| Entry |
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| Name |
Fluticasone propionate (JAN/USP);
Cutivate (TN);
Flonase (TN);
Flovent (TN) |
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| Product |
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| Generic |
FLUTICASONE (Direct RX), FLUTICASONE (Lake Erie Medical DBA Quality Care Products LLC), FLUTICASONE (NuCare Pharmaceuticals), FLUTICASONE (Preferred Pharmaceuticals), FLUTICASONE (Proficient Rx LP), FLUTICASONE (RPK Pharmaceuticals), FLUTICASONE PROPIONATE (A-S Medication Solutions), FLUTICASONE PROPIONATE (A-S Medication Solutions), FLUTICASONE PROPIONATE (A-S Medication Solutions), FLUTICASONE PROPIONATE (A-S Medication Solutions), FLUTICASONE PROPIONATE (A-S Medication Solutions), FLUTICASONE PROPIONATE (A-S Medication Solutions), FLUTICASONE PROPIONATE (A-S Medication Solutions), FLUTICASONE PROPIONATE (A-S Medication Solutions), FLUTICASONE PROPIONATE (Apotex Corp.), FLUTICASONE PROPIONATE (Asclemed USA), FLUTICASONE PROPIONATE (Bryant Ranch Prepack), FLUTICASONE PROPIONATE (Bryant Ranch Prepack), FLUTICASONE PROPIONATE (Bryant Ranch Prepack), FLUTICASONE PROPIONATE (Bryant Ranch Prepack), FLUTICASONE PROPIONATE (Bryant Ranch Prepack), FLUTICASONE PROPIONATE (Bryant Ranch Prepack), FLUTICASONE PROPIONATE (Bryant Ranch Prepack), FLUTICASONE PROPIONATE (Bryant Ranch Prepack), FLUTICASONE PROPIONATE (Cosette Pharmaceuticals), FLUTICASONE PROPIONATE (Cosette Pharmaceuticals), FLUTICASONE PROPIONATE (Direct_RX), FLUTICASONE PROPIONATE (E. Fougera & Co. a division of Fougera Pharmaceuticals), FLUTICASONE PROPIONATE (Glenmark Pharmaceuticals), FLUTICASONE PROPIONATE (Golden State Medical Supply), FLUTICASONE PROPIONATE (Hikma Pharmaceuticals USA), FLUTICASONE PROPIONATE (NuCare Pharmaceuticals), FLUTICASONE PROPIONATE (NuCare Pharmaceuticals), FLUTICASONE PROPIONATE (Padagis Israel Pharmaceuticals), FLUTICASONE PROPIONATE (Padagis Israel Pharmaceuticals), FLUTICASONE PROPIONATE (Padagis Israel Pharmaceuticals), FLUTICASONE PROPIONATE (Prasco Laboratories), FLUTICASONE PROPIONATE (Prasco Laboratories), FLUTICASONE PROPIONATE (Preferred Pharmaceuticals), FLUTICASONE PROPIONATE (Preferred Pharmaceuticals), FLUTICASONE PROPIONATE (Proficient Rx LP), FLUTICASONE PROPIONATE (Proficient Rx LP), FLUTICASONE PROPIONATE (Proficient Rx LP), FLUTICASONE PROPIONATE (Proficient Rx LP), FLUTICASONE PROPIONATE (Quality Care Products), FLUTICASONE PROPIONATE (REMEDYREPACK), FLUTICASONE PROPIONATE (RPK Pharmaceuticals), FLUTICASONE PROPIONATE (RPK Pharmaceuticals), FLUTICASONE PROPIONATE (RPK Pharmaceuticals), FLUTICASONE PROPIONATE (RPK Pharmaceuticals), FLUTICASONE PROPIONATE (Redpharm Drug), FLUTICASONE PROPIONATE (Taro Pharmaceuticals U.S.A.), FLUTICASONE PROPIONATE SPRAY, METERED (Chartwell RX) |
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| Formula |
C25H31F3O5S
|
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| Exact mass |
500.1844
|
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| Mol weight |
500.57
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| Structure |
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| Simcomp |
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| Class |
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
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| Remark |
| Product (DG00420): | D01708<JP/US> D06315<JP/US> |
| Product (mixture): | D08699<JP/US> D10506<JP> D11656<US> |
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| Efficacy |
Antiasthmatic, Anti-inflammatory, Glucocorticoid receptor agonist |
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| Disease |
|
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| Target |
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
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| Interaction |
|
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| Structure map |
| map07225 | Glucocorticoid and mineralocorticoid receptor agonists/antagonists |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
D DERMATOLOGICALS
D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
D07A CORTICOSTEROIDS, PLAIN
D07AC Corticosteroids, potent (group III)
D07AC17 Fluticasone
D01708 Fluticasone propionate (JAN/USP) <JP/US>
R RESPIRATORY SYSTEM
R01 NASAL PREPARATIONS
R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
R01AD Corticosteroids
R01AD08 Fluticasone
D01708 Fluticasone propionate (JAN/USP) <JP/US>
R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
R03B OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS
R03BA Glucocorticoids
R03BA05 Fluticasone
D01708 Fluticasone propionate (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
Dermatological Agents
Dermatitis and Pruitus Agents
Glucocorticoids, Medium Potency
Fluticasone
D01708 Fluticasone propionate (JAN/USP)
Respiratory Tract/Pulmonary Agents
Anti-inflammatories, Inhaled Corticosteroids
Fluticasone
D01708 Fluticasone propionate (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
13 Agents affecting sensory organs
132 Otic and nasal agents
1329 Others
D01708 Fluticasone propionate (JAN/USP)
2 Agents affecting individual organs
22 Respiratory organ agents
229 Miscellaneous
2290 Miscellaneous
D01708 Fluticasone propionate (JAN/USP)
Risk category of Japanese OTC drugs [BR:br08312]
Designated second-class OTC drugs
Inorganic and organic chemicals
Fluticasone propionate
D01708 Fluticasone propionate (JAN/USP)
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00420 Fluticasone
D01708 Fluticasone propionate
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00420 Fluticasone
D01708 Fluticasone propionate
Drug classes [BR:br08332]
Anti-inflammatory
DG01955 Corticosteroid
D01708 Fluticasone propionate
Target-based classification of drugs [BR:br08310]
Nuclear receptors
Estrogen like receptors
3-Ketosteroid receptor
NR3C1 (GR)
D01708 Fluticasone propionate (JAN/USP) <JP/US>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D01708
Topical steroids potency [br08317.html]
Classification in the USA
D01708
Rx-to-OTC switch list in the USA [br08315.html]
D01708
Rx-to-OTC switch list in Japan [br08314.html]
D01708
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00420 Fluticasone
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00420 Fluticasone
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 34
1 C2x C 19.6000 -28.4200
2 C5x C 19.6000 -29.7500
3 C2x C 20.7900 -30.4500
4 C2y C 21.9100 -29.7500
5 C1z C 21.9100 -28.4200
6 C2x C 20.7900 -27.7200
7 C1y C 23.1000 -30.4500
8 C1x C 24.3600 -29.7500
9 C1y C 24.3600 -28.4200
10 C1z C 23.1000 -27.7200
11 C1y C 25.4100 -27.7200
12 C1z C 25.4100 -26.3900
13 C1x C 24.3600 -25.6900
14 C1y C 23.1000 -26.3900
15 C1x C 27.7200 -27.7200
16 C1y C 27.7200 -26.3900
17 C1z C 26.5300 -25.6900
18 O5x O 18.4100 -30.4500
19 C1a C 21.9100 -27.0200
20 X F 23.1000 -29.0500
21 O1a O 21.9100 -25.6900
22 C1a C 25.4100 -24.9900
23 O7a O 27.9300 -24.7800
24 C1a C 29.1200 -26.3900
25 X F 23.1000 -31.8500
26 C5a C 26.5300 -24.2900
27 O5a O 27.7900 -23.5900
28 S2a S 25.2700 -23.5900
29 C1b C 24.0800 -24.2900
30 X F 22.8900 -23.5900
31 C7a C 29.1200 -24.0800
32 C1b C 30.3100 -24.7800
33 C1a C 31.5000 -24.0800
34 O6a O 29.1200 -22.6800
BOND 37
1 1 2 1
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 1
6 1 6 2
7 4 7 1
8 7 8 1
9 8 9 1
10 9 10 1
11 5 10 1
12 9 11 1
13 11 12 1
14 12 13 1
15 13 14 1
16 10 14 1
17 11 15 1
18 15 16 1
19 16 17 1
20 12 17 1
21 2 18 2
22 5 19 1 #Up
23 10 20 1 #Down
24 14 21 1 #Up
25 12 22 1 #Up
26 17 23 1 #Down
27 16 24 1 #Down
28 7 25 1 #Down
29 17 26 1 #Up
30 26 27 2
31 26 28 1
32 28 29 1
33 29 30 1
34 31 32 1
35 31 23 1
36 32 33 1
37 31 34 2
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