KEGG   DRUG: Donepezil
Entry
D07869                      Drug                                   
Name
Donepezil (JAN/INN);
Donaz (TN);
Allydone (TN)
Formula
C24H29NO3
Exact mass
379.2147
Mol weight
379.492
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01595  Cholinesterase inhibitor
  DG01593  Acetylcholinesterase inhibitor
 DG01968  Antidementia agent
Metabolizing enzyme substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Therapeutic category: 1190
ATC code: N06DA02
Chemical structure group: DG00983
Product (DG00983): D07869<JP> D00670<JP/US>
Product (mixture): D11387<US>
Efficacy
Dementia therapeutic agent, Acetylcholinesterase inhibitor
Target
ACHE [HSA:43] [KO:K01049]
  Pathway
hsa00564  Glycerophospholipid metabolism
hsa04725  Cholinergic synapse
Metabolism
Enzyme: CYP3A4 [HSA:1576]; CYP2D6 [HSA:1565]
Interaction
Structure map
map07056  Agents for Alzheimer-type dementia
map07220  Cholinergic and anticholinergic drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06D ANTI-DEMENTIA DRUGS
    N06DA Anticholinesterases
     N06DA02 Donepezil
      D07869  Donepezil (JAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   119  Miscellaneous
    1190  Miscellaneous
     D07869  Donepezil (JAN/INN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01595  Cholinesterase inhibitor
   DG01593  Acetylcholinesterase inhibitor
    DG00983  Donepezil
     D07869  Donepezil
  DG01968  Antidementia agent
   DG00983  Donepezil
    D07869  Donepezil
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00983  Donepezil
    D07869  Donepezil
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00983  Donepezil
     D07869  Donepezil
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   Carboxylic-ester hydrolases
    ACHE
     D07869  Donepezil (JAN/INN) <JP>
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D07869
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D07869
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D07869
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01595  Cholinesterase inhibitor
   DG01593  Acetylcholinesterase inhibitor
    DG00983  Donepezil
  DG01968  Antidementia agent
   DG00983  Donepezil
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00983  Donepezil
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00983  Donepezil
Other DBs
CAS: 120014-06-4
PubChem: 96024565
ChEBI: 53289
LigandBox: D07869
NIKKAJI: J549.465F
LinkDB
KCF data

ATOM        28
            1   C8y C    26.5300  -17.3600
            2   C8x C    26.5300  -18.7600
            3   C8x C    27.7200  -19.4600
            4   C8x C    28.9100  -18.7600
            5   C8x C    28.9100  -17.3600
            6   C8x C    27.7200  -16.6600
            7   C1b C    25.2700  -16.6600
            8   N1y N    24.0800  -17.3600
            9   C1x C    22.8900  -16.6600
            10  C1x C    21.7000  -17.3600
            11  C1y C    21.7000  -18.7600
            12  C1x C    22.8900  -19.4600
            13  C1x C    24.0800  -18.7600
            14  C1b C    20.4400  -19.4600
            15  C1y C    19.2500  -18.7600
            16  C5x C    19.2500  -17.3600
            17  C8y C    17.9900  -16.8700
            18  C8y C    17.0800  -17.9900
            19  C1x C    17.9200  -19.1800
            20  O5x O    20.4400  -16.5900
            21  C8x C    17.4300  -15.5400
            22  C8y C    16.0300  -15.3300
            23  C8y C    15.1900  -16.4500
            24  C8x C    15.6800  -17.7800
            25  O2a O    15.5400  -14.0700
            26  C1a C    14.2100  -14.0700
            27  O2a O    13.8600  -16.4500
            28  C1a C    13.0900  -15.2600
BOND        31
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     1   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14    8  13 1
            15   11  14 1
            16   14  15 1
            17   15  16 1
            18   16  17 1
            19   17  18 1
            20   18  19 1
            21   15  19 1
            22   16  20 2
            23   17  21 2
            24   21  22 1
            25   22  23 2
            26   23  24 1
            27   18  24 2
            28   22  25 1
            29   25  26 1
            30   23  27 1
            31   27  28 1

» Japanese version   » Back

KEGG   DRUG: Donepezil hydrochloride
Entry
D00670                      Drug                                   
Name
Donepezil hydrochloride (JP18/USP);
Aricept (TN)
Product
ADLARITY (Corium), ARICEPT (Eisai)
  Generic
DONEPEZIL (American Health Packaging), DONEPEZIL (Bryant Ranch Prepack), DONEPEZIL (Camber Pharmaceuticals), DONEPEZIL (NuCare Pharmaceuticals), DONEPEZIL HYDROCHLORIDE (A-S Medication Solutions), DONEPEZIL HYDROCHLORIDE (ACI Healthcare USA), DONEPEZIL HYDROCHLORIDE (Alembic Pharmaceuticals), DONEPEZIL HYDROCHLORIDE (Aurobindo Pharma Limited), DONEPEZIL HYDROCHLORIDE (Bryant Ranch Prepack), DONEPEZIL HYDROCHLORIDE (Bryant Ranch Prepack), DONEPEZIL HYDROCHLORIDE (Bryant Ranch Prepack), DONEPEZIL HYDROCHLORIDE (Bryant Ranch Prepack), DONEPEZIL HYDROCHLORIDE (Bryant Ranch Prepack), DONEPEZIL HYDROCHLORIDE (Bryant Ranch Prepack), DONEPEZIL HYDROCHLORIDE (Bryant Ranch Prepack), DONEPEZIL HYDROCHLORIDE (Bryant Ranch Prepack), DONEPEZIL HYDROCHLORIDE (Bryant Ranch Prepack), DONEPEZIL HYDROCHLORIDE (Bryant Ranch Prepack), DONEPEZIL HYDROCHLORIDE (Bryant Ranch Prepack), DONEPEZIL HYDROCHLORIDE (Cadila Pharmaceuticals Limited), DONEPEZIL HYDROCHLORIDE (Cardinal Health), DONEPEZIL HYDROCHLORIDE (Direct Rx), DONEPEZIL HYDROCHLORIDE (DirectRx), DONEPEZIL HYDROCHLORIDE (Direct_Rx), DONEPEZIL HYDROCHLORIDE (Direct_Rx), DONEPEZIL HYDROCHLORIDE (Direct_Rx), DONEPEZIL HYDROCHLORIDE (Dr. Reddys Laboratories Limited), DONEPEZIL HYDROCHLORIDE (Dr. Reddys Laboratories Limited), DONEPEZIL HYDROCHLORIDE (Golden State Medical Supply), DONEPEZIL HYDROCHLORIDE (Golden State Medical Supply), DONEPEZIL HYDROCHLORIDE (Graviti Pharmaceuticals Private Limited), DONEPEZIL HYDROCHLORIDE (Lupin Pharmaceuticals), DONEPEZIL HYDROCHLORIDE (Macleods Pharmaceuticals Limited), DONEPEZIL HYDROCHLORIDE (Major Pharmaceuticals), DONEPEZIL HYDROCHLORIDE (NCS HealthCare of KY), DONEPEZIL HYDROCHLORIDE (NCS HealthCare of KY), DONEPEZIL HYDROCHLORIDE (NuCare Pharmaceuticals), DONEPEZIL HYDROCHLORIDE (PD-Rx Pharmaceuticals), DONEPEZIL HYDROCHLORIDE (Preferred Pharmaceuticals), DONEPEZIL HYDROCHLORIDE (Preferred Pharmaceuticals), DONEPEZIL HYDROCHLORIDE (Proficient Rx LP), DONEPEZIL HYDROCHLORIDE (Proficient Rx LP), DONEPEZIL HYDROCHLORIDE (REMEDYREPACK), DONEPEZIL HYDROCHLORIDE (REMEDYREPACK), DONEPEZIL HYDROCHLORIDE (Rising Pharma Holdings), DONEPEZIL HYDROCHLORIDE (Sandoz), DONEPEZIL HYDROCHLORIDE (ScieGen Pharmaceuticals), DONEPEZIL HYDROCHLORIDE (Solco Healthcare US), DONEPEZIL HYDROCHLORIDE (Solco Healthcare US), DONEPEZIL HYDROCHLORIDE (Strides Pharma Science Limited), DONEPEZIL HYDROCHLORIDE (Sun Pharmaceutical Industries), DONEPEZIL HYDROCHLORIDE (Torrent Pharmaceuticals Limited), DONEPEZIL HYDROCHLORIDE (Unichem Pharmaceuticals (USA)), DONEPEZIL HYDROCHLORIDE (Zydus Lifesciences Limited), DONEPEZIL HYDROCHLORIDE (Zydus Lifesciences Limited), DONEPEZIL HYDROCHLORIDE (Zydus Lifesciences Limited), DONEPEZIL HYDROCHLORIDE (Zydus Pharmaceuticals USA), DONEPEZIL HYDROCHLORIDE (Zydus Pharmaceuticals USA)
Formula
C24H29NO3. HCl
Exact mass
415.1914
Mol weight
415.9529
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01595  Cholinesterase inhibitor
  DG01593  Acetylcholinesterase inhibitor
 DG01968  Antidementia agent
Metabolizing enzyme substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Therapeutic category: 1190
ATC code: N06DA02
Chemical structure group: DG00983
Product (DG00983): D07869<JP> D00670<JP/US>
Product (mixture): D11387<US>
Efficacy
Dementia therapeutic agent, Acetylcholinesterase inhibitor
  Disease
Dementia of the Alzheimer’s type [DS:H00056]
Target
ACHE [HSA:43] [KO:K01049]
  Pathway
hsa00564  Glycerophospholipid metabolism
hsa04725  Cholinergic synapse
Metabolism
Enzyme: CYP3A4 [HSA:1576]; CYP2D6 [HSA:1565]
Interaction
Structure map
map07056  Agents for Alzheimer-type dementia
map07220  Cholinergic and anticholinergic drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06D ANTI-DEMENTIA DRUGS
    N06DA Anticholinesterases
     N06DA02 Donepezil
      D00670  Donepezil hydrochloride (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
 Antidementia Agents
  Cholinesterase Inhibitors
   Donepezil
    D00670  Donepezil hydrochloride (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   119  Miscellaneous
    1190  Miscellaneous
     D00670  Donepezil hydrochloride (JP18/USP)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01595  Cholinesterase inhibitor
   DG01593  Acetylcholinesterase inhibitor
    DG00983  Donepezil
     D00670  Donepezil hydrochloride
  DG01968  Antidementia agent
   DG00983  Donepezil
    D00670  Donepezil hydrochloride
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00983  Donepezil
    D00670  Donepezil hydrochloride
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00983  Donepezil
     D00670  Donepezil hydrochloride
Drug classes [BR:br08332]
 Neuropsychiatric agent
  DG01968  Antidementia agent
   D00670  Donepezil hydrochloride
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   Carboxylic-ester hydrolases
    ACHE
     D00670  Donepezil hydrochloride (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00670  Donepezil hydrochloride
  D00670  Donepezil hydrochloride tablets
  D00670  Donepezil hydrochloride fine granules
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00670
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01595  Cholinesterase inhibitor
   DG01593  Acetylcholinesterase inhibitor
    DG00983  Donepezil
  DG01968  Antidementia agent
   DG00983  Donepezil
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00983  Donepezil
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00983  Donepezil
Other DBs
CAS: 120011-70-3
PubChem: 7847736
ChEBI: 4696
LigandBox: D00670
NIKKAJI: J567.261I
LinkDB
KCF data

ATOM        29
            1   X   Cl   25.2087  -22.5699
            2   C8y C    24.0800  -25.5500
            3   C8x C    24.0800  -26.9500
            4   C8x C    25.2924  -27.6500
            5   C8x C    26.5049  -26.9500
            6   C8x C    26.5049  -25.5500
            7   C8x C    25.2924  -24.8500
            8   C1b C    22.8676  -24.8500
            9   N1y N    21.6721  -25.5404
            10  C1x C    20.4847  -24.8549
            11  C1x C    19.2723  -25.5550
            12  C1y C    19.2724  -26.9550
            13  C1x C    20.4597  -27.6404
            14  C1x C    21.6721  -26.9404
            15  C1b C    18.0455  -27.6636
            16  C1y C    16.8381  -26.9666
            17  C5x C    16.8881  -25.5501
            18  C8y C    15.5615  -25.0643
            19  C8y C    14.6895  -26.1759
            20  C1x C    15.4772  -27.3487
            21  O5x O    18.0372  -24.7769
            22  C8x C    15.0396  -23.7652
            23  C8y C    13.6536  -23.5677
            24  C8y C    12.7816  -24.6793
            25  C8x C    13.3035  -25.9784
            26  O2a O    13.1387  -22.2867
            27  C1a C    11.7702  -22.2314
            28  O2a O    11.4279  -24.6970
            29  C1a C    10.7132  -23.4957
BOND        31
            1     2   3 2
            2     3   4 1
            3     4   5 2
            4     5   6 1
            5     6   7 2
            6     2   7 1
            7     2   8 1
            8     8   9 1
            9     9  10 1
            10   10  11 1
            11   11  12 1
            12   12  13 1
            13   13  14 1
            14    9  14 1
            15   12  15 1
            16   15  16 1
            17   16  17 1
            18   17  18 1
            19   18  19 1
            20   19  20 1
            21   16  20 1
            22   17  21 2
            23   18  22 2
            24   22  23 1
            25   23  24 2
            26   24  25 1
            27   19  25 2
            28   23  26 1
            29   26  27 1
            30   24  28 1
            31   28  29 1

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