| Entry |
|
|---|
| Name |
Fludrocortisone acetate (JP18/USP);
Florinef acetate (TN) |
|---|
| Product |
|
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| Generic |
FLUDROCORTISONE ACETATE (American Health Packaging), FLUDROCORTISONE ACETATE (Amneal Pharmaceuticals NY LLC), FLUDROCORTISONE ACETATE (Amneal Pharmaceuticals of New York LLC), FLUDROCORTISONE ACETATE (AvKARE), FLUDROCORTISONE ACETATE (AvPAK), FLUDROCORTISONE ACETATE (Bryant Ranch Prepack), FLUDROCORTISONE ACETATE (Bryant Ranch Prepack), FLUDROCORTISONE ACETATE (Cardinal Health 107), FLUDROCORTISONE ACETATE (Major Pharmaceuticals), FLUDROCORTISONE ACETATE (NCS HealthCare of KY), FLUDROCORTISONE ACETATE (NorthStar Rx LLC), FLUDROCORTISONE ACETATE (Novitium Pharma LLC), FLUDROCORTISONE ACETATE (Teva Pharmaceuticals USA) |
|---|
| Formula |
C23H31FO6
|
|---|
| Exact mass |
422.2105
|
|---|
| Mol weight |
422.49
|
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| Structure |
|
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| Simcomp |
|
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| Class |
Anti-inflammatory
DG01955 Corticosteroid
|
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| Remark |
| Therapeutic category: | 2459 |
| Product (DG00506): | D00986<JP/US> |
|
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| Efficacy |
Salts metabolic regulator, Replenisher (glucocorticoid), Mineralocorticoid receptor agonist |
|---|
| Disease |
|
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| Comment |
mineralocorticoid
|
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| Target |
|
|---|
| Pathway |
| hsa04960 | Aldosterone-regulated sodium reabsorption |
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07225 | Glucocorticoid and mineralocorticoid receptor agonists/antagonists |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
H02 CORTICOSTEROIDS FOR SYSTEMIC USE
H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
H02AA Mineralocorticoids
H02AA02 Fludrocortisone
D00986 Fludrocortisone acetate (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
Fludrocortisone
D00986 Fludrocortisone acetate (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
24 Hormones
245 Adrenal hormone preparations
2459 Others
D00986 Fludrocortisone acetate (JP18/USP)
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG00506 Fludrocortisone
D00986 Fludrocortisone acetate
Drug classes [BR:br08332]
Anti-inflammatory
DG01955 Corticosteroid
D00986 Fludrocortisone acetate
Target-based classification of drugs [BR:br08310]
Nuclear receptors
Estrogen like receptors
3-Ketosteroid receptor
NR3C2 (MR)
D00986 Fludrocortisone acetate (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00986 Fludrocortisone acetate
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG00506 Fludrocortisone
|
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 30
1 C1x C 18.2700 -29.8900
2 C5x C 18.2700 -31.2900
3 C2x C 19.4600 -31.9900
4 C2y C 20.7200 -31.2900
5 C1z C 20.7200 -29.8900
6 C1x C 19.4600 -29.1900
7 C1x C 21.9100 -31.9900
8 C1x C 23.1000 -31.2900
9 C1y C 23.1000 -29.8900
10 C1z C 21.9100 -29.1900
11 C1y C 24.2900 -29.1900
12 C1z C 24.2900 -27.7900
13 C1x C 23.1000 -27.0900
14 C1y C 21.9100 -27.7900
15 O5x O 17.0800 -31.9900
16 C1a C 20.7200 -28.4900
17 O1a O 20.7200 -27.0900
18 C1a C 24.2900 -26.3900
19 X F 21.9100 -30.5900
20 C1x C 26.7149 -29.1900
21 C1x C 26.7149 -27.7900
22 C1z C 25.5024 -27.0900
23 C5a C 25.5024 -25.6902
24 O5a O 24.2732 -24.9803
25 C1b C 26.6980 -24.9998
26 O7a O 27.8852 -25.6852
27 C7a C 29.0766 -24.9972
28 C1a C 30.2659 -25.6839
29 O6a O 29.0767 -23.5903
30 O1a O 26.6979 -26.3996
BOND 33
1 1 2 1
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 1
6 1 6 1
7 4 7 1
8 7 8 1
9 8 9 1
10 9 10 1
11 5 10 1
12 9 11 1
13 11 12 1
14 12 13 1
15 13 14 1
16 10 14 1
17 2 15 2
18 5 16 1 #Up
19 14 17 1 #Up
20 12 18 1 #Up
21 10 19 1 #Down
22 11 20 1
23 20 21 1
24 21 22 1
25 12 22 1
26 22 23 1 #Up
27 23 24 2
28 23 25 1
29 25 26 1
30 26 27 1
31 27 28 1
32 27 29 2
33 22 30 1 #Down
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