| Entry |
|
|---|
| Name |
Fludarabine (INN);
Fluradosa (TN) |
|---|
| Formula |
C10H12FN5O4
|
|---|
| Exact mass |
285.0873
|
|---|
| Mol weight |
285.23
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Antineoplastic
DG02018 Antimetabolite
DG01958 Nucleic acid derivative, antineoplastic
DG01439 Arabinofuranosyl type antineoplastic
|
|---|
| Remark |
| Product (DG00685): | D01907<JP/US> |
|
|---|
| Efficacy |
Antineoplastic, Antimetabolite |
|---|
| Comment |
Arabinofuranosyl derivative
|
|---|
| Target |
RRM1 [HSA: 6240] [KO: K10807] DNA polymerase RNA polymerase |
|---|
| Pathway |
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07041 | Antineoplastics - antimetabolic agents |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L01 ANTINEOPLASTIC AGENTS
L01B ANTIMETABOLITES
L01BB Purine analogues
L01BB05 Fludarabine
D07966 Fludarabine (INN)
Drug groups [BR:br08330]
Antineoplastic
DG02018 Antimetabolite
DG01958 Nucleic acid derivative, antineoplastic
DG01439 Arabinofuranosyl type antineoplastic
DG00685 Fludarabine
D07966 Fludarabine
Target-based classification of drugs [BR:br08310]
Enzymes
Oxidoreductases (EC1)
Ribonucleoside-diphosphate reductase
RRM1
D07966 Fludarabine (INN)
Prodrugs [br08324.html]
D07966
Drug groups [BR:br08330]
Antineoplastic
DG02018 Antimetabolite
DG01958 Nucleic acid derivative, antineoplastic
DG01439 Arabinofuranosyl type antineoplastic
DG00685 Fludarabine
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 20
1 C1y C 23.1000 -18.6200
2 C1y C 24.5000 -18.6200
3 C1y C 24.9200 -17.2900
4 O2x O 23.8000 -16.4500
5 C1y C 22.6800 -17.2900
6 O1a O 22.4000 -19.8100
7 O1a O 25.2000 -19.8100
8 N5x N 27.3000 -18.6900
9 C8y C 27.3000 -17.2900
10 N4y N 26.1100 -16.5900
11 C1b C 21.4900 -16.5900
12 C8y C 28.4900 -19.3900
13 N5x N 29.7500 -18.6900
14 C8y C 29.7500 -17.2900
15 C8y C 28.4900 -16.5900
16 N5x N 28.2100 -15.2600
17 C8x C 26.8800 -15.1200
18 N1a N 30.8700 -16.5900
19 X F 28.4900 -20.7900
20 O1a O 20.2719 -17.2801
BOND 22
1 1 2 1
2 2 3 1
3 3 4 1
4 4 5 1
5 1 5 1
6 1 6 1 #Down
7 2 7 1 #Up
8 8 9 1
9 9 10 1
10 3 10 1 #Up
11 5 11 1 #Up
12 8 12 2
13 12 13 1
14 13 14 2
15 14 15 1
16 9 15 2
17 15 16 1
18 16 17 2
19 17 10 1
20 14 18 1
21 12 19 1
22 11 20 1
|
|---|
