KEGG   DRUG: Flecainide
Entry
D07962                      Drug                                   
Name
Flecainide (INN)
Formula
C17H20F6N2O3
Exact mass
414.1378
Mol weight
414.3427
Structure
Simcomp
Class
Cardiovascular agent
 DG01653  Antiarrhythmics
  DG01652  Class I antiarrhythmic agent
   DG01650  Class Ic antiarrhythmic agent
Metabolizing enzyme substrate
 DG01644  CYP2D6 substrate
Remark
Same as: C07001
ATC code: C01BC04
Chemical structure group: DG00201
Product (DG00201): D00638<JP/US>
Efficacy
Antiarrhythmic, Sodium channel blocker
Target
SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]
  Pathway
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04728  Dopaminergic synapse
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Structure map
map07037  Antiarrhythmic drugs
map07231  Sodium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01B ANTIARRHYTHMICS, CLASS I AND III
    C01BC Antiarrhythmics, class Ic
     C01BC04 Flecainide
      D07962  Flecainide (INN)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01653  Antiarrhythmics
   DG01652  Class I antiarrhythmic agent
    DG01650  Class Ic antiarrhythmic agent
     DG00201  Flecainide
      D07962  Flecainide
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00201  Flecainide
    D07962  Flecainide
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D07962  Flecainide (INN)
    SCN2A
     D07962  Flecainide (INN)
    SCN3A
     D07962  Flecainide (INN)
    SCN4A
     D07962  Flecainide (INN)
    SCN5A
     D07962  Flecainide (INN)
    SCN8A
     D07962  Flecainide (INN)
    SCN9A
     D07962  Flecainide (INN)
    SCN10A
     D07962  Flecainide (INN)
    SCN11A
     D07962  Flecainide (INN)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D07962
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01653  Antiarrhythmics
   DG01652  Class I antiarrhythmic agent
    DG01650  Class Ic antiarrhythmic agent
     DG00201  Flecainide
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00201  Flecainide
Other DBs
CAS: 54143-55-4
PubChem: 96024657
ChEBI: 75984
LigandBox: D07962
NIKKAJI: J12.413C
LinkDB
KCF data

ATOM        28
            1   C1x C    18.1300  -17.2900
            2   C1x C    18.1300  -18.6900
            3   N1x N    19.3900  -19.3900
            4   C1y C    20.5800  -18.6900
            5   C1x C    20.5800  -17.2900
            6   C1x C    19.3900  -16.5900
            7   C1b C    21.8400  -19.3900
            8   N1b N    23.0300  -18.6900
            9   C5a C    24.2200  -19.3900
            10  C8y C    25.4100  -18.6900
            11  O5a O    24.2200  -20.7900
            12  C8y C    26.6000  -19.3900
            13  C8x C    27.7900  -18.6900
            14  C8x C    27.7900  -17.2900
            15  C8y C    26.6000  -16.5900
            16  C8x C    25.4100  -17.2900
            17  O2a O    26.6000  -15.1900
            18  C1b C    27.8600  -14.4200
            19  C1d C    29.0500  -15.1200
            20  X   F    30.2400  -15.8200
            21  X   F    28.3500  -16.3800
            22  X   F    29.7500  -13.9300
            23  O2a O    26.6000  -20.7900
            24  C1b C    27.7900  -21.4900
            25  C1d C    28.9800  -20.7900
            26  X   F    30.1700  -20.0900
            27  X   F    29.6800  -21.9800
            28  X   F    28.2800  -19.5300
BOND        29
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    9  11 2
            12   10  12 2
            13   12  13 1
            14   13  14 2
            15   14  15 1
            16   15  16 2
            17   10  16 1
            18   15  17 1
            19   17  18 1
            20   18  19 1
            21   19  20 1
            22   19  21 1
            23   19  22 1
            24   12  23 1
            25   23  24 1
            26   24  25 1
            27   25  26 1
            28   25  27 1
            29   25  28 1

» Japanese version   » Back

KEGG   DRUG: Flecainide acetate
Entry
D00638                      Drug                                   
Name
Flecainide acetate (JP18/USP);
Tambocor (TN)
Product
  Generic
Formula
C17H20F6N2O3. C2H4O2
Exact mass
474.1589
Mol weight
474.3947
Structure
Simcomp
Class
Cardiovascular agent
 DG01653  Antiarrhythmics
  DG01652  Class I antiarrhythmic agent
   DG01650  Class Ic antiarrhythmic agent
Metabolizing enzyme substrate
 DG01644  CYP2D6 substrate
Remark
Therapeutic category: 2129
ATC code: C01BC04
Chemical structure group: DG00201
Product (DG00201): D00638<JP/US>
Efficacy
Antiarrhythmic, Sodium channel blocker
  Disease
Atrial fibrillation/flutter [DS:H00731]
Target
SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]
  Pathway
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04728  Dopaminergic synapse
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Structure map
map07037  Antiarrhythmic drugs
map07231  Sodium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01B ANTIARRHYTHMICS, CLASS I AND III
    C01BC Antiarrhythmics, class Ic
     C01BC04 Flecainide
      D00638  Flecainide acetate (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Antiarrhythmics
   Vaughn Williams-Class I
    Flecainide
     D00638  Flecainide acetate (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   212  Antiarrhythmic agents
    2129  Others
     D00638  Flecainide acetate (JP18/USP)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01653  Antiarrhythmics
   DG01652  Class I antiarrhythmic agent
    DG01650  Class Ic antiarrhythmic agent
     DG00201  Flecainide
      D00638  Flecainide acetate
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00201  Flecainide
    D00638  Flecainide acetate
Drug classes [BR:br08332]
 Cardiovascular agent
  DG01653  Antiarrhythmics
   D00638  Flecainide acetate
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D00638  Flecainide acetate (JP18/USP) <JP/US>
    SCN2A
     D00638  Flecainide acetate (JP18/USP) <JP/US>
    SCN3A
     D00638  Flecainide acetate (JP18/USP) <JP/US>
    SCN4A
     D00638  Flecainide acetate (JP18/USP) <JP/US>
    SCN5A
     D00638  Flecainide acetate (JP18/USP) <JP/US>
    SCN8A
     D00638  Flecainide acetate (JP18/USP) <JP/US>
    SCN9A
     D00638  Flecainide acetate (JP18/USP) <JP/US>
    SCN10A
     D00638  Flecainide acetate (JP18/USP) <JP/US>
    SCN11A
     D00638  Flecainide acetate (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00638  Flecainide acetate
  D00638  Flecainide acetate
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00638
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01653  Antiarrhythmics
   DG01652  Class I antiarrhythmic agent
    DG01650  Class Ic antiarrhythmic agent
     DG00201  Flecainide
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00201  Flecainide
Other DBs
CAS: 54143-56-5
PubChem: 7847704
ChEBI: 5091
LigandBox: D00638
NIKKAJI: J244.931E
LinkDB
KCF data

ATOM        32
            1   C1x C     3.7100  -14.3500
            2   C1x C     3.7100  -15.7500
            3   N1x N     4.9224  -16.4500
            4   C1y C     6.1349  -15.7500
            5   C1x C     6.1349  -14.3500
            6   C1x C     4.9224  -13.6500
            7   C1b C     7.3660  -16.4610
            8   N1b N     8.5712  -15.7653
            9   C5a C     9.7535  -16.4481
            10  C8y C    10.9475  -15.7588
            11  O5a O     9.7535  -17.8498
            12  C8y C    12.1354  -16.4448
            13  C8x C    13.3479  -15.7449
            14  C8x C    13.3480  -14.3449
            15  C8y C    12.1601  -13.6589
            16  C8x C    10.9476  -14.3588
            17  O2a O    12.1601  -12.2501
            18  C1b C    13.3874  -11.5414
            19  C1d C    14.5904  -12.2360
            20  X   F    15.8028  -12.9360
            21  X   F    13.8771  -13.4722
            22  X   F    15.2764  -11.0472
            23  O2a O    12.1354  -17.8498
            24  C1b C    13.3288  -18.5389
            25  C1d C    14.5148  -17.8542
            26  X   F    15.7273  -17.1542
            27  X   F    15.2066  -19.0527
            28  X   F    13.8071  -16.6279
            29  C6a C    19.2500  -15.3300
            30  C1a C    20.4639  -16.0327
            31  O6a O    18.0419  -16.0327
            32  O6a O    19.2500  -13.9303
BOND        32
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    9  11 2
            12   10  12 2
            13   12  13 1
            14   13  14 2
            15   14  15 1
            16   15  16 2
            17   10  16 1
            18   15  17 1
            19   17  18 1
            20   18  19 1
            21   19  20 1
            22   19  21 1
            23   19  22 1
            24   12  23 1
            25   23  24 1
            26   24  25 1
            27   25  26 1
            28   25  27 1
            29   25  28 1
            30   29  30 1
            31   29  31 1
            32   29  32 2

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