAMINE MESYLATE (Sagent Pharmaceuticals), DIHYDROERGOTAMINE MESYLATE NASAL (Cipla USA)
Formula
C33H37N5O5. CH4SO3
Exact mass
679.2676
Mol weight
679.78
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01472  Dopamine agonist
  DG01468  Dopamine D2-receptor agonist
 DG01964  Ergot alkaloid
  DG01982  Antimigraine, ergot alkaloid
Analgesic
 DG01518  5-HT1B/1D-receptor agonist
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
ATC code: N02CA01
Chemical structure group: DG00833
Product (DG00833): D02211<US>
Efficacy
Antimigraine, Vasoconstrictor, Serotonin receptor agonist
Comment
Ergot alkaloid
Acute treatment of migraine headaches with or without aura
Target
HTR1B [HSA:3351] [KO:K04153]
HTR1D [HSA:3352] [KO:K04153]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Structure map
map07048  Antimigraines
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N02 ANALGESICS
   N02C ANTIMIGRAINE PREPARATIONS
    N02CA Ergot alkaloids
     N02CA01 Dihydroergotamine
      D02211  Dihydroergotamine mesylate (USP) <US>
USP drug classification [BR:br08302]
 Antimigraine Agents
  Ergot Alkaloids
   Dihydroergotamine
    D02211  Dihydroergotamine mesylate (USP)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01472  Dopamine agonist
   DG01468  Dopamine D2-receptor agonist
    DG00833  Dihydroergotamine
     D02211  Dihydroergotamine mesylate
  DG01964  Ergot alkaloid
   DG01982  Antimigraine, ergot alkaloid
    DG00833  Dihydroergotamine
     D02211  Dihydroergotamine mesylate
 Analgesic
  DG01518  5-HT1B/1D-receptor agonist
   DG00833  Dihydroergotamine
    D02211  Dihydroergotamine mesylate
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00833  Dihydroergotamine
     D02211  Dihydroergotamine mesylate
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Serotonin
    HTR1B
     D02211  Dihydroergotamine mesylate (USP) <US>
    HTR1D
     D02211  Dihydroergotamine mesylate (USP) <US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D02211  Dihydroergotamine mesilate
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D02211
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01472  Dopamine agonist
   DG01468  Dopamine D2-receptor agonist
    DG00833  Dihydroergotamine
  DG01964  Ergot alkaloid
   DG01982  Antimigraine, ergot alkaloid
    DG00833  Dihydroergotamine
 Analgesic
  DG01518  5-HT1B/1D-receptor agonist
   DG00833  Dihydroergotamine
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00833  Dihydroergotamine
Other DBs
CAS: 6190-39-2
PubChem: 7849271
ChEBI: 59756
LigandBox: D02211
NIKKAJI: J220.302B
LinkDB
KCF data

ATOM        48
            1   C1z C    21.8848  -14.3760
            2   N1y N    21.8849  -15.6808
            3   C1y C    23.0033  -13.6769
            4   O2x O    20.7198  -13.6769
            5   O1a O    21.8382  -13.0246
            6   C1y C    23.0033  -16.3333
            7   C5x C    19.5548  -15.6808
            8   N1y N    24.1684  -14.3760
            9   C1x C    23.0033  -12.3721
            10  C1z C    19.5548  -14.3760
            11  C5x C    24.1684  -15.6808
            12  C1b C    23.0033  -17.6847
            13  O5x O    18.6227  -16.6129
            14  C1x C    25.2868  -13.7235
            15  C1x C    25.2868  -12.3721
            16  N1b N    17.8771  -13.6304
            17  C1a C    19.5548  -12.9313
            18  O5x O    25.2868  -16.3799
            19  C8y C    24.1218  -18.3372
            20  C5a C    16.3859  -14.3294
            21  C8x C    24.1218  -19.6420
            22  C8x C    25.2868  -17.6847
            23  C1y C    16.3859  -15.6808
            24  O5a O    15.2207  -13.6769
            25  C8x C    25.2402  -20.2944
            26  C8x C    26.4052  -18.3372
            27  C1x C    15.2207  -16.3333
            28  C1x C    17.5509  -16.3333
            29  C8x C    26.4052  -19.6420
            30  C1y C    15.2207  -17.6381
            31  N1y N    17.5509  -17.6381
            32  C8y C    14.1023  -18.2906
            33  C1y C    16.3859  -18.3372
            34  C1a C    18.6693  -18.3372
            35  C8y C    14.1023  -19.6420
            36  C8x C    12.9373  -17.6381
            37  C1x C    16.3859  -19.6420
            38  C8y C    15.2207  -20.2944
            39  C8y C    12.9373  -20.2944
            40  C8x C    11.8189  -18.2906
            41  C8x C    15.2207  -21.5993
            42  N4x N    12.9373  -21.5993
            43  C8x C    11.8189  -19.6420
            44  S4a S    30.3778  -16.8923
            45  C1a C    28.9779  -16.8923
            46  O1d O    31.7777  -16.8923
            47  O1d O    30.3778  -15.4924
            48  O1d O    30.3778  -18.2923
BOND        54
            1     1   5 1 #Down
            2     2   6 1
            3     2   7 1
            4     3   8 1
            5     3   9 1
            6     4  10 1
            7     6  11 1
            8     6  12 1 #Down
            9     7  13 2
            10    8  14 1
            11    9  15 1
            12   10  16 1
            13   10  17 1 #Up
            14   11  18 2
            15   12  19 1
            16   16  20 1
            17   19  21 2
            18   19  22 1
            19   23  20 1 #Up
            20   20  24 2
            21   21  25 1
            22   22  26 2
            23   23  27 1
            24   23  28 1
            25   25  29 2
            26   27  30 1
            27   28  31 1
            28   30  32 1
            29   30  33 1
            30   31  34 1
            31   32  35 1
            32   32  36 2
            33   33  37 1
            34   35  38 1
            35   35  39 2
            36   36  40 1
            37   38  41 2
            38   39  42 1
            39   39  43 1
            40    7  10 1
            41    8  11 1
            42   14  15 1
            43   26  29 1
            44   31  33 1
            45   37  38 1
            46   40  43 2
            47   41  42 1
            48    1   2 1
            49    1   3 1
            50    1   4 1
            51   44  45 1
            52   44  46 1
            53   44  47 2
            54   44  48 2

» Japanese version   » Back

KEGG   DRUG: Dihydroergotamine tartrate
Entry
D07838                      Drug                                   
Name
Dihydroergotamine tartrate;
Divegal (TN)
Formula
(C33H37N5O5)2. C4H6O6
Exact mass
1316.5754
Mol weight
1317.44
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01472  Dopamine agonist
  DG01468  Dopamine D2-receptor agonist
 DG01964  Ergot alkaloid
  DG01982  Antimigraine, ergot alkaloid
Analgesic
 DG01518  5-HT1B/1D-receptor agonist
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
ATC code: N02CA01
Chemical structure group: DG00833
Product (DG00833): D02211<US>
Efficacy
Antimigraine, Vasoconstrictor, Serotonin receptor agonist
Comment
Ergot alkaloid
Target
HTR1B [HSA:3351] [KO:K04153]
HTR1D [HSA:3352] [KO:K04153]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Structure map
map07048  Antimigraines
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N02 ANALGESICS
   N02C ANTIMIGRAINE PREPARATIONS
    N02CA Ergot alkaloids
     N02CA01 Dihydroergotamine
      D07838  Dihydroergotamine tartrate
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01472  Dopamine agonist
   DG01468  Dopamine D2-receptor agonist
    DG00833  Dihydroergotamine
     D07838  Dihydroergotamine tartrate
  DG01964  Ergot alkaloid
   DG01982  Antimigraine, ergot alkaloid
    DG00833  Dihydroergotamine
     D07838  Dihydroergotamine tartrate
 Analgesic
  DG01518  5-HT1B/1D-receptor agonist
   DG00833  Dihydroergotamine
    D07838  Dihydroergotamine tartrate
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00833  Dihydroergotamine
     D07838  Dihydroergotamine tartrate
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Serotonin
    HTR1B
     D07838  Dihydroergotamine tartrate
    HTR1D
     D07838  Dihydroergotamine tartrate
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D07838
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01472  Dopamine agonist
   DG01468  Dopamine D2-receptor agonist
    DG00833  Dihydroergotamine
  DG01964  Ergot alkaloid
   DG01982  Antimigraine, ergot alkaloid
    DG00833  Dihydroergotamine
 Analgesic
  DG01518  5-HT1B/1D-receptor agonist
   DG00833  Dihydroergotamine
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00833  Dihydroergotamine
Other DBs
CAS: 5989-77-5
PubChem: 96024535
ChEBI: 59757
LigandBox: D07838
NIKKAJI: J231.221B
LinkDB
KCF data

ATOM        96
            1   C1z C    24.2900  -15.6800
            2   N1y N    24.3600  -17.0100
            3   C1y C    25.4800  -15.0500
            4   O2x O    23.1700  -15.0500
            5   O1a O    24.2900  -14.3500
            6   C1y C    25.4800  -17.6400
            7   C5x C    21.9800  -17.0100
            8   N1y N    26.6000  -15.6800
            9   C1x C    25.4800  -13.7200
            10  C1z C    21.9800  -15.6800
            11  C5x C    26.6000  -17.0100
            12  C1b C    25.4800  -18.9700
            13  O5x O    21.0700  -17.9200
            14  C1x C    27.7200  -15.0500
            15  C1x C    27.7200  -13.7200
            16  N1b N    20.3000  -14.9100
            17  C1a C    21.9800  -14.2800
            18  O5x O    27.7900  -17.7100
            19  C8y C    26.6000  -19.6700
            20  C5a C    18.8300  -15.6800
            21  C8x C    26.6000  -21.0000
            22  C8x C    27.7900  -18.9700
            23  C1y C    18.8300  -17.0100
            24  O5a O    17.6400  -14.9800
            25  C8x C    27.7200  -21.6300
            26  C8x C    28.9100  -19.6700
            27  C1x C    17.6400  -17.6400
            28  C1x C    19.9500  -17.6400
            29  C8x C    28.9100  -21.0000
            30  C1y C    17.6400  -18.9700
            31  N1y N    19.9500  -18.9700
            32  C8y C    16.5200  -19.6000
            33  C1y C    18.8300  -19.6700
            34  C1a C    21.1400  -19.6700
            35  C8y C    16.5200  -20.9300
            36  C8x C    15.4000  -18.9700
            37  C1x C    18.8300  -21.0000
            38  C8y C    17.6400  -21.6300
            39  C8y C    15.4000  -21.6300
            40  C8x C    14.2100  -19.6000
            41  C8x C    17.6400  -22.9600
            42  N4x N    15.4000  -22.9600
            43  C8x C    14.2100  -20.9300
            44  O6a O    32.2700  -19.3200
            45  C6a C    33.4600  -18.6200
            46  C1c C    34.7200  -19.3200
            47  C1c C    35.9100  -18.6200
            48  C6a C    37.1000  -19.3200
            49  O6a O    38.3600  -18.6200
            50  O6a O    37.1000  -20.7200
            51  O6a O    33.4600  -17.2200
            52  O1a O    34.7200  -20.7200
            53  O1a O    35.9100  -17.2200
            54  C1z C    24.2900  -15.6800
            55  O1a O    24.2900  -14.3500
            56  N1y N    24.3600  -17.0100
            57  C1y C    25.4800  -17.6400
            58  C5x C    26.6000  -17.0100
            59  O5x O    27.7900  -17.7100
            60  N1y N    26.6000  -15.6800
            61  C1y C    25.4800  -15.0500
            62  C1x C    25.4800  -13.7200
            63  C1x C    27.7200  -13.7200
            64  C1x C    27.7200  -15.0500
            65  C1b C    25.4800  -18.9700
            66  C8y C    26.6000  -19.6700
            67  C8x C    26.6000  -21.0000
            68  C8x C    27.7200  -21.6300
            69  C8x C    28.9100  -21.0000
            70  C8x C    28.9100  -19.6700
            71  C8x C    27.7900  -18.9700
            72  C5x C    21.9800  -17.0100
            73  O5x O    21.0700  -17.9200
            74  C1z C    21.9800  -15.6800
            75  O2x O    23.1700  -15.0500
            76  N1b N    20.3000  -14.9100
            77  C5a C    18.8300  -15.6800
            78  C1y C    18.8300  -17.0100
            79  C1x C    17.6400  -17.6400
            80  C1y C    17.6400  -18.9700
            81  C8y C    16.5200  -19.6000
            82  C8y C    16.5200  -20.9300
            83  C8y C    17.6400  -21.6300
            84  C8x C    17.6400  -22.9600
            85  N4x N    15.4000  -22.9600
            86  C8y C    15.4000  -21.6300
            87  C8x C    14.2100  -20.9300
            88  C8x C    14.2100  -19.6000
            89  C8x C    15.4000  -18.9700
            90  C1x C    18.8300  -21.0000
            91  C1y C    18.8300  -19.6700
            92  N1y N    19.9500  -18.9700
            93  C1x C    19.9500  -17.6400
            94  C1a C    21.1400  -19.6700
            95  O5a O    17.6400  -14.9800
            96  C1a C    21.9800  -14.2800
BOND        109
            1    44  45 1
            2    45  46 1
            3    46  47 1
            4    47  48 1
            5    48  49 1
            6    48  50 2
            7    45  51 2
            8    46  52 1 #Up
            9    47  53 1 #Up
            10    1   5 1 #Down
            11    2   6 1
            12    2   7 1
            13    3   8 1
            14    3   9 1
            15    4  10 1
            16    6  11 1
            17    6  12 1 #Down
            18    7  13 2
            19    8  14 1
            20    9  15 1
            21   10  16 1
            22   10  17 1 #Up
            23   11  18 2
            24   12  19 1
            25   16  20 1
            26   19  21 2
            27   19  22 1
            28   23  20 1 #Up
            29   20  24 2
            30   21  25 1
            31   22  26 2
            32   23  27 1
            33   23  28 1
            34   25  29 2
            35   27  30 1
            36   28  31 1
            37   30  32 1
            38   30  33 1
            39   31  34 1
            40   32  35 1
            41   32  36 2
            42   33  37 1
            43   35  38 1
            44   35  39 2
            45   36  40 1
            46   38  41 2
            47   39  42 1
            48   39  43 1
            49    7  10 1
            50    8  11 1
            51   14  15 1
            52   26  29 1
            53   31  33 1
            54   37  38 1
            55   40  43 2
            56   41  42 1
            57    1   2 1
            58    1   3 1
            59    1   4 1
            60   54  55 1 #Down
            61   56  57 1
            62   56  72 1
            63   61  60 1
            64   61  62 1
            65   75  74 1
            66   57  58 1
            67   57  65 1 #Down
            68   72  73 2
            69   60  64 1
            70   62  63 1
            71   74  76 1
            72   74  96 1 #Up
            73   58  59 2
            74   65  66 1
            75   76  77 1
            76   66  67 2
            77   66  71 1
            78   78  77 1 #Up
            79   77  95 2
            80   67  68 1
            81   71  70 2
            82   78  79 1
            83   78  93 1
            84   68  69 2
            85   79  80 1
            86   93  92 1
            87   80  81 1
            88   80  91 1
            89   92  94 1
            90   81  82 1
            91   81  89 2
            92   91  90 1
            93   82  83 1
            94   82  86 2
            95   89  88 1
            96   83  84 2
            97   86  85 1
            98   86  87 1
            99   72  74 1
            100  60  58 1
            101  64  63 1
            102  70  69 1
            103  92  91 1
            104  90  83 1
            105  88  87 2
            106  84  85 1
            107  54  56 1
            108  54  61 1
            109  54  75 1
BRACKET     1    13.3000  -23.9400   13.3000  -12.7400
            1    29.6800  -12.7400   29.6800  -23.9400
            1  2
 ORIGINAL  1    1   5   2   6  11  18   8   3   9  15  14  44  12  19  21  25
            1   29  26  22   7  13  10   4  16  20  23  27  30  32  35  38  41
            1   42  39  43  40  36  37  33  31  28  34  46  45  24  17
 REPEAT    1   57  58  59  60  61  62  63  64  65  66  67  68  69  70  71  72
            1   73  74  75  76  77  78  79  80  81  82  83  84  85  86  87  88
            1   89  90  91  92  93  94  95  96  97  98  99 100 101 102

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